Host-Inducible Immunogenic Sphingomyelinase-Like Protein, Lk73.5, of Leptospira interrogans

Infection and Immunity

Volumn 72, Issue 2, 2004, Pages 742-749

  Artiushin, S ^a   Timoney, J F ^a   Nally, J ^a,b   Verma, A ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; GENOMIC DNA; RECOMBINANT PROTEIN; RECOMBINANT PROTEIN LK73.5; SPHINGOMYELIN PHOSPHODIESTERASE; UNCLASSIFIED DRUG; VIRULENCE FACTOR;

AMINO ACID SEQUENCE; ANIMAL CELL; ANTIBODY RESPONSE; ARTICLE; BACTERIAL VIRULENCE; CYTOTOXICITY; DNA SEQUENCE; ENDOTHELIUM CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; ERYTHROCYTE; GENOME; HEMOLYSIS; HORSE; IMMUNE RESPONSE; IMMUNOGENICITY; LEPTOSPIRA; LEPTOSPIRA INTERROGANS; LEPTOSPIROSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYACRYLAMIDE GEL ELECTROPHORESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RABBIT; SOUTHERN BLOTTING; WESTERN BLOTTING;

AMINO ACID SEQUENCE; ANIMALS; BACTERIAL PROTEINS; BACTERIAL VACCINES; BASE SEQUENCE; ENDOTHELIAL CELLS; ENZYME INDUCTION; HORSES; LEPTOSPIRA INTERROGANS; MOLECULAR SEQUENCE DATA; SEQUENCE HOMOLOGY; SPHINGOMYELIN PHOSPHODIESTERASE;

EID: 0842305637     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.72.2.742-749.2004     Document Type: Article

References (52)

1. Ballard, S. A., M. Go, R. P. Segers, and B. Adler. 1998. Molecular analysis of the dnaK locus of Leptospira interrogans serovar garts scrovar Copenhageni. Gene 216: 21-29.
2. Ballard, S. A., R. P. Segers, N. Bleumink Pluym, J. Fyfe, S. Faine, and B. Adler. 1993. Molecular analysis of the hsp (groE) operon of Leptospira interrogans serovar copenhageni. Mol. Microbiol. 8:739-751.
3. Bolin, C. A., and J. A. Cassells. 1990. Isolation of Leptospira interrogans serovar bratislava from stillborn and weak pigs in Iowa. J. Am. Vet. Med. Assoc. 196:1601-1604.
4. Bolin, C. A., J. A. Cassells, R. L. Zuerner, and G. Trueba. 1991. Effect of vaccination with a monovalent Leptospira interrogans serovar hardjo type hardjo-bovis vaccine on type hardjo-bovis infection of cattle. Am. J. Vet. Res. 52:1639-1643.
5. Bolin, C. A., R. L. Zuerner, and G. Trueba. 1989. Effect of vaccination with a pentavalent leptospiral vaccine containing Leptospira interrogans serovar hardjo type hardjo-bovis on type hardjo-bovis infection of cattle. Am. J. Vet. Res. 50:2004-2008.
6. Branger, C., C. Sonrier, B. Chatrenet, B. Klonjkowski, N. Ruvoen-Clouet, A. Aubert, G. Andre-Fontaine, and M. Eloit. 2001. Identification of the hemolysis-associated protein 1 as a cross-protective immunogen of Leptospira interrogans by adenovirus-mediated vaccination. Infect. Immun. 69:6831-6838.
7. Braun, V., and H. C. Wu. 1994. Lipoproteins, structure, function, biosynthesis and model for protein export, p. 319-341. In J.-M. Ghuysen and R. Hakenbeck (ed.), New comprehensive biochemistry, vol. 27. Bacterial cell wall. Elsevier Science, Amsterdam, The Netherlands.
8. Centers for Disease Control and Prevention. 1998. Update: leptospirosis and unexplained acute febrile illness among athletes participating in triathlons-Illinois and Wisconsin, 1998. JAMA 280:1474-1475.
9. Centers for Disease Control and Prevention. 2001. Update: outbreak of acute febrile illness among athletes participating in Eco-Challenge-Sabah 2000-Borneo, Malaysia, 2000. Morb. Mortal. Wkly. Rep. 50:21-24.
10. Chang, Y. F., V. Novosol, S. P. McDonough, C. F. Chang, R. H. Jacobson, T. Divers, F. W. Quimby, S. Shin, and D. H. Lein. 2000. Experimental infection of ponies with Borrelia burgdorferi by exposure to Ixodid ticks. Vet. Pathol. 37: 68-76.
11. Chang, Y.-F., V. Novosol, E. Dubovi, S. J. Wong, F. K. Chu, C.-F. Chang, F. D. Piero, S. Shin, and D. H. Lein. 1998. Experimental infection of the human granulocytic ehrlichiosis agent in horses. Vet. Parasitol. 78:137-245.
12. Chu, K. M., R. Rathinam, P. Namperumalsamy, and D. Dean. 1998. Identification of Leptospira species in the pathogenesis of uveitis and determination of clinical ocular characteristics in south India. J. Infect. Dis. 177:1314-1321.
13. Girons, I. S., P. Bourhy, C. Ottone, M. Picardeau, D. Yelton, R. W. Hendrix, P. Glaser, and N. Charon. 2000. The LE1 bacteriophage replicates as a plasmid within Leptospira biflexa: construction of an L. biflexa-Escherichia coli shuttle vector. J. Bacteriol. 182:5700-5705.
14. Gonzalez-Zorn, B., G. Dominguez-Bernal, M. Suarez, M. T. Ripio, Y. Vega, S. Novella, and J. A. Vazquez-Boland. 1999. The smcL gene of Listeria ivanovii encodes a sphingomyelinase C that mediates bacterial escape from the phagocytic vacuole. Mol, Microbiol. 33:510-523.
15. Guerreiro, H., J. Croda, B. Flannery, M. Mazel, J. Matsunaga, M. Galvao Reis, P. N. Levett, A. I. Ko, and D. A. Haake. 2001. Leptospiral proteins recognized during the humoral immune response to leptospirosis in humans. Infect. Immun. 69:4958-4968.
16. Haake, D. A. 2000. Spirochaetal lipoproteins and pathogenesis. Microbiology 146:1491-1504.
17. Haake, D. A., C. I. Champion, C. Martinich, E. S. Shang, D. R. Blanco, J. N. Miller, and M. A. Lovett. 1993. Molecular cloning and sequence analysis of the gene encoding OmpL1, a transmembrane outer membrane protein of pathogenic Leptospira spp. J. Bacteriol. 175:4225-4234.
18. Haake, D. A., G. Chao, R. L. Zuerner, J. K. Barnett, D. Barnett, M. Mazel, J. Matsunaga, P. N. Levett, and C. A. Bolin. 2000. The leptospiral major outer membrane protein LipL32 is a lipoprotein expressed during mammalian infection. Infect. Immun. 68:2276-2285.
19. Haake, D. A., M. K. Mazel, A. M. McCoy, F. Milward, G. Chao, J. Matsunaga, and E. A. Wagar. 1999. Leptospiral outer membrane proteins OmpL1 LipL41 exhibit synergistic immunoprotection. Infect. Immun. 67:6572-6582.
20. Handfield, M., J. L. Brady, A. Progulske-Fox, and J. D. Hillman. 2000. IVIAT: a novel method to identify microbial genes expressed specifically during human infections. Trends Microbiol. 8:336-339.
21. Handfield, M., and R. C. Levesque. 1999. Strategies for isolation of in vivo expressed genes from bacteria. FEMS Microbiol. Rev. 23:69-91.
22. Hedges, J., C. Demaula, B. Moore, B. McLaughlin, S. Simon, and N. MacLachlan. 2001. Characterization of equine E-selectin. Immunology 103:498-504.
23. Johansen, T., F. B. Haugli, H. Ikezawa, and C. Little. 1988. Bacillus cereus strain SE-1: nucleotide sequence of the sphingomyelinase C gene., Nucleic Acids Res. 16:10370.
24. Johnson, R. C., and V. G. Harris. 1967. Differentiation of pathogenic and saprophytic leptospires, I. Growth at low temperatures. J. Bacteriol. 94:27-31.
25. Jusuf, S. D. 1997. Proteins of Leptospira interrogans serovar pomona type kennewicki reactive with serum antibodies of aborting mares and their fetuses. Doctoral dissertation. University of Kentucky, Lexington.
26. Kalsow, C. M., and A. E. Dwyer. 1998. Retinal immunopathology in horses with uveitis. Ocul. Immunol. Inflamm. 6:239-251.
27. Ko, A. I., M. Galvao Reis, C. M. Ribeiro Dourado, W. D. Johnson, Jr., and L. W. Riley. 1999. Urban epidemic of severe leptospirosis in Brazil. Lancet 354:820-825.
28. Lee, S. H., K. A. Kim, Y. G. Park, I. W. Seong, M. J. Kim, and Y. J. Lee. 2000. Identification and partial characterization of a novel hemolysin from Leptospira interrogans serovar lai. Gene 254:19-28.
29. Lee, S. H., S. Kim, S. C. Park, and M. J. Kim. 2002. Cytotoxic activities of Leptospira interrogans hemolysin SphH as a pore-forming protein on mammalian cells. Infect. Immun. 70:315-322.
30. Levett, P. N. 2001. Leptospirosis. Clin. Microbiol. Rev. 14:296-326.
31. Lewis, D.E.A., and S. Adhya. 2002. In vitro repression of the gal promoters by GalR and HU depends on the proper helical phasing of the two operators. J. Biol. Chem. 277:2498-2504.
32. Matsunaga, J., T. A. Young, J. K. Barnett, D. Barnett, C. A. Bolin, and D. A. Haake. 2002. Novel 45-kilodalton leptospiral protein that is processed to a 31-kilodalton growth-phase-regulated peripheral membrane protein. Infect. Immun. 70:323-334.
33. Moore, B. D., U. B. R. Balasuriya, Jodi F. Hedges, and N. J. MacLachlan. 2002. Growth characteristics of a highly virulent, a moderately virulent, and an avirulent strain of equine arteritis virus in primary equine endothelial cells are predictive of their virulence to horses. Virology 298:39-44.
34. Naiman, B. M., D. Alt, C. A. Bolin, R. Zuerner, and C. L. Baldwin. 2001. Protective killed Leptospira borgpetersenii vaccine induces potent Th1 immunity comprising responses by CD4 and γδ T lymphocytes. Infect. Immun. 69:7550-7558.
35. +γδ and CD4 T cells. Infect. Immun. 70:6147-6157.
36. Nally, J. E., S. Artiushin, and J. F. Timoney. 2001. Molecular characterization of thermoinduced immunogenic proteins Q1p42 and Hsp15 of Leptospira interrogans. Infect. Immun. 69:7616-7624.
37. Palaniappan, R. U. M., Y.-F. Chang, S. S. D. Jusuf, S. Artiushin, J. F. Timoney, S. P. McDonough, S. C. Barr, T. J. Divers, K. W. Simpson, P. L. McDonough, and H. O. Mohammed. 2002. Cloning and molecular characterization of an immunogenic LigA protein of Leptospira interrogans, Infect. Immun. 70:5924-5930.
38. Plank, R., and D. Dean. 2000. Overview of the epidemiology, microbiology, and pathogenesis of Leptospira spp. in humans. Microbes Infect. 2:1265-1276.
39. Projan, S. J., K. J., B. Kreiswirth, S. L. Moghazeh, W. Eisner, and R. P. Novick. 1989. Nucleotide sequence: the beta-hemolysin gene of Staphylococcus aureus. Nucleic Acids Res. 17:3305.
40. Rathinam, S. R., S. Rathnam, S. Selvaraj, D. Dean, R. A. Nozik, and P. Namperumalsamy. 1997. Uveitis associated with an epidemic outbreak of leptospirosis. Am. J. Ophthalmol. 124:71-79.
41. Ren, S.-X., G. Fu, X.-G. Jiangk, R. Zeng, Y.-G. Miao, H. Xu, Y.-X. Zhang, H. Xiong, G. Lu, L.-F. Lu, H.-Q. Jiang, J. Jia, Y.-F. Tu, J.-X. Jiang, W.-Y. Gu, Y.-Q. Zhang, Z. Cai, H.-H. Sheng, H.-F. Yin, Y. Zhang, G.-F. Zhu, M. Wank, H.-L. Huangk, Z. Qian, S.-Y. Wang, Wei Ma, Z.-J. Yao, Y. Shen, B.-Q. Qiang, Q.-C. Xia, X.-K. Guo, A. Danchinq, I. S. Girons, R. L. Somerville, Y.-M. Wen, M.-H. Shik, Z. Chen, J.-G. Xuk, and G.-P. Zhao. 2003. Unique physiological and pathogenic features of Leptospira interrogans revealed by whole-genome sequencing. Nature 422:88-893.
42. Segers, R. P., A. van der Drift, A. de Nijs, P. Corcione, B. A. van der Zeijst, and W. Gaastra. 1990. Molecular analysis of a sphingomyelinase C gene from Leptospira interrogans serovar hardjo. Infect. Immun. 58:2177-2185.
43. Semsey, S., M. Geanacopoulos, D. E. A. Lewis, and S. Adhya. 2002. Operator-bound GalR dimers close DNA loops by direct interaction: tetramerization and inducer binding. EMBO J. 21:4349-4356.
44. Shang, E., T. Summers, and D. Haake. 1996. Molecular cloning and sequence analysis of the gene encoding LipL41, a surface-exposed lipoprotein of pathogenic Leptospira species. Infect. Immun. 64:2322-2330.
45. Sonrier, C., C. Branger, V. Michel, N. Ruvoen-Clouet, J. P. Ganiere, and G. Andre-Fontaine. 2001. Evidence of cross-protection within Leptospira interrogans in an experimental model. Vaccine 19:86-94.
46. 2+-dependent sphingomyelinase/hemolysin of an aquatic bacterium, Pseudomonas sp. strain TK4. J. Bacteriol. 184:540-546.
47. Sutcliffe, I., and R. Russell. 1995. Lipoproteins of gram-positive bacteria. J. Bacteriol. 177:1123-1128.
48. Sutcliffe, I. C., and D. J. Harrington. 2002. Pattern searches for the identification of putative lipoprotein genes in Gram-positive bacterial genomes. Microbiology 148:2065-2077.
49. Trevejo, R. T., J. G. Rigau Perez, D. A. Ashford, E. M. McClure, C. Jarquin Gonzalez, J. J. Amador, J. O. de los Reyes, A. Gonzalez, S. R. Zaki, W. J. Shieh, R. G. McLean, R. S. Nasci, R. S. Weyant, C. A. Bolin, S. L. Bragg, B. A. Perkins, and R. A. Spiegel. 1998. Epidemic leptospirosis associated with pulmonary hemorrhage-Nicaragua, 1995. J Infect. Dis. 178:1457-1463.
50. Vinetz, J. M. 2001. Leptospirosis. Curr. Opin. Infect. Dis. 14:527-538.
51. Wollanke, B., B. W. Rohrbach, and H. Gerhards. 2001. Serum and vitreous humor antibody titers in and isolation of Leptospira interrogans from horses with recurrent uveitis. J. Am. Vet. Med. Assoc. 219:795-800.
52. Zaki, S. R., and W. J. Shieh. 1996. Leptospirosis associated with outbreak of acute febrile illness and pulmonary haemorrhage, Nicaragua, 1995. Lancet 347:535-536.