Competitive binding of postsynaptic density 95 and Ca 2+-calmodulin dependent protein kinase II to N-methyl-D-aspartate receptor subunit 2B in rat brain

Acta Pharmacologica Sinica

Volumn 25, Issue 2, 2004, Pages 176-180

  Meng, Fan Jie ^a   Guo, Jun ^a   Song, Bo ^a   Yan, Xue Bo ^a   Zhang, Guang Yi ^a  

^a XUZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Brain ischemia; Ca2+ calmodulin dependent protein kinase; N methyl D aspartate receptors

Indexed keywords

1 [N,O BIS(5 ISOQUINOLINESULFONYL) N METHYLTYROSYL] 4 PHENYLPIPERAZINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; POSTSYNAPTIC DENSITY PROTEIN 95; PROTEIN KINASE (CALCIUM,CALMODULIN) II; RECEPTOR SUBUNIT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING COMPETITION; BRAIN; BRAIN ISCHEMIA; BRAIN PERFUSION; CONTROLLED STUDY; DISSOCIATION; HIPPOCAMPUS; IMMUNOBLOTTING; IMMUNOPRECIPITATION; MALE; NONHUMAN; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RAT;

1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE; ANIMALS; BINDING, COMPETITIVE; BRAIN ISCHEMIA; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; HIPPOCAMPUS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MEMBRANE PROTEINS; NERVE TISSUE PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE; REPERFUSION INJURY;

EID: 0442278006     PISSN: 16714083     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Kistner U, Wenzel BM, Veh RW, Cases-Langhoff C, Garner AM, Appeltauer U, et al. SAP90, a rat presynaptic protein related to the product of the drosophila tumor suppressor gene dlg-A. J Biol Chem 1993; 268: 4580-3.
2. Morais Cabral JH, Petosa C, Sutcliffe MJ, Raza S, Byron O, Poy F, et al. Crystal structure of a PDZ domain. Nature 1996; 382: 649-52.
3. Kim JH, Liao D, Lau LF, Huganir RL. SynGAP: a synaptic RasGAP that associates with the PSD-95/SAP90 protein family. Neuron 1998; 20: 683-91.
4. Christopherson KS, Hillier BJ, Lim WA, Bredt DS. PSD-95 assembles a ternary complex with the N-methyl-D-aspartic acid receptor and a bivalent neuronal NO synthase PDZ domain. J Biol Chem 1999; 274: 27467-73.
5. Lim IA, Hall DD, Hell JW. Selectivity and promiscuity of the first and second PDZ domains of PSD-95 and synapse-associated protein 102. J Biol Chem 2002; 277: 21697-711.
6. Sprengel R, Suchanek B, Amico C, Brusa R, Burnashev N, Rozov A, et al. Importance of the intracellular domain of NR2 subunits for NMDA receptor function in vivo. Cell 1998; 92: 279-89.
7. Braun AP, Schulan H. The multifunctional calcium/calmodulin-dependent protein kinase: from form to function. Annu Rev Physiol 1995; 57: 417-45.
8. 2+-calmodulin-dependent protein kinase II is associated with the N-methyl-D-aspartate receptor. Proc Natl Acad Sci USA 1999; 96: 3239-44.
9. Strack S, McNeill RB, Colbran RJ. Mechanism and regulation of calcium/calmodulin-dependent protein kinase II targeting to the NR2B subunit of the N-methyl-D-aspartate receptor. J Biol Chem 2000; 275: 23798-806.
10. 2+-calmodulin-dependent protein kinase II translocated to the postsynaptic density. Brain Res Mol Brain Res 2000; 81: 118-28.
11. Pulsinelli WA, Brierley JB. A new model of bilateral hemispheric ischemia in the nanesthetized rat. Stroke 1979; 10: 267-72.
12. 2+-calmodulin-dependent protein kinase II-alpha in rat hippocampus in a model of ischemia tolerance. Neuroscience 2000; 96: 665-74.
13. Liu Y, Zhang GY, Gao C, Hou XY. NMDA receptor activation results in tyrosine phosphorylation of NMDA receptor subunit 2A(NR2A) and interaction of Pyk2 and Src with NR2A after transient cerebral ischemia and reperfusion. Brain Res 2001; 909: 51-8.
14. Towbin H, Staehelin T, Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci USA 1979; 76: 4350-4.
15. Takagi N, Logan R, Teves L, Wallace MC, Gurd JW. Altered interaction between PSD-95 and the NMDA receptor following transient global ischemia. J Neurochem 2000; 74: 169-78.
16. 2+-calmodulin-dependent protein kinase II and postsynaptic density 95 for binding to the NR2A subunit of the NMDA receptor. J Neurosci 2001; 21: 1501-9.
17. 2+-calmodulin dependent protein kinase II. J Biol Chem 1990; 265: 4315-20.