Alzheimer's Therapeutics: Neurotrophin Domain Small Molecule Mimetics

Journal of Molecular Neuroscience

Volumn 20, Issue 3, 2003, Pages 323-326

  Massa, Stephen M ^a   Xie, Youmei ^a,b   Longo, Frank M ^a,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b SUN YAT SEN UNIVERSITY   (China)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Mimetic; Nerve growth factor; Neurotrophin; p75; TrkA

Indexed keywords

NERVE GROWTH FACTOR; NERVE GROWTH FACTOR RECEPTOR; NEUROTROPHIN; NEUROTROPHIN RECEPTOR; PEPTIDE; PROTEIN P75; NEUROPROTECTIVE AGENT; PROTEIN TYROSINE KINASE A;

ANIMAL CELL; ARTICLE; BIOASSAY; COMPUTER MODEL; CONTROLLED STUDY; CRYSTAL STRUCTURE; DATA BASE; DRUG DESIGN; EMBRYO; MOLECULAR SIZE; MOUSE; NERVE CELL NECROSIS; NONHUMAN; PHARMACOPHORE; PROTEIN DOMAIN; SCREENING; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; ALZHEIMER DISEASE; ANIMAL; CELL CULTURE; CHEMICAL STRUCTURE; CHEMISTRY; CHICK EMBRYO; CONFORMATION; DRUG EFFECT; DRUG SCREENING; MOLECULAR MIMICRY; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE;

ANIMALIA;

ALZHEIMER DISEASE; ANIMALS; CELLS, CULTURED; CHICK EMBRYO; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; MICE; MOLECULAR CONFORMATION; MOLECULAR MIMICRY; MOLECULAR STRUCTURE; NERVE GROWTH FACTORS; NEUROPROTECTIVE AGENTS; PROTEIN STRUCTURE, TERTIARY; RECEPTOR, NERVE GROWTH FACTOR; RECEPTOR, TRKA; RECEPTORS, NERVE GROWTH FACTOR;

EID: 0642370866     PISSN: 08958696     EISSN: None     Source Type: Journal    
DOI: 10.1385/JMN:20:3:323     Document Type: Article

References (25)

1. Bergmann I., Reiter R., Toyka K. V., and Koltzenburg M. (1998) Nerve growth factor evokes hyperalgesiain mice lacking the low-affinity neurotrophin receptor p75. Neurosci. Lett. 255, 87-90.
2. Braan A. B., Tcherpakov M., Williams I. M., Futerman A. H., and Fainzilber M. (2002) Nerve growth factor-induced p75-mediated death of cultured hippocampal neurons is age-dependent and transduced through ceramide generated by neural sphingomyelinase. J. Biol. Chem. 277, 9812-9818.
3. Casaccia-Bonnefil P., Carter B. D., Dobrowsky R. T., and Chao M. V. (1996) Death of oligodendrocytes mediated by the interaction of nerve growth factor with its receptor p75. Nature 383, 716-719.
4. DeFreitas M. F., McQuillen P. S., and Shatz C. J. (2001) A novel p75NTR signaling pathway promotes survival, not death, of immunopurified neocortical subplate neurons. J. Neurosci. 21, 5121-5129.
5. Dobrowsky R. T. and Carter B. D. (2000) p75 neurotrophin receptor signaling: mechanisms for neurotrophic modulation of cell stress? J. Neurosci. Res. 61, 237-243.
6. Fahnestock M., Michalski B., Xu B., and Coughlin M. D. (2001) The precursor pro-nerve growth factor is the predominant form of nerve growth factor in brain and is increased in Alzheimer's disease. Mol. Cell. Neurosci. 18, 210-220.
7. Frade J. M., Rodriguez-Tebar A., and Barde Y. A. (1996) Induction of cell death by endogenous nerve growth factor through its p75 receptor. Nature 383, 166-168.
8. Goslin K., Asmussen H., and Banker G. (1998) Rat hippocampal neurons in low density culture, in Culturing Nerve Cells (Banker G. and Goslin K., eds.), MIT Press, Cambridge, MA, pp. 339-370.
9. Hempstead B. L. (2002) The many faces of p75NTR. Curr. Opin. Neurobiol. 12, 260-267.
10. Kawasumi M., Hashimoto Y., Chiba T., et al. (2002) Molecular mechanisms for neuronal cell death by Alzheimer's amyloid precursor protein-relevant insults. Neurosignals 11, 236-250.
11. Khursigara G., Bertin J., Yano H., Moffett H., DiStefano P. S., and Chao M. V. (2001) A prosurvival function for the p75 receptor death domain mediated via the caspase recruitment domain receptor-interacting protein 2. J. Neurosci. 21, 5854-5863.
12. Lee R., Kermani P., Teng K., and Hempstead B. (2001) Regulation of cell survival by secreted proneurotrophins. Science 294, 1945-1948.
13. Longo F. M., Manthorpe M., Xie Y. M., and Varon S. (1997) Synthetic NGF peptide derivatives prevent neuronal death via a p75 receptor-dependent mechanism. J. Neurosci. Res. 48, 1-17.
14. Maliartchouk S., Debeir T., Beglova N., Cuello A. C., Gehring K., and Saragovi H. U. (2000) Genuine monovalent ligands of TrkA nerve growth factor receptors reveal a novel pharmacological mechanism of action. J. Biol. Chem. 275, 9946-9956.
15. NTR signaling in survival and death: can intracellular mediators provide an explanation? J. Neurosci. Res. 68, 373-384.
16. Massa S. M., Xie Y., and Longo F. M. (2002) Alzheimer's therapeutics: neurotrophin small molecule mimetics. J. Mol. Neurosci. 19, 107-111.
17. McDonald N. Q. and Chao M. V. (1995) Structural determinants of neurotrophin action. J. Biol. Chem. 270, 19,669-19,672.
18. Poduslo J. F. and Curran G. L. (1996) Permeability at the blood-brain and blood-nerve barriers of the neurotrophic factors: NGF, CNTF, NT-3, BDNF. Mol. Brain Res. 36, 280-286.
19. NTR. Cytokine Growth Factor Rev. 14, 224-239.
20. Roux P. P., Bhakar A. L., Kennedy T. E., and Barker P. A. (2001) The p75 neurotrophin receptor activates Akt (Protein Kinase B) through a phosphatidylinositol 3-kinase-dependent pathway. J. Biol. Chem. 276, 23,097-23,104.
21. Savage M. J., Lin Y-G., Ciallella J. R., Flood D. G., and Scott R. W. (2002) Activation of c-Jun N-terminal kinase and p38 in an Alzheimer's disease model is associated with amyloid deposition. J. Neurosci. 22, 3376-3385.
22. Sofroniew M. V., Howe C. L., and Mobley W. C. (2001) Nerve growth factor signaling, neuroprotection, and neural repair. Annu. Rev. Neurosci. 24, 1217-1281.
23. Tuszynski M. H. (2002) Growth-factor gene therapy for neurodegenerative disorders. Lancet Neurol. 1, 51-57.
24. Xie Y., Tisi M. A., Yeo T. T., and Longo F. M. (2000) NGF loop 4 dimeric mimetics activate ERK and AKT and prevent neuronal death. J. Biol. Chem. 275, 29,868-29,874.
25. Yaar M., Zhai S., Fines R. E., Eisenhauer P. B., Arble B. L., Stewart K. B., and Gilchrest B. A. (2002) Amyloid β binds trimers as well as monomers of the 75-kDa neurotrophin receptor and activates receptor signal