Susceptibility to endotoxin induced uveitis is not reduced in mice deficient in BLT1, the high affinity leukotriene B4 receptor

British Journal of Ophthalmology

Volumn 88, Issue 2, 2004, Pages 273-275

  Smith, J R ^a   Subbarao, K ^b   Franc, D T ^a   Haribabu, B ^b   Rosenbaum, J T ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b University of Louisville School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOTACTIC FACTOR; ENDOTOXIN; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; LEUKOTRIENE B4 RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTERIOR EYE CHAMBER; ARTICLE; BLT1 GENE; CELL INFILTRATION; CONTROLLED STUDY; ESCHERICHIA COLI; EXPERIMENTAL MOUSE; FEMALE; GENE; KNOCKOUT MOUSE; LEUKOCYTE COUNT; LEUKOCYTE MIGRATION; MALE; MONONUCLEAR CELL; MOUSE; NONHUMAN; POLYMORPHONUCLEAR CELL; PRIORITY JOURNAL; RECEPTOR AFFINITY; STATISTICAL SIGNIFICANCE; TISSUE SECTION; UVEITIS; WILD TYPE;

ANIMALS; ANTERIOR CHAMBER; CHEMOTACTIC FACTORS; DISEASE SUSCEPTIBILITY; ESCHERICHIA COLI; FEMALE; LEUKOCYTE COUNT; LIPOPOLYSACCHARIDES; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; RECEPTORS, LEUKOTRIENE B4; UVEITIS, ANTERIOR;

EID: 0942290461     PISSN: 00071161     EISSN: None     Source Type: Journal    
DOI: 10.1136/bjo.2003.027243     Document Type: Article

References (12)

1. Rosenbaum JT, McDevitt HO, Guss RB, et al. Endotoxin-induced uveitis in rats as a model for human disease. Nature 1980;286:611-13.
2. Rosenbaum JT, Raymond W. Monocyte chemotactic activity induced by intravitreal endotoxin. Invest Ophthalmol Vis Sci 1985;26:1267-73.
3. Becker MD, O'Rourke LM, Blackman WS, et al. Reduced leukocyte migration, but normal rolling and arrest, in interleukin-8 receptor homologue knockout mice. Invest Ophthalmol Vis Sci 2000;41:1812-17.
4. Smith JR, Hart PH, Coster DJ, et al. Mice deficient in TNFR p55 and p75, IL-4 or iNOS are susceptible to endotoxin-induced uveitis. Invest Ophthalmol Vis Sci 1998;39:658-61.
5. Smith MJ, Ford-Hutchinson AW, Bray MA. Leukotriene B: a potential mediator of inflammation. J Pharm Pharmacol 1980;32:517-18.
6. Herbort CP, Okumura A, Mochizuki M. Endotoxin-induced uveitis in the rat. A study of the role of inflammatory mediators. Graefes Arch Clin Exp Ophthalmol 1988;226:553-8.
7. Bhattacherjee P. The role of arachidonate metabolites in ocular inflammation. Prog Clin Biol Res 1989;312:211-27.
8. Haribabu B, Verghese MW, Steeber DA, et al. Targeted disruption of the leukotriene B4 receptor in mice reveals its role in inflammation and platelet-activated anaphylaxis. J Exp Med 2000;192:433-8.
9. Smith JR, Hart PH, Williams KA. Basic pathogenic mechanisms operating in experimental models of acute anterior uveitis. Immunol Cell Biol 1998;76:497-512.
10. Toda A, Yokomizo T, Shimizu T. Leukotriene B4 receptors. Prostaglandins Other Lipid Mediat 2002;68-69:575-85.
11. Bhattacherjee P, Henderson B. Inflammatory responses to intraocularly injected interleukin 1. Curr Eye Res 1987;6:929-34.
12. Parker JA, Goetzl EJ, Friedlaender MH. Leukotrienes in the aqueous humor of patients with uveitis. Arch Ophthalmol 1986;104:722-4.