메뉴 건너뛰기




Volumn 286, Issue 2 55-2, 2004, Pages

Molecular mechanism of nucleotide-induced primary granule release in human neutrophils: Role for the P2Y2 receptor

Author keywords

Adenosine triphosphate; Elastase release; Extracellular nucleotides; Fibrinogen; Uridine triphosphate

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ARACHIDONATE 5 LIPOXYGENASE; ARACHIDONIC ACID; CALCIUM; ELASTASE; FIBRINOGEN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; NUCLEOTIDE; PERTUSSIS TOXIN; PURINE P2Y2 RECEPTOR; SYNAPTOPHYSIN; URIDINE TRIPHOSPHATE;

EID: 0742323132     PISSN: 03636143     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpcell.00287.2003     Document Type: Article
Times cited : (65)

References (57)
  • 1
    • 0025091183 scopus 로고
    • Signal transduction initiated by extracellular nucleotides regulates the high affinity ligand recognition of the adhesive receptor CD11b/CD18
    • Altieri DC, Wiltse WL, and Edgington TS. Signal transduction initiated by extracellular nucleotides regulates the high affinity ligand recognition of the adhesive receptor CD11b/CD18. J Immunol 145: 662-670, 1990.
    • (1990) J Immunol , vol.145 , pp. 662-670
    • Altieri, D.C.1    Wiltse, W.L.2    Edgington, T.S.3
  • 2
    • 0025254423 scopus 로고
    • Exposure of human neutrophils to exogenous nucleotides causes elevation in intracellular calcium, transmembrane calcium fluxes, and an alteration of a cytosolic factor resulting in enhanced superoxide production in response to FMLP and arachidonic acid
    • Axtell RA, Sandborg RR, Smolen JE, Ward PA, and Boxer LA. Exposure of human neutrophils to exogenous nucleotides causes elevation in intracellular calcium, transmembrane calcium fluxes, and an alteration of a cytosolic factor resulting in enhanced superoxide production in response to FMLP and arachidonic acid. Blood 75: 1324-1332, 1990.
    • (1990) Blood , vol.75 , pp. 1324-1332
    • Axtell, R.A.1    Sandborg, R.R.2    Smolen, J.E.3    Ward, P.A.4    Boxer, L.A.5
  • 3
    • 0025014783 scopus 로고
    • Extracellular adenosine nucleotides stimulate protein kinase C activity and human neutrophil activation
    • Balazovich KJ and Boxer LA. Extracellular adenosine nucleotides stimulate protein kinase C activity and human neutrophil activation. J Immunol 144: 631-637, 1990.
    • (1990) J Immunol , vol.144 , pp. 631-637
    • Balazovich, K.J.1    Boxer, L.A.2
  • 5
    • 0024531616 scopus 로고
    • Identification and distribution of fibrinogen, fibrin, and fibrin(ogen) degradation products in atherosclerosis. Use of monoclonal antibodies
    • Bini A, Fenoglio JJ Jr, Mesa-Tejada R, Kudryk B, and Kaplan KL. Identification and distribution of fibrinogen, fibrin, and fibrin(ogen) degradation products in atherosclerosis. Use of monoclonal antibodies. Arteriosclerosis 9: 109-121, 1989.
    • (1989) Arteriosclerosis , vol.9 , pp. 109-121
    • Bini, A.1    Fenoglio Jr., J.J.2    Mesa-Tejada, R.3    Kudryk, B.4    Kaplan, K.L.5
  • 6
    • 0018131748 scopus 로고
    • 1-Phenyl-3-pyrazolidone: An inhibitor of cyclo-oxygenase and lipoxygenase pathways in lung and platelets
    • Blackwell GJ and Flower RJ. 1-phenyl-3-pyrazolidone: an inhibitor of cyclo-oxygenase and lipoxygenase pathways in lung and platelets. Prostaglandins 16: 417-425, 1978.
    • (1978) Prostaglandins , vol.16 , pp. 417-425
    • Blackwell, G.J.1    Flower, R.J.2
  • 7
    • 0028989330 scopus 로고
    • G protein-coupled P2 purinoceptors: From molecular biology to functional responses
    • Boarder MR, Weisman GA, Turner JT, and Wilkinson GF. G protein-coupled P2 purinoceptors: from molecular biology to functional responses. Trends Pharmacol Sci 16: 133-139, 1995.
    • (1995) Trends Pharmacol Sci , vol.16 , pp. 133-139
    • Boarder, M.R.1    Weisman, G.A.2    Turner, J.T.3    Wilkinson, G.F.4
  • 8
    • 0024240402 scopus 로고
    • The human neutrophil. Function and dysfunction
    • Borregaard N. The human neutrophil. Function and dysfunction. Eur J Haematol 41: 401-413, 1988.
    • (1988) Eur J Haematol , vol.41 , pp. 401-413
    • Borregaard, N.1
  • 9
    • 0030766582 scopus 로고    scopus 로고
    • Stage-specific expression of P2Y receptors, ecto-apyrase, and ecto-5′-nucleotidase in myeloid leukocytes
    • Clifford EE, Martin KA, Dalal P, Thomas R, and Dubyak GR. Stage-specific expression of P2Y receptors, ecto-apyrase, and ecto-5′-nucleotidase in myeloid leukocytes. Am J Physiol Cell Physiol 273: C973-C987, 1997.
    • (1997) Am J Physiol Cell Physiol , vol.273
    • Clifford, E.E.1    Martin, K.A.2    Dalal, P.3    Thomas, R.4    Dubyak, G.R.5
  • 10
    • 0029043582 scopus 로고
    • How MAP kinases are regulated
    • Cobb MH and Goldsmith EJ. How MAP kinases are regulated. J Biol Chem 270: 14843-14846, 1995.
    • (1995) J Biol Chem , vol.270 , pp. 14843-14846
    • Cobb, M.H.1    Goldsmith, E.J.2
  • 11
    • 0024602269 scopus 로고
    • ATP stimulates secretion in human neutrophils and HL60 cells via a pertussis toxin-sensitive guanine nucleotide-binding protein coupled to phospholipase C
    • Cockcroft S, and Stutchfield J. ATP stimulates secretion in human neutrophils and HL60 cells via a pertussis toxin-sensitive guanine nucleotide-binding protein coupled to phospholipase C. FEBS Lett 245: 25-29, 1989.
    • (1989) FEBS Lett , vol.245 , pp. 25-29
    • Cockcroft, S.1    Stutchfield, J.2
  • 12
    • 0024440968 scopus 로고
    • The receptors for ATP and fMetLeuPhe are independently coupled to phospholipases C and A2 via G-protein(s). Relationship between phospholipase C and A2 activation and exocytosis in HL60 cells and human neutrophils
    • Cockcroft S, and Stutchfield J. The receptors for ATP and fMetLeuPhe are independently coupled to phospholipases C and A2 via G-protein(s). Relationship between phospholipase C and A2 activation and exocytosis in HL60 cells and human neutrophils. Biochem J 263: 715-723, 1989.
    • (1989) Biochem J , vol.263 , pp. 715-723
    • Cockcroft, S.1    Stutchfield, J.2
  • 13
    • 0031437421 scopus 로고    scopus 로고
    • Cloning of a human purinergic P2Y receptor coupled to phospholipase C and adenylyl cyclase
    • Communi D, Govaerts C, Parmentier M, and Boeynaems JM. Cloning of a human purinergic P2Y receptor coupled to phospholipase C and adenylyl cyclase. J Biol Chem 272: 31969-31973, 1997.
    • (1997) J Biol Chem , vol.272 , pp. 31969-31973
    • Communi, D.1    Govaerts, C.2    Parmentier, M.3    Boeynaems, J.M.4
  • 14
    • 0025923083 scopus 로고
    • Chronic treatment with P2-purinergic receptor agonists induces phenotypic modulation of the HL-60 and U937 human myelogenous leukemia cell lines
    • Cowen DS, Berger M, Nuttle L, and Dubyak GR. Chronic treatment with P2-purinergic receptor agonists induces phenotypic modulation of the HL-60 and U937 human myelogenous leukemia cell lines. J Leukoc Biol 50: 109-122, 1991.
    • (1991) J Leukoc Biol , vol.50 , pp. 109-122
    • Cowen, D.S.1    Berger, M.2    Nuttle, L.3    Dubyak, G.R.4
  • 15
    • 0024547883 scopus 로고
    • Extracellular adenosine triphosphate activates calcium mobilization in human phagocytic leukocytes and neutrophil/monocyte progenitor cells
    • Cowen DS, Lazarus HM, Shurin SB, Stoll SE, and Dubyak GR. Extracellular adenosine triphosphate activates calcium mobilization in human phagocytic leukocytes and neutrophil/monocyte progenitor cells. J Clin Invest 83: 1651-1660, 1989.
    • (1989) J Clin Invest , vol.83 , pp. 1651-1660
    • Cowen, D.S.1    Lazarus, H.M.2    Shurin, S.B.3    Stoll, S.E.4    Dubyak, G.R.5
  • 17
    • 0037380778 scopus 로고    scopus 로고
    • Knock-out mice reveal tissue-specific roles of P2Y receptor subtypes in different epithelia
    • Dubyak GR. Knock-out mice reveal tissue-specific roles of P2Y receptor subtypes in different epithelia. Mol Pharmacol 63: 773-776, 2003.
    • (2003) Mol Pharmacol , vol.63 , pp. 773-776
    • Dubyak, G.R.1
  • 18
    • 0025569654 scopus 로고
    • Activation of inositol phospholipid-specific phospholipase C by P2-purinergic receptors in human phagocytic leukocytes. Role of pertussis toxin-sensitive G proteins
    • discussion 244-245
    • Dubyak GR and Cowen DS. Activation of inositol phospholipid-specific phospholipase C by P2-purinergic receptors in human phagocytic leukocytes. Role of pertussis toxin-sensitive G proteins. Ann NY Acad Sci 603: 227-244; discussion 244-245, 1990.
    • (1990) Ann NY Acad Sci , vol.603 , pp. 227-244
    • Dubyak, G.R.1    Cowen, D.S.2
  • 20
    • 0027436824 scopus 로고
    • Functional expression and photoaffinity labeling of a cloned P 2U purinergic receptor
    • Erb L, Lustig KD, Sullivan DM, Turner JT, and Weisman GA. Functional expression and photoaffinity labeling of a cloned P2U purinergic receptor. Proc Natl Acad Sci USA 90: 10449-10453, 1993.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 10449-10453
    • Erb, L.1    Lustig, K.D.2    Sullivan, D.M.3    Turner, J.T.4    Weisman, G.A.5
  • 21
    • 0026469691 scopus 로고
    • Extracellular ATP stimulates elastase secretion from human neutrophils and increases lung resistance and secretion from normal rat airways after intratracheal instillation
    • Flezar M, Olivenstein R, Cantin A, and Heisler S. Extracellular ATP stimulates elastase secretion from human neutrophils and increases lung resistance and secretion from normal rat airways after intratracheal instillation. Can J Physiol Pharmacol 70: 1065-1068, 1992.
    • (1992) Can J Physiol Pharmacol , vol.70 , pp. 1065-1068
    • Flezar, M.1    Olivenstein, R.2    Cantin, A.3    Heisler, S.4
  • 23
    • 0022629214 scopus 로고
    • Extracellular A.T.P. effects, sources and fate
    • Gordon JL. Extracellular ATP: effects, sources and fate. Biochem J 233: 309-319, 1986.
    • (1986) Biochem J , vol.233 , pp. 309-319
    • Gordon, J.L.1
  • 24
    • 0021895138 scopus 로고
    • 2+ indicators with greatly improved fluorescence properties
    • 2+ indicators with greatly improved fluorescence properties. J Biol Chem 260: 3440-3450, 1985.
    • (1985) J Biol Chem , vol.260 , pp. 3440-3450
    • Grynkiewicz, G.1    Poenie, M.2    Tsien, R.Y.3
  • 26
    • 0018614306 scopus 로고
    • Direct measurement of platelet secretion in whole blood
    • Ingerman CM, Smith JB, and Silver MJ. Direct measurement of platelet secretion in whole blood. Thromb Res 16: 335-344, 1979.
    • (1979) Thromb Res , vol.16 , pp. 335-344
    • Ingerman, C.M.1    Smith, J.B.2    Silver, M.J.3
  • 27
    • 0031907232 scopus 로고    scopus 로고
    • Distribution of P2Y receptor subtypes on haematopoietic cells
    • Jin J, Dasari VR, Sistare FD, and Kunapuli SP. Distribution of P2Y receptor subtypes on haematopoietic cells. Br J Pharmacol 123: 789-794, 1998.
    • (1998) Br J Pharmacol , vol.123 , pp. 789-794
    • Jin, J.1    Dasari, V.R.2    Sistare, F.D.3    Kunapuli, S.P.4
  • 31
    • 0029162304 scopus 로고
    • Pharmacological selectivity of the cloned human P2U-purinoceptor: Potent activation by diadenosine tetraphosphate
    • Lazarowski ER, Watt WC, Stutts MJ, Boucher RC, and Harden TK. Pharmacological selectivity of the cloned human P2U-purinoceptor: potent activation by diadenosine tetraphosphate. Br J Pharmacol 116: 1619-1627, 1995.
    • (1995) Br J Pharmacol , vol.116 , pp. 1619-1627
    • Lazarowski, E.R.1    Watt, W.C.2    Stutts, M.J.3    Boucher, R.C.4    Harden, T.K.5
  • 33
    • 0030614859 scopus 로고    scopus 로고
    • Down-regulation of P2U-purinergic nucleotide receptor messenger RNA expression during in vitro differentiation of human myeloid leukocytes by phorbol esters or inflammatory activators
    • Martin KA, Kertesy SB, and Dubyak GR. Down-regulation of P2U-purinergic nucleotide receptor messenger RNA expression during in vitro differentiation of human myeloid leukocytes by phorbol esters or inflammatory activators. Mol Pharmacol 51: 97-108, 1997.
    • (1997) Mol Pharmacol , vol.51 , pp. 97-108
    • Martin, K.A.1    Kertesy, S.B.2    Dubyak, G.R.3
  • 35
    • 0030470605 scopus 로고    scopus 로고
    • ADP receptors on platelets
    • Mills DC. ADP receptors on platelets. Thromb Haemost 76: 835-856, 1996.
    • (1996) Thromb Haemost , vol.76 , pp. 835-856
    • Mills, D.C.1
  • 36
    • 0342313568 scopus 로고    scopus 로고
    • Kinase pathways in chemoattractant-induced degranulation of neutrophils: The role of p38 mitogen-activated protein kinase activated by Src family kinases
    • Mocsai A, Jakus Z, Vantus T, Berton G, Lowell CA, and Ligeti E. Kinase pathways in chemoattractant-induced degranulation of neutrophils: the role of p38 mitogen-activated protein kinase activated by Src family kinases. J Immunol 164: 4321-4331, 2000.
    • (2000) J Immunol , vol.164 , pp. 4321-4331
    • Mocsai, A.1    Jakus, Z.2    Vantus, T.3    Berton, G.4    Lowell, C.A.5    Ligeti, E.6
  • 38
    • 0029788548 scopus 로고    scopus 로고
    • Uridine nucleotide selectivity of three phospholipase C-activating P2 receptors: Identification of a UDP-selective, a UTP-selective, and an ATP- and UTP-specific receptor
    • Nicholas RA, Watt WC, Lazarowski ER, Li Q, and Harden K. Uridine nucleotide selectivity of three phospholipase C-activating P2 receptors: identification of a UDP-selective, a UTP-selective, and an ATP- and UTP-specific receptor. Mol Pharmacol 50: 224-229, 1996.
    • (1996) Mol Pharmacol , vol.50 , pp. 224-229
    • Nicholas, R.A.1    Watt, W.C.2    Lazarowski, E.R.3    Li, Q.4    Harden, K.5
  • 39
    • 0023645617 scopus 로고
    • P2-purinergic receptors are coupled to two signal transduction systems leading to inhibition of cAMP generation and to production of inositol trisphosphate in rat hepatocytes
    • Okajima F, Tokumitsu Y, Kondo Y, and Ui M. P2-purinergic receptors are coupled to two signal transduction systems leading to inhibition of cAMP generation and to production of inositol trisphosphate in rat hepatocytes, J Biol Chem 262: 13483-13490, 1987.
    • (1987) J Biol Chem , vol.262 , pp. 13483-13490
    • Okajima, F.1    Tokumitsu, Y.2    Kondo, Y.3    Ui, M.4
  • 41
    • 0018722331 scopus 로고
    • Vascular endothelial and smooth muscle cells in culture selectively release adenine nucleotides
    • Pearson JD and Gordon JL. Vascular endothelial and smooth muscle cells in culture selectively release adenine nucleotides. Nature 281: 384-386, 1979.
    • (1979) Nature , vol.281 , pp. 384-386
    • Pearson, J.D.1    Gordon, J.L.2
  • 42
    • 0029888085 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase in neutrophils and enucleate neutrophil cytoplasts: Evidence for regulation of cell-cell adhesion
    • Pillinger MH, Feoktistov AS, Capodici C, Solitar B, Levy J, Oei TT, and Philips MR. Mitogen-activated protein kinase in neutrophils and enucleate neutrophil cytoplasts: evidence for regulation of cell-cell adhesion. J Biol Chem 271: 12049-12056, 1996.
    • (1996) J Biol Chem , vol.271 , pp. 12049-12056
    • Pillinger, M.H.1    Feoktistov, A.S.2    Capodici, C.3    Solitar, B.4    Levy, J.5    Oei, T.T.6    Philips, M.R.7
  • 43
    • 0032535680 scopus 로고    scopus 로고
    • Adhesion-dependent release of elastase from human neutrophils in a novel, flow-based model: Specificity of different chemotactic agents
    • Rainger GE, Rowley AF, and Nash GB. Adhesion-dependent release of elastase from human neutrophils in a novel, flow-based model: specificity of different chemotactic agents. Blood 92: 4819-4827, 1998.
    • (1998) Blood , vol.92 , pp. 4819-4827
    • Rainger, G.E.1    Rowley, A.F.2    Nash, G.B.3
  • 44
    • 0031754497 scopus 로고    scopus 로고
    • Receptors for purines and pyrimidines
    • Ralevic V and Burnstock G. Receptors for purines and pyrimidines. Pharmacol Rev 50: 413-492, 1998.
    • (1998) Pharmacol Rev , vol.50 , pp. 413-492
    • Ralevic, V.1    Burnstock, G.2
  • 46
    • 0036533481 scopus 로고    scopus 로고
    • Soluble fibrinogen modulates neutrophil functionality through the activation of an extracellular signal-regulated kinase-dependent pathway
    • Rubel C, Fernandez GC, Rosa FA, Gomez S, Bompadre MB, Coso OA, Isturiz MA, and Palermo MS. Soluble fibrinogen modulates neutrophil functionality through the activation of an extracellular signal-regulated kinase-dependent pathway. J Immunol 168: 3527-3535, 2002.
    • (2002) J Immunol , vol.168 , pp. 3527-3535
    • Rubel, C.1    Fernandez, G.C.2    Rosa, F.A.3    Gomez, S.4    Bompadre, M.B.5    Coso, O.A.6    Isturiz, M.A.7    Palermo, M.S.8
  • 47
    • 0024593398 scopus 로고
    • Activation of NADPH oxidase by purine and pyrimidine nucleotides involves G proteins and is potentiated by chemotactic peptides
    • Seifert R, Burde R, and Schultz G. Activation of NADPH oxidase by purine and pyrimidine nucleotides involves G proteins and is potentiated by chemotactic peptides. Biochem J 259: 813-819, 1989.
    • (1989) Biochem J , vol.259 , pp. 813-819
    • Seifert, R.1    Burde, R.2    Schultz, G.3
  • 48
    • 0024523242 scopus 로고
    • Purine and pyrimidine nucleotides potentiate activation of NADPH oxidase and degranulation by chemotactic peptides and induce aggregation of human neutrophils via G proteins
    • Seifert R, Wenzel K, Eckstein F, and Schultz G. Purine and pyrimidine nucleotides potentiate activation of NADPH oxidase and degranulation by chemotactic peptides and induce aggregation of human neutrophils via G proteins. Eur J Biochem 181: 277-285, 1989.
    • (1989) Eur J Biochem , vol.181 , pp. 277-285
    • Seifert, R.1    Wenzel, K.2    Eckstein, F.3    Schultz, G.4
  • 49
    • 0032579001 scopus 로고    scopus 로고
    • Activation of P2Y2 receptors by UTP and ATP stimulates mitogen-activated kinase activity through a pathway that involves related adhesion focal tyrosine kinase and protein kinase C
    • Soltoff SP, Avraham H, Avraham S, and Cantley LC. Activation of P2Y2 receptors by UTP and ATP stimulates mitogen-activated kinase activity through a pathway that involves related adhesion focal tyrosine kinase and protein kinase C. J Biol Chem 273: 2653-2660, 1998.
    • (1998) J Biol Chem , vol.273 , pp. 2653-2660
    • Soltoff, S.P.1    Avraham, H.2    Avraham, S.3    Cantley, L.C.4
  • 50
    • 0033838392 scopus 로고    scopus 로고
    • Signal transduction and white cell maturation via extracellular ATP and the P2Y11 receptor
    • Van der Weyden L, Conigrave AD, and Morris MB. Signal transduction and white cell maturation via extracellular ATP and the P2Y11 receptor. Immunol Cell Biol 78: 369-374, 2000.
    • (2000) Immunol Cell Biol , vol.78 , pp. 369-374
    • Van Der Weyden, L.1    Conigrave, A.D.2    Morris, M.B.3
  • 51
    • 0023248514 scopus 로고
    • Role of a guanine nucleotide regulatory protein in the activation of phospholipase C by different chemoattractants
    • Verghese MW, Charles L, Jakoi L, Dillon SB, and Snyderman R. Role of a guanine nucleotide regulatory protein in the activation of phospholipase C by different chemoattractants. J Immunol 138: 4374-4380, 1987.
    • (1987) J Immunol , vol.138 , pp. 4374-4380
    • Verghese, M.W.1    Charles, L.2    Jakoi, L.3    Dillon, S.B.4    Snyderman, R.5
  • 52
    • 0029666263 scopus 로고    scopus 로고
    • P2U agonists induce chemotaxis and actin polymerization in human neutrophils and differentiated HL60 cells
    • Verghese MW, Kneisler TB, and Boucheron JA. P2U agonists induce chemotaxis and actin polymerization in human neutrophils and differentiated HL60 cells. J Biol Chem 271: 15597-15601, 1996.
    • (1996) J Biol Chem , vol.271 , pp. 15597-15601
    • Verghese, M.W.1    Kneisler, T.B.2    Boucheron, J.A.3
  • 55
    • 0028094759 scopus 로고
    • Fibrinogen mediates platelet-polymorphonuclear leukocyte cooperation during immune-complex glomerulonephritis in rats
    • Wu X, Helfrich MH, Horton MA, Feigen LP, and Lefkowith JB. Fibrinogen mediates platelet-polymorphonuclear leukocyte cooperation during immune-complex glomerulonephritis in rats. J Clin Invest 94: 928-936, 1994.
    • (1994) J Clin Invest , vol.94 , pp. 928-936
    • Wu, X.1    Helfrich, M.H.2    Horton, M.A.3    Feigen, L.P.4    Lefkowith, J.B.5
  • 56
    • 0025781249 scopus 로고
    • Guanine-nucleotide- and adenine-nucleotide-dependent regulation of phospholipase D in electropermeabilized HL-60 granulocytes
    • Xie MS and Dubyak GR. Guanine-nucleotide- and adenine-nucleotide-dependent regulation of phospholipase D in electropermeabilized HL-60 granulocytes. Biochem J 278: 81-89, 1991.
    • (1991) Biochem J , vol.278 , pp. 81-89
    • Xie, M.S.1    Dubyak, G.R.2
  • 57
    • 0029878880 scopus 로고    scopus 로고
    • Biphasic effect of ATP on neutrophil functions mediated by P2U and adenosine A2A receptors
    • Zhang Y, Palmblad J, and Fredholm BB. Biphasic effect of ATP on neutrophil functions mediated by P2U and adenosine A2A receptors. Biochem Pharmacol 51: 957-965, 1996.
    • (1996) Biochem Pharmacol , vol.51 , pp. 957-965
    • Zhang, Y.1    Palmblad, J.2    Fredholm, B.B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.