Delayed intracranial delivery of a nitric oxide donor from a controlled-release polymer prevents experimental cerebral vasospasm in rabbits

Neurosurgery

Volumn 55, Issue 6, 2004, Pages 1393-1399

  Pradilla, Gustavo ^a   Thai, Quoc Anh ^a   Legnani, Federico G ^a,b   Hsu, Wesley ^a   Kretzer, Ryan M ^a   Wang, Paul P ^a   Tamargo, Rafael J ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b SAN GERARDO HOSPITAL   (Italy)

Author keywords

Diethylenetriamine nitric oxide; Polymer; Rabbit; Subarachnoid hemorrhage; Vasospasm

Indexed keywords

DIETHYLENETRIAMINE; DIETHYLENETRIAMINE NITRIC OXIDE ETHYLENE VINYL ACETATE POLYMER; ETHYLENE VINYL ACETATE COPOLYMER; NITRIC OXIDE; POLYMER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BASILAR ARTERY; BRAIN ANGIOGRAPHY; BRAIN ARTERY ANEURYSM; BRAIN EDEMA; BRAIN VASOSPASM; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DOSE RESPONSE; DRUG DELIVERY SYSTEM; IMPLANTATION; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; RABBIT; STATISTICAL SIGNIFICANCE; STUDENT T TEST; SUBARACHNOID HEMORRHAGE; VASOSPASM;

ANIMALS; DELAYED-ACTION PREPARATIONS; DISEASE MODELS, ANIMAL; DRUG ADMINISTRATION SCHEDULE; DRUG IMPLANTS; NITRIC OXIDE DONORS; POLYMERS; RABBITS; RANDOM ALLOCATION; VASOSPASM, INTRACRANIAL;

EID: 10044289649     PISSN: 0148396X     EISSN: None     Source Type: Journal    
DOI: 10.1227/01.NEU.0000143615.26102.1A     Document Type: Article

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