Mechanism of action studies of cytotoxic marine alkaloids: Ascididemin exhibits thiol-dependent oxidative DNA cleavage

Tetrahedron Letters

Volumn 41, Issue 10, 2000, Pages 1667-1670

  Matsumoto, Sandra S ^a   Sidford, Mathew H ^c   Holden, Joseph A ^b   Barrows, Louis R ^a   Copp, Brent R ^c  

^a UNIVERSITY OF UTAH   (United States)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

Alkaloid; Cytotoxins; Marine metabolites

Indexed keywords

ACRIDONE DERIVATIVE; ALKALOID; ASCIDIDEMIN; CYTOTOXIN; DNA TOPOISOMERASE (ATP HYDROLYSING); HEME OXYGENASE; THIOL DERIVATIVE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DNA CLEAVAGE; DNA DAMAGE; DRUG MECHANISM; DRUG STRUCTURE; IN VITRO STUDY; LEUKEMIA CELL; MOUSE; NONHUMAN; OXIDATION; OXIDATIVE STRESS; STRUCTURE ACTIVITY RELATION;

EID: 0034603455     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(00)00011-3     Document Type: Article

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10. 50 concentrations of ascididemin arrested cells in the G1 phase (cells hesitating to enter DNA synthesis).
11. Heme oxygenase-1 (HO-1) is a 32 kDa oxidative stress response protein that acts as a general cellular defense against oxidative stress. Compounds 1, 3 and 6 were strong inducers of HO-1 in AA8 CHO wild type cells as determined by Western Blot analysis.