Distinct transcriptional control and action of fibroblast growth factor receptor 4 in differentiating skeletal muscle cells

Laboratory Investigation

Volumn 84, Issue 12, 2004, Pages 1571-1580

  Yu, ShunJiang ^a   Zheng, Lei ^a   Trinh, Denny K ^a   Asa, Sylvia L ^b   Ezzat, Shereen ^a,c  

^a MOUNT SINAI HOSPITAL   (Canada)

^b UNIVERSITY HEALTH NETWORK   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

FGF; Fibroblast growth factor receptor 4; Myoblasts; Sp1; Sp3

Indexed keywords

FIBROBLAST GROWTH FACTOR RECEPTOR 4; MITOGEN ACTIVATED PROTEIN KINASE 1; OLIGONUCLEOTIDE; PREGNANCY SPECIFIC BETA1 GLYCOPROTEIN;

ADENOVIRUS; ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL TYPE; COMPARATIVE STUDY; CONTROLLED STUDY; CORRELATION ANALYSIS; GEL MOBILITY SHIFT ASSAY; GENE DELETION; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; MUSCLE CELL; MYOBLAST; MYOTUBE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SKELETAL MUSCLE; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

ANIMALS; BASE SEQUENCE; CELL DIFFERENTIATION; CELL LINE; DNA PRIMERS; MICE; MOLECULAR SEQUENCE DATA; MUSCLE FIBERS; MUSCLE, SKELETAL; MUTAGENESIS; MYOBLASTS; PLASMIDS; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 4; RECEPTORS, FIBROBLAST GROWTH FACTOR; SEQUENCE DELETION; TRANSCRIPTION, GENETIC;

EID: 10044242729     PISSN: 00236837     EISSN: None     Source Type: Journal    
DOI: 10.1038/labinvest.3700187     Document Type: Article

References (29)

1. Itoh N, Mima T, Mikawa T. Loss of fibroblast growth factor receptors is necessary for terminal differentiation of embryonic limb muscle. Development 1996;122:291-300.
2. Givol D, Yayon A. Complexity of FGF receptors: genetic basis for structural diversity and functional specificity. FASEB J 1992;6:3362-3369.
3. Yan G, Wang F, Fukabori Y, et al. Expression and transformation of a variant of the heparin-binding fibroblast growth factor receptor (flg) gene resulting from splicing of the exon at alternate 3′-acceptor site. Biochem Biophys Res Commun 1992;183:423-430.
4. Peters KG, Werner S, Chen G, et al. Two FGF receptor genes are differentially expressed in epithelial and mesenchymal tissues during limb formation and organogenesis in the mouse. Development 1992;114:233-243.
5. Crumley G, Bellot F, Kaplow JM, et al. High-affinity binding and activation of a truncated FGF receptor by both aFGF and bFGF. Oncogene 1991;6:2255-2262.
6. Hanneken A, Ying W, Ling N, et al. Identification of soluble forms of the fibroblast growth factor receptor in blood. Proc Natl Acad Sci USA 1994;91:9170-9174.
7. Ezzat S, Zheng L, Yu S, et al. A soluble dominant negative fibroblast growth factor receptor 4 isoform in human mcf-7 breast cancer cells. Biochem Biophys Res Commun 2001;287:60-65.
8. Ezzat S, Zheng L, Zhu XF, et al. Targeted expression of a human pituitary tumor-derived isoform of FGF receptor-4 recapitulates pituitary tumorigenesis. J Clin Invest 2002;109:69-78.
9. Yu S, Asa SL, Weigel RJ, et al. Pituitary tumor AP-2alpha recognizes a cryptic promoter in intron 4 of fibroblast growth factor receptor 4. J Biol Chem 2003;278:19597-19602.
10. Fu L, John LM, Adams SH, et al. Fibroblast growth factor 19 increases metabolic rate and reverses dietary and leptin-deficient diabetes. Endocrinology 2004;145:2594-2603.
11. Yu C, Wang F, Kan M, et al. Elevated cholesterol metabolism and bile acid synthesis in mice lacking membrane tyrosine kinase receptor FGFR4. J Biol Chem 2000;275:15482-15489.
12. Shimada T, Kakitani M, Yamazaki Y, et al. Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism. J Clin Invest 2004;113:561-568.
13. Moore JW, Dionne C, Jaye M, et al. The mRNAs encoding acidic FGF, basic FGF and FGF receptor are coordinately downregulated during myogenic differentiation. Development 1991;111:741-748.
14. Kontaridis MI, Liu X, Zhang L, et al. Role of SHP-2 in fibroblast growth factor receptor-mediated suppression of myogenesis in C2C12 myoblasts. Mol Cell Biol 2002;22:3875-3891.
15. Marics I, Padilla F, Guillemot JF, et al. FGFR4 signaling is a necessary step in limb muscle differentiation. Development 2002;129:4559-4569.
16. Khan J, Wei JS, Ringner M, et al. Classification and diagnostic prediction of cancers using gene expression profiling and artificial neural networks. Nat Med 2001;7:673-679.
17. Yu S, Zheng L, Asa SL, et al. Fibroblast growth factor receptor 4 (FGFR4) mediates signaling to the prolactin but not the FGFR4 promoter. Am J Physiol Endocrinol Metab 2002;283:E490-E495.
18. Celli G, LaRochelle WJ, Mackem S, et al. Soluble dominant-negative receptor uncovers essential roles for fibroblast growth factors in multi-organ induction and patterning. EMBO J 1998;17:1642-1655.
19. Trinh DK, Zhang K, Hossain M, et al. Pax-6 activates endogenous proglucagon gene expression in the rodent gastrointestinal epithelium. Diabetes 2003;52:425-433.
20. Yu S, Asa SL, Ezzat S. Fibroblast growth factor receptor 4 is a target for the zinc-finger transcription factor Ikaros in the pituitary. Mol Endocrinol 2002;16:1069-1078.
21. Kostrzewa M, Muller U. Genomic structure and complete sequence of the human FGFR4 gene. Mamm Genome 1998;9:131-135.
22. Becker M, Brauninger A, Wolf G, et al. Identification and functional characterization of the human and murine fibroblast growth factor receptor 4 promoters. Biochem Biophys Res Commun 2000;276:493-501.
23. Ezzat S, Yu S, Asa SL. Ikaros isoforms in human pituitary tumors: distinct localization, histone acetylation, and activation of the 5′ fibroblast growth factor receptor-4 promoter. Am J Pathol 2003;163:1177-1184.
24. Saito H, Kouhara H, Kasayama S, et al. Characterization of the promoter region of the murine fibroblast growth factor receptor 1 gene. Biochem Biophys Res Commun 1992;183:688-693.
25. Patel SG, Funk PE, DiMario JX. Regulation of avian fibroblast growth factor receptor 1 (FGFR-1) gene expression during skeletal muscle differentiation. Gene 1999;237:265-276.
26. Avivi A, Skorecki K, Yayon A, et al. Promoter region of the murine fibroblast growth factor receptor 2 (bek/KGFR) gene. Oncogene 1992;7:1957-1962.
27. Parakati R, DiMario JX. Sp1- and Sp3-mediated transcriptional regulation of the fibroblast growth factor receptor 1 gene in chicken skeletal muscle cells. J Biol Chem 2002;277:9278-9285.
28. Pownall ME, Gustafsson MK, Emerson Jr CP. Myogenic regulatory factors and the specification of muscle progenitors in vertebrate embryos. Annu Rev Cell Dev Biol 2002;18:747-783.
29. Boilly B, Vercoutter-Edouart AS, Hondermarck H, et al. FGF signals for cell proliferation and migration through different pathways. Cytokine Growth Factor Rev 2000;11:295-302.