Myelin inhibitors: Does NO mean GO?

Nature Reviews Neuroscience

Volumn 5, Issue 2, 2004, Pages 157-161

  Raisman, Geoffrey ^a  

^a NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

MYELIN;

ASTROCYTE; BRAIN; CENTRAL NERVOUS SYSTEM; MYELINATED NERVE; NERVE FIBER GROWTH; NERVE REGENERATION; NONHUMAN; OLIGODENDROGLIA; OPTIC NERVE INJURY; PRIORITY JOURNAL; REVIEW; SPINAL CORD; SPINAL CORD INJURY;

MAMMALIA;

EID: 0742271135     PISSN: 1471003X     EISSN: None     Source Type: Journal    
DOI: 10.1038/nrn1328     Document Type: Review

References (56)

1. Filbin, M. T. Myelin-associated inhibitors of axonal regeneration in the adult mammalian CNS. Nature Rev. Neurosci. 4, 703-713 (2003).
2. McKerracher, L. & Winton, M. J. Nogo on the go. Neuron 36, 345-348 (2002).
3. Schnell, L. & Schwab, M. E. Axonal regeneration in the rat spinal cord produced by an antibody against myelin-associated neurite growth inhibitors. Nature 343, 269-272 (1990).
4. Schwab, M. E. & Thoenen, H. Dissociated neurons regenerate into sciatic but not optic nerve explants in culture irrespective of neurotrophic factors. J. Neurosci. 5, 2415-2423 (1985).
5. Crutcher, K. A. Tissue sections from the mature rat brain and spinal cord as substrates for neurite outgrowth in vitro: extensive growth on gray matter but little growth on white matter. Exp. Neurol. 104, 39-54 (1989).
6. Hunt, D., Coffin, R. S. & Anderson, P. N. The Nogo receptor, its ligands and axonal regeneration in the spinal cord; a review. J. Neurocytol. 31, 93-120 (2002).
7. Hunt, D., Coffin, R. S., Prinjha, R. K., Campbell, G. & Anderson, P. N. Nogo-A expression in the intact and injured nervous system. Mol. Cell. Neurosci. (in the press).
8. Hunt, D., Mason, M. R., Campbell, G., Coffin, R. & Anderson, P. N. Nogo receptor mRNA expression in intact and regenerating CNS neurons. Mol. Cell. Neurosci. 20, 537-552 (2002).
9. Huang, D. W., McKerracher, L., Braun, P. E. & David, S. A therapeutic vaccine approach to stimulate axon regeneration in the adult mammalian spinal cord. Neuron 24, 639-647 (1999).
10. Kim, J. E., Li S. X., GrandPré, T., Qiu, D. & Strittmatter, S. M. Axon regeneration in young adult mice lacking Nogo-A/B. Neuron 38, 187-199 (2003).
11. Woolf, C. J. No Nogo: now where to go? Neuron 38, 153-156 (2003).
12. Zheng, B. H. et al. Lack of enhanced spinal regeneration in Nogo-deficient mice. Neuron 38, 213-224 (2003).
13. Simonen, M. et al. Systemic deletion of the myelin-associated outgrowth inhibitor Nogo-A improves regenerative and plastic responses after spinal cord injury. Neuron 38, 201-211 (2003).
14. Davies, S. J. A. et al. Regeneration of adult axons in white matter tracts of the central nervous system. Nature 390, 680-683 (1997).
15. Wictorin, K., Brundin, P., Sauer, H., Lindvall, O. & Björklund, A. Long distance directed axonal growth from human dopaminergic mesencephalic neuroblasts implanted along the nigrostriatal pathway in 6-hydroxydopamine lesioned adult rats. J. Comp. Neurol. 323, 475-494 (1992).
16. Davies, S. J. A. & Silver, J. Adult axon regeneration in adult CNS white matter. Trends Neurosci. 21, 515 (1998).
17. Davies, S. J. A., Field, P. M. & Raisman, G. Long fibre growth by axons of embryonic mouse hippocampal neurons micro-transplanted into the adult rat fimbria. Eur. J. Neurosci. 5, 95-106 (1993).
18. Li Y. & Raisman, G. Long axon growth from embryonic neurons transplanted into myelinated tracts of the adult rat spinal cord. Brain Res. 629, 115-127 (1993).
19. Li, Y., Field, P. M. & Raisman, G. Repair of adult rat corticospinal tract by transplants of olfactory ensheathing cells. Science 277, 2000-2002 (1997).
20. Li, Y. & Raisman, G. Sprouts from cut corticospinal axons persist in the presence of astrocytic scarring in long-term lesions of the adult rat spinal cord. Exp. Neurol. 134, 102-111 (1995).
21. Bradbury, E. J. et al. Chondroitinase ABC promotes functional recovery after spinal cord injury. Nature 416, 636-640 (2002).
22. Grimpe, B. & Silver, J. The extracellular matrix in axon regeneration. Prog. Brain Res. 137, 333-349 (2002).
23. Silver, J. & Miller, J. H. Regeneration beyond the glial scar. Nature Rev. Neurosci. 5, 146-156 (2004).
24. Suzuki, M. & Raisman, G. The glial framework of central white matter tracts: segmented rows of contiguous interfascicular oligodendrocytes and solitary astrocytes give rise to a continuous meshwork of transverse and longitudinal processes in the adult rat fimbria. Glia 6, 222-235 (1992).
25. Meier, C. & Sollmann, H. Glial outgrowth and central-type myelination of regenerating axons in spinal nerve roots following transaction and suture: light and electron microscopic study in the pig. Neuropathol. appl. Neurobiol. 4, 21-35 (1978).
26. Houlé, J. The structural integrity of glial scar tissue associated with a chronic spinal cord lesion can be altered by transplanted fetal spinal cord tissue. J. Neurosci. Res. 31, 120-130 (1992).
27. Li, Y., Field, P. M. & Raisman, G. Regeneration of adult rat corticospinal axons induced by transplanted olfactory ensheathing cells. J. Neurosci. 18, 10514-10524 (1998).
28. McDonald, J. W., Althomsons, S. P., Hyrc, K. L., Choi, D. W. & Goldberg, M. P. Oligodendrocytes from forebrain are highly vulnerable to AMPA/kainate receptor-mediated excitotoxicity. Nature Med. 4, 291-297 (1998).
29. Li, Y., Field, P. M. & Raisman, G. Death of oligodendrocytes and microglial phagocytosis of myelin precede immigration of Schwann cells into the spinal cord. J. Neurocytol. 28, 417-427 (1999).
30. Warden, P. et al. Delayed glial cell death following Wallerian degeneration in white matter tracts after spinal cord dorsal column cordotomy in adult rats. Exp. Neurol. 168, 213-224 (2001).
31. Li, Y., Sauvé, Y., Li, D., Lund, R. D. & Raisman, G. Transplanted olfactory ensheathing cells promote regeneration of cut adult rat optic nerve axons. J. Neurosci. 23, 7922-7930 (2003).
32. Fawcett, J. W., Housden, E., Smith-Thomas, L. & Meyer, R. L. The growth of axons in three-dimensional astrocyte cultures. Dev. Biol. 135, 449-458 (1989).
33. Baird, D. H., Hatten, M. E. & Mason, C. A. Cerebellar target neurons provide a stop signal for afferent neurite extension in vitro. J. Neurosci, 12, 619-634 (1992).
34. Bovolenta, P. & Mason, C. Growth cone morphology varies with position in the developing mouse visual pathway from retina to first targets. J. Neurosci. 7, 1447-1460 (1987).
35. Tessier-Lavigne, M. & Goodman, C. S. The molecular biology of axon guidance. Science 274, 1123-1133 (1996).
36. Araújo, S. J. & Tear, G. Axon guidance mechanisms and molecules: lessons from invertebrates. Nature Rev. Neurosci. 4, 910-922 (2003).
37. Hopker, V. H., Shewan, D., Tessier-Lavigne, M., Poo, M. & Holt, C. Growth-cone attraction to netrin-1 is converted to repulsion by laminin-1. Nature 401, 69-73 (1999).
38. Schwab, M. E., Kapfhammer, J. P. & Bandtlow, C. E. Inhibitors of neurite growth. Annu. Rev. Neurosci. 16, 565-595 (1993).
39. Schwab, M. E. & Schnell, L. Channeling of developing rat corticospinal tract axons by myelin-associated neurite growth inhibitors. J. Neurosci. 11, 709-721 (1991).
40. Vanek, P., Thallmair, M., Schwab, M. E. & Kapfhammer, J. P. Increased lesion-induced sprouting of corticospinal fibres in the myelin-free rat spinal cord. Eur. J. Neurosci. 10, 45-56 (1998).
41. Li, D., Field, P. M. & Raisman, G. Failure of axon regeneration in postnatal rat entorhino-hippocampal slice co-culture is due to maturation of the axon, not that of the pathway or target. Eur. J. Neurosci. 7, 1164-1171 (1995).
42. Bouslama-Oueghlani, L., Wehrle, R., Sotelo, C. & Dusart, I. The developmental loss of the ability of Purkinje cells to regenerate their axons occurs in the absence of myelin: an in vitro model to prevent myelination. J. Neurosci. 23, 8318-8329 (2003).
43. Maxwell, W. L., Follows, R., Ashhurst, D. E. & Berry, M. The response of the cerebral hemisphere of the rat to injury. II. The neonatal rat. Philos. Trans. R. Soc. Lond. B 328, 501-513 (1990).
44. Maxwell, W. L., Follows, R., Ashhurst, D. E. & Berry, M. The response of the cerebral hemisphere of the rat to injury. I. The mature rat. Philos. Trans. R. Soc. Lond. B 328, 479-500 (1990).
45. Kliot, M., Smith, G. M., Siegal, J. D. & Silver, J. Astrocyte-polymer implants promote regeneration of dorsal root fibers into the adult mammalian spinal cord. Exp. Neurol. 109, 57-69 (1990).
46. De Kort, E. J. M., Gribnau, A. A. M., Van Aanholt, H. T. H. & Nieuwenhuys, R. On the development of the pyramidal tract in the rat. I. The morphology of the growth zone. Anat. Embryol. 172, 195-204 (1985).
47. Pettigrew, D. B. & Crutcher, K. A. White matter of the CNS supports or inhibits neurite outgrowth in vitro depending on geometry. J. Neurosci. 19, 8358-8366 (1999).
48. Pettigrew, D. B. & Crutcher, K. A. Myelin contributes to the parallel orientation of axonal growth on white matter in vitro. BMC Neurosci. 2, 9 (2001).
49. Pettigrew, D. B., Shockley, K. P. & Crutcher, K. A. Disruption of spinal cord white matter and sciatic nerve geometry inhibits axonal growth in vitro in the absence of glial scarring. BMC Neurosci. 2, 8 (2001).
50. Rarner, M. S., Duraisingam, I., Priestley, J. V. & McMahon, S. B. Two-tiered inhibition of axon regeneration at the dorsal root entry zone. J. Neurosci. 21, 2651-2660 (2001).
51. Raineteau, O. & Schwab, M. E. Plasticity of motor systems after incomplete spinal cord injury. Nature Rev. Neurosci. 2, 263-273 (2001).
52. David, S. & Aguayo, A. J. Axonal elongation into peripheral nervous system 'bridges' after central nervous system injury in adult rats. Science 214, 931-933 (1981).
53. Rossi, F., Jankovski, A. & Sotelo, C. Differential regenerative response of Purkinje cell and inferior olivary axons confronted with embryonic grafts: environmental cues versus intrinsic neuronal determinants. J. Comp. Neurol. 359, 663-677 (1995).
54. Davies, S. J. A., Field, P. M. & Raisman, G. Regeneration of cut adult axons fails even in the presence of continuous aligned glial pathways. Exp. Neurol. 142, 203-216 (1996).
55. Davies, S. J. A. et al. Robust adult axon regeneration in central nervous system white matter tracts. Soc. Neurosci. Abstr. 23, 1448 (1997).
56. Li, Y. & Raisman, G. Schwann cells induce sprouting in motor and sensory axons in the adult rat spinal cord. J. Neurosci. 14, 4050-4063 (1994).