Role of Ionic Fluxes in the Apoptotic Cell Death of Cultured Cerebellar Granule Neurons

Neurochemical Research

Volumn 29, Issue 1, 2004, Pages 227-238

  Franco Cea, A ^a   Valencia, A ^a   Sanchez Armass S ^c   Dominguez G ^a   Moran J ^a,b  

^a INSTITUTO DE FISIOLOGÍA CELULAR   (Mexico)

^b UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

^c UNIVERSIDAD AUTÓNOMA DE SAN LUIS POTOSÍ   (Mexico)

Author keywords

Apoptosis; Caspases; DIDS; PH; Potassium; Volume regulation

Indexed keywords

4,4' DIISOTHIOCYANATOSTILBENE 2,2' DISULFONIC ACID; 5 (N ETHYL N ISOPROPYL)AMILORIDE; 5 NITRO 2 (3 PHENYLPROPYLAMINO)BENZOIC ACID; AMILORIDE; BUMETANIDE; CASPASE 3; FUROSEMIDE; N ETHYLMALEIMIDE; POTASSIUM CHLORIDE; STAUROSPORINE; TAMOXIFEN;

ACIDIFICATION; ALKALINIZATION; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CELL PH; CELL SURVIVAL; CEREBELLUM; CONTROLLED STUDY; ENZYME ACTIVATION; GRANULE CELL; ION CURRENT; NERVE CELL CULTURE; NONHUMAN; POLYMERIZATION; PRIORITY JOURNAL; RAT;

ANIMALS; APOPTOSIS; CELLS, CULTURED; CEREBELLUM; CYTOPLASMIC GRANULES; ION TRANSPORT; NEURONS; POTASSIUM; STAUROSPORINE;

ANIMALIA;

EID: 0842301312     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1023/B:NERE.0000010501.25627.0f     Document Type: Article

References (39)

1. Oppenheim, R., Prevette, D., Tytell, M., and Homma S. 1990. Naturally occurring and induced neuronal death in the chick embryo in vivo requires protein and RNA synthesis: Evidences for the role of cell death genes. Dev Biol. 138:104.
2. Meier, P., Finch, A., and Evan, G. 2000. Apoptosis in development. Nature 407:796-801.
3. Martin, S. J. and Green, D. R. 1995. Protease activation during apoptosis: Death by a thousand cuts? Cell. 82:349-352.
4. Cohen, G. M. 1997. Caspases: The executioners of apoptosis. Biochem. J. 326:1-16.
5. Nardi, N., Avidan, G., Daily, D., Zilkha-Falb, R., and Barzilai, A. 1997. Biochemical and temporal analysis of events associated with apoptosis induced by lowering the extracellular potassium concentration in mouse cerebellar granule neurons. J. Neurochem. 68:750-759.
6. Ni, B., Wu, X., Du, Y., Su, Y., Hamilton-Byrd, E., Rockey, P. K., Rosteck, P. Jr., Poirier, G. G., and Paul, S. M. 1997. Cloning and expression of a rat brain interleukin-1α-converting enzyme (ICE)-related protease (IRP) and its possible role in apoptosis of cultured cerebellar granule neurons. J. Neurosci. 17:1561-1569.
7. Morán, J., Itoh, T., Reddy, U., Chen, M., Alnemri, E., and Pleasure, D. 1999. Caspase-3 expression by cerebellar granule neurons is regulated by calcium and cyclic AMP. J. Neurochem. 73:568-577.
8. Hengartner, M. O. 2000. The biochemistry of apoptosis. Nature 407:770-776.
9. Kumar, S., and Vaux, D. 2002. A Cinderella caspase takes center stage. Science 297:1290-1291.
10. Balàzs, R., Jorgensen, O. S. and Hack, N. 1988. N-Methyl-D-aspartate promotes the survival of cerebellum granule cells in culture. Neuroscience 27:437-451.
11. Gallo, V., Kingsbury, A., Balazs, R., and Jorgensen, O. S. 1987. The role of depolarization in the survival and differentiation of cerebellar granule cells in culture. J. Neurosci. 7:2203-2213.
12. D'Mello, S. R., Galli, C., Ciotti, T., and Calissano, P. 1993. Induction of apoptosis in cerebellar granule neurons by low potassium: Inhibition of death by insulin-like growth factor I and cAMP. Proc. Natl. Acad. Sci. USA 90:10989-10993.
13. + efflux in the activation of apoptosis. J. Biol. Chem. 272:32436-32442.
14. + supresses the activation of apoptosis in lymphocytes. J. Biol. Chem. 272:30567-30576.
15. Yu, S. P., Yhe, C. H. Sensi, S. L., Guag, B. J., Calzoniero, L. M., Farhangrazi, Z. S., Ying, H. S., Tian, M., Dugan, L. L., and Choi, D. W. 1997. Mediation of neuronal apoptosis by enhancement of outward potassium current. Science 278:114.
16. Shrode, L. D., Tapper, H., and Grinstein, S. 1997. Role of intracellular pH in proliferation, transformation and apoptosis. J. Bioenerg. Biomem 29:393-399.
17. 3(-) exchanger in spontaneous thymocyte apoptosis. J. Immunol. 157: 1107-1116.
18. Fujita, H., Ishizaki, Y., Yanagisawa, A., Morita, I. Murota, S., and Ishikawa, K. 1999. Possible involvement of a chloride-bicarbonate exchanger in apoptosis of endothelial cells and cardiomyocytes. Cell Biol. Int. 23:241-249.
19. Perez-Sala, D., Collado-Escobar, D., and Mollinedo, R. 1995. Intracellular alkalinization suppresses levostatin-induced apoptosis in HL-60 cells through the inactivation of a pH-dependent endonuclease. J. Biol. Chem 279:6235-6242.
20. Matsuyama, S. J. Llopis, J., Deveraux, O. L., Tsen, J., and Reed, J. C. 2000. Changes in intramitochondrial and cytosolic pH: Early events that modulate caspases activation during apoptosis. Nat. Cell Biol. 2:318.
21. Ding, D., Moskowitz, S. I., Li, R., Lee, S. B., Esteban, M., Tomaselli, K., Chan, J., and Bergold, P. J. 2000. Acidosis induces necrosis and apoptosis of cultured hippocampal neurons. Exp. Neurol. 162:1-12.
22. Vincent, A. M., TenBroeke, M., and Maiese, K. 1999. Metabotropic glutamate receptors prevent programmed cell death through the modulation of neuronal endonuclease activity and intracellular pH Exp. Neurol 155:79-94.
23. Vincent, A. M., TenBroeke, M., and Maiese, K. 1999. Neuronal intracellular pH directly mediates nitric oxide-induced programmed cell death. J. Neurobiol. 40:171-184.
24. Morán, J. and Patel, A. J. 1989. Effect of potassium depolarization on phosphate-activated glutaminase activity in primary cultures of cerebellar granule neurons and astroglial cells during development. Dev. Brain. Res. 46:97-105.
25. Valencia, A. and Morán, J. 2001. Role of oxidative stress in the apoptotic cell death of cultured cerebellar granule neurons. J. Neurosci. Res. 64:284-297.
26. Sanchez-Armass, S., Martinez-Zaguilan, R., Martinez, G. M., and Gillies, R. J. 1994. Regulation of pH in rat brain synaptosomes: I. Role of sodium, bicarbonate, and potassium. J. Neurophysiol. 71:2236-2248.
27. Caballero-Benitez, A. and Moran, J. 2003. Caspase activation pathways in the apoptotic cell death of cultured cerebellar granule neurons. J. Neurosci. Res. 71:383-396.
28. Himi, T., Ishizaki, Y., and Murota, S. 2002. 4,4′ -Diisothiocyano-2,2′-stilbenedisulfonate protects cultured cerebellar granule neurons from death. Life Sci 70:1235-1249.
29. Pasantes-Morales, H., Chacón, E., Murray, R. A., and Morán, J. 1994. Properties of osmolyte fluxes activated during regulatory volume decrease in cultured cerebellar granule neurons. J. Neurosci. Res. 37:720-727.
30. Lauritzen, I, De Weille, J. R., and Lazdunski, M. 1997. The potassium channel opener (-)-cromakalim prevents glutamate-induced cell death in hippocampal neurons. J. Neurochem. 69:1570-1579.
31. Poppe, M., Reimertz, C., Düßmann, H., Krohn, A. J., Luetjens, C. M., Böckelmann, D., Nieminen, A., Kögel, D. and Prehn, H. M. 2001. Dissipation of potassium and proton gradients inhibits mitochondrial hyperpolarization and cytochrome c release during neural apoptosis. J. Neurosci. 21:4551-4563.
32. Walev, I., Reske, K., Palmer, M., Valeva, A., and Bhakdi, S. 1995. Potassium-inhibited processing of IL-1 beta in humans monocytes. EMBO J. 14:1607-1614.
33. Pasantes-Morales, H. Volume regulation in brain cells:cellular and molecular mechanisms. Met. Brain Dis. 11:187-204.
34. Benson, R. S. P., Heer, S., Dive, C., and Watson, A. J. M. 1996. Characterization of cell volume loss in CEM-C7A cell during dexamethasone-induced apoptosis. Am. J. Physiol. 39: 1190-1203.
35. Bortner, C. D., Hughes, F. M., and Cidlowski, J. A. 1997. Cell volume regulation, ions, and apoptosis. Pages 63-70, in Shi et al., (eds): Programmed Cell Death, New York: Plenum.
36. Bortner, C. D. and Cidlowski, J. A. 1996. Absence of volume regulatory mechanisms contributes to the rapid activation of apoptosis in thymocytes. Am. J. Physiol. 40:950-961.
37. Lang, F., Madlung, J., Siemen, D., Ellory, C., Lepple-Wienhues, A., and Gulbins, E. 2000. The involvement of caspases in the CD95 (Fas/Apo-1) but not swelling-induced cellular taurine release from Jukart T-lymphocytes. Eur J. Physiol. 440:93-99.
38. Moran, J., Hernandez-Pech, E., and Pasantes-Morales, H. 2000. Release of taurine in apoptotic cerebellar granule neurons in culture. Eur J. Physiol. 439:270-277.
39. Lang, F., Chang, R. C. C., Staub, A., Baethmann, A., and Presnils, N. 2000. Contribution of anion transporters to the acidosis-induced swelling and intracellular acidification of glial cells. J. Neurochem. 75:125-132.