Quantitative evaluation of noncovalent chorismate mutase-inhibitor binding by ESI-MS

Journal of the American Society for Mass Spectrometry

Volumn 14, Issue 12, 2003, Pages 1470-1476

  Wendt, Silke ^a,b   McCombie, Gregor ^a,c   Daniel, Jürg ^a   Kienhöfer, Alexander ^a   Hilvert, Donald ^a   Zenobi, Renato ^a  

^a ETH ZURICH   (Switzerland)

^b INSTITUTE OF EPIDEMIOLOGY   (Germany)

^c NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL BONDS; DISSOCIATION; ENZYME INHIBITION; MASS SPECTROMETRY; MOLECULAR WEIGHT; MOLECULES; STOICHIOMETRY; SUBSTRATES; TITRATION;

NONCOVALENT COMPLEXES;

ENZYMES;

CHORISMATE MUTASE; CHORISMATE MUTASE INHIBITOR; ENZYME INHIBITOR; UNCLASSIFIED DRUG;

SPECTROMETRY;

ANALYTIC METHOD; BINDING SITE; COMPLEX FORMATION; CONFERENCE PAPER; COVALENT BOND; DATA ANALYSIS; DRUG BINDING; MASS SPECTROMETRY; MOLECULAR WEIGHT; QUANTITATIVE ANALYSIS; STOICHIOMETRY; TITRIMETRY;

EID: 0344925616     PISSN: 10440305     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jasms.2003.08.003     Document Type: Conference Paper

References (28)

1. Beck J.L., Colgrave M.L., Ralph S.F., Sheil M.M. Electrospray Ionization Mass Spectrometry of Oligonucleotide Complexes with Drugs, Metals, and Proteins. Mass Spectrom. Rev. 20:2001;61.
2. Loo J.A. Studying Noncovalent Protein Complexes by Electrospray Ionization Mass Spectrometry. Mass Spectrom. Rev. 16:1997;1-23.
3. Loo J.A. Electrospray Ionization Mass Spectrometry A Technology for Studying Noncovalent Macromolecular Complexes . Int. J. Mass Spectrom. 200:2000;175-186.
4. Daniel J.M., Friess S.D., Rajagopalan S., Wendt S., Zenobi R. Quantitative Determination of Noncovalent Binding Interactions Using Soft Ionization Mass Spectrometry. Int. J. Mass Spectrom. 216:2002;1-27.
5. Fändrich M., Tito M.A., Leroux M.R., Rostom A.A., Hartl F.U., Dobson C.M., Robinson C.V. Observation of the Noncovalent Assembly and Disassembly Pathways of the Chaperone Complex MtGimC by Mass Spectrometry. Proc. Natl. Acad. Sci. U.S.A. 97:2000;14151-14155.
6. Loo J.A., Hu P., McConnell P., Mueller W.T., Sawyer T.K., Thanabal V. A Study of Src SH2 Domain Protein-Phosphopeptide Binding Interactions by Electrospray Ionization Mass Spectrometry. J. Am. Soc. Mass Spectrom. 8:1997;234-243.
7. Li Y.-T., Hsieh Y.-L., Henion J.D., Ocain T.D., Schiehser G.A., Ganem B. Analysis of the Energetics of Gas-Phase Immunophilin-Ligand Complexes by Ion Spray Mass Spectrometry. J. Am. Chem. Soc. 116:1994;7487-7493.
8. Robinson C.V., Chung E.W., Kragelund B.B., Knudsen J., Aplin R.T., Poulsen F.M., Dobson C.M. Probing the Nature of Noncovalent Interactions by Mass Spectrometry. A Study of Protein-CoA Ligand Binding and Assembly. J. Am. Chem. Soc. 118:1996;8646-8653.
9. Lim H.-K., Hsieh Y.L., Ganem B., Henion J. Recognition of Cell-Wall Peptide Ligands by Vancomycin Group Antibiotics Studies Using Ion Spray Mass Spectrometry . J. Mass Spectrom. 30:1995;708-714.
10. Greig M.J., Gaus H.-J., Cummins L.L., Sasmor H., Griffey R.H. Measurement of Macromolecular Binding Using Electrospray Mass Spectrometry. Determination of Dissociation Constants from Oligonucleotide-Serum Albumin Complexes. J. Am. Chem. Soc. 117:1995;10765-10766.
11. Ayed A., Krutchinsky A.N., Ens W., Standing K.G., Duckworth H.W. Quantitative Evaluation of Protein-Protein and Ligand-Protein Equilibria of a Large Allosteric Enzyme by Electrospray Ionization Time-of-Flight Mass Spectrometry. Rapid Commun. Mass Spectrom. 12:1998;339-344.
12. Smith R.D., Bruce J.E., Wu Q., Lei P. New Mass Spectrometric Methods for the Study of Noncovalent Associations of Biopolymers. Chem. Soc. Rev. 26:1997;192-202.
13. Griffey R.H., Sannes-Lowery K.A., Drader J.J., Mohan V., Swayze E.E., Hofstadler S.A. Characterization of Low-Affinity Complexes Between RNA and Small Molecules Using Electrospray Ionization Mass Spectrometry. J. Am. Chem. Soc. 122:2000;9933-9938.
14. Sannes-Lowery K.A., Griffey R.H., Hofstadler S.A. Measuring Dissociation Constants of RNA and Aminoglycoside Antibiotics by Electrospray Mass Spectrometry. Anal. Biochem. 280:2000;264-271.
15. Chook Y.M., Ke H.M., Lipscomb W.N. Crystal-Structures of the Monofuctional Chorismate Mutase from Bacillus subtilis and Its Complex with a Transition-State Analog. Proc. Natl. Acad. Sci. U.S.A. 90:1993;8600-8603.
16. Gray J.V., Even D., Knowles J.R. Monofuctional Chorismate Mutase from Bacillus subtilis - Kinetic and C-13 NMR Studies on the Interactions of the Enzyme with Its Ligands. Biochemistry. 29:1990;8872-8878.
17. Bartlett P.A., Nakagawa Y., Johnson C.R., Reich S.H., Luis A. Chorismate Mutase Inhibitors - Synthesis and Evaluation of Some Potential Transition-State Analogs. J. Org. Chem. 53:1988;3195-3210.
18. Kast P., Grisostomi C., Chen I.A., Li S., Krengel U., Xue Y., Hilvert D. A Strategically Positioned Cation is Crucial for Efficient Catalysis by Chorismate Mutase. J. Biol. Chem. 275:2000;36832-36838.
19. Mattei P., Kast P., Hilvert D. Bacillus subtilis Chorismate Mutase is Partially Diffusion-Controlled. Eur. J. Biochem. 261:1999;25-32.
20. Sanger F., Nicklen S., Coulson A.R. DNA Sequencing with Chain-Terminating Inhibitors. Proc. Natl. Acad. Sci. U.S.A. 74:1977;5463-5467.
21. MacBeath G., Kast P., Hilvert D. A Small, Thermostable, and Monofunctional Chorismate Mutase from the Archaeon Methanococcus jannaschii. Biochemistry. 37:1998;10062-10073.
22. Chao H.S., Berchtold G.A. Inhibition of Chorismate Mutase Activity of Chorismate Mutase-Prephenate Dehydrogenase from Aerobacter aerogenes. Biochemistry. 21:1982;2778-2781.
23. Lemaire D., Marie G., Serani L., Laprevote O. Stabilization of Gas-Phase Noncovalent Macromolecular Complexes in Electrospray Mass Spectrometry Using Aqueous Triethylammonium Bicarbonate Buffer. Anal. Chem. 73:2001;1699-1706.
24. Felitsyn N., Peschke M., Kebarle P. Origin and Number of Charges Observed on Multiply-Protonated Native Proteins Produced by ESI. Int. J. Mass Spectrom. 219:2002;39-62.
25. Gamper M., Hilvert D., Kast P. Probing the Role of the C-Terminus of Bacillus subtilis Chorismate Mutase by a Novel Random Protein-Termination Strategy. Biochemistry. 39:2000;14087-14094.
26. Cload S.T., Liu D.R., Pastor R.M., Schultz P.G. Mutagenesis Study of Active Site Residues in Chorismate Mutase from Bacillus subtilis. J. Am. Chem. Soc. 118:1996;1787-1788.
27. Reinsch C. Smoothing by Spline Functions. Numer. Math. 10:1967;177-183.
28. Tanford C. Physical Chemistry of Macromolecules. 1961;Wiley, New York.