Serotonin and the cardiovascular system: Role of the serotoninergic 5-HT2B receptor;Sérotonine et système cardio-vasculaire: Rôle du récepteur sérotoninergique 5-HT2B

Bulletin de l'Academie Nationale de Medecine

Volumn 187, Issue 1, 2003, Pages 117-127

  Launay, Jean Marie ^a   Godeau, Pierre ^b  

^a HÔPITAL LARIBOISIÈRE   (France)

^b NONE

Author keywords

Heart; Mice, knockout; Serotonin

Indexed keywords

SEROTONIN; SEROTONIN 2 RECEPTOR;

ANIMAL; ARTICLE; CONGENITAL HEART MALFORMATION; CONGESTIVE CARDIOMYOPATHY; CYTOLOGY; ECHOCARDIOGRAPHY; ELECTROENCEPHALOGRAPHY; FEMALE; FETUS DEATH; GENETICS; HEART; HEART MUSCLE; HUMAN; MALE; MOUSE; MOUSE MUTANT; MUTATION; NEWBORN; PHYSIOLOGY; PREGNANCY; PRENATAL DEVELOPMENT; PROTO ONCOGENE; SIGNAL TRANSDUCTION;

ANIMALS; ANIMALS, NEWBORN; CARDIOMYOPATHY, DILATED; ECHOCARDIOGRAPHY; ELECTROENCEPHALOGRAPHY; FEMALE; FETAL DEATH; GENES, ERBB-2; HEART; HEART DEFECTS, CONGENITAL; HUMANS; MALE; MICE; MICE, KNOCKOUT; MUTATION; MYOCARDIUM; PREGNANCY; RECEPTORS, SEROTONIN, 5-HT2; SEROTONIN; SIGNAL TRANSDUCTION;

EID: 0642275454     PISSN: 00014079     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0001-4079(19)34085-3     Document Type: Article

References (45)

1. VILLALON C.M., SAXENA P.R. - Serotonin receptors as cardiovascular targets. Drug Discovery Today, 1997, 2, 294-300.
2. FRISHMAN W.H., GREWALL P. - Serotonin and the heart. Ann. Med., 2000, 32, 195-209.
3. JONES B.J., BLACKBURN T.P. - The medical benefit of 5-HT research. Pharmacol. Biochem. Behav., 2002, 71, 555-568.
4. HOYER D., HANNON J.P., MARTIN G.R. - Molecular, pharmacological and functional diversity of 5-HT receptors. Pharmacol. Biochem. Behav., 2002, 71, 533-554.
5. LORIC S., MAROTEAUX L., KELLERMANN O., LAUNAY J.-M. - Functional serotonin-2B receptors are expressed by a teratocarcinoma-derived cell line during serotoninergic differentiation. Mol. Pharmacol., 1995, 47, 458-466.
6. 2B receptor. J. Biol. Chem., 1996, 271, 3141-3147.
7. NEBIGIL C.G., LAUNAY J.-M., HICKEL P., TOURNOIS C., MAROTEAUX L. - 5-Hydroxytryptamine 2B receptor regulates cell-cycle progression : cross-talk with tyrosine kinase pathways. Proc. Natl. Acad. Sci. USA, 2000, 97, 2591-2596.
8. TOURNOIS C., MUTEL V., MANIVET P., LAUNAY J.-M., KELLERMANN O. - Cross-talk between 5-hydroxytryptamine receptors in a serotonergic cell line. Involvement of arachidonic acid metabolism. J. Biol. Chem., 1998, 273, 17498-17503.
9. 2B receptor. J. Biol. Chem., 2000, 275, 9324-9331.
10. FOGUET M., HOYER D., PARDO L.A., PAREKH A., KLUXEN F.W., KALKMAN H.O., et al. - Cloning and functional characterization of the rat stomach fundus serotonin receptor. EMBO J., 1992, 11, 3481-3487.
11. 2-like receptor. Expression in brain, heart and intestine. FEBS Lett., 1992, 312, 203-207.
12. 1D receptors. FEBS Lett., 1994, 352, 203-207.
13. ULLMER C., SCHMUCK K., KALKMAN H.O., LÜBBERT H. - Expression of serotonin receptor mRNAs in blood vessels. FEBS Lett., 1995, 370, 215-221.
14. 2B receptor in mouse gut, cardiovascular system and brain. FEBS Lett., 1996, 391, 45-51.
15. 2B receptor, homologous subtype or species variant ? Behav. Brain Res., 1996, 73, 253-257.
16. MURPHY D.L., WICHEMS C.H., LI Q., HEILS A. - Molecular manipulations as tools for enhancing our understanding of 5-HT neurotransmission. Trends Pharmacol. Sci., 1999, 20, 246-252.
17. LAUDER J.M. - Neurotransmitters as growth regulatory signals : role of receptors and second messengers. Trends Neurosci., 1993, 16, 233-240.
18. YAVARONE M.S., SHUEY D.L., TAMIR H., SADLER T.W., LAUDER J.M. - Serotonin and cardiac morphogenesis in the mouse embryo. Teratology, 1993, 47, 573-584.
19. 2B receptor-mediated serotonin morphogenetic functions in mouse cranial neural crest and myocardiac cells. Development, 1997, 124, 1745-1755.
20. NEBIGIL C.G., CHOI D.-S., DIERICH A., HICKEL P., LE MEUR M., MESSADDEQ N., et al. - Serotonin 2B receptor is required for heart development. Proc. Natl. Acad. Sci. USA, 2000, 97, 9508-9513.
21. OFFERMANS S., ZHAO L.P., GOHLA A., SAROSI I., SIMON M.I., WILKIE T.M. - Embryonic cardiomyocyte hypoplasia and craniofacial defects in G alpha q/G alpha 11-mutant mice. EMBO J., 1998, 17, 4304-4312.
22. YANAGISAWA H., YANAGISAWA M., KAPUR R.P., RICHARDSON J.A., WILLIAMS S.C., CLOUTHIER D.E., et al. - Dual genetic pathways of endothelin-mediated intercellular signaling revealed by targeted disruption of endothelin converting enzyme-1 gene. Development, 1998, 125, 825-836.
23. KURIHARA Y., KURIHARA H., SUZUKI H., KADAME T., MAEMURA K., NAGAI R., et al. - Elevated blood pressure and craniofacial abnormalities in mice deficient in endothelin-1. Nature, 1994, 368, 703-710.
24. ADAMS J.W., BROWN J.H. - G-proteins in growth and apoptosis : lessons from the heart. Oncogene, 2001, 20, 1626-1634.
25. HEIN L., STEVENS M.E., BARSH G.S., PRATT R.E., KOBILKA B.K., DZAU V.J. - Overexpression of angiotensin AT1 receptor transgene in the mouse myocardium produces a lethal phenotype associated with myocyte hyperplasia and heart block. Proc. Natl. Acad. Sci. USA, 1997, 94, 631-6396.
26. DORN G.W.II, TEPE N.M., LORENZ J.N., KOCH W.J., LIGGETT S.B. - Low-and high-level transgenic expression of beta2-adrenergic receptors differentially affect cardiac hypertrophy and function in Galphaq-overexpressing mice. Proc. Natl. Acad. Sci. USA, 1999, 96, 6400-6405.
27. EMANUELI C., MAESTRI R., CORRADI D., MARCHIONE R., MINASI A., TOZZI M.G., et al. - Dilated and failing cardiomyopathy in bradykinin B(2) receptor knockout mice. Circulation, 1999, 100, 2359-2365.
28. OZCELIK C., ERDMANN B., PILZ B., WETTSCHURECK N., BRITSCH S., HÜBNER N., et al. - Conditional mutation of the ErbB2 (HER2) receptor in cardiomyocytes leads to dilated cardiomyopathy. Proc. Natl. Acad. Sci. USA, 2002, 99, 8880-8885.
29. LEE K.F., SIMON H., CHEN H., BATES B., HUNG M.C., HAUSER C. - Requirement for neuregulin receptor erbB2 in neural and cardiac development. Nature, 1995, 378, 394-398.
30. MORRIS J.K., LIN W., HAUSER C., MARCHUK Y., GETMAN D., LEE K.F. - Rescue of the cardiac defect in ErbB2 mutant mice reveals essential roles of ErbB2 in peripheral nervous system development. Neuron, 1999, 23, 273-283.
31. NEBIGIL C.G., HICKEL P., MESSADDEQ N., VONESCH J.-L., DOUCHET P., MONASSIER L., et al. - Ablation of serotonin 5-HT2B receptors in mice leads to abnormal cardiac structure and function. Circulation, 2001, 103, 2973-2979.
32. MANN D.L., URABE Y., KENT R.L., VINCIGUERRA S., COOPER G.T. - Cellular versus myocardial basis for the contractile dysfunction of hypertrophied myocardium. Circ. Res., 1991, 68, 402-415.
33. SCHAPER J., FROEDE R., HEIN S., BUCK A., HASHIZUME H., SPEISER B., et al. - Impairment of the myocardial ultrastructure and changes of the cytoskeleton in dilated cardiomyopathy. Circulation, 1991, 83, 504-514.
34. BELTRAMI C.A., FINATO N., ROCCO M., FARUGLIO G.A., PURICELLI C., CIGOLA E., et al. - The cellular basis of dilated cardiomyopathy in humans. J. Mol. Cell. Cardiol., 1995, 27, 291-305.
35. SOLER A.P., KNUDSEN K.A. - N-cadherin involvement in cardiac myocyte interaction and myofibrillogenesis. Dev. Biol., 1994, 162, 9-17.
36. RADICE G.L., RAYBURN H., MATSUNAMI H., KNUDSEN K.A., TAKEICHI M., HYNES R.O. - Developmental defects in mouse embryos lacking N-cadherin. Dev. Biol., 1997, 181, 64-78.
37. WANG X., GERDES A.M. - Chronic pressure overload cardiac hypertrophy and failure in guinea-pigs : III. Intercalated disc remodeling. J. Mol. Cell. Cardiol., 1999, 31, 333-343.
38. COLAS J.-F., LAUNAY J.-M., VONESCH J.-L., HICKEL P., MAROTEAUX L. - Serotonin synchronises convergent extension of ectoderm with morphogenetic gastrulation movements in Drosophila. Mech. Dev., 1999, 87, 77-91.
39. ROUX C., MADANI M., LAUNAY J.-M., REY F., CITADELLE D., MULLIEZ N., et al. - Serotonin deficiency in phenylketonuria embryopathy. Toxicol. In Vitro, 1995, 9, 653-662.
40. ROBIOLIO P.A., RIGOLIN V.H., WILSON J.S., HARRISON J.K., SANDERS L.L., BASHORE T.M., et al. - Carcinoid heart disease. Correlation of high serotonin levels with vavular abnormalities detected by cardiac catheterization and echocardiography. Circulation, 1995, 92, 790-795.
41. ROTHMAN R.B., BAUMANN M.H., SAVAGE J.E., RAUSER L., MC BRIDE A., HUFEISEN S.J., et al. - Evidence for possible involvement of 5-HT(2B) receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications. Circulation, 2000, 102, 2836-2841.
42. LAUNAY J.-M., HERVÉ P., PEOC'H K., TOURNOIS C., CALLEBERT J., NEBIGIL C.G., et al. - Function of the serotonin 5-hydroxytryptamine 2B receptor in pulmonary hypertension. Nature Med., 2002, 10, 1129-1135.
43. 1. Mol. Genet. Metab., 2000, 71, 418-435.
44. LE CONIAT M., CHOI D.-S., MAROTEAUX L., LAUNAY J.-M., BERGER R. - The 5-HT2B receptor gene maps to 2q36.3-2q37.1. Genomics, 1996, 32, 173-175.
45. SIU B.L., NIIMURA H., OSBORNE J.A., FATKIN D., MC RAE C., SOLOMON S., et al. - Familial dilated cardiomyopathy locus maps to chromosome 2q31. Circulation, 1999, 99, 1022-1026.