Megazol combined with suramin improves a new diagnosis index of the early meningo-encephalitic phase of experimental African trypanosomiasis

Tropical Medicine and International Health

Volumn 9, Issue 1, 2004, Pages 83-91

  Darsaud, Annabelle ^a,b   Chevrier, Céline ^a   Bourdon, Lionel ^a   Dumas, Michel ^b   Buguet, Alain ^a,c   Bouteille, Bernard ^b  

^a CENTRE DE RECHERCHES   (France)

^b UNIVERSITY OF LIMOGES   (France)

^c SERVICE DE SANTÉ DES ARMÉES   (France)

Author keywords

Body weight; Combination therapy; Food intake; Megazol; Rat; Suramin; Trypanosomiasis

Indexed keywords

2 AMINO 5 (1 METHYL 5 NITRO 2 IMIDAZOLYL) 1,3,4 THIADIAZOLE; SURAMIN;

TRYPANOSOMIASIS;

AFRICAN TRYPANOSOMIASIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DRUG EFFICACY; EXPERIMENTAL INFECTION; EXPERIMENTAL MODEL; FOOD INTAKE; HEMATOCRIT; MALE; MENINGOENCEPHALITIS; MICROCYTIC ANEMIA; NONHUMAN; RAT; SPECIES COMPARISON; TRYPANOSOMA BRUCEI;

ANEMIA; ANIMALS; BODY WEIGHT; DRUG THERAPY, COMBINATION; EATING; HEMATOCRIT; MALE; MENINGOENCEPHALITIS; PARASITEMIA; RATS; RATS, SPRAGUE-DAWLEY; SURAMIN; THIADIAZOLES; TRYPANOCIDAL AGENTS; TRYPANOSOMA BRUCEI BRUCEI; TRYPANOSOMIASIS, AFRICAN;

ANIMALIA; PROTOZOA; TRYPANOSOMA; TRYPANOSOMA BRUCEI BRUCEI;

EID: 0842330283     PISSN: 13602276     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-3156.2003.01154.x     Document Type: Article

References (47)

1. Apted FIC (1970) Clinical manifestations and diagnosis of sleeping sickness. In: The African Trypanosomiases (ed. HW Mulligan) George Allen and Unwin, London, pp. 661-683.
2. Barrett MP, Fairlamb AH, Rousseau B, Chauvière G & Perié J (2000) Uptake of the nitroimidazole drug megazol by African trypanosomes. Biochemical Pharmacology 59, 615-620.
3. Bentivoglio M, Grassi-Zucconi G, Olsson T & Kristensson K (1994) Trypanosoma brucei and the nervous system. Trends in Neurosciences 17, 325-329.
4. Berkelhammer G & Asato G (1968) 2-Amino-5-(1-methyl-5-nitro-2- imidazolyl)-1,3,4-thidiazole. A new antimicrobiolical agent. Science 162, 1146.
5. Bhagwat SS & Williams M (1997) P-2 purine and pyrimidine receptors: emerging superfamilies of G-protein-coupled and ligand-gated ion channel receptors. European Journal of Medicinal Chemistry 32, 183-193.
6. Bouteille B & Chauvière G (1999) Implication du megazol dans la chimiothérapie des trypanosomes. Médecine Tropicale 59, 321-330.
7. Bouteille B, Darde ML & Pestre-Alexandre M (1988) Action des médicaments testés en milieu acellulaire et chez la souris infectée par Trypanosoma brucei brucei. Bulletin de la Société de Pathologie Exotique 81, 533-542.
8. Bouteille B, Darde ML & Pestre-Alexandre M (1990) Trypanosomose à Trypanosoma brucei brucei: traitement par des associations. Bulletin de la Société Française de Parasitologie 6, 15-20.
9. Bouteille B, Marie-Daragon A, Chauvière G et al. (1995) Effect of megazol on Trypanosoma brucei brucei acute and subacute infections in Swiss mice. Acta Tropica 60, 73-80.
10. Brun R, Schumacher R, Schmid C, Kunz C & Burri C (2001) The phenomenon of treatment failures in Human African Trypanosomiasis. Tropical Medicine and International Health 6, 906-914.
11. Buguet A, Bert J, Tapie P et al. (1993) Sleep-wake cycle in human African trypanosomiasis. Journal of Clinical Neurophysiology 10, 190-196.
12. Burden EJ, Schumacher E & Kelly M (1968) 2-Amino-5-(1-Methyl-5-Nitro- 2-Imidazollyl)-1,3,4-thidiazole, a new antimicrobial agent. VII. Action against subcutaneous Trichomonas vaginalis infections in mice. Antimicrobial Agents and Chemotherapy 7, 538-540.
13. Chauvière G, Bouteille B, Enanga B et al. (2003) Synthesis and biological activity of nitro heterocycles analogous to megazol, a trypanocidal lead. Journal of Medical Chemistry 46, 427-440.
14. Darsaud A, Bourdon L, Chevrier C et al. (2003) Clinical follow-up in the rat experimental model of African trypanosomiasis. Experimental Biology and Medicine 228, 1355-1362.
15. De Koning HP, MacLeod A, Barrett MP, Cover B & Jarvis SM (2000) Further evidence for a link between melarsoprol resistance and P2 transporter function in African trypanosomes. Molecular and Biochemical Parasitology 106, 181-185.
16. Densie H & Barrett MP (2001) Uptake and mode of action of drugs used against sleeping sickness. Biochemical Pharmacology 61, 1-5.
17. Dumas M, Bouteille B & Buguet A (1999) Progress in Human African Trypanosomiasis, Sleeping Sickness. Springer-Verlag, Paris, Vol. 1, p. 344.
18. Enanga B, Labat C, Boudra H et al. (1997) Simple high-performance liquid chromatographic method to analyse megazol in human and rat plasma. Journal of Chromatography 696, 261-266.
19. Enanga B, Keita M, Chauvière G, Dumas M & Bouteille B (1998) Megazol combined with suramin: a chemotherapy regimen which reversed the CNS pathology in a model of human African trypanosomiasis in mice. Tropical Medicine and International Health 3, 736-741.
20. Enanga B, Boudra H, Chauvière G et al. (1999) Pharmacokinetics, metabolism and excretion of megazol, a new potent trypanocidal drug in animals. Arzneimittel-Forschung/Drug Research 49, 441-447.
21. Enanga B, Mezui Ndong J, Boudra H et al. (2000) Pharmacokinetics, metabolism and excretion of megazol in a Trypanosoma brucei gambiense primate model of human African trypanosomiasis. Preliminary study. Arzneimittel- Forschung/Drug Research 50, 158-162.
22. Greenwood BM & Whittle HC (1980) The pathogenesis of sleeping sickness. Transactions of the Royal Society of Tropical Medicine and Hygiene 74, 716-725.
23. Hawking F (1940) Concentration of Bayer 205 (Germanin) in human blood and cerebrospinal fluid after treatment. Transactions of the Royal Society of Tropical Medicine and Hygiene 34, 37-52.
24. Hunter CA & Kennedy PGE (1992) Immunopathology in central nervous system human African trypanosomiasis. Journal of Neuroimmunology 36, 91-95.
25. Jennings FW (1990) Future prospects for the chemotherapy of human trypanosomiasis. 2. Combination therapy and African trypanosomiasis. Transactions of the Royal Society of Tropical Medicine and Hygiene 84, 618-621.
26. Jennings FW & Gray GD (1983) Relapsed parasitaemia following chemotherapy of chronic Trypanosoma brucei in mice and its relation to cerebral trypanosomes. Contribution of Microbiological Immunology 7, 147-154.
27. Jennings FW, Urquhart GM, Murray PK & Miller BM (1983) Treatment with suramin and 2-substituted 5-nitroimidazoles of chronic murine Trypanosoma brucei infections with central nervous system involvement. Transactions of the Royal Society of Tropical Medicine and Hygiene 77, 693-698.
28. Jennings FW, Urquhart GM, Murray PK & Miller BM (1984) The use of 2-substituted 5-nitroimidazoles in the treatment of chronic murine Trypanosoma brucei infections with central nervous system involvement. Zeitschrift für Parasitenkunde 70, 691-697.
29. Jennings FW, Chauvière G, Viode C & Murray M (1996) Topical chemotherapy for experimental African trypanosomiasis with cerebral involvement: the use of melarsoprol combined with the 5-nitroimidazole, megazol. Tropical Medicine and International Health 3, 363-366.
30. Jennings FW, Rodgers J, Bradley B, Gettinby G, Kennedy PGE & Murray M (2002) Human African trypanosomiasis: potential therapeutic benefits of an alternative suramin and melarsoprol regimen. Parasitology International 51, 381-388.
31. Keita M, Bouteille B, Enanga B, Vallat JM & Dumas M (1997) Trypanosoma brucei brucei: a long-term model of human African trypanosomiasis in mice, meningo-encephalitis, astrocytosis and neurological disorders. Experimental Parasitology 85, 183-192.
32. King BF, Neary JT, Zhu Q, Wang S, Norenberg MD & Burnstock G (1996) P-2 purinoreceptors in rat cortical astrocytes: expression, calcium-imaging and signalling studies. Neuroscience 74, 1187-1196.
33. Masake RA, Nantulya VM, Akol GW & Musoke AJ (1984) Cerebral trypanosomiasis in cattle with mixed Trypanosoma congolense and T. b. brucei infections. Acta Tropica 41, 237-246.
34. Molyneux DH, Pentreath V & Doua F (1996) African Trypanosomiasis in man. In: Manson's Tropical Diseases (ed. GC Cook), 20th edn, Philadelphia: WB Saunders, Vol. 63, pp. 1171-1196.
35. Montmayeur A & Buguet A (1994) Time-related changes in the sleep-wake cycle of rats infected with Trypanosoma brucei brucei. Neuroscience Letters 168, 172-174.
36. Mulenga C, Mhlanga JDM, Kristensson K & Robertson B (2001) Trypanosoma brucei brucei crosses the blood-brain barrier while tight junction proteins are preserved in a rat chronic disease model. Neuropathology and applied Neurobiology 27, 77-85.
37. Pentreath VW (1989) Neurobiology of sleeping sickness. Parasitology Today 5, 215-218.
38. Rameau JP, Devillers J, Declercq JP, Chauvière G & Perié J (1996) Molecular structure of megazol the 2 amino-5-(1-methyl-5- nitro-2-imidazolyl)-1,2,4 thiadiazol. A concerted study by X-ray cristallography and molecular mechanic. Structural Chemistry 7, 187-204.
39. Raseroka BH & Ormerod WE (1986) The trypanocidal effect of drugs in different parts of the brain. Transactions of the Royal Society of Tropical Medicine and Hygiene 80, 634-641.
40. Schmidt H (1983) The pathogenesis of trypanosomiasis of the CNS. Studies on parasitological and neurohistological findings in Trypanosoma rhodesiense infected vervet monkeys. Virchow Archives 399, 333-343.
41. Schultzberg M, Ambatsis M, Samuelsson EB, Kristensson K & Van Meirvenne N (1988) Spread of Trypanosoma brucei to the nervous system: early attack on the circumventricular organs and sensory ganglia. Journal of Neuroscience Research 21, 51-61.
42. Smith DH, Pepin J & Stich AHR (1998) Human African trypanosomiasis: an emerging public health crisis. British Medical Bulletin 54, 341-355.
43. Spigelman MK, Zapulla RA, Johnson J, Goldsmith SJ, Malis LI & Holland JS (1986) Etoposide induced blood brain disruption effect of drug compared with that of solvent. Cancer Research 46, 1453-1457.
44. Tsuhako MH, Alves MJM, Colli W, Brener Z & Augusto O (1989) Restricted bioreductive metabolism of a nitroimidazole-thiadiazole derivative with curative action in experimental Trypanosoma cruzi infections. Biochemical Pharmacology 15, 4491-4496.
45. Viode C, Bettache N, Cenas N et al. (1999) Enzymatic reduction studies of nitroheterocycles. Biochemical Pharmacology 57, 549-557.
46. Wellde BT, Reardon MJ, Chumo DA et al. (1989) Cerebral trypanosomiasis in naturally infected cattle in Lambwe Valley, South Nyanza, Kenya. Annals of Tropical Medicine and Parasitology, 83 (Suppl. 1), 151-160.
47. World Health Organisation (1998) Control and surveillance of African trypanosomiasis. Report of a WHO Expert Committee. Technical Report Series, 881, 1-113.