Patch-clamp capacitance measurements: New insights into the endocytic uptake of transferrin

Blood cells, molecules & diseases

Volumn 29, Issue 3, 2002, Pages 459-464

  Schwake, Lukas ^a   Henkel, Andreas W ^b   Riedel, Hans D ^a   Stremmel, Wolfgang ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

HFE PROTEIN, HUMAN; HLA ANTIGEN CLASS 1; IRON; MEMBRANE PROTEIN; TRANSFERRIN;

CYTOPLASM VESICLE; ENDOCYTOSIS; HELA CELL; HUMAN; METABOLISM; METHODOLOGY; PATCH CLAMP; PHYSIOLOGY; REVIEW;

CYTOPLASMIC VESICLES; ENDOCYTOSIS; HELA CELLS; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; IRON; MEMBRANE PROTEINS; PATCH-CLAMP TECHNIQUES; TRANSFERRIN;

EID: 0642349205     PISSN: 10799796     EISSN: None     Source Type: Journal    
DOI: 10.1006/bcmd.2002.0584     Document Type: Article

References (22)

1. E. Audinat B. Lambolez J. Rossier Functional and molecular analysis of glutamate-gated channels by patch-clamp and RT-PCR at the single cell level Neurochem. Int. 28 1996 119 136
2. B. Corsi S. Levi A. Cozzi A. Corti D. Altimare A. Albertini P. Arosio Overexpression of the hereditary hemochromatosis protein, HFE, in HeLa cells induces an iron-deficient phenotype FEBS Lett. 460 1999 149 152
3. J.M. Fernandez E. Neher B.D. Gomperts Capacitance measurements reveal stepwise fusion events in degranulating mast cells Nature 312 1984 453 455
4. R.E. Fleming M.C. Migas X. Zhou J. Jiang R.S. Britton E.M. Brunt S. Tomatsu A. Waheed B.R. Bacon W.S. Sly Mechanism of increased iron absorption in murine model of hereditary hemochromatosis: increased duodenal expression of the iron transporter DMT1 Proc. Natl. Acad. Sci. USA 96 1999 3143 3148
5. C.N. Gross A. Irrinki J.N. Feder C.A. Enns Co-trafficking of HFE, a nonclassical major histocompatibility complex class I protein, with the transferrin receptor implies a role in intracellular iron regulation J. Biol. Chem. 273 1998 22068 22074
6. O.P. Hamill A. Marty E. Neher B. Sakmann F.J. Sigworth Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches Pflugers Arch. 391 1981 85 100
7. A.W. Henkel H. Meiri H. Horstmann M. Lindau W. Almers Rhythmic opening and closing of vesicles during constitutive exo- and endocytosis in chromaffin cells EMBO J. 19 2000 84 93
8. J.M. Levsky S.M. Shenoy R.C. Pezo R.H. Singer Single-cell gene expression profiling Science 297 2002 836 840
9. M. Lindau E. Neher Patch-clamp techniques for time-resolved capacitance measurements in single cells Pflugers Arch. 411 1988 137 146
10. K. Lollike N. Borregaard M. Lindau The exocytotic fusion pore of small granules has a conductance similar to an ion channel J. Cell. Biol. 129 1995 99 104
11. K. Lollike M. Lindau Membrane capacitance techniques to monitor granule exocytosis in neutrophils J. Immunol. Methods 232 1999 111 120
12. G. Montosi P. Paglia C. Garuti C.A. Guzman J.M. Bastin M.P. Colombo A. Pietrangelo Wild-type HFE protein normalizes transferrin iron accumulation in macrophages from subjects with hereditary hemochromatosis Blood 96 2000 1125 1129
13. E. Neher B. Sakmann Single-channel currents recorded from membrane of denervated frog muscle fibres Nature 260 1976 799 802
14. E. Neher A. Marty Discrete changes of cell membrane capacitance observed under conditions of enhanced secretion in bovine adrenal chromaffin cells Proc. Natl. Acad. Sci USA 79 1982 6712 6716
15. E. Neher B. Sakmann The patch clamp technique Sci. Am. 266 1992 44 51
16. C.C. Philpott Molecular aspects of iron absorption: insights into the role of HFE in hemochromatosis Hepatology 35 2002 993 1001
17. H.D. Riedel M.U. Muckenthaler S.G. Gehrke I. Mohr K. Brennan T. Herrmann B.A. Fitscher M.W. Hentze W. Stremmel HFE downregulates iron uptake from transferrin and induces iron- regulatory protein activity in stably transfected cells Blood 94 1999 3915 3921
18. A. Rolfs M.A. Hediger Metal ion transporters in mammals: structure, function and pathological implications J. Physiol. 518 1999 1 12
19. C.N. Roy D.M Penny J.N. Feder C.A. Enns The hereditary hemochromatosis protein, HFE, specifically regulates transferrin-mediated iron uptake in HeLa cells J. Biol. Chem. 274 1999 9022 9028
20. S. Scepek J.R. Coorssen M. Lindau Fusion pore expansion in horse eosinophils is modulated by Ca2+ and protein kinase C via distinct mechanisms EMBO J. 17 1998 4340 4345
21. L. Schwake A.W. Henkel H.D. Riedel T. Schlenker M. Both A. Migala B. Hadaschik N. Henfling W. Stremmel Regulation of transferrin-induced endocytosis by wild-type and C282Y-mutant HFE in transfected HeLa cells Am. J. Physiol. Cell Physiol. 282 2002 C973 C979
22. G. Zupancic L. Kocmur P. Veranic S. Grilc M. Kordas R. Zorec The separation of exocytosis from endocytosis in rat melanotroph membrane capacitance records J. Physiol. 480 1995 539 552