Evidence that translocation of anthrax toxin's lethal factor is initiated by entry of its N terminus into the protective antigen channel

Proceedings of the National Academy of Sciences of the United States of America

Volumn 101, Issue 48, 2004, Pages 16756-16761

  Zhang, Sen ^a   Finkelstein, Alan ^b   Collier, R John ^a,b,c  

^a HARVARD MEDICAL SCHOOL   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^c PharmAthene Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTHRAX TOXIN; ANTIGEN; BIOTIN; NICKEL; STREPTAVIDIN;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL MEMBRANE; CONTROLLED STUDY; ELECTRIC POTENTIAL; GENE DELETION; LETHAL GENE; LIPID BILAYER; NONHUMAN; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, BACTERIAL; BACTERIAL TOXINS; BASE SEQUENCE; CELL MEMBRANE; CHO CELLS; CRICETINAE; DNA PRIMERS; LIPID BILAYERS; MOLECULAR SEQUENCE DATA; PROTEIN TRANSPORT; SEQUENCE HOMOLOGY, AMINO ACID;

ANIMALIA; ANTHRAX; MAMMALIA;

EID: 10044247127     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0405754101     Document Type: Article

References (35)

1. Collier, R. J. & Young, J. A. (2003) Annu. Rev. Cell Dev. Biol. 19, 45-70.
2. Leppla, S. H. (2000) in Bacterial Protein Toxins, eds. Aktories, K. & Just, I. (Springer, Berlin), pp. 445-472.
3. Pimental, R. A., Christensen, K. A., Krantz, B. A. & Collier, R. J. (2004) Biochem. Biophys. Res. Commun. 322, 258-262.
4. Klimpel, K. R., Molloy, S. S., Thomas, G. & Leppla, S. H. (1992) Proc. Natl. Acad. Sci. USA 89, 10277-10281.
5. Milne, J. C., Furlong, D., Hanna, P. C., Wall, J. S. & Collier, R. J. (1994) J. Biol. Chem. 269, 20607-20612.
6. Elliott, J. L., Mogridge, J. & Collier, R. J. (2000) Biochemistry 39, 6706-6713.
7. Mogridge, J., Cunningham, K. & Collier, R. J. (2002) Biochemistry 41, 1079-1082.
8. Blaustein, R. O., Koehler, T. M., Collier, R. J. & Finkelstein, A. (1989) Proc. Natl. Acad. Sci. USA 86, 2209-2213.
9. Petosa, C., Collier, R. J., Klimpel, K. R., Leppla, S. H. & Liddington, R. C. (1997) Nature 385, 833-838.
10. Benson, E. L., Huynh, P. D., Finkelstein, A. & Collier, R. J. (1998) Biochemistry 37, 3941-3948.
11. Blaustein, R. O. & Finkelstein, A. (1990) J. Gen. Physiol. 96, 905-919.
12. Finkelstein, A. (1994) Toxicology 87, 29-41.
13. Wesche, J., Elliott, J. L., Falnes, P. O., Olsnes, S. & Collier, R. J. (1998) Biochemistry 37, 15737-15746.
14. Cunningham, K., Lacy, D. B., Mogridge, J. & Collier, R. J. (2002) Proc. Natl. Acad. Sci. USA 99, 7049-7053.
15. Sellman, B. R., Nassi, S. & Collier, R. J. (2001) J. Biol. Chem. 276, 8371-8376.
16. Jakes, K. S., Kienker, P. K., Slatin, S. L. & Finkelstein, A. (1998) Proc. Natl. Acad. Sci. USA 95, 4321-4326.
17. Qiu, X. Q., Jakes, K. S., Kienker, P. K., Finkelstein, A. & Slatin, S. L. (1996) J. Gen. Physiol. 107, 313-328.
18. Mueller, P., Rudin, D. O., Tien, H. & Westcott, W. C. (1963) J. Phys. Chem. 67, 534-535.
19. Zhao, J., Milne, J. C. & Collier, R. J. (1995) J. Biol. Chem. 270, 18626-18630.
20. Kandel, J., Collier, R. J. & Chung, D. W. (1974) J. Biol. Chem. 249, 2088-2097.
21. Pannifer, A. D., Wong, T. Y., Schwarzenbacher, R., Renatus, M., Petosa, C., Bienkowska, J., Lacy, D. B., Collier, R. J., Park, S., Leppla, S. H., et al. (2001) Nature 414, 229-233.
22. Zhang, S., Udho, E., Wu, Z., Collier, R. J. & Finkelstein, A. (2004) Biophys. J., 87, in press.
23. Van Dyke, R. W. & Belcher, J. D. (1994) Am. J. Physiol. 266, C81-C94.
24. Rybak, S. L., Lanni, F. & Murphy, R. F. (1997) Biophys. J. 73, 674-687.
25. Sonawane, N. D., Thiagarajah, J. R. & Verkman, A. S. (2002) J. Biol. Chem. 277, 5506-5513.
26. Abrami, L., Lindsay, M., Parton, R. G., Leppla, S. H. & van der Goot, F. G. (2004) J. Cell Biol. 166, 645-651.
27. Blanke, S. R., Milne, J. C., Benson, E. L. & Collier, R. J. (1996) Proc. Natl. Acad. Sci. USA 93, 8437-8442.
28. Arora, N. & Leppla, S. H. (1994) Infect. Immun. 62, 4955-4961.
29. Milne, J. C., Blanke, S. R., Hanna, P. C. & Collier, R. J. (1995) Mol. Microbiol. 15, 661-666.
30. Krantz, B. A., Trivedi, A. D., Cunningham, K., Christensen, K. A. & Collier, R. J. (2004) J. Mol. Biol. 344, 739-756.
31. Falnes, P. O., Choe, S., Madshus, I. H., Wilson, B. A. & Olsnes, S. (1994) J. Biol. Chem. 269, 8402-8407.
32. Ren, J., Kachel, K., Kim, H., Malenbaum, S. E., Collier, R. J. & London, E. (1999) Science 284, 955-957.
33. Lacy, D. B., Wigelsworth, D., Harrison, S. C. & Collier, R. J. (2004) Proc. Natl. Acad. Sci. USA 101, 13147-131511.
34. Santelli, E., Bankston, L. A., Leppla, S. H. & Liddington, R. C. (2004) Nature 430, 905-908.
35. Ratts, R., Zeng, H., Berg, E. A., Blue, C., McComb, M. E., Costello, C. E., vanderSpek, J. C. & Murphy, J. R. (2003) J. Cell Biol. 160, 1139-1150.