Synthesis and biological evaluation of new imidazole, pyrimidine, and purine derivatives and analogs as inhibitors of xanthine oxidase

Journal of Medicinal Chemistry

Volumn 39, Issue 13, 1996, Pages 2529-2535

  Biagi, Giuliana ^b   Costantini, Alberto ^a   Costantino, Luca ^a   Giorgi, Irene ^b   Livi, Oreste ^b   Pecorari, Piergiorgio ^a   Rinaldi, Marcella ^a   Scartoni, Valerio ^b  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^b UNIVERSITY OF PISA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

[1,3]THIAZINO[2,3 I]PURINONE DERIVATIVE; ALLOPURINOL; IMIDAZOLE DERIVATIVE; PURINE DERIVATIVE; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG; XANTHINE OXIDASE INHIBITOR;

AMINO ACID SUBSTITUTION; ARTICLE; BLOOD VESSEL PERMEABILITY; DRUG EFFICACY; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME INHIBITION; HYDROXYLATION; NONHUMAN; TISSUE INJURY;

ALLOPURINOL; ENZYME INHIBITORS; IMIDAZOLES; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; PURINES; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; XANTHINE OXIDASE;

EID: 0030014367     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm950876u     Document Type: Article

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