Effects of hypophysectomy and recombinant human growth hormone on material and geometric properties and the pre- and post-yield behavior of femurs in young rats

Bone

Volumn 34, Issue 1, 2004, Pages 203-215

  Feldman, Sara ^a   Cointry, Gustavo R ^a   Leite Duarte, María E ^b   Sarrió, Leandro ^a   Ferretti, José L ^a   Capozza, Ricardo F ^a  

^a UNIVERSIDAD NACIONAL DE ROSARIO   (Argentina)

^b Universidade Federai Fluminense   (Brazil)

Author keywords

Bone architecture; Bone biomechanics; Bone material properties; Bone strength; Growth hormone; Hypophysectomy; Muscle bone interactions; Peripheral quantitative computed tomography (pQCT)

Indexed keywords

BIOMATERIAL; CORTICOTROPIN; PROLACTIN; RECOMBINANT GROWTH HORMONE; THYROID HORMONE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOMECHANICS; BONE DEVELOPMENT; BONE MASS; BONE MINERAL; BONE REMODELING; BONE STRENGTH; BONE STRUCTURE; BONE TISSUE; CONTROLLED STUDY; CORRELATION ANALYSIS; CORTICAL BONE; CRYSTAL STRUCTURE; DEMINERALIZATION; DIAPHYSIS; ELASTICITY; FEMALE; FEMUR; FIBER; GASTROCNEMIUS MUSCLE; GEOMETRY; HYPOPHYSECTOMY; JOINT FUNCTION; MUSCLE DEVELOPMENT; MUSCLE MASS; MUSCULOSKELETAL FUNCTION; NONHUMAN; PERIOSTEUM; POSTOPERATIVE PERIOD; RAT; RIGIDITY; TISSUE STRUCTURE; VOLUMETRY;

EID: 0942289882     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2003.09.006     Document Type: Article

References (54)

1. Andreassen T.T., Jörgensen P.H., Flyvbjerg A., Orskov H., Oxlund H. Growth hormone stimulates bone formation and strength of cortical bone in aged rats. J. Bone Miner. Res. 10:1995;1057-1067.
2. Andreassen T.T., Oxlund H. The influence of combined parathyroid hormone and growth hormone treatment on cortical bone in aged ovariectomized rats. J. Bone Miner. Res. 15:2000;2266-2275.
3. Bak B., Jörgensen P.H., Andreassen T.T. Increased mechanical strength of healing rat tibial fractures treated with biosynthetic human growth hormone. Bone. 11:1990;233-239.
4. Banu M.J., Orhii P.B., Majia W.et al. Analysis of the effects of growth hormone, voluntary exercise, and food restriction on diaphyseal bone in female F344 rats. Bone. 25:1999;469-480.
5. Bauss E., Lang K., Dony C., Kling L. The complex of recombinant human insulin-like growth factor-I (rhIGF-I) and its binding protein-5 (IGFBP-5) induces local bone formation in murine calvariae and in rat cortical bone after local or systemic administration. Growth Horm. IGF Res. 11:2001;1-9.
6. Bernhart F.W., Tomarelli R.M. A salt mixture supplying the National Research Council estimates of the mineral requirements of the rat. J. Nutr. 89:1966;495-500.
7. Chen M.M., Yeh J.K., Aloia J.F. Skeletal alterations in hypophysectomized rats. 2. A histomorphometric study on tibial cortical bone. Anat. Rec. 241:1995;513-518.
8. Chen M.M., Yeh J.K., Aloia J.F. Histologic evidence: growth hormone completely prevents reduction in cortical bone gain and partially prevents cancellous osteopenia in tibia of hypophysectomized rats. Anat. Rec. 249:1997;163-172.
9. Clark R.G., Robinson I.C.A.F., Skottner A. Growth responses to recombinant human insulin-like growth factor I (IGF-I) and human growth hormone (hGH) in a mutant dwarf rat. J. Physiol. (London). 398:1988;80P.
10. Coindre J.M., David J.P., Riviere L.et al. Bone loss in hypothyroidism with hormone replacement: a histomorphometric study. Arch. Intern. Med. 146:1986;48-53.
11. Currey J.D. The mechanical properties of bone. Clin. Orthop. Relat. Res. 73:1970;210-231.
12. Currey J.D. The effect of porosity and mineral content on the Young's modulus of elasticity of compact bone. J. Biomech. 21:1988;131-135.
13. Daugaard J.R., Laustsen J.L., Hansen B.S., Richter E.A. Growth hormone induces muscle fibre type transformation in growth-hormone-deficient rats. Acta Physiol. Scand. 164:1998;119-126.
14. Everitt A.V., Delbridge L. Two phases of collagen aging in the tail tendon of hypophysectomized rats. Exp. Gerontol. 7:1972;45-51.
15. Ferretti J.L., Capozza R.F., Mondelo N., Zanchetta J.R. Interrelationships between densitometrical, geometric and mechanical properties of rat femurs. Inferences concerning mechanical regulation of bone modeling. J. Bone Miner. Res. 8:1993;1389-1396.
16. Ferretti J.L., Capozza R.F., Zanchetta J.R. Mechanical validation of a tomographic (pQCT) index for the noninvasive assessment of rat femur bending strength. Bone. 18:1996;97-102.
17. Ferretti J.L. Biomechanical properties of bone. Genant H.K., Guglielmi G., Jergas M. Bone Densitometry and Osteoporosis. 1997;143-161 Springer, Berlin.
18. Ferretti J.L. Peripheral quantitative computed tomography (pQCT) for evaluating structural and mechanical properties of small bone. An Y.H., Draughn R.A. Mechanical Testing of Bone and the Bone-Implant Interface. 1999;385-406 CRC Press, Boca Raton, FL.
19. Ferretti J.L., Cointry G.R., Capozza R.F., Capiglioni R., Chiappe M.A. Analysis of biomechanical effects on bone and on the bone-muscle interactions in small animal models. J. Musculoskelet. Neuron Interact. 1:2001;263-274.
20. Forwood M.R., Li L., Kelly W.L., Bennett M.B. Growth hormone is permissive for skeletal adaptation to mechanical loading. J. Bone Miner. Res. 16:2001;2284-2290.
21. Frost H.M. The mechanostat: a proposed pathogenetic mechanism of osteoporoses and the bone mass effects of mechanical and nonmechanical agents. Bone Miner. 2:1987;73-80.
22. Frost H.M. Could some biomechanical effects of growth hormone help to explain its effects on bone formation and resorption? Bone. 23:1998;395-398.
23. Frost H.M. Growth hormone and osteoporosis: an overview of endocrinological and pharmacological insights from the Utah Paradigm of Skeletal Physiology. Horm. Res. 54:2000;36-43.
24. Halloran B.P., Bickle D.D., Harris J.et al. Skeletal unloading induces selective resistance to the anabolic actions of growth hormone on bone. J Bone Miner. Res. 10:1995;1168-1176.
25. Jepsen K.J., Goldstein S.A., Kuhn J.L., Schaffler M.B., Bonadio J. Type-I collagen mutation compromises the post-yield behavior of Mov13 long bone. J. Orthop. Res. 14:1996;493-499.
26. Jörgensen P.H., Bak B., Andreassen T.T. Mechanical properties and biochemical composition of rat cortical femur and tibia after long-term treatment with biosynthetic growth hormone. Bone. 12:1991;353-359.
27. Kann P., Piepkorn B., Schehler B.et al. Effect of long-term treatment with GH on bone metabolism, bone mineral density and bone elasticity in GH-deficient adults. Clin. Endocrinol. 48:1998;561-568.
28. Katz E.P., Wachtel E., Yamauchi M., Mechanic G.L. The structure of mineralized collagen fibrils. Connect. Tissue Res. 21:1989;149-158.
29. Kidder L.S., Schmidt I.U., Evans G.L., Turner R.T. Effects of growth hormone and low dose estrogen on bone growth and turnover in long bones of hypophysectomized rats. Calcif. Tissue Int. 61:1997;225-327.
30. Klein L., Zilka J.M. Comparison of whole calvarial bones and long bones during early growth in rats. Calcif. Tissue Res. 20:1976;217-227.
31. Kohles S.S., Martinez D.A., Bowers J.R., Vailas A.C., Vanderby R. Effect of a growth hormone treatment on bone orthotropic elasticity in dwarf rats. Ann. Biomed. Eng. 25:1997;77-85.
32. Kohles S.S., Martinez D.A. Elastic and physicochemical relationships within cortical bone. J. Biomed. Mater. Res. 49:1999;479-488.
33. Laftman P., Holmström T., Kairento A.L.et al. No effect of growth hormone on recovery of load-protected bone: cortical bone mass and strength studied in rabbits. Acta Orthop. Scand. 59:1988;24-28.
34. Landis W.J. The strength of a calcified tissue depends in part on the molecular structure and organization of its constituent mineral crystals and their organic matrix. Bone. 16:1995;533-544.
35. Lissett C.A., Shalet S.M. Effects of growth hormone on bone and muscle. Growth Horm. IGF Res. 10:2000;95-101.
36. Martin R.B., Burr D.B., Sharkey N.A. Skeletal Tissue Mechanics. 1998;127-208 Springer, New York.
37. Martinez D.A., Vailas A.C., Grindeland R.E. Cortical bone maturation in young hypophysectomized rats. Am. J. Physiol.: Endocrinol. Metab. 260:1991;E690-E694.
38. Martinez D.A., Orth M.W., Carr K.E., Vanderby R., Vailas A.C. Cortical bone growth and maturational changes in dwarf rats induced by recombinant human growth hormone. Am. J. Physiol.: Endocrinol. Metab. 33:1996;E51-E59.
39. Mosekilde Li., Melsen F. Morphometric and dynamic studies of bone changes in hypothyroidism. Acta Pathol. Microbiol. Scand. 86:1976;56-62.
40. Mosekilde Li., Thomsen J.S., Orhii P.B.et al. Additive effect of voluntary exercise and growth hormone treatment on bone strength assessed at four different skeletal sites in an aged rat model. Bone. 24:1999;71-80.
41. Ortöft G., Oxlund H., Jörgensen P.H., Andreassen T.T. Glucocorticoid treatment or food deprivation counteract the stimulating effect of growth hormone on rat cortical bone strength. Acta Pediatr. Scand. 81:1992;912-917.
42. Ortöft G., Bruel A., Andreassen T.T., Oxlund H. Growth hormone is not able to counteract osteopenia of rat cortical bone by glucocorticoid with protracted effect. Bone. 17:1995;543-548.
43. Ortöft G., Oxlund H. Qualitative alterations of cortical bone in female rats after long-term administration of growth hormone and glucocorticoid. Bone. 18:1996;581-590.
44. Oxlund H., Barckman M., Ortöft G., Andreassen T.T. Reduced concentrations of collagen cross-links are associated with reduced strength of bone. Bone. 17(Suppl. 4):1995;365S-371S.
45. Oxlund H., Andersen N.B., Ortöft G., Orskov H., Andreassen T.T. Growth hormone and mild exercise in combination markedly enhance cortical bone formation and strength in old rats. Endocrinology. 139:1998;1899-1904.
46. Svobda E.L.A., Howley T.P., Deporter D.A. Collagen fiber diameter and its relation to collagen turnover in three soft tissues in the rat. Connect. Tissue Res. 12:1983;43-48.
47. Tseng K.F., Bonadio J.F., Stewart T.A., Baker A.R., Goldstein S.A. Local expression of human growth hormone in bone results in impaired mechanical integrity in the skeletal tissue of transgenic mice. J. Orthop. Res. 14:1996;598-604.
48. Tseng K.F., Goldstein S.A. Systemic over-secretion of growth hormone in transgenic mice results in a specific pattern of skeletal modeling and adaptation. J. Bone Miner. Res. 13:1998;706-715.
49. Urist M.R. Growth hormone and skeletal tissue metabolism. Bourne G.H. Biochemistry and Physiology of Bone. 1985;155-195 Academic Press, London.
50. Wainwright S.A., Briggs W.D., Currey J.D., Gosline J.M. Mechanical Design in Organisms. 1976;19-60 Edward Arnold, London.
51. Wright N.M., Renault J., Hollis B., Bell N.H., Key L.L. Effect of growth hormone on bone: bone mineral density, trabecular bone volume, and alkaline phosphatase improve or are restored in the dwarf rat treated with growth hormone. J. Bone Miner. Res. 10:1995;127-131.
52. Yeh J.K., Aloia J.F., Chen M. Growth hormone administration potentiates the effect of treadmill exercise on long bone formation but not on the vertebrae in middle-aged rats. Calcif. Tissue Int. 54:1994;38-43.
53. Yeh J.K., Chen M.M., Aloia J.F. Skeletal alterations in hypophysectomized rats. 1. A histomorphometric study on tibial cancellous bone. Anat. Rec. 24:1995;505-512.
54. Zioupos P., Currey J.D., Sedman A.J. An examination of the micromechanics of failure of bone and antler by acoustic emission tests and laser scanning confocal microscopy. Med. Eng. Phys. 16:1994;203-212.