Minimizing inclusion body formation during recombinant protein production in Escherichia coli at bench and pilot plant scale

Enzyme and Microbial Technology

Volumn 34, Issue 3-4, 2004, Pages 235-241

  Hoffmann, Frank ^b   Van Den Heuvel, Joop ^a   Zidek, Nadine ^a   Rinas, Ursula ^a  

^a HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

^b MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

Cultivation; Escherichia coli; hFGF 2; High cell density; Inclusion bodies; Recombinant protein production; galactosidase fusion protein

Indexed keywords

ANTIBODIES; CELLS; ENZYMES; PILOT PLANTS; VOLUMETRIC ANALYSIS;

CELL DENSITY;

ESCHERICHIA COLI;

BASIC FIBROBLAST GROWTH FACTOR; BETA GALACTOSIDE; HYBRID PROTEIN; RECOMBINANT PROTEIN;

ARTICLE; CELL DENSITY; CELL FRACTIONATION; CELL INCLUSION; DRY MASS; ESCHERICHIA COLI; FED BATCH REACTOR; GLUCOSE INTAKE; NONHUMAN; VOLUMETRY;

ESCHERICHIA COLI;

EID: 0442292087     PISSN: 01410229     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.enzmictec.2003.10.011     Document Type: Article

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