CD27-triggering on primary plasma cell leukaemia cells has anti-apoptotic effects involving mitogen activated protein kinases

British Journal of Haematology

Volumn 124, Issue 3, 2004, Pages 299-308

  Guikema, Jeroen E J ^a,b   Vellenga, Edo ^b   Abdulahad, Wayel H ^a   Hovenga, Sjoerd ^b   Bos, Nicolaas A ^a,b  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

^b UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

Apoptosis; CD27; Extracellular regulated kinase 1 2; p38; Plasma cell leukaemia

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CD27 ANTIGEN; CD70 ANTIGEN; DEXAMETHASONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE P38; TRANSCRIPTION FACTOR AP 1;

ANTIGEN EXPRESSION; APOPTOSIS; ARTICLE; CANCER PATIENT; CELL STIMULATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; LEUKEMIA CELL; PLASMA CELL LEUKEMIA; PRIORITY JOURNAL; PROTEIN FUNCTION; PURIFICATION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANTIGENS, CD27; APOPTOSIS; BLOTTING, WESTERN; BUTADIENES; DEXAMETHASONE; ELECTROPHORETIC MOBILITY SHIFT ASSAY; ENZYME INHIBITORS; GLUCOCORTICOIDS; HUMANS; IMIDAZOLES; LEUKEMIA, PLASMACYTIC; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASES; NITRILES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PYRIDINES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STATISTICS, NONPARAMETRIC; TRANSCRIPTION FACTOR AP-1; TUMOR CELLS, CULTURED;

EID: 0842308836     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.2003.04783.x     Document Type: Article

References (56)

1. Agematsu, K., Nagumo, H., Oguchi, Y., Nakazawa, T., Fukushima, K., Yasui, K., Ito, S., Kobata, T., Morimoto, C. & Komiyama, A. (1998) Generation of plasma cells from peripheral blood memory B cells: synergistic effect of interleukin-10 and CD27/CD70 interaction. Blood, 91, 173-180.
2. Agematsu, K., Hokibara, S., Nagumo, H., Shinozaki, K., Yamada, S. & Komiyama, A. (1999) Plasma cell generation from B-lymphocytes via CD27/CD70 interaction. Leukemia and Lymphoma, 35, 219-225.
3. Agematsu, K., Hokibara, S., Nagumo, H. & Komiyama, A. (2000) CD27: a memory B-cell marker. Immunology Today, 21, 204-206.
4. Aggarwal, B.B. (2000) Tumour necrosis factors receptor associated signalling molecules and their role in activation of apoptosis, JNK and NF-kappaB. Annals of Rheumatic Diseases, 59(Suppl. 1), i6-16.
5. Akiba, H., Nakano, H., Hishinaka, S., Shindo, M., Kobata, T., Atsuta, M., Morimoto, C., Ware, CF., Malinin, N.L., Wallach, D., Yagita, H. & Okumura, K. (1998) CD27, a member of the tumor necrosis factor receptor superfamily, activates NF-κB and stress-activated protein kinase/c-jun N-terminal kinase via TRAF2, TRAF5, and NF-κB-inducing kinase. Journal of Biological Chemistry, 273, 13353-13358.
6. Avet-Loiseau, H., Andree-Ashley, L.E., Moore, D., Mellerin, M.P., Feusner, J., Bataille, R. & Pallavicini, M.G. (1997) Molecular cytogenetic abnormalities in multiple myeloma and plasma cell leukemia measured using comparative genomic hybridization. Genes Chromosomes and Cancer, 19, 124-133.
7. Avet-Loiseau, H., Daviet, A., Brigaudeau, C., Callet-Bauchu, E., Terre, C., Lafage-Pochitaloff, M., Desangles, F., Ramond, S., Talmant, P. & Bataille, R. (2001) Cytogenetic, interphase, and multicolor fluorescence in situ hybridization analyses in primary plasma cell leukemia: a study of 40 patients at diagnosis, on behalf of the Intergroupe Francophone du Myelome and the Groupe Francais de Cytogenetique Hematologique. Blood, 97, 822-825.
8. Birkenkamp, K.U., Dokter, W.H., Esselink, M.T., Jonk, L.J., Kruijer, W. & Vellenga, E. (1999) A dual function for p38 MAP kinase in hematopoietic cells: involvement in apoptosis and cell activation. Leukemia, 13, 1037-1045.
9. Camerini, D., Walz, G., Loenen, W.A., Borst, J. & Seed, B. (1991) The T cell activation antigen CD27 is a member of the nerve growth factor/tumor necrosis factor receptor gene family. Journal of Immunology, 147, 3165-3169.
10. Chauhan, D., Kharbanda, S., Ogata, A., Urashima, M., Teoh, G., Robertson, M., Kufe, D.W. & Anderson, K.C. (1997a) Interleukin-6 inhibits Fas-induced apoptosis and stress-activated protein kinase activation in multiple myeloma cells. Blood, 89, 227-234.
11. Chauhan, D., Kharbanda, S., Ogata, A., Urashima, M., Teoh, G., Robertson, M., Kufe, D.W. & Anderson, K.C. (1997b) Interleukin-6 inhibits Fas-induced apoptosis and stress-activated protein kinase activation in multiple myeloma cells. Blood, 89, 227-234.
12. Cuenda, A., Rouse, J., Doza, Y.N., Meier, R., Cohen, P., Gallagher, T.F., Young, P.R. & Lee, J.C. (1995) SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1. FEBS Letters, 364, 229-233.
13. Dimopoulos, M.A., Palumbo, A., Delasalle, K.B. & Alexanian, R. (1994) Primary plasma cell leukaemia. British Journal of Haematology, 88, 754-759.
14. Farstad, I.N., Carlsen, H., Morton, H.C. & Brandtzaeg, P. (2000) Immunoglobulin A cell distribution in the human small intestine: phenotypic and functional characteristics. Immunology, 101, 354-363.
15. Favata, M.F., Horiuchi, K.Y., Manos, E.J., Daulerio, A.J., Stradley, D.A., Feeser, W.S., Van Dyk, D.E., Pitts, W.J., Earl, R.A., Hobbs, F., Copeland, R.A., Magolda, R.L., Scherle, P.A. & Trzaskos, J.M. (1998) Identification of a novel inhibitor of mitogen-activated protein kinase kinase. Journal of Biological Chemistry, 273, 18623-18632.
16. Feinman, R., Koury, J., Thames, M., Barlogie, B., Epstein, J. & Siegel, D.S. (1999) Role of NF-kappaB in the rescue of multiple myeloma cells from glucocorticoid-induced apoptosis by bcl-2. Blood, 93, 3044-3052.
17. Fuhler, G.M., Drayer, A.L. & Vellenga, E. (2003) Decreased phosphorylation of protein kinase B and extracellular signal-regulated kinase in neutrophils from patients with myelodysplasia. Blood, 101, 1172-1180.
18. Funakoshi, M., Sonoda, Y., Tago, K., Tominaga, S. & Kasahara, T. (2001) Differential involvement of p38 mitogen-activated protein kinase and phosphatidyl inositol 3-kinase in the IL-1-mediated NF-kappa B and AP-1 activation. International Immunopharmacology, 1, 595-604.
19. Garcia-Sanz, R., Orfao, A., Gonzalez, M., Tabernero, M.D., Blade, J., Moro, M.J., Fernandez-Calvo, J., Sanz, M.A., Perez-Simon, J.A., Rasillo, A. & Miguel, J.F. (1999) Primary plasma cell leukemia: clinical, immunophenotypic, DNA ploidy, and cytogenetic characteristics. Blood, 93, 1032-1037.
20. Gravestein, L.A., Amsen, D., Boes, M., Calvo, C.R., Kruisbeek, A.M. & Borst, J. (1998) The TNF receptor family member CD27 signals to jun N-terminal kinase via TRAF2. European Journal of Immunology, 28, 2208-2216.
21. Guikema, J.E.J., Hovenga, S., Vellenga, E., Conradie, J.J., Abdulahad, W.H., Bekkema, R., Smit, J.W., Zhan, F., Shaughnessy, J. & Bos, N.A. (2003) CD27 is heterogeneously expressed in multiple myeloma; low CD27 expression in patients with high-risk disease. British Journal of Haematology, 121, 36-43.
22. Gutierrez, N.C., Hernandez, J.M., Garcia, J.L., Canizo, M.C., Gonzalez, M., Hernandez, J., Gonzalez, M.B., Garcia-Marcos, M.A. & San Miguel, J.F. (2001) Differences in genetic changes between multiple myeloma and plasma cell leukemia demonstrated by comparative genomic hybridization. Leukemia, 15, 840-845.
23. Hardin, J., MacLeod, S., Grigorieva, L., Chang, R., Barlogie, B., Xiao, H. & Epstein, J. (1994) Interleukin-6 prevents dexamethasone-induced myeloma cell death. Blood, 84, 3063-3070.
24. Hayman, S.R. & Fonseca, R. (2001) Plasma cell leukemia. Current Treatment Options in Oncology, 2, 205-216.
25. Helmberg, A., Auphan, N., Caelles, C. & Karin, M. (1995) Glucocorticoid-induced apoptosis of human leukemic cells is caused by the repressive function of the glucocorticoid receptor. EMBO Journal, 14, 452-460.
26. Hideshima, T., Richardson, P., Chauhan, D., Palombella, V.J., Elliott, P.J., Adams, J. & Anderson, K.C. (2001) The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells. Cancer Research, 61, 3071-3076.
27. Hideshima, T., Akiyama, M., Hayashi, T., Richardson, P., Schlossman, R., Chauhan, D. & Anderson, K.C. (2003) Targeting p38 MAPK inhibits multiple myeloma cell growth in the bone marrow milieu. Blood, 101, 703-705.
28. Hintzen, R.Q., de Jong, R., Lens, S.M. & van Lier, R.A.W. (1994) CD27: marker and mediator of T-cell activation. Immunology Today, 15, 307-311.
29. Hovenga, S., de Wolf, J.T., Klip, H. & Vellenga, E. (1997) Consolidation therapy with autologous stem cell transplantation in plasma cell leukemia after VAD, high-dose cyclophosphamide and EDAP courses: a report of three cases and a review of the literature. Bone Marrow Transplantation, 20, 901-904.
30. Jonveaux, P. & Berger, R. (1992) Chromosome studies in plasma cell leukemia and multiple myeloma in transformation. Genes Chromosomes and Cancer, 4, 321-325.
31. Jung, J., Choe, J., Li, L. & Choi, Y.S. (2000) Regulation of CD27 expression in the course of germinal center B cell differentiation: the pivotal role of IL-10. European Journal of Immunology, 30, 2437-2443.
32. Kawano, M., Hirano, T., Matsuda, T., Taga, T., Horii, Y., Iwato, K., Asaoku, H., Tang, B., Tanabe, O. & Tanaka, H. (1988) Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas. Nature, 332, 83-85.
33. Klein, B., Zhang, X.G., Jourdan, M., Content, J., Houssiau, F., Aarden, L., Piechaczyk, M. & Bataille, R. (1989) Paracrine rather than autocrine regulation of myeloma-cell growth and differentiation by interleukin-6. Blood, 73, 517-526.
34. Klein, B., Zhang, X.G., Lu, Z. & Bataille, R. (1995) Interleukin-6 in multiple myeloma. Blood, 85, 863-872.
35. + peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (memory) B cells. Journal of Experimental Medicine, 188, 1679-1689.
36. Kyle, R.A., Maldonado, J.E. & Bayrd, E.D. (1974) Plasma cell leukemia. Report on 17 cases. Archives of Internal Medicine, 133, 813-818.
37. Lens, S.M., de Jong, R., Hintzen, R.Q., Koopman, G., van Lier, R.A. & van Oers, R.H. (1995) CD27-CD70 interaction: unravelling its implication in normal and neoplastic B-cell growth. Leukemia and Lymphoma, 18, 51-59.
38. Lens, S.M., Tesselaar, K., van Oers, M.H. & van Lier, R.A. (1998) Control of lymphocyte function through CD27-CD70 interactions. Seminars in Immunology, 10, 491-499.
39. Lichtenstein, A., Tu, Y., Fady, C., Vescio, R. & Berenson, J. (1995) Interleukin-6 inhibits apoptosis of malignant plasma cells. Cellular Immunology, 162, 248-255.
40. van Lier, R.A., Borst, J., Vroom, T.M., Klein, H., Van Mourik, P., Zeijlemaker, W.P. & Melief, C.J. (1987) Tissue distribution and biochemical and functional properties of Tp55 (CD27), a novel T cell differentiation antigen. Journal of Immunology, 139, 1589-1596.
41. Liu, P., Oken, M. & Van Ness, B. (1999) Interferon-alpha protects myeloma cell lines from dexamethasone-induced apoptosis. Leukemia, 13, 473-480.
42. Maurer, D., Holter, W., Majdic, O., Fischer, G.F. & Knapp, W. (1990) CD27 expression by a distinct subpopulation of human B lymphocytes. European Journal of Immunology, 20, 2679-2684.
43. Nakano, H., Sakon, S., Koseki, H., Takemori, T., Tada, K., Matsumoto, M., Munechika, E., Sakai, T., Shirasawa, T., Akiba, H., Kobata, T., Santee, S.M., Ware, C.F., Rennert, P.D., Taniguchi, M., Yagita, H. & Okumura, K. (1999) Targeted disruption of TRAF5 gene causes defects in CD40- and CD27-mediated lymphocyte activation. Proceedings of the National Academy of Sciences of the United States of America, 96, 9803-9808.
44. Ogata, A., Chauhan, D., Teoh, G., Treon, S.P., Urashima, M., Schlossman, R.L. & Anderson, K.C. (1997) IL-6 triggers cell growth via the Ras-dependent mitogen-activated protein kinase cascade. Journal of Immunology, 159, 2212-2221.
45. Pellat-Deceunynck, C., Barille, S., Jego, G., Puthier, D., Robillard, N., Pineau, D., Rapp, M.J., Harousseau, J.L., Amiot, M. & Bataille, R. (1998) The absence of CD56 (NCAM) on malignant plasma cells is a hallmark of plasma cell leukemia and of a special subset of multiple myeloma. Leukemia, 12, 1977-1982.
46. Prasad, KV., Ao, Z., Yoon, Y., Wu, M.X., Rizk, M., Jacquot, S. & Schlossman, S.F. (1997) CD27, a member of the tumor necrosis factor receptor family, induces apoptosis and binds to Siva, a proapoptotic protein. Proceedings of the National Academy of Sciences of the United States of America, 94, 6346-6351.
47. Sheth, K., Friel, J., Nolan, B. & Bankey, P. (2001) Inhibition of p38 mitogen activated protein kinase increases lipopolysaccharide induced inhbition of apoptosis in neutrophils by activating extra-cellular signal-regulated kinase. Surgery, 130, 242-248.
48. Singh, R.P., Dhawan, P., Golden, C., Kapoor, G.S. & Mehta, K.D. (1999) One-way cross-talk between p38(MAPK) and p42/44(MAPK). Inhibition of p38(MAPK) induces low density lipoprotein receptor expression through activation of the p42/44(MAPK) cascade. Journal of Biological Chemistry, 274, 19593-19600.
49. Tangye, S.G., Liu, Y.J., Aversa, G., Phillips, J.H. & de Vries, J.E. (1998) Identification of functional human splenic memory B cells by expression of CD148 and CD27. Journal of Experimental Medicine, 188, 1691-1703.
50. Tuyt, L.M., Dokter, W.H., Birkenkamp, K., Koopmans, S.B., Lummen, C., Kruijer, W. & Vellenga, E. (1999) Extracellular-regulated kinase 1/2, Jun N-terminal kinase, and c-Jun are involved in NF-kappa B-dependent IL-6 expression in human monocytes. Journal of Immunology, 162, 4893-4902.
51. Wesselborg, S., Bauer, M.K., Vogt, M., Schmitz, M.L. & Schulze-Osthoff, K. (1997) Activation of transcription factor NF-kappaB and p38 mitogen-activated protein kinase is mediated by distinct and separate stress effector pathways. Journal of Biological Chemistry, 272, 12422-12429.
52. Xiao, Y.Q., Malcolm, K., Worthen, G.S., Gardai, S., Schiemann, W.P., Fadok, V.A., Bratton, D.L. & Henson, P.M. (2002) Cross-talk between ERK and p38 MAPK mediates selective suppression of pro-inflammatory cytokines by transforming growth factor-beta. Journal of Biological Chemistry, 277, 14884-14893.
53. Xu, F.H., Sharma, S., Gardner, A., Tu, Y., Raitano, A., Sawyers, C. & Lichtenstein, A. (1998) Interleukin-6-induced inhibition of multiple myeloma cell apoptosis: support for the hypothesis that protection is mediated via inhibition of the JNK/SAPK pathway. Blood, 92, 241-51.
54. Yamamoto, H., Kishimoto, T. & Minamoto, S. (1998) NF-κB activation in CD27 signaling: involvement of TNF receptor-associated factors in its signaling and identification of functional region of CD27. Journal of Immunology, 161, 4753-4759.
55. Yang-Yen, H.F., Chambard, J.C., Sun, Y.L., Smeal, T., Schmidt, T.J., Drouin, J. & Karin, M. (1990) Transcriptional interference between c-Jun and the glucocorticoid receptor: mutual inhibition of DNA binding due to direct protein-protein interaction. Cell, 62, 1205-1215.
56. Zhang, H., Shi, X., Hampong, M., Blanis, L. & Pelech, S. (2001) Stress-induced inhibition of ERK1 and ERK2 by direct interaction with p38 MAP kinase. Journal of Biological Chemistry, 276, 6905-6908.