Immunoenhancing activity of protopanaxatriol-type ginsenoside-F3 in murine spleen cells

Acta Pharmacologica Sinica

Volumn 25, Issue 12, 2004, Pages 1671-1676

  Yu, Jun Li ^a   Dou, De Qiang ^b   Chen, Xiao Hong ^a   Yang, Hong Zhen ^a   Guo, Na ^b   Cheng, Gui Fang ^a  

^a INSTITUTE OF MATERIA MEDICA   (China)

^b SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Cytokines; Ginsenoside F3; Immunity; Transcription factors

Indexed keywords

CONCANAVALIN A; CYTOKINE; GAMMA INTERFERON; GINSENOSIDE; GINSENOSIDE F3; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; PROTOPANAXATRIOL; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GATA 3; TRANSCRIPTION FACTOR T BET; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG STRUCTURE; ENZYME LINKED IMMUNOSORBENT ASSAY; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION; GINSENG; IMMUNOSTIMULATION; MALE; MOUSE; NONHUMAN; PROTEIN DNA BINDING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPLEEN CELL;

ANIMALS; CELL PROLIFERATION; CELL SEPARATION; CYTOKINES; GINSENOSIDES; MALE; MICE; MICE, INBRED BALB C; PANAX; PLANT LEAVES; PLANTS, MEDICINAL; SAPOGENINS; SPLEEN; TRITERPENES;

EID: 10344242422     PISSN: 16714083     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Yu SC, Li XY. Effect of ginsenoside on IL-1 beta and IL-6 mRNA expression in hippocampal neurons in chronic inflammation model of aged rats. Acta Pharmacol Sin 2000; 21: 915-8.
2. Zhou DL, Kitts DD. Peripheral blood mononuclear cell production of TNF-alpha in response to North American ginseng stimulation. Can J Physiol Pharmacol 2002; 80: 1030-3.
3. Cho JY, Kim AR, Yoo ES, Baik KU, Park MH. Ginsenosides from Panax ginseng differentially regulate lymphocyte proliferation. Planta Med 2002; 68: 497-500.
4. Liu YH, Liu YF, Guo XX. Current studies on anti-endotoxic chemical components of traditional Chinese medicine in China. Acta Pharmacol Sin 2001; 22: 1071-7.
5. Hsieh CS, Macatonia SE, Tripp CS, Wolf SF, O'Garra A. Murphy KM. Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages. Science 1993; 260: 547-9.
6. Shier P, Hofstra CL, Ma XJ, Wu Y, Ngo K, Fung-Leung WP. Tbt-1, a new T-box transcription factor induced in activated Th1 and CD8 + T cells. Immunogenetics 2000; 51: 771-8.
7. Szabo SJ, Kim ST, Costa GL, Zhang X, Fathman CG, Glimcher LH. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 2000; 100: 655-69.
8. Zhang DH, Cohn L, Ray P, Bottomly K, Ray A. Transcription factor GATA-3 is differentially expressed in murine Th1 and Th2 cells and controls Th2-specific expression of the interleukin-5 gene. J Biol Chem 1997; 272: 21597-603.
9. Chakir H, Wang H, Lefebvre DE, Webb J, Scott FW. T-bet/GATA-3 ratio as a measure of the Th1/Th2 cytokine profile in mixed cell populations: predominant role of GATA-3. J Immunol Methods 2003; 278: 157-69.
10. Dou DQ, Chen YJ, Liang LH, Pang FG, Shimizu N, Takeda T. Six new dammarane-type triterpene saponins from the leaves of Panax ginseng. Chem Pharm Bull 2001; 49: 442-6.
11. Dou DQ, Hou WB, Chen YJ. Studies on the characteristic constituents of Chinese ginseng and American ginseng. Planta Med 1998; 64: 585-6.
12. Li LC, Shen F, Hou Q, Cheng GF. Inhibitory effect and mechanism of action of sanggenon C on human polymorphonuclear leukocyte adhesion to human synovial cells. Acta Pharmacol Sin 2002; 23: 138-42.
13. Kim HM, Shin HY, Jeong HJ, An HJ, Kim NS, Chae HJ, et al. Reduced IL-2 but elevated IL-4, IL-6, and IgE serum levels in patients with cerebral infarction during the acute stage. J Mol Neurosci 2000; 14: 191-6.
14. Jeong HJ, Kim BS, Kim KS, Kim HM. Regulatory effect of cytokine production in asthma patients by SOOJI CHIM (Koryo Hand Acupuncture Therapy). Immunopharmacol Immunotoxicol 2002; 24: 265-74.
15. Ferreira V, Sidenius N, Tarantino N, Hubert P, Chatenoud L, Blasi F, et al. In vivo inhibition of NF-kappa B in T-lineage cells leads to a dramatic decrease in cell proliferation and cytokine production and to increased cell apoptosis in response to mitogenic stimuli, but not to abnormal thymopoiesis. J Immunol 1999; 162: 6442-50.
16. Aronica MA, Mora AL, Mitchell DB, Finn PW, Johnson JE, Sheller JR, et al. Preferential role for NF-kappa B/Rel signaling in the type 1 but not type 2 T cell-dependent immune response in vivo. J Immunol 1999; 163: 5116-24.