Functional MRI of elderly persons can give us a more complete picture of brain functions;Funktionell MRI av äldre kan ge en mer komplett bild av hjärnans funktioner

Lakartidningen

Volumn 100, Issue 51-52, 2003, Pages 4278-4282

  Nyström, Harriet ^a   Vannini, Patrizia ^a   Wahlund, Lars Olof ^b,c  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b Huddinge Universitetssjukhus   (Sweden)

^c Neurotec   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

AGED; ALZHEIMER DISEASE; ARTICLE; BRAIN FUNCTION; COGNITION; CONTROLLED STUDY; DIAGNOSTIC IMAGING; HUMAN; IN VIVO STUDY; NERVE CONDUCTION; NUCLEAR MAGNETIC RESONANCE IMAGING;

AGED; ALZHEIMER DISEASE; BRAIN; CEREBROVASCULAR CIRCULATION; COGNITION; FEMALE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MEMORY DISORDERS; MICROCIRCULATION; MIDDLE AGED; PSYCHOMOTOR PERFORMANCE;

EID: 0442324814     PISSN: 00237205     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Ogawa S, Tank DW, Menon R, Ellerman JM, Kim SG, Merkle H, et al. Intrinsic signal changes accompanying sensory stimulation: Functional brain mapping with magnetic resonance imaging. Proc Natl Acad Sci U S A 1992;89:5951-5.
2. Kwong KK, Belliveau JW, Chesler DA, Goldberg IE, Weisskoff RM, Poncelet BP. Dynamic magnetic resonance imaging of human brain activity during primary sensory stimulation. Proc Natl Acad Sci U S A 1992;89(12):5675-9.
3. Logothetis NK, Pauls J, Augath M, Trinath T, Oeltermann A. Neurophysiological investigation of the basis of the fMRI signal. Nature 2001;412:150-7.
4. Heeger DJ, Ress D. What does fMRI tell us about neuronal activity. Nature Reviews Neuroscience 2002;3:142-51.
5. Raichle ME. BOLD insights. Nature 2001;412:128-30.
6. Arthurs OJ, Boniface S. How well do we understand the neural origins of the fMRI BOLD signal. Trends Neurosci 2002;25(1):27-31.
7. Menon RS, Kim SG. Spatial and temporal limits in cognitive neuroimaging with fMRI. Trends in Cognitive Sciences 1999;3(6):207-16.
8. Waldvogel D, van Gelderen P, Immisch I, Pfeiffer C, Hallet M. The variability of serial fMRI data: Correlation between a visual and a motor task. Neuroreport 2000;11(17):3843-7.
9. Scholtz SK, O'Leary DS, Boles Ponto LL, Watkins GL, Hichwa RD, Andreasen NC. Age-related changes in regional cerebral blood flow among young to mid-life adults. Neuroreport 1999;10(12):2493-6.
10. Taoka T, Iwasaki S, Uchida H, Fukusumi A, Nakagawa H, Takayama K et al. Age correlation of the time lag in signal change om EPI-fMRI. J Comput Assist Tomogr 1998;22(4):514-7.
11. Buckner RL, Snyder AZ, Sanders AL, Raichle ME, Morris JC. Functional brain imaging of young, nondemented, and demented older adults. J Cogn Neurosci 2000;12:Suppl 2:24-34.
12. Désposito M, Zarahn E, Aguirre GK, Rypma B. The effect of normal aging on the coupling of neural activity to the bold hemodynamic response. Neuroimage 1999;10:6-14.
13. Farkas E, Luiten PGM. Cerebral microvascular pathology in aging and Alzheimer's disease. Prog Neurobiol 2001;64:575-611.
14. Pineiro R, Pendlebury S, Johansen-Berg H, Matthews PM. Altered hemodynamic responses in patients after subcortical stroke measured by functional MRI. Stroke 2002;33:103-9.
15. Everitt BJ, Robbins TW. Central cholinergic systems and cognition. Annu Rev Psychol 1997;48:649-84.
16. Bleys RLAW, Cowen T. Innervation of cerebral blood vessels: Morphology, plasticity, age-related, and Alzheimer's disease-related neurodegeneration. Micros Res and Techn 2001;53:106-18.
17. Langley LK, Madden DJ. Functional neuroimaging of memory: Implications for cognitive aging. Microsc Res and Techn 2000;51:75-84.
18. Maguire EA. Neuroimaging, memory and the human hippocampus. Rev Neurol (Paris) 2001;157(8-9):791-4.
19. Strange BA, Fletcher PC, Henson RN, Friston KJ, Dolan RJ. Segregating the functions of human hippocampus. Proc Natl Acad Sci U S A 1999;96:4034-9.
20. Rombouts SA, Barkhof F, Veltman DJ, Machielsen WC, Witter MP, Bierlaagh MA, et al. Functional MR Imaging in Alzheimer's disease during memory encoding. AJNR Am J Neuroradiol 2000;21:1869-75.