Stability of admixture containing morphine sulfate, bupivacaine hydrochloride, and clonidine hydrochloride in an implantable infusion system

Journal of Pain and Symptom Management

Volumn 28, Issue 6, 2004, Pages 603-611

  Classen, Ashley M ^a   Wimbish, Gary H ^a   Kupiec, Thomas C ^a,b  

^a Trinity Pain Medicine Associates   (United States)

^b Analytical Research Laboratories   (United States)

Author keywords

bupivacaine; clonidine; Implantable pump; morphine sulfate; stability

Indexed keywords

BUPIVACAINE; CLONIDINE; MORPHINE SULFATE;

ARTICLE; BODY TEMPERATURE; CATALYSIS; DRUG MIXTURE; DRUG STABILITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INCUBATION TIME; MINIPUMP; SIMULATION;

ANALGESICS; BUPIVACAINE; CLONIDINE; COMPLEX MIXTURES; DRUG COMBINATIONS; DRUG STABILITY; DRUG STORAGE; HUMANS; INFUSION PUMPS, IMPLANTABLE; INJECTIONS, SPINAL; MORPHINE; PAIN; QUALITY ASSURANCE, HEALTH CARE;

EID: 10344258587     PISSN: 08853924     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpainsymman.2004.04.011     Document Type: Article

References (38)

1. N.G. Rainov, V. Hoidecke, and W. Kburkert Long-term intrathecal infusion of drug combinations for chronic back and leg pain J Pain Symptom Manage 22 4 2001 862 871
2. G. Bennett, M. Seratini, K. Burchiel, E. Buchser, and A. Classen Evidence-based review of the literature on intrathecal delivery of pain medication J Pain Symptom Manage 20 2 2000 S12 S36
3. G. Bennett, T. Deer, and S. Du Pen Future directions in the management of pain by intraspinal drug delivery J Pain Symptom Manage 20 2 2000 S44 S50
4. S.J. Hassenbusch, and R.K. Portenoy Current practices in intraspinal therapy-a survey of clinical trends and decision making J Pain Symptom Manage 20 1 2000 S4 S11
5. H.A. Paice, W. Winkelmuller, and K.J. Burchiel Clinical realities and economic considerations: efficacy of intrathecal pain therapy J Pain Symptom Manage 14 Suppl 1997 S14 S16
6. M.A. Chaney Side effects of intrathecal and epidural opioids Can J Anesth 42 1995 891 903
7. R.K. Portenoy, and S.R. Savage Clinical realities and economic considerations: special therapeutic issues in intrathecal therapy - tolerance and addiction J Pain Symptom Manage 14 Suppl 1997 S27 S35
8. T.L. Yaksh, S. Hassenbusch, and K. Burchiel Inflammatory masses associated with intrathecal drug infusion: a review of preclinical evidence and human data Pain Medicine 3 2002 300 312
9. M. Sjoberg, P. Nitescu, and L. Applegren Long-term intrathecal morphine and bupivacaine in patients with refractory cancer pain Anesthesiology 80 1994 284 297
10. B.J. Crul, R.T. Van Dongen, and D.G. Snijdclaar Long-term continuous intrathecal administration of morphine and bupivacaine at the upper cervical level: access by a lateral C1-C2 approach Anesth Analg 79 1994 594 597
11. S. Mercadante Intrathecal morphine and bupivacaine in advanced cancer pain patients implanted at home J Pain Symptom Manage 9 1994 201 207
12. R.T.M. Van Dongen, B.J.P. Crul, and M. De Bock Long-term intrathecal infusion of morphine and morphine-bupivacaine mixtures in the treatment of cancer pain: a retrospective analysis of 51 cases Pain 55 1993 119 123
13. P.V. Nitescu, P.O. Dahm, and L. Appelgren Continuous infusion of opioid and bupivacaine by externalized intrathecal catheters in long-term treatment of refractory nonmalignant pain Clin J Pain 14 1998 17 28
14. T. Buchheit, and R. Rauck Subarachnoid techniques for cancer pain therapy: when, why and how? Curr Rev Pain 3 3 1999 198 205
15. Y.E. Mironer, J.C. Haasis, and I. Chapple Efficacy and safety of intrathecal opioid/bupivacaine mixture in chronic nonmalignant pain: a double-blind, randomized, crossover, multicenter study by the National Forum of Independent Pain Clinicians (NFIPC) Neuromodulation 5 4 2002 208 213
16. B. Akerman, W. Arwestrom, and C. Post Local anesthetics potentiate spinal morphine antinociception Anesth Analg 67 1988 943 948
17. F.A. Gopi, A.K. Rattan, and J.S. McDonald Role of spinal opioid receptors in the antinociceptive interactions between intrathecal morphine and bupivacaine Anesth Analg 74 1974 726 734
18. R.T.M. Van Dongern, B.J.P. Crul, and J. Van Egmond Intrathecal coadministration of bupivacaine diminishes morphine dose progression during long-term intrathecal infusion in cancer patients Clin J Pain 15 1999 166 172
19. C.A. Fairbanks, L.S. Stone, and K.F. Kitto Alpha (2C)-adrenergic receptors mediate spinal analgesia and opioid synergy J Pharmacol Exp Ther 300 1 2002 282 290
20. K. Honda, K. Koga, and T. Moriyama Intrathecal alpha2 adrenoceptor agonist clonidine inhibits mechanical transmission in mouse spinal cord via activation of muscarinic M1 receptors Neurosci Lett 322 3 2002 161 164
21. K. Kumar, M. Kelly, and T. Pirlot Continuous intrathecal morphine treatment for chronic pain of nonmalignant etiology: long-term benefits and efficacy Surg Neurol 55 2 2001 79 88
22. P.J. Siddall, A.R. Molloy, and S. Walker The efficacy of intrathecal morphine and clonidine in the treatment of pain after spinal cord injury Anesth Analg 91 6 2000 493 1498
23. M.H. Ossipov, Y. Lopez, and D. Bian Synergistic antinociceptive interactions of morphine and clonidine in rats with nerve-ligation injury Anesth 86 1 1997 196 204
24. E.I. Uhle, R. Becker, S. Gatsche, and H. Bertalanffy Continuous intrathecal clonidine administration for the treatment of neuropathic pain Sterotact Funct Neurosurg 75 4 2000 167 175
25. T.L. Yaksh, K.A. Horais, and N.A. Tozier Chronically infused intrathecal morphine in dogs Anesthesiology 99 2003 174 187
26. T. Buchheit, and R. Rauck Subarachnoid techniques for cancer pain therapy: when, why and how Curr Rev Pain 3 3 1999 198 205
27. P.S. Tumber, and D.R. Fitzgibbon The control of severe cancer pain by continuous intrathecal infusion and patient controlled intrathecal analgesia with morphine, bupivacaine and clonidine Pain 78 3 1998 217 220
28. S. Mercadante Neuraxial techniques for cancer pain: an option about unresolved therapeutic dilemmas Req Anesth Pain Med 24 1 1999 74 83
29. I. Dobrydnjov, K. Axelsson, J. Samarutel, and B. Holmstrom Postoperative pain relief following intrathecal bupivacaine combined with intrathecal or oral clonidine Acta Anaesthesiol Scand 46 7 2002 806 814
30. S. Hassenbusch, J. Garber, and E. Buchser Alternative intrathecal agents for the treatment of pain Neuromodulation 2 1999 85 91
31. S. Mercadante Problems of long-term spinal opioid treatment in advance cancer patients Pain 79 1999 1 13
32. V.C. Anderson, and K.J. Burchiel A prospective study of long-term intrathecal morphine in the management of chronic nonmalignant pain Neurosurgery 44 1999 289 300
33. E.S. Krames Practical issues when using neuraxial infusion Oncology 13 1999 37 44
34. K.R. Hildebrand, D.D. Elsberry, and T.R. Deer Stability, compatibility and safety of intrathecal bupivacaine administered chronically via an implantable delivery system Clin J Pain 17 2001 239 244
35. H. Wulf, M. Gleim, and C. Mignat The stability of mixtures of morphine hydrochloride, bupivacaine hydrochloride and clonidine hydrochloride in portable pump reservoirs for the management of chronic pain syndromes J Pain Symptom Manage 9 5 1994 308 311
36. A. Vermiere, and J.P. Remon Stability and compatibility of morphine Int J Pharm 187 1999 17 51
37. K.R. Hildebrand, D.D. Elsberry, and S.J. Hassenbusch Stability and compatibility of morphine-clonidine admixtures in an implantable infusion system J Pain Symptom Manage 25 5 2003 464 471
38. S. Hassenbusch, K. Burchiel, and R.J. Coffey Management of intrathecal catheter-tip inflammatory masses: a consensus statement Pain Med 3 4 2002 313 323