Detailed Model of Intersegmental Coordination in the Timing Network of the Leech Heartbeat Central Pattern Generator

Journal of Neurophysiology

Volumn 91, Issue 2, 2004, Pages 958-977

  Jezzini, Sami H ^a   Hill, Andrew A V ^a   Kuzyk, Pavlo ^a   Calabrese, Ronald L ^a  

^a EMORY UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; HEART BEAT; INTERNEURON; LEECH; MODEL; NERVE CELL NETWORK; NONHUMAN; OSCILLATION; OSCILLATOR; PATTERN GENERATOR; PRIORITY JOURNAL; SYNAPSE;

ACTION POTENTIALS; ANIMALS; HEART RATE; LEECHES; NEURAL NETWORKS (COMPUTER); TIME FACTORS;

EID: 0842287532     PISSN: 00223077     EISSN: None     Source Type: Journal    
DOI: 10.1152/jn.00656.2003     Document Type: Article

References (65)

1. Angstadt JD and Calabrese RL. A hyperpolarization-activated inward current in heart interneurons of the medicinal leech. J Neurosci 9: 2846-2857, 1989.
2. Angstadt JD and Calabrese RL. Calcium currents and graded synaptic transmission between heart interneurons of the leech. J Neurosci 11: 746-759, 1991.
3. Bem T, Cabelguen JM, Ekeberg Ö, and Grillner S. From swimming to walking: a single basic network for two different behaviors. Biol Cybern 88: 79-90, 2003.
4. Bower JM and Beeman D. The Book of Genesis: Exploring Realistic Neural Models with the General Neural Simulation System. New York: Springer-Verlag, 1998.
5. Buchanan JT. Neural network simulations of coupled locomotor oscillators in the lamprey spinal cord. Biol Cybern 66: 367-374, 1992.
6. Calabrese RL. The neural control of alternate heartbeat coordination states in the leech. J Comp Physiol 122: 111-143, 1977.
7. Calabrese RL, Nadim F, and Olsen ØH. Heartbeat control in the medicinal leech: a model system for understanding the origin, coordination, and modulation of rhythmic motor patterns. J Neurobiol 27: 390-402, 1995.
8. Cang J and Friesen WO. Sensory modification of leech swimming: rhythmic activity of ventral stretch receptors can change intersegmental phase relationships. J Neurosci 20: 7822-7829, 2000.
9. Cang J and Friesen WO. Model for intersegmental coordination of leech swimming: central and sensory mechanisms. J Neurophysiol 87: 2760-2769, 2002.
10. Cohen AH, Holmes PJ, and Rand RH. The nature of the coupling between segmental oscillators of the lamprey spinal generator for locomotion: a mathematical model. J Math Biol 13: 345-369, 1982.
11. Cymbalyuk GS, Gaudry Q, Masino MA, and Calabrese RL. Bursting in leech heart interneurons: cell-autonomous and network-based mechanisms. J Neurosci 22: 10580-10592, 2002.
12. Di Prisco GV, Wallen P, and Grillner S. Synaptic effects of intraspinal stretch receptor neurons mediating movement-related feedback during locomotion. Brain Res 530: 161-166, 1990.
13. Ekeberg Ö and Grillner S. Simulations of neuromuscular control in lamprey swimming. Philos Trans R Soc Lond 354: 895-902, 1999.
14. Friesen WO and Cang J. Sensory and central mechanisms control intersegmental coordination. Curr Opin Neurobiol 11: 678-683, 2001.
15. Friesen WO and Pearce RA. Mechanisms of intersegmental coordination in leech locomotion. SINS 5: 41-47, 1993.
16. Grillner S, Matsushima T, Wadden T, Tegnér J, El Manira A, and Wallén P. The neurophysiological bases of undulatory locomotion in vertebrates. SINS 5: 17-27, 1993.
17. Hill AAV, Lu J, Masino MA, Olsen ØH, and Calabrese RL. A model of a segmental oscillator in the leech heartbeat neuronal network. J Comput Neurosci 10: 281-302, 2001.
18. Hill AAV, Masino MA, and Calabrese RL. Model of intersegmental coordination in the leech heartbeat neuronal network. J Neurophysiol 87: 1586-1602, 2002.
19. Hill AA, Masino MA and Calabrese RL. Intersegmental coordination of rhythmic motor patterns. J Neurophysiol 90: 531-538, 2003.
20. Hodgkin AL and Huxley AF. A quantitative description of membrane current and its application to conduction and excitation in nerve. J Physiol 117: 500-544, 1952.
21. Ikeda K and Wiersma CAG. Autogenic rhythmicity in the abdominal ganglion of the crayfish: the control of swimmeret movements. Comp Biochem Physiol 12: 107-115, 1964.
22. 2+ dynamics during spontaneous and evoked activity of leech heart interneurons: low-threshold Ca currents and graded synaptic transmission. J Neurosci 20: 4930-4943, 2000.
23. 2+ in leech heart interneurons. J Neurosci 23: 1206-1218, 2003.
24. Jezzini SH, Hill AAV, and Calabrese RL. Dynamic activity of a coordinating fiber with two initiation sites. Soc Neurosci Abstr 30: 164.1, 2000.
25. Jones SR, Mulloney B, Kaper TJ, and Kopell N. Coordination of cellular patten-generating circuits that control limb movements: the sources of stable differences in intersegmental phases. J Neurosci 23: 3457-3468, 2003.
26. Kopell N and Ermentrout GB. Coupled oscillators and the design of central pattern generators. Math Biosci 90: 87-109, 1988.
27. 2+ currents in graded and spike-mediated synaptic transmission between leech heart interneurons. J Neurophysiol 77: 1779-1794, 1997.
28. Masino MA and Calabrese RL. Phase relationships between segmentally organized oscillators in the leech heartbeat pattern generating network. J Neurophysiol 87: 1572-1585, 2002a.
29. Masino MA and Calabrese RL. Period differences between segmental oscillators produce intersegmental phase differences in the leech heartbeat timing network. J Neurophysiol 87: 1603-1615, 2002b.
30. Masino MA and Calabrese RL. A functional asymmetry in the leech heartbeat timing network is revealed by driving the network across various cycle periods. J Neurosci 22: 4418-4427, 2002c.
31. Matsushima T and Grillner S. Intersegmental coordination of undulatory movements - a "trailing oscillator" hypothesis. Neuroreport 1: 97-100, 1990.
32. Matsushima T and Grillner S. Neural mechanisms of intersegmental coordination in lamprey: local excitability changes modify the phase coupling along the spinal cord. J Neurophysiol 67: 373-388, 1992.
33. Merrywest SD, McDearmid JR, Kjaerulff O, Kiehn O, and Sillar KT. Mechanisms underlying the noradrenergic modulation of longitudinal coordination during swimming in Xenopus laevis tadpoles. Eur J Neurosci 17: 1013-1022, 2003.
34. Mulloney B. A test of the excitability-gradient hypothesis in the swimmeret system of crayfish. J Neurosci 17: 1860-1868, 1997.
35. Mulloney B, Skinner FK, Namba H, and Hall WM. Intersegmental coordination of swimmeret movements: mathematical models and neural circuits. Ann NY Acad Sci 860: 266-280, 1998.
36. Murchison D, Chrachri A, and Mulloney B. A separate local pattern-generating circuit controls the movements of each swimmeret in crayfish. J Neurophysiol 70: 2620-2631, 1993.
37. Nadim F, Olsen ØH, De Schutter E, and Calabrese RL. Modeling the leech heartbeat elemental oscillator. I. Interactions of intrinsic and synaptic currents. J Comput Neurosci 2: 215-235, 1995.
38. Nicholls J and Wallace BG. Modulation of transmission at an inhibitory synapse in the central nervous system of the leech. J Physiol 281: 157-170, 1978a.
39. Nicholls J and Wallace BG. Quantal analysis of transmitter release at an inhibitory synapse in the central nervous system of the leech. J Physiol 281: 171-85, 1978b.
40. Olsen ØH and Calabrese RL. Activation of intrinsic and synaptic currents in leech heart interneurons by realistic waveforms. J Neurosci 16: 4958-4970, 1996.
41. Olsen ØH, Nadim F, and Calabrese RL. Modeling the leech heartbeat elemental oscillator. II. Exploring the parameter space. J Comput Neurosci 2: 237-257, 1995.
42. Opdyke CA and Calabrese RL. A persistent sodium current contributes to oscillatory activity in heart interneurons of the medicinal leech. J Comp Physiol [A] 175: 781-789, 1994.
43. Perkel DH and Mulloney B. Electrotonic properties of neurons: steady-state compartmental model. J Neurophysiol 41: 621-639, 1978.
44. Peterson EL. Generation and coordination of heartbeat timing oscillation in the medicinal leech. I. Oscillation in isolated ganglia. J Neurophysiol 49: 611-626, 1983a.
45. Peterson EL. Generation and coordination of heartbeat timing oscillation in the medicinal leech. II. Intersegmental coordination. J Neurophysiol 49: 627-638, 1983b.
46. Rall W. Core conductor theory and cable properties of neurons. In: The Nervous System, Cellular Biology of Neurons, edited by Kandel ER. Bethesda, MD: Am. Physiol. Soc., 1977, p. 39-97.
47. Roberts A and Tunstall MJ. Mutual re-excitation with post-inhibitory rebound: a simulation study on the mechanisms for locomotor rhythm generation in the spinal cord of xenopus embryos. Eur J Neurosci 2: 11-23, 1990.
48. Sigvardt KA. Intersegmental coordination in the lamprey central pattern generator for locomotion. SINS 5: 3-15, 1993.
49. Sigvardt KA and Miller WL. Analysis and modeling of the locomotor central pattern generator as a network of coupled oscillators. Ann NY Acad Sci 860: 250-265, 1998.
50. Sigvardt KA and Williams TL. Effects of local oscillator frequency on intersegmental coordination in the lamprey locomotor CPG: theory and experiment. J Neurophysiol 76: 4094-4103, 1996.
51. 2 on outward currents and oscillatory activity in heart interneurons of the medicinal leech. J Neurosci 12: 525-537, 1992.
52. Skinner FK, Kopell N, and Mulloney B. How does the crayfish swimmeret system work? Insights from nearest-neighbor coupled oscillator models. J Comput Neurosci 4: 151-160, 1997.
53. Skinner FK and Mulloney B. Intersegmental coordination in invertebrates and vertebrates. Curr Opin Neurobiol 8: 725-732, 1998a.
54. Skinner FK and Mulloney B. Intersegmental coordination of limb movements during locomotion: mathematical models predict circuits that drive swimmeret beating. J Neurosci 18: 3831-3842, 1998b.
55. Thompson WJ and Stent GS. Neuronal control of heartbeat in the medicinal leech. I. Generation of the vascular constriction rhythm by heart motor neurons. J Comp Physiol 111: 261-279, 1976a.
56. Thompson WJ and Stent GS. Neuronal control of heartbeat in the medicinal leech. II. Intersegmental coordination of heart motor neuron activity by heart interneurons. J Comp Physiol 111: 281-307, 1976b.
57. Thompson WJ and Stent GS. Neuronal control of heartbeat in the medicinal leech. III. Synaptic relations of the heart interneurons. J Comp Physiol 111: 309-333, 1976c.
58. Tunstall MJ, Roberts A, and Soffe SR. Modelling inter-segmental coordination of neuronal oscillators: synaptic mechanisms for uni-directional coupling during swimming in Xenopus tadpoles. J Comput Neurosci 13: 143-158, 2002.
59. Tunstall MJ and Sillar KT. Physiological and developmental aspects of intersegmental coordination in Xenopus embryos and tadpoles. SINS 5: 29-40, 1993.
60. Ullström M, Hellgren-Kotaleski J, Tegnér J, Aurell E, Grillner S, and Lansner A. Activity-dependent modulation of adaptation produces a constant burst proportion in a model of the lamprey spinal locomotor generator. Biol Cybern 79: 1-14, 1998.
61. Wallén P, Ekeberg Ö, Lansner A, Brodin L, Tråvén H, and Grillner S. A computer-based model for realistic simulations of neural networks. II. The segmental network generating locomotor rhythmicity in the lamprey. J Neurophysiol 68: 1939-1950, 1992.
62. Wallén P and Williams TL. Fictive locomotion in the lamprey spinal cord in vitro compared with swimming in the intact and spinal animal. J Physiol 347: 225-239, 1984.
63. Wenning A, Cymbalyuk G, and Calabrese RL. Heartbeat control in leeches. I. Constriction pattern and neural modulation of blood pressure in intact animals. J Neurophysiol 90: 382-396, 2003a.
64. Wenning A, Hill AAV, and Calabrese RL. Heartbeat control in leeches. II. Fictive motor pattern. J Neurophysiol 90: 397-409, 2003b.
65. Williams TL, Sigvardt KA, Kopell N, Ermentrout GB, and Remler MP. Forcing of coupled nonlinear oscillators: studies of intersegmental coordination in the lamprey locomotor central pattern generator. J Neurophysiol 64: 862-871, 1990.