Focal adhesion kinase overexpression in endometrial neoplasia

Applied Immunohistochemistry and Molecular Morphology

Volumn 12, Issue 4, 2004, Pages 342-345

  Livasy, Chad A ^a,c   Moore, Dominic ^b,c   Cance, William G ^d   Lininger, Ruth A ^a,c  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b University of North Carolina at Chapel Hill   (United States)

^c UNIVERSITY OF NORTH CAROLINA   (United States)

^d UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

Endometrial carcinoma; FAK; Focal adhesion kinase; p53

Indexed keywords

FOCAL ADHESION KINASE; FORMALDEHYDE; MONOCLONAL ANTIBODY; PARAFFIN; PROTEIN P53;

ARTICLE; CANCER GRADING; CARCINOGENESIS; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOPLASM; DNA MICROARRAY; ENDOMETRIUM CARCINOMA; ENDOMETRIUM HYPERPLASIA; ENDOMETRIUM TUMOR; EXTRACELLULAR MATRIX; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; METASTASIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; UPREGULATION;

EID: 10044290586     PISSN: 15412016     EISSN: None     Source Type: Journal    
DOI: 10.1097/00129039-200412000-00009     Document Type: Article

References (20)

1. Xu LH, Owens LV, Sturge G, et al. Attenuation of the expression of the focal adhesion kinase induces apoptosis in tumor cells. Cell Growth Differ. 1996;7:413-418.
2. Frisch SM, Vuori K, Ruoslahti E, et al. Control of adhesion-dependent cell survival by focal adhesion kinase. J Cell Biol. 1996;134:793-799.
3. Hungerford JE, Compton MT, Matter ML, et al. Inhibition of pp125FAK in cultured fibroblasts results in apoptosis. J Cell Biol. 1996;135:1383-1390.
4. Cary LA, Chang JF, Guan JL. Stimulation of cell migration by overexpression of focal adhesion kinase and its association with Src and Fyn. J Cell Sci. 1996;109:1787-1794.
5. Kornberg L, Earp HS, Parsons JT, et al. Cell adhesion or integrin clustering increases phosphorylation of a focal adhesion-associated tyrosine kinase. J Biol Chem. 1992;267:23439-23442.
6. Lipfert L, Haimovich B, Schaller MD, et al. Integrin-dependent phosphorylation and activation of the protein tyrosine kinase pp125FAK in platelets. J Cell Biol. 1992;119:905-912.
7. Schlaepfer DD, Hanks SK, Hunter T, et al. Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase. Nature. 1994;372:786-791.
8. Guan JL. Role of focal adhesion kinase in integrin signaling. Int J Biochem Cell Biol. 1997;29:1085-1096.
9. Sonoda Y, Matsumoto Y, Funakoshi M, et al. Anti-apoptotic role of focal adhesion kinase (FAK): induction of inhibitor-of-apoptosis proteins and apoptosis suppression by the overexpression of FAK in a human leukemic cell line, HL-60. J Biol Chem. 2000;275:16309-16315.
10. Xu L, Yang XH, Bradham CA, et al. The focal adhesion kinase suppresses transformation-associated, anchorage-independent apoptosis in human breast cancer cells. J Biol Chem. 2000;275:30597-30604.
11. Schaller MD, Borgman CA, Cobb BS, et al. pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions. Proc Natl Acad Sci USA. 1992;89:5192-5196.
12. Weiner TM, Liu ET, Craven RJ, et al. Expression of growth factor receptors, the focal adhesion kinase, and other tyrosine kinases in human soft tissue tumors. Ann Surg Oncol. 1994;1:18-27.
13. Weiner TM, Liu ET, Craven RJ, et al. Expression of focal adhesion kinase gene and invasive cancer. Lancet. 1993;342:1024-1025.
14. Owens LV, Xu L, Craven RJ, et al. Overexpression of the focal adhesion kinase (p125FAK) in invasive human tumors. Cancer Res. 1995;55:2752-2755.
15. Cance WG, Harris JE, Iacocca MV, et al. Immunohistochemical analyses of focal adhesion kinase expression in benign and malignant human breast and colon tissues: correlation with preinvasive and invasive phenotypes. Clin Cancer Res. 2000;6:2417-2423.
16. Judson PL, He X, Cance WG, et al. Overexpression of focal adhesion kinase, a protein tyrosine kinase, in ovarian carcinoma. Cancer. 1999;86:1551-1556.
17. Han NM, Fleming RY, Curley SA, et al. Overexpression of focal adhesion kinase (p125FAK) in human colorectal carcinoma liver metastases: independence from c-src or c-yes activation. Ann Surg Oncol. 1997;4:264-268.
18. Tremblay Y, Hauck W, Aprikian AG, et al. Focal adhesion kinase (pp125FAK) expression, activation and association with paxicillin and p50CSK in human metastatic prostate carcinoma. Int J Cancer. 1996;68:164-171.
19. Oktay MH, Oktay K, Hamele-Bena D, et al. Focal adhesion kinase as a marker of malignant phenotype in breast and cervical carcinomas. Hum Pathol. 2003;34:240-245.
20. Wang D, Grammer JR, Cobbs CS, et al. p125 focal adhesion kinase promotes astocytoma cell proliferation in vivo. J Cell Sci. 2000;113:4221-4230.