Human Serum Albumin and its N-Terminal Tetrapeptide (DAHK) Block Oxidant-Induced Neuronal Death

Stroke

Volumn 35, Issue 2, 2004, Pages 590-595

  Gum, Elizabeth T ^a   Swanson, Raymond A ^a   Alano, Conrad ^a   Liu, Jialing ^a   Hong, Shwuhuey ^a   Weinstein, Philip R ^a   Panter, S Scott ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b SAN FRANCISCO VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Albumins; Antioxidants; Copper; Ischemia; Neurons

Indexed keywords

AMINO TERMINAL TETRAPEPTIDE; ASCORBIC ACID; ASPARTYLALANYLHISTIDYLLYSINE; COPPER; COPPER CHLORIDE; HUMAN SERUM ALBUMIN; HYDROGEN PEROXIDE; OXIDIZING AGENT; TETRAPEPTIDE; TRANSITION ELEMENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN ISCHEMIA; BRAIN NERVE CELL; CATALYST; CELL PROTECTION; CELL SURVIVAL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; HEMODYNAMICS; METAL BINDING; MOLECULAR WEIGHT; MOUSE; NERVE CELL CULTURE; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; STROKE;

ANIMALS; ASCORBIC ACID; ASTROCYTES; CELL DEATH; CELL SURVIVAL; CELLS, CULTURED; COCULTURE TECHNIQUES; COPPER; DOSE-RESPONSE RELATIONSHIP, DRUG; EXCITATORY AMINO ACID AGONISTS; HUMANS; HYDROGEN PEROXIDE; MICE; N-METHYLASPARTATE; NEURONS; OLIGOPEPTIDES; OXIDANTS; OXIDATIVE STRESS; SERUM ALBUMIN;

EID: 0842289185     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.STR.0000110790.05859.DA     Document Type: Article

References (35)

1. Belayev L, Khoutorova L, Deisher TA, Belayev A, Busto R, Zhang Y, Zhao W, Ginsberg MD. Neuroprotective effect of SolCD39, a novel platelet aggregation inhibitor, on transient middle cerebral artery occlusion in rats. Stroke. 2003;34:758-763.
2. Belayev L, Zhao W, Pattany PM, Weaver RG, Huh PW, Lin B, Busto R, Ginsberg MD. Diffusion-weighted magnetic resonance imaging confirms marked neuroprotective efficacy of albumin therapy in focal cerebral ischemia. Stroke. 1998;29:2587-2599.
3. Belayev L, Saul I, Huh PW, Finotti N, Zhao W, Busto R, Ginsberg MD. Neuroprotective effect of high-dose albumin therapy against global ischemic brain injury in rats. Brain Res. 1999;845:107-111.
4. Belayev L, Liu Y, Zhao W, Busto R, Ginsberg MD. Human albumin therapy of acute ischemic stroke: marked neuroprotective efficacy at moderate doses and with a broad therapeutic window. Stroke. 2001;32: 553-560.
5. Belayev L, Pinard E, Nallet H, Seylaz J, Liu Y, Riyamongkol P, Zhao W, Busto R, Ginsberg MD. Albumin therapy of transient focal cerebral ischemia: in vivo analysis of dynamic microvascular responses. Stroke. 2002;33:1077-1084.
6. Ginsberg MD. Adventures in the pathophysiology of brain ischemia: penumbra, gene expression, neuroprotection: the 2002 Thomas Willis lecture. Stroke. 2003;34:214-223.
7. Matsui T, Sinyama H, Asano T. Beneficial effect of prolonged administration of albumin on ischemic cerebral edema and infarction after occlusion of middle cerebral artery in rats. Neurosurgery. 1993;33: 293-300; comment 300.
8. Rodriguez de Turco EB, Belayev L, Liu Y, Busto R, Parkins N, Bazan NG, Ginsberg MD. Systemic fatty acid responses to transient focal cerebral ischemia: influence of neuroprotectant therapy with human albumin. J Neurochem. 2002;83:515-524.
9. Liu Y, Belayev L, Zhao W, Busto R, Belayev A, Ginsberg MD. Neuroprotective effect of treatment with human albumin in permanent focal cerebral ischemia: histopathology and cortical perfusion studies. Eur J Pharmacol. 2001;428:193-201.
10. Emerson TE Jr. Unique features of albumin: a brief review. Crit Care Med. 1989;17:690-694.
11. Bar-Or D, Curtís G, Rao N, Bampos N, Lau E. Characterization of the CO(2+) and Ni(2+) binding amino-acid residues of the N-terminus of human albumin: an insight into the mechanism of a new assay for myocardial ischemia. Eur J Biochem. 2001;268:42-47.
12. Bar-Or D, Thomas GW, Rael LT, Lau EP, Winkler JV. Asp-Ala-His-Lys (DAHK) inhibits copper-induced oxidative DNA double strand breaks and telomere shortening, Biochem Biophys Res Commun. 2001;282: 356-360.
13. Bar-Or D, Rael LT, Lau EP, Rao NK, Thomas GW, Winkler JV, Yukl RL, Kingston RG, Curtis CG. An analog of the human albumin N-terminus (Asp-Ala-His-Lys) prevents formation of copper-induced reactive oxygen species. Biochem Biophys Res Commun. 2001;284: 856-862.
14. Bar-Or D, Winkler JV, Vanbenthuysen K, Harris L, Lau E, Hetzel FW. Reduced albumin-cobalt binding with transient myocardial ischemia after elective percutaneous transluminal coronary angioplasty: a preliminary comparison to creatine kinase-MB, myoglobin, and troponin I. Am Heart J. 2001;141:985-991.
15. Bar-Or D, Rael LT, Winkler JV, Yukl RL, Thomas GW, Shimonkevitz RP. Copper inhibits activated protein C: Protective effect of human albumin and an analogue of its high-affinity copper-binding site, D-DAHK. Biochem Biophys Res Commun. 2002;290:1388-1392.
16. Sutherland FJ, Bar-Or D, Curtis CG, Hearse DJ. Attenuation of trace element-mediated injury during ischemia and reperfusion by an N-terminus analogue of human albumin (h4dus60131). J Cardiovasc Pharmacol. 2002;39:722-728.
17. Anderson CM, Norquist BA, Vesce S, Nicholls DG, Soine WH, Duan S, Swanson RA. Barbiturates induce mitochondrial depolarization and potentiate excitotoxic neuronal death. J Neurosci. 2002;22:9203-9209.
18. Ying W, Han SK, Miller JW, Swanson RA. Acidosis potentiates oxidative neuronal death by multiple mechanisms. J Neurochem. 1999;73: 1549-1556.
19. Edidin M. A rapid, quantitative fluorescence assay for cell damage by cytotoxic antibodies. J Immunol. 1970;104:1303-1306.
20. Mischel RE, Kim YS, Sheldon RA, Ferriero DM. Hydrogen peroxide is selectively toxic to immature murine neurons in vitro. Neurosci Lett. 1997;231:17-20.
21. Lovstad RA. A kinetic study on the copper-albumin catalyzed oxidation of ascorbate. Biometals. 2002;15:351-355.
22. Simpson JA, Cheeseman KH, Smith SE, Dean RT. Free-radical generation by copper ions and hydrogen peroxide: stimulation by HEPES buffer. Biochem J. 1988;254:519-523.
23. Frenkel K, Blum F, Troll W. Copper ions and hydrogen peroxide form hypochlorite from NaCl thereby mimicking myeloperoxidase. J Cell Biochem. 1986;30:181-193.
24. Tien M, Aust SD. Comparative aspects of several model lipid peroxidation systems. In: Yagi K, ed. Lipid Peroxides in Biology and Medicine. New York, NY: Academic Press; 1982:23-39.
25. Remmers M, Schmidt-Kastner R, Belayev L, Lin B, Busto R, Ginsberg MD. Protein extravasation and cellular uptake after high-dose human-albumin treatment of transient focal cerebral, ischemia in rats. Brain Res. 1999;827:237-242.
26. Dugan LL, Gabrielsen JK, Yu SP, Lin TS, Choi DW. Buckminsterfullerenol free radical scavengers reduce excitotoxic and apoptotic death of cultured cortical neurons. Neurobiol Dis. 1996;3:129-135.
27. Lipton P. Ischemic cell death in brain neurons. Physiol Rev. 1999;79: 1431-1568.
28. Reiber H. Dynamics of brain-derived proteins in cerebrospinal fluid. Clin Chim Acta. 2001;310:173-186.
29. Scientific Tables. Ardsley, NY: Geigy Pharmaceuticals Division of Ciba-Geigy Corporation; 1970.
30. Chruscinska E, Dyba M, Micera G, Ambroziak W, Olczak J, Zabrocki J, Kozlowski H. Binding ability of Cu2+ ions by opiate-like fragments of bovine casein. J Inorg Biochem. 1997;66:19-22.
31. Predki PF, Harford C, Brar P, Sarkar B. Further characterization of the N-terminal copper(II)- and nickel(II)-binding motif of proteins: studies of metal binding to chicken serum albumin and the native sequence peptide. Biochem J. 1992;287(pt 1):211-215.
32. Tieghem E, Van Dael H, Van Cauwelaert F. Comparison of the Cu2+ binding to bovine, goat and human alpha-lactalbumin. Biochem Int. 1991; 23:119-126.
33. Zamora PO, Mercer-Smith JA, Marek MJ, Schulte LD, Rhodes BA. Similarity of copper and technetium binding sites in human IgG. Int J Rad Appl Instrum B. 1992;19:797-802.
34. Gutteridge JM, Wilkins S. Copper salt-dependent hydroxyl radical formation: damage to proteins acting as antioxidants. Biochim Biophys Acta. 1983;759:38-41.
35. Rowley DA, Halliwell B. Superoxide-dependent and ascorbate-dependent formation of hydroxyl radicals in the presence of copper salts: a physiologically significant reaction? Arch Biochem Biophys. 1983;225: 279-284.