The use of recombinant human bone morphogenetic protein 2 (rhBMP-2) to promote spinal fusion in a nonhuman primate anterior interbody fusion model

Spine

Volumn 25, Issue 6 SUPPL., 2000, Pages

  Hecht, Brian P ^a   Fischgrund, Jeffrey S ^a,c   Herkowitz, Harry N ^a   Penman, Lori ^a   Toth, Jeffrey M ^b   Shirkhoda, Ali ^a  

^a WILLIAM BEAUMONT HOSPITAL   (United States)

^b MEDICAL COLLEGE OF WISCONSIN   (United States)

^c 16800 W 12 Mile Rd ^*  (United States)

Author keywords

Interbody fusion; Primate; Recombinant human bone morphogenetic protein; Spine fusion

Indexed keywords

BONE MORPHOGENETIC PROTEIN 2; COLLAGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE GRAFT; CONTROLLED STUDY; FEMALE; IN VIVO STUDY; INTERMETHOD COMPARISON; LUMBOSACRAL SPINE; MACACA; NONHUMAN; OSSIFICATION; PRIORITY JOURNAL; PSEUDARTHROSIS; SPINE FUSION; SPONGE;

EID: 0034654110     PISSN: 03622436     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007632-200003151-00014     Document Type: Article

References (39)

1. Aspenberg P, Lohmander LS, Thorngren K. Failure of bone induction by bone matrix in adult monkeys. J Bone Joint Surg [Br] 1988;70:625-7.
2. Benedict JJ, Prewett AB, Kern MN, Fox WC, Aufdemorte TB, Poser JW. The Evaluation in Primates of a Bovine-Derived Osteogenic Factor Using the Analytical Bone Implant Model [abstract]. Presented at the Annual meeting of the Society for Biomaterials 1989:125.
3. Boden SD, Horton WC, Martin G, Truss T, Sandhu H. Laparoscopic anterior spinal arthrodesis with rhBMP-2 in a titanium interbody threaded cage. J Spinal Disord 1998;11:95-101.
4. Boden SD, Moskovitz PA, Martin G. Video-Assisted Lateral Intertransverse Process Arthrodesis: Validation of a New Minimally Invasive Lumbar Spinal Fusion Technique in the Nonhuman Primate (Rhesus) Model. Proceedings of the 12th annual meeting of the North American Spine Society, New York, NY, October 22-25.
5. Boden SD, Schimandle JH, Hutton WC. Lumbar intertransverse process spine arthrodesis using a bovine-derived osteoinductive bone protein. J Bone Joint Surg [Am] 1995;77:1404-17.
6. Bolesta MJ, Welch RD, Viere RG. Healing of Anterior Interbody Fusions with Recombinant Human Bone Morphogenetic Protein. Proceedings of the 12th annual meeting of the North American Spine Society, New York, NY, October 22-25, 1997.
7. Cockin J. Complications at the donor site. J Bone Joint Surg [Br] 1971;53: 153.
8. Cook SD, Dalton JE, Tan EH, Whitecloud TS, Rueger DC. In vivo evaluation of recombinant human osteogenic protein (rhOP-1) implants as a bone graft substitute for spinal fusions. Spine 1994;19:1655-63.
9. Damien CJ, Parsons JR. Bone graft and bone graft substitutes: A review of current technology and applications. J Appl Biomater 1991;2:187-208.
10. Davis H. Increasing rates of cervical and lumbar spine surgery in the United States, 1979-1990. Spine 1994;19:1117-24.
11. King FA, Yarbrough CJ. Medical and behavioral benefits from primate research. Physiologist 1985;28:2.
12. Kirker-Head CA, Gerhart TN, Schelling SH, Hennig GE, Wang E, Holtrop ME. Long-term healing of bone using recombinant human bone morphogenetic protein 2. Clin Orthop 1995;318:222-30.
13. Kurz LT, Garfin SR, Booth RE. Harvesting autogenous iliac bone: Review of complications and techniques. Spine 1989;1324-31.
14. Lee SC, Shea M, Battle MA, Kozitza K, Hayes WC. Healing of large segmental defects in rat femurs is aided by RhBMP-2 in PLGA matrix. J Biomed Mater Res 1994;28:1149-56.
15. Miyamoto S, Takaoka K, Ono K. Bone induction in monkeys by bone morphogenetic protein: A transfilter technique. J Bone Joint Surg [Br] 1993;75:107-10.
16. Miyamoto S, Takaoka K, Yonenobu K, Ono K. Ossification of the ligamentum flavum induced by bone morphogenetic protein: An experimental study in mice. J Bone Joint Surg [Br] 1992;74:279-83.
17. Morone MA, Boden SD, Hair G, et al. Gene expression during lumbar spine fusion: A molecular basis for preventing nonunions. Clin Orthop. In press.
18. Morone MA, Martin GM, Hair G, Racine MA. Gene expression during posterolateral lumbar spine fusion: Effect of BMP-2. Clin Orthop. In press.
19. Muschler GF, Hyodo A, Manning T, Kambic H, Easley K. Evaluation of human bone morphogenetic protein 2 in a canine spinal fusion model. Clin Orthop 1994;308:229-40.
20. Ripamonti U. Bone induction in nonhuman primates: An experimental study on the baboon. Clin Orthop 1991;269:284-94.
21. Ripamonti U. Calvarial regeneration in primate with autolyzed antigen-extracted allogeneic bone. Clin Orthop 1992;282:293-303.
22. Ripamonti U. Delivery systems for bone morphogenetic proteins: A summary of experimental studies in primate models. Ann Chir Gynaecol Suppl 1993; 207:13-24.
23. Ripamonti U, Ma S, Reddi AH. Induction of bone in composites of osteogenin and porous hydroxyapatite in baboons. Plast Reconstr Surg 1992;89:731-9.
24. Ripamonti U, Ma S, Vanden Heever B, Reddi AH. Osteogenin, a bone morphogenic protein, absorbed on porous hydroxyapatite substrata, induces rapid bone differentiation in calvarial defects of adult primates. Plast Reconstr Surg 1992;90:382-93.
25. Sacks S. Anterior interbody fusion of the lumbar spine. J Bone Joint Surg [Br] 1965;47:211-23.
26. Saito H, Mimatsu K, Sato K, Hashizume Y. Histopathologic and morphometric study of spinal cord lesion in a chronic cord compression model using bone morphogenetic protein in rabbits. Spine 1992;17:1368-74.
27. Sandhu H, Rabo M, et al. rhBMP-2 augmentation of titanium fusion cages for experimental anterior lumbar fusion. Proceedings of the International Society for the Study of the Lumbar Spine, Singapore, 1997.
28. Schimandle JH, Boden SD, Hutton WC. Experimental spinal fusion with recombinant human bone morphogenetic protein-2. Spine 1995;20:1326-37.
29. Steinmann JC, Herkowitz HN. Pseudarthrosis of the spine. Clin Orthop 1992;284:80-90.
30. Summers BN, Eisenstein SM. Donor site pain from the ilium: A complication of lumbar spine fusion. J Bone Joint Surg [Br] 1989;71:677-80.
31. Turner JA, Ersek M, Herron L, et al. Patient outcomes after lumbar spinal fusions. JAMA 1992:268:907-11.
32. Urist MR. Bone: Formation by autoinduction. Science 1965;150:893-99.
33. Urist MR, Delange RF, Finerman GAM. Bone cell differentiation and growth factors. Science 1983;220:680-6.
34. Wang EA, Rosen V, D'Alessandro JS, et al. Recombinant human bone morphogenetic protein induces bone formation. Proc Natl Acad Sci USA 1990;87: 2220-4.
35. White AA-III, Panjabi MM. Clinical Biomechanics of the Spine. Philadelphia: Lippincott, 1978:383-95.
36. Wisneski RJ. Surgical treatment: The role of fusion in lumbar disc disease. Semin Spine Surg 1989;1:60-7.
37. Wittenberg RH, Moeller J, Shea M, White AA, Hayes CC. Compressive strength of autologous and allogenous bone grafts for thoracolumbar and cervical spine fusion. Spine 1990;15:1073-8.
38. Wozney JM. The bone morphogenetic protein family and osteogenesis. Mol Reprod Dev 1992;32:160-7.
39. Younger EM, Chapman MW. Morbidity at bone graft donor sites. J Orthop Trauma 1989;3:192-5.