Blocking B7 and CD40 co-stimulatory molecules decreases antiviral T cell activity

Clinical and Experimental Immunology

Volumn 135, Issue 2, 2004, Pages 253-258

  Vermeiren, J ^a   Ceuppens, J L ^a   Haegel Kronenberger, H ^b   De Boer, M ^c   Boon, L ^c   Van Gool, S W ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b TRANSGENE S A   (France)

^c PanGenetics BV   (Netherlands)

Author keywords

Adenovirus; Co stimulation; Monocyte; T cell

Indexed keywords

B7 ANTIGEN; CD40 ANTIGEN; CD40 LIGAND MONOCLONAL ANTIBODY; CD86 ANTIGEN; GAMMA INTERFERON; GREEN FLUORESCENT PROTEIN; MONOCLONAL ANTIBODY;

ANTIGEN PRESENTING CELL; ANTIVIRAL ACTIVITY; ARTICLE; BIOACCUMULATION; CELL PROLIFERATION; CELL STIMULATION; COCULTURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; GENE INDUCTION; GRAFT REJECTION; HUMAN; HUMAN CELL; IMMUNOPROPHYLAXIS; IMMUNOREACTIVITY; IN VITRO STUDY; MARKER GENE; MONOCYTE; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; TRANSACTIVATION; TRANSGENE;

ADENOVIRIDAE; ADULT; ANTIBODIES, BLOCKING; ANTIGEN-PRESENTING CELLS; ANTIGENS, CD; ANTIGENS, CD40; ANTIGENS, CD80; ANTIGENS, CD86; BIOLOGICAL MARKERS; CELL DIVISION; CELLS, CULTURED; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GREEN FLUORESCENT PROTEINS; HUMANS; IMMUNE TOLERANCE; INDICATORS AND REAGENTS; INTERFERON TYPE II; INTERLEUKIN-13; LUMINESCENT PROTEINS; LYMPHOCYTE ACTIVATION; MALE; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; MONOCYTES; T-LYMPHOCYTES; TRANSDUCTION, GENETIC; TRANSGENES;

EID: 0842265533     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2003.02363.x     Document Type: Article

References (35)

1. Gudmundsdottir H, Turka LA. T cell co-stimulatory blockade: new therapies for transplant rejection. J Am Soc Nephrol 1999; 10:1356-65.
2. Wekerle T, Kurtz J, Bigenzahn S, Takeuchi Y, Sykes M. Mechanisms of transplant tolerance induction using co-stimulatory blockade. Curr Opin Immunol 2002; 14:592-600.
3. Van Gool SW, Vandenberghe P, de Boer M, Ceuppens JL. CD80, CD86 and CD40 provide accessory signals in a multiple step T cell activation model. Immunol Rev 1996; 153:47-83.
4. Van Gool SW, Vermeiren J, Rafiq K, Lorré K, de Boer M, Ceuppens JL. Blocking CD40-CD154 and CD80/CD86-CD28 interactions during primary allogeneic stimulation results in T cell anergy and high IL-10 production. Eur J Immunol 1999; 29:2367-75.
5. Larsen CP, Elwood ET, Alexander DZ et al. Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways. Nature 1996; 381:434-8.
6. Kirk AD, Harlan DM, Armstrong NN et al. CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates. Proc Natl Acad Sci USA 1997; 94:8789-94.
7. Sun H, Subbotin V, Chen C et al. Prevention of chronic rejection in mouse aortic allografts by combined treatment with CTLA4-Ig and anti-CD40 ligand monoclonal antibody. Transplantation 1997; 64:1838-43.
8. Haanstra KG, Ringers J, Sick EA et al. Prevention of kidney allograft rejection using anti-CD40 and anti-CD86 in primates. Transplantation 2003; 75:637-43.
9. Wekerle T, Kurtz J, Ito H et al. Allogeneic bone marrow transplantation with co-stimulatory blockade induces macrochimerism and tolerance without cytoreductive host treatment. Nat Med 2000; 6:464-9.
10. Marshall LS, Aruffo A, Ledbetter JA, Noelle RJ. The molecular basis for T cell help in humoral immunity: CD40 and its ligand, gp39. J Clin Immunol 1993; 13:165-74.
11. Sigal LJ, Reiser H, Rock KL. The role of B7-1 and B7-2 co-stimulation for the generation of CTL responses in vivo. J Immunol 1998; 161:2740-5.
12. Schoenberger SP, Toes RE, van der Voort EI, Offringa R, Melief CJ. T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions. Nature 1998; 393:480-3.
13. McAdam AJ, Farkash EA, Gewurz BE, Sharpe AH. B7 co-stimulation is critical for antibody class switching and CD8 (+) cytotoxic T-lymphocyte generation in the host response to vesicular stomatitis virus. J Virol 2000; 74:203-8.
14. de Boer M, Kasran A, Kwekkeboom J, Walter H, Vandenberghe P, Ceuppens JL. Ligation of B7 with CD28/CTLA-4 on T cells results in CD40 ligand expression, interleukin-4 secretion and efficient help for antibody production by B cells. Eur J Immunol 1993; 23:3120-5.
15. Klaus SJ, Pinchuk LM, Ochs HD et al. Costimulation through CD28 enhances T cell-dependent B cell activation via CD40-CD40L interaction. J Immunol 1994; 152:5643-52.
16. de Boer M, Conroy L, Min HY, Kwekkeboom J. Generation of monoclonal antibodies to human lymphocyte cell surface antigens using insect cells expressing recombinant proteins. J Immunol Meth 1992; 152:15-23.
17. de Boer M, Parren P, Dove J, Ossendorp P, van der Horst G, Reeder J. Functional characterization of a novel anti-B7 monoclonal antibody. Eur J Immunol 1992; 22:3071-5.
18. Kwekkeboom J, de Rijk D, Kasran A, Barcy S, De Groot C, de Boer M. Helper effector function of human T cells stimulated by anti-CD3 MoAb can be enhanced by co-stimulatory signals and is partially dependent on CD40-CD40 ligand interaction. Eur J Immunol 1994; 24:508-17.
19. Engel P, Gribben JG, Freeman GJ et al. The B7-2 (B70) co-stimulatory molecule expressed by monocytes and activated B lymphocytes is the CD86 differentiation antigen. Blood 1994:84:1402-7.
20. Ceuppens JL, Baroja ML, Lorre K, Van Damme J, Billiau A. Human T cell activation with phytohemagglutinin. The function of IL-6 as an accessory signal. J Immunol 1988; 141:3868-74.
21. Lyakh LA, Koski GK, Young HA, Spence SE, Cohen PA, Rice NR. Adenovirus type 5 vectors induce dendritic cell differentiation in human CD14 (+) monocytes cultured under serum-free conditions. Blood 2002; 99:600-8.
22. Qin L, Ding Y, Pahud DR, Chang E, Imperiale MJ, Bromberg JS. Promoter attenuation in gene therapy: interferon-gamma and tumor necrosis factor-alpha inhibit transgene expression. Hum Gene Ther 1997; 8:2019-29.
23. Schreiber RD, Farrar MA. The biology and biochemistry of interferon-gamma and its receptor. Gastroenterol Jpn 1993; 28 (Suppl. 4):88-94; discussion 95-6.
24. Molinier-Frenkel V, Gahery-Segard H, Mehtali M et al. Immune response to recombinant adenovirus in humans: capsid components from viral input are targets for vector-specific cytotoxic T lymphocytes. J Virol 2000; 74:7678-52.
25. Wong P, Pamer EG. Feedback regulation of pathogen-specific T cell priming. Immunity 2003; 18:499-511.
26. Jackson GG, Muldoon RL. Viruses causing common respiratory infection in man. IV. Reoviruses and adenoviruses. J Infect Dis 1973; 128:811-66.
27. Yi-qun Z, Joost van Neerven RJ, Kasran A, de Boer M, Ceuppens JL. Differential requirements for co-stimulatory signals from B7 family members by resting versus recently activated memory T cells towards soluble recall antigens. Int Immunol 1996; 8:37-44.
28. Yi-qun Z, Lorre K, de Boer M, Ceuppens JL. B7-blocking agents, alone or in combination with cyclosporin A, induce antigen-specific anergy of human memory T cells. J Immunol 1997; 158:4734-40.
29. Van Gool SW, de Boer M, Ceuppens JL. The combination of anti-B7 monoclonal antibody and cyclosporin A induces alloantigen-specific anergy during a primary mixed lymphocyte reaction. J Exp Med 1994; 179:715-20.
30. Chakrabarti S, Mautner V, Osman H et al. Adenovirus infections following allogeneic stem cell transplantation: incidence and outcome in relation to graft manipulation, immunosuppression, and immune recovery. Blood 2002; 100:1619-27.
31. Kay MA, Holterman AX, Meuse L et al. Long-term hepatic adenovirus-mediated gene expression in mice following CTLA4Ig administration. Nature Genet 1995; 11:191-7.
32. Kay MA, Meuse L, Gown AM et al. Transient immunomodulation with anti-CD40 ligand antibody and CTLA4Ig enhances persistence and secondary adenovirus-mediated gene transfer into mouse liver. Proc Natl Acad Sci USA 1997; 94:4686-91.
33. Wilson CB, Embree LJ, Schowalter D et al. Transient inhibition of CD28 and CD40 ligand interactions prolongs adenovirus-mediated transgene expression in the lung and facilitates expression after secondary vector administration. J Virol 1998; 72:7542-50.
34. Jiang ZL, Reay D, Kreppel F et al. Local high-capacity adenovirus-mediated mCTLA4Ig and mCD40Ig expression prolongs recombinant gene expression in skeletal muscle. Mol Ther 2001; 3:892-900.
35. Ziller C, Stoeckel F, Boon L, Haegel-Kronenberger H. Transient blocking of both B7.1 (CD80) and B7.2 (CD86) in addition to CD40-CD40L interaction fully abrogates the immune response following systemic injection of adenovirus vector. Gene Ther 2002; 9:537-46.