Pneumocystis jirovecii Dihydrofolate Reductase Polymorphisms Associated with Failure of Prophylaxis

Journal of Eukaryotic Microbiology

Volumn 50, Issue SUPPL., 2003, Pages 656-657

  Nahimana, Aimable ^a   Rabodonirina, Meja ^b   Francioli, Patrick ^a   Bille, Jacques ^a   Hauser, Philippe M ^a  

^a LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^b CROIX ROUSSE HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIFUNGAL AGENT; COTRIMOXAZOLE; DIHYDROFOLATE REDUCTASE;

POLYMORPHISM;

AMINO ACID SUBSTITUTION; CONFERENCE PAPER; ENZYMOLOGY; GENETIC POLYMORPHISM; GENETICS; HUMAN; MISSENSE MUTATION; PNEUMOCYSTIS JIROVECI; PNEUMOCYSTIS PNEUMONIA;

AMINO ACID SUBSTITUTION; ANTIFUNGAL AGENTS; HUMANS; MUTATION, MISSENSE; PNEUMOCYSTIS JIROVECI; PNEUMONIA, PNEUMOCYSTIS; POLYMORPHISM, GENETIC; TETRAHYDROFOLATE DEHYDROGENASE; TRIMETHOPRIM-SULFAMETHOXAZOLE COMBINATION;

PNEUMOCYSTIS; PNEUMOCYSTIS CARINII; PNEUMOCYSTIS JIROVECII;

EID: 0348226890     PISSN: 10665234     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1550-7408.2003.tb00673.x     Document Type: Conference Paper

References (4)

1. Cody, V., Galitsky, N., Rak, D., Luft, J.R., Pangborn, W. & Queener, S.F. 1999. Ligand-induced conformational changes in the crystal structures of Pneumocystis carinii dihydrofolate reductase complexes with folate and NADP+. Biochemistry, 38:4303-4312.
2. Kazanjian, P., Locke, A.B., Hossler, P.A., Lane, B.R., Bartlett, M.S., Smith, J.W., Cannon, M. & Meshnick, S.R. 1998. Pneumocystis carinii mutations associated with sulfa and sulfone prophylaxis failures in AIDS patients. AIDS, 12:873-878.
3. Ma, L., Borio, L., Masur, H. & Kovacs, J.A. 1999. Pneumocystis carinii dihydropteroate synthase but not dihydrofolate reductase gene mutations correlate with prior trimethoprim-sulfamethoxazole or dapson use. J. infect. Dis., 180:1969-1978.
4. Takahashi, T., Endo, T., Nakamura, T., Sakashita, H., Kimura, K., Ohnishi, K., Kitamura, Y. & Iwamoto, A. 2002. Dihydrofolate reductase gene polymorphisms in Pneumocystis carinii f. sp.hominis in Japan. J. Med. Microbiol., 51:510-515.