Members of a Novel Family of Mammalian Protein Kinases Complement the DNA-Negative Phenotype of a Vaccinia Virus ts Mutant Defective in the B1 Kinase

Journal of Virology

Volumn 78, Issue 4, 2004, Pages 1992-2005

  Boyle, Kathleen A ^a   Traktman, Paula ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASEIN KINASE I; CASEIN KINASE IALPHA2; DNA; PROTEIN KINASE; PROTEIN KINASE B1; UNCLASSIFIED DRUG; VIRUS DNA; VIRUS ENZYME; VIRUS PROTEIN; VIRUS PROTEIN H5; VRK1 ENZYME;

ALLELE; ANIMAL CELL; ARTICLE; CATALYSIS; DEFECTIVE VIRUS; DNA SYNTHESIS; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME SPECIFICITY; ENZYME SUBSTRATE; GENE REPLICATION; GENETIC COMPLEMENTATION; HIGH TEMPERATURE PROCEDURES; HUMAN; HUMAN CELL; IN VIVO STUDY; LETHAL MUTANT; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; SPECIES DIFFERENCE; TEMPERATURE SENSITIVE MUTANT; TEMPERATURE SENSITIVITY; VACCINIA VIRUS; VACCINIA VIRUS TS; VIRUS CULTURE; VIRUS MUTANT; VIRUS RECOMBINANT; WILD TYPE;

AMINO ACID SEQUENCE; ANIMALS; CELL LINE; DNA, VIRAL; GENETIC COMPLEMENTATION TEST; HUMANS; L CELLS (CELL LINE); MICE; MOLECULAR SEQUENCE DATA; MUTATION; PHENOTYPE; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; PROTEINS; RECOMBINATION, GENETIC; SEQUENCE ALIGNMENT; TEMPERATURE; VACCINIA VIRUS; VIRAL PROTEINS; VIRUS REPLICATION;

EID: 0842347704     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.78.4.1992-2005.2004     Document Type: Article

References (48)

1. Barcia, R., S. Lopez-Borges, F. M. Vega, and P. A. Lazo. 2002. Kinetic properties of p53 phosphorylation by the human vaccinia-related kinase 1. Arch. Biochem. Biophys. 399:1-5.
2. Beaud, G., and R. Beaud. 1997. Preferential virosomal location of underphosphorylated H5R protein synthesized in vaccinia virus-infected cells. J. Gen. Virol. 78:3297-3302.
3. Beaud, G., and R. Beaud. 2000. Temperature-dependent phosphorylation state of the H5R protein synthesised at the early stage of infection in cells infected with vaccinia virus ts mutants of the B1R and F10L protein kinases. Intervirology 43:67-70.
4. Beaud, G., R. Beaud, and D. P. Leader. 1995. Vaccinia virus gene H5R encodes a protein that is phosphorylated by the multisubstrate vaccinia virus B1R protein kinase. J. Virol. 69:1819-1826.
5. Black, E. P., N. Moussatche, and R. C. Condit. 1998. Characterization of the interactions among vaccinia virus transcription factors G2R, A18R, and H5R. Virology 245:313-322.
6. Challberg, M. D., and P. T. Englund. 1979. Purification and properties of the deoxyribonucleic acid polymerase induced by vaccinia virus. J. Biol. Chem. 254:7812-7819.
7. Challberg, M. D., and P. T. Englund. 1979. The effect of template secondary structure on vaccinia DNA polymerase. J. Biol. Chem. 254:7820-7826.
8. DeMasi, J., and P. Traktman. 2000. Clustered charge-to-alanine mutagenesis of the vaccinia virus H5 gene: isolation of a dominant, temperature-sensitive mutant with a profound defect in morphogenesis. J. Virol. 74:2393-2405.
9. Domi, A., and G. Beaud. 2000. The punctate sites of accumulation of vaccinia virus early proteins are precursors of sites of viral DNA synthesis. J. Gen. Virol. 81:1231-1235.
10. Evans, E., N. Klemperer, R. Ghosh, and P. Traktman. 1995. The vaccinia virus D5 protein, which is required for DNA replication, is a nucleic acid-independent nucleoside triphosphatase. J. Virol. 69:5353-5361.
11. Evans, E., and P. Traktman. 1987. Molecular genetic analysis of a vaccinia virus gene with an essential role in DNA replication. J. Virol. 61:3152-3162.
12. Grimley, P. M., E. N. Rosenblum, S. J. Mims, and B. Moss. 1970. Interruption by Rifampin of an early stage in vaccinia virus morphogenesis: accumulation of membranes which are precursors of virus envelopes. J. Virol. 6:519-533.
13. Gross, S. D., and R. A. Anderson. 1998. Casein kinase I: spatial organization and positioning of a multifunctional protein kinase family. Cell. Signal. 10:699-711.
14. Hanks, S. K., and T. Hunter. 1995. Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification. FASEB J. 9:576-596.
15. Hanks, S. K., A. M. Quinn, and T. Hunter. 1988. The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. Science 241:42-52.
16. Hoekstra, M. F., R. M. Liskay, A. C. Ou, A. J. DeMaggio, D. G. Burbee, and F. Heffron. 1991. HRR25, a putative protein kinase from budding yeast: association with repair of damaged DNA. Science 253:1031-1034.
17. Ishii, K., and B. Moss. 2001. Role of vaccinia virus A20R protein in DNA replication: construction and characterization of temperature-sensitive mutants. J. Virol. 75:1656-1663.
18. Klemperer, N., W. McDonald, K. Boyle, B. Unger, and P. Traktman. 2001. The A20R protein is a stoichiometric component of the processive form of vaccinia virus DNA polymerase. J. Virol. 75:12298-12307.
19. Koerner, T. J., J. E. Hill, A. M. Myers, and A. Tzagoloff. 1991. High-expression vectors with multiple cloning sites for construction of trpE fusion genes: pATH vectors. Methods Enzymol. 194:477-490.
20. Kovacs, G. R., and B. Moss. 1996. The vaccinia virus H5R gene encodes late gene transcription factor 4: purification, cloning, and overexpression. J. Virol. 70:6796-6802.
21. Kovacs, G. R., N. Vasilakis, and B. Moss. 2001. Regulation of viral intermediate gene expression by the vaccinia virus B1 protein kinase. J. Virol. 75:4048-4055.
22. Liu, K., B. Lemon, and P. Traktman. 1995. The dual-specificity phosphatase encoded by vaccinia virus, VH1, is essential for viral transcription in vivo and in vitro. J. Virol. 69:7823-7834.
23. Lopez-Borges, S., and P. A. Lazo. 2000. The human vaccinia-related kinase 1 (VRK1) phosphorylates threonine-18 within the mdm-2 binding site of the p53 tumour suppressor protein. Oncogene 19:3656-3664.
24. McCraith, S., T. Holtzman, B. Moss, and S. Fields. 2000. Genome-wide analysis of vaccinia virus protein-protein interactions. Proc. Natl. Acad. Sci. USA 97:4879-4884.
25. McDonald, W. F., V. Crozel-Goudot, and P. Traktman. 1992. Transient expression of the vaccinia virus DNA polymerase is an intrinsic feature of the early phase of infection and is unlinked to DNA replication and late gene expression. J. Virol. 66:534-547.
26. McDonald, W. F., N. Klemperer, and P. Traktman. 1997. Characterization of a processive form of the vaccinia virus DNA polymerase. Virology 234:168-175.
27. McDonald, W. F., and P. Traktman. 1994. Overexpression and purification of the vaccinia virus DNA polymerase. Protein Expr. Purif. 5:409-421.
28. McDonald, W. F., and P. Traktman. 1994. Vaccinia virus DNA polymerase. In vitro analysis of parameters affecting processivity. J. Biol. Chem. 269: 31190-31197.
29. Nezu, J., A. Oku, M. H. Jones, and M. Shimane. 1997. Identification of two novel human putative serine/threonine kinases, VRK1 and VRK2, with structural similarity to vaccinia virus B1R kinase. Genomics 45:327-331.
30. Nichols, R. J., and P. Traktman. Characterization of three paralogous members of the mammalian vaccinia related kinase (VRK) family. J. Biol. Chem., in press.
31. Preston, V. G., A. J. Darling, and I. M. McDougall. 1988. The herpes simplex virus type 1 temperature-sensitive mutant ts1222 has a single base pair deletion in the small subunit of ribonucleotide reductase. Virology 167:458-467.
32. Puckett, C., and B. Moss. 1983. Selective transcription of vaccinia virus genes in template dependent soluble extracts of infected cells. Cell 35:441-448.
33. Punjabi, A., K. Boyle, J. DeMasi, O. Grubisha, B. Unger, M. Khanna, and P. Traktman. 2001. Clustered charge-to-alanine mutagenesis of the vaccinia virus A20 gene: temperature-sensitive mutants have a DNA-minus phenotype and are defective in the production of processive DNA polymerase activity. J. Virol. 75:12308-12318.
34. Rempel, R. E., M. K. Anderson, E. Evans, and P. Traktman. 1990. Temperature-sensitive vaccinia virus mutants identify a gene with an essential role in viral replication. J. Virol. 64:574-583.
35. Rempel, R. E., and P. Traktman. 1992. Vaccinia virus B1 kinase: phenotypic analysis of temperature-sensitive mutants and enzymatic characterization of recombinant proteins. J. Virol. 66:4413-4426.
36. Rochester, S. C., and P. Traktman. 1998. Characterization of the single-stranded DNA binding protein encoded by the vaccinia virus I3 gene. J. Virol. 72:2917-2926.
37. Senkevich, T. G., J. J. Bugert, J. R. Sisler, E. V. Koonin, G. Darai, and B. Moss. 1996. Genome sequence of a human tumorigenic poxvirus: prediction of specific host response-evasion genes. Science 273:813-816.
38. Senkevich, T. G., E. V. Koonin, J. J. Bugert, G. Darai, and B. Moss. 1997. The genome of molluscum contagiosum virus: analysis and comparison with other poxviruses. Virology 233:19-42.
39. Sridhar, P., and R. C. Condit. 1983. Selection for temperature-sensitive mutations in specific vaccinia virus genes: isolation and characterization of a virus mutant which encodes a phosphonoacetic acid-resistant, temperature-sensitive DNA polymerase. Virology 128:444-457.
40. Stuart, D. T., C. Upton, M. A. Higman, E. G. Niles, and G. McFadden. 1993. A poxvirus-encoded uracil DNA glycosylase is essential for virus viability. J. Virol. 67:2503-2512.
41. Taddie, J. A., and P. Traktman. 1991. Genetic characterization of the vaccinia virus DNA polymerase: identification of point mutations conferring altered drug sensitivities and reduced fidelity. J. Virol. 65:869-879.
42. Taddie, J. A., and P. Traktman. 1993. Genetic characterization of the vaccinia virus DNA polymerase: cytosine arabinoside resistance requires a variable lesion conferring phosphonoacetate resistance in conjunction with an invariant mutation localized to the 3′-5′ exonuclease domain. J. Virol. 67: 4323-4336.
43. Tartaglia, J., A. Piccini, and E. Paoletti. 1986. Vaccinia virus rifampicin-resistance locus specifies a late 63,000 Da gene product. Virology 150:45-54.
44. Traktman, P., M. K. Anderson, and R. E. Rempel. 1989. Vaccinia virus encodes an essential gene with strong homology to protein kinases. J. Biol. Chem. 264:21458-21461.
45. Traktman, P., M. Kelvin, and S. Pacheco. 1989. Molecular genetic analysis of vaccinia virus DNA polymerase mutants. J. Virol. 63:841-846.
46. Traktman, P., K. Liu, J. DeMasi, R. Rollins, S. Jesty, and B. Unger. 2000. Elucidating the essential role of the A14 phosphoprotein in vaccinia virus morphogenesis: construction and characterization of a tetracycline-inducible recombinant. J. Virol. 74:3682-3695.
47. Vega, F. M., P. Gonzalo, M. L. Gaspar, and P. A. Lazo. 2003. Expression of the VRK (vaccinia-related kinase) gene family of p53 regulators in murine hematopoietic development. FEBS Lett. 544:176-180.
48. Zelko, I., R. Kobayashi, P. Honkakoski, and M. Negishi. 1998. Molecular cloning and characterization of a novel nuclear protein kinase in mice. Arch. Biochem. Biophys. 352:31-36.