Could some biomechanical effects of growth hormone help to explain its effects on bone formation and resorption?

Bone

Volumn 23, Issue 5, 1998, Pages 395-398

  Frost, H M ^a  

^a Southern Colorado Clinic   (United States)

Author keywords

Biomechanics; Bone; Growth hormone; Modeling; Osteoblasts; Remodeling

Indexed keywords

GROWTH HORMONE;

ARTICLE; BIOMECHANICS; BONE DEVELOPMENT; BONE GROWTH; BONE METABOLISM; BONE STRENGTH; BONE STRESS; HUMAN; NONHUMAN; OSSIFICATION; OSTEOBLAST; OSTEOCLAST;

ANIMALS; BIOMECHANICS; BONE RESORPTION; GROWTH HORMONE; HUMANS; HYPOPHYSECTOMY; IMMOBILIZATION; OSTEOBLASTS; OSTEOGENESIS; RATS;

EID: 0031712569     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/S8756-3282(98)00122-7     Document Type: Article

References (35)

1. Andreassen T.T., Jorgensen P.H., Flyvberg A., Orskov H., Oxlund H. Growth hormone stimulates bone formation and strength of cortical bone in aged rats. J Bone Miner Res. 10:1995;1057-1067.
2. Bouillon R. Growth hormone and bone. Horm Res. 36:(Suppl.):1991;49-55.
3. Burr D.B. Muscle strength, bone mass, and age-related bone loss. J Bone Miner Res. 12:1997;1547-1551.
4. Burr D.B., Milgrom C., Fyrhie D., Forwood M., Nyska M., Finestone A., Saiag E., Simkin A. In vivo measurement of human tibial strains during vigorous activity. Bone. 18:1995;405-410.
5. Carlson, C. S., Weckel, B. M., Loeser, R. F., Lee, H. L., Gardin, J. F., and Jerome, C. P. Long-term anabolic steroid treatment increases body weight and bone volume but not osteoarthritis severity in monkeys [Abstract 222]. Orthop Res Soc 1996.
6. Chen M.-M., Yeh J.K., Aloia J.F. Skeletal alterations in hypophysectomized rats II. A histomorphometric study on tibial cortical bone . Anat Rec. 241:1995;513-518.
7. Crowninshield R.D., Johnston R.C., Andrews J.G., Brand R.A. A biomechanical investigation of the human hip. J Biomech. 11:1978;75-85.
8. Favus M.J. Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, 3rd ed. 1996;Lippincott-Raven, New York.
9. Frost H.M. Perspectives: On increased fractures during the human adolescent growth spurt Summary of a new vital-biomechanical explanation . J Bone Miner Metab. 15:1997;115-121.
10. Frost H.M. Osteoporoses Their nature, and therapeutic targets (insights from a new paradigm) . Whitfield J.F., Morely P. Anabolic Treatments for Osteoporosis. 1997;1-29 CRC, Boca Raton, FL.
11. Halloran B.P., Bickle D.D., Harris J., Autry C.O., Currier P.A., Tanner S., Patterson-Buckendahl P., Morey-Holton E. Skeletal unloading induces selective resistance to the anabolic actions of growth hormone on bone. J Bone Miner Res. 10:1995;1168-1176.
12. Jee W.S.S. The skeletal tissues. Weiss L. Cell and Tissue Biology A Textbook of Histology . 1989;211-259 Urban and Schwartzenberg, Baltimore.
13. Jee W.S.S., Frost H.M. Skeletal adaptations during growth. In Triangle (Sandoz). 31:1992;77-88.
14. Jee W.S.S., Li X.J. Adaptation of cancellous bone to overloading in the adult rat A single photon absorptiometry and histomorphometry study . Anat Rec. 227:1990;418-426.
15. Jee W.S.S., Li X.J., Schaffler M.B. Adaptation of diaphyseal structure with aging and increased mechanical usage in the adult rat A histomorphometrical and biomechanical study . Anat Rec. 230:1991;332-338.
16. Kannus P., Sievanen H., Vuori L. Physical loading, exercise and bone. Bone. 18:(Suppl. 1):1996;1-3.
17. Kiratli B.J. Immobilization osteopenia. Marcus R., Feldman D., Kelsey J. Osteoporosis. 1996;833-850 Academic, Orlando, FL.
18. Li X.J., Jee W.S.S. Adaptation of diaphyseal structure to aging and decreased mechanical loading in the adult rat A densitometric and histomorphometric study . Anat Rec. 229:1991;291-297.
19. Li X.J., Jee W.S.S., Chow S.-Y., Woodbury D.M. Adaptation of cancellous bone to aging and immobilization in the rat A single photon absorptiometry and histomorphometry study . Anat Rec. 227:1990;12-24.
20. Martin R.B., Burr D.B. Structure, Function and Adaptation of Compact Bone. 1989;Raven, New York.
21. Nordin M., Frankel V.H. Basic Biomechanics of the Musculoskeletal System, 2nd ed. 1989;Lea and Febiger, Philadelphia.
22. Nunamaker D.M., Butterweck D.M., Provost M.P. Fatigue fractures in thoroughbred race horses Relationship with age, peak bone strain and running . J Orthop Res. 8:1990;604-611.
23. Parfitt A.M. Skeletal heterogeneity and the purposes of bone remodeling. Maraus R., Feldman D., Kelsey J. Osteoporoses. 1996;315-329 Academic, New York.
24. Raisz L.G. Hormonal regulation of bone growth and remodelling. Ciba Found Symp. 136:1988;226-238.
25. Schiltz P.M., Ohta T., Glass D., Mohan S., Baylink D.J. Growth hormone stimulates cortical bone formation in immature hypophysectomized rats. Endocrin Res. 18:1992;19-30.
26. Schönau E. Paediatric Osteology New Trends and Diagnostic Possibilities . 1996;Elsevier, Amsterdam.
27. Simon S.R., Radin E.L. Biomechanics of joints. Kelly W.N.K., Haris E.D., Ruddy S., Sledge C.B. Textbook of Rheumatology. 1993;1675-1678 Saunders, Philadelphia.
28. Takahashi H.E. Spinal Disorders in Growth and Aging. 1995;Springer, Tokyo.
29. Turner C.H., Takano Y., Owan I. Aging changes mechanical loading thresholds for bone formation in rats. J Bone Miner Res. 10:1995;1544-1549.
30. Vanderschueren D., Bouillon R. Androgens and bone. Calcif Tissue Int. 56:1995;341-346.
31. Verhaeghe J., Van Bree R., Van Herck E., Thomas H., Skottner A., Dequeker J., Mosekilde L., Einhorn T.A., Bouillon R. Effects of recombinant human growth hormone and insulin-like growth factor-I, with or without 17β-estradiol, on bone and mineral homeostasis of aged ovariectomized rats. J Bone Miner Res. 11:1996;1723-1735.
32. Wilson J.D., Foster D.W. William's Textbook of Endocrinology, 8th Ed. 1992;Saunders, Philadelphia.
33. Wronski T.J., Morey E.R. Skeletal abnormalities in rats induced by weightlessness. Metab Bone Dis Rel Res. 4:1982;69-76.
34. Wronski T.J., Morey E.R. Effect of spaceflight on periosteal bone formation in rats. Am J Physiol. 13:1993;305-309.
35. Yeh J.K., Chen M.M., Aloia J.F. Skeletal alterations in hypophysectomizd rats I. A histomorphometric study in tibial cancellous bone . Anat Rec. 241:1995;505-512.