Protein extravasation and cellular uptake after high-dose human-albumin treatment of transient focal cerebral ischemia in rats

Brain Research

Volumn 827, Issue 1-2, 1999, Pages 237-242

  Remmers, Michel ^a   Schmidt Kastner, Rainald ^a   Belayev, Ludmila ^a   Lin, Baowan ^a   Busto, Raul ^a   Ginsberg, Myron D ^a  

^a UNIVERSITY OF MIAMI   (United States)

Author keywords

Blood brain barrier; Immunohistochemistry; Infarction; Stroke

Indexed keywords

HUMAN SERUM ALBUMIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN INFARCTION; BRAIN ISCHEMIA; CELL TRANSPORT; CONTROLLED STUDY; EXTRAVASATION; IMMUNOHISTOCHEMISTRY; MALE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN TRANSPORT; RAT;

ALBUMINS; ANIMALS; BLOOD-BRAIN BARRIER; CEREBRAL INFARCTION; CEREBROVASCULAR DISORDERS; HUMANS; IMMUNOGLOBULIN G; INJECTIONS, INTRAVENOUS; ISCHEMIC ATTACK, TRANSIENT; MALE; NEURONS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0033535805     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(99)01304-9     Document Type: Article

References (20)

1. Albayrak S., Zhao Q., Siesjö B.K., Smith M.-L. Effect of transient focal ischemia on blood-brain barrier permeability in the rat: correlation to cell injury. Acta Neuropathol. 94:1997;158-163.
2. Belayev L., Busto R., Zhao W., Ginsberg M.D. Quantitative evaluation of blood-brain barrier permeability following middle cerebral artery occlusion in rats. Brain Res. 739:1996;88-96.
3. Belayev L., Alonso O.F., Busto R., Zhao W., Ginsberg M.D. Middle cerebral artery occlusion in the rat by intraluminal suture. Neurological and pathological evaluation of an improved model. Stroke. 27:1996;1616-1623.
4. Belayev L., Busto R., Zhao W., Clemens J.A., Ginsberg M.D. Effect of delayed albumin hemodilution on infarction volume and brain edema after transient middle cerebral artery occlusion in rats. J. Neurosurg. 87:1997;595-601.
5. Belayev L., Zhao W., Pattany P.M., Weaver R.G., Huh P.W., Lin B., Busto R., Ginsberg M.D. Diffusion-weighted magnetic resonance imaging confirms marked neuroprotective efficacy of albumin therapy in focal cerebral ischemia. Stroke. 29:1998;2587-2599.
6. Dietrich W.D., Busto R., Watson B.D., Scheinberg P., Ginsberg M.D. Photochemically induced cerebral infarction: II. Edema and blood-brain barrier disruption. Acta Neuropathol. 72:1987;326-334.
7. Emerson T.E. Jr. Unique features of albumin: a brief review. Crit. Care Med. 17:1989;690-694.
8. Halliwell B. Albumin - an important extracellular antioxidant? Biochem. Pharmacol. 37:1988;569-571.
9. Huh P.W., Belayev L., Zhao W., Busto R., Saul I., Ginsberg M.D. The effect of high-dose albumin therapy on local cerebral perfusion after transient cerebral ischemia in rats. Brain Res. 804:1998;105-113.
10. Kitagawa K., Matsumoto M., Tagaya M., Ueda H., Oku N., Kuwabara K., Ohtsuki T., Handa N., Kimura K., Kamada T. Temporal profile of serum albumin extravasation following cerebral ischemia in a newly established reproducible gerbil model for vasogenic brain edema: a combined immunohistochemical and dye tracer analysis. Acta Neuropathol. 82:1991;164-171.
11. Klatzo I. Pathophysiological aspects of brain edema. Acta Neuropathol. 72:1987;236-239.
12. Maeda M., Akai F., Nishida S., Yanaghihara T. Intracerebral distribution of albumin after transient cerebral ischemia: light and electron microscopic immunocytochemical investigation. Acta Neuropathol. 84:1992;59-66.
13. 2 antagonist, markedly reduces infarct size following middle cerebral artery occlusion in the rat. Neurology. 38:1988;1667-1673.
14. Nordborg C., Sokrab T.E.O., Johansson B.B. The relationship between plasma protein extravasation and remote tissue changes after experimental brain infarction. Acta Neuropathol. 82:1991;118-126.
15. Ohata K., Marmarou A., Povlishock J.T. An immunocytochemical study of protein clearance in brain infusion edema. Acta Neuropathol. 81:1990;162-177.
16. G. Paxinos, C. Watson, The Rat Brain in Stereotaxic Coordinates, 4th edn., Academic Press, San Diego, 1998.
17. Schmidt-Kastner R., Szymas J., Hossmann K.-A. Immunohistochemical study of glial reaction and serum-protein extravasation in relation to neuronal damage in rat hippocampus after ischemia. Neuroscience. 38:1990;527-540.
18. Schmidt-Kastner R., Meller D., Bellander D.-M., Strömberg I., Olson L., Ingvar M. A one-step immunohistochemical method for detection of blood-brain barrier disturbances for immunoglobulins in lesioned rat brain with special reference to false-positive staining in immunohistochemistry. J. Neurosci. Methods. 46:1993;121-132.
19. Wasil M., Halliwell B., Hutchison D.C.S., Baum H. The antioxidant action of human extracellular fluids. Biochem. J. 243:1987;219-223.
20. Zea Longa E., Weinstein P.R., Carlson S., Cummins R. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke. 20:1989;84-91.