The Possible Role of Tissue-Type Plasminogen Activator (tPA) and tPA Blockers in the Pathogenesis and Treatment of Alzheimer's Disease

Journal of Molecular Neuroscience

Volumn 20, Issue 3, 2003, Pages 287-289

  Melchor, Jerry P ^a   Pawlak, Robert ^a   Chen, Zulin ^a   Strickland, Sidney ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

Author keywords

A degradation; A deposition; Plasmin; tPA

Indexed keywords

AMYLOID BETA PROTEIN; MESSENGER RNA; PLASMIN; TISSUE PLASMINOGEN ACTIVATOR; ENZYME INHIBITOR; NEUROTOXIN; PLASMINOGEN;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CELL; CELL DEATH; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MOUSE; NERVE CELL LESION; NEUROFIBRILLARY TANGLE; NEUROTOXICITY; NONHUMAN; PATHOGENESIS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SENILE PLAQUE; UPREGULATION; ANIMAL; BRAIN; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; METABOLISM; MOUSE MUTANT; NERVE CELL; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY;

ANIMALIA;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMALS; BRAIN; ENZYME INHIBITORS; MICE; MICE, KNOCKOUT; NEURONS; NEUROTOXINS; PLASMINOGEN; RNA, MESSENGER; TISSUE PLASMINOGEN ACTIVATOR; UP-REGULATION;

EID: 0642279043     PISSN: 08958696     EISSN: None     Source Type: Journal    
DOI: 10.1385/JMN:20:3:287     Document Type: Article

References (21)

1. Chen Z.-L. and Strickland S. (1997) Neuronal death in the hippocampus is promoted by plasmin-catalyzed degradation of laminin. Cell 91, 917-925.
2. Citron M., Oltersdorf T., Haass C., McConlogue L., Hung A. Y., Seubert P., et al. (1992) Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production. Nature 360, 672-674.
3. Duff K., Eckman C., Zehr C., Yu X., Prada C. M., Pereztur J., et al. (1996) Increased amyloid-β 42(43) in brains of mice expressing mutant presenilin 1. Nature 383, 710-713.
4. Eckman E. A., Reed D. K., and Eckman C. B. (2001) Degradation of the Alzheimer's amyloid β peptide by endothelin-converting enzyme. J. Biol. Chem. 276, 24,540-24,548.
5. Franklin K. B. J. and Paxinos G. (1997) The Mouse Brain in Stereotaxic Coordinates. Academic Press, Inc., San Diego, CA.
6. Frautschy S. A., Horn D. L., Sigel J. J., Harris-White M. E., Mendoza J. J., Yang F., et al. (1998) Protease inhibitor coinfusion with amyloid beta-protein results in enhanced deposition and toxicity in rat brain. J. Neurosci. 18, 8311-8321.
7. Haass C., Schlossmacher M. G., Hung A. Y., Vigo-Pelfrey C., Mellon A., Ostaszewski B. L., et al. (1992) Amyloid β-peptide is produced by cultured cells during normal metabolism. Nature 359, 322-325.
8. Iwata N., Tsubuki S., Takaki Y., Shirotani K., Lu B., Gerard N. P., et al. Metabolic regulation of brain Aβ by neprilysin. Science 292, 1550-1552.
9. Kingston, I. B., Castro M. J., and Anderson S. (1995) In vitro stimulation of tissue-type plasminogen activator by Alzheimer Amyloid beta-peptide analogues. Nat.Med. 1, 138-142.
10. Sappino A.-P, Madani R., Huarte J., Belin D., Kiss J. Z., Wohlwend A., and Vassali J.-D. (1993) Extracellular Proteolysis in the adult murine brain. J. Clin. Invest. 92, 679-685.
11. Schmued L. C. and Hopkins K. J. (2000) Fluoro-Jade B: a high affinity fluorescent marker for the localization of neuronal degeneration. Brain Res. 874, 123-130.
12. Selkoe D. J. (2001) Alzheimer's disease: genes, proteins, and therapy. Physiol. Rev. 81, 742-760.
13. Tanzi R. E., Kovacs D. M., Kim T.-W., Moir R. D., Guennette S. Y., and Wasco W. (1996) The gene defects responsible for familial Alzheimer's disease. Neurobiol. Dis. 3, 159-168.
14. Tsirka S. E., Gualandris A., Amaral D. G., and Strickland S. (1995) Excitotoxin-induced neuronal degeneration and seizure are mediated by tissue plasminogen activator. Nature 377, 340-344.
15. Tsirka S. E., Rogove A. D., and Strickland S. (1996) Neuronal cell death and tPA. Nature 384, 123-124.
16. Tsirka S. E., Rogove A. D., Bugge T. H., Degen J. L., and Strickland S. (1997) An extracellular proteolytic cascade promotes neuronal degeneration in the mouse hippocampus. j. Neurosci. 17, 543-552.
17. Tucker H. M., Kihiko M., Caldwell J. N., Wright S., Kawarabayashi T., Price D., et al. (2000a) The plasmin system is induced by and degrades amyloid-beta aggregates. J. Neurosci. 20, 3937-3946.
18. Tucker H. M., Kihiko-Ehmann M., Wright S., Rydel R. E., and Estus S. (2000b) Tissue plasminogen activator requires plasminogen to modulate amyloid-beta neurotoxicity and deposition. J. Neurochem. 75, 2172-2177.
19. Vassalli J.-D., Sappino A.-P., and Belin D. (1991) The plasminogen activator/plasmin system. J. Clin. Invest. 88, 1067-1072.
20. Vekrellis K., Ye Z., Qiu W. Q., Walsh D., Hartley D., Chesneau V., et al. (2000) Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme. J. Neurosci. 20, 1657-1665.
21. Wyss-Coray T., Masliah E., Mallory M., McConlogue L., Johnson-Wood K., Lin C., and Mucke L. (1997) Amyloidogenic role of the cytokine TGF-β1 in transgenic mice and Alzheimer's disease. Nature 389, 603-606.