Genetic knock out of 60 kD Ro (or SSA), a common lupus autoantigen, induces lupus

Trends in Immunology

Volumn 25, Issue 1, 2004, Pages 1-3

  Scofield, R Hal ^a  

^a OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIGEN; RO AUTOANTIGEN; UNCLASSIFIED DRUG; RIBONUCLEOPROTEIN; SMALL CYTOPLASMIC RNA; SSA2 PROTEIN, HUMAN; SSA2 PROTEIN, MOUSE;

AUTOIMMUNE DISEASE; GENETIC CODE; GENETIC VARIABILITY; GENETICS; HUMAN; IMMUNOPATHOGENESIS; KNOCKOUT GENE; KNOCKOUT MOUSE; NONHUMAN; PHENOTYPE; SHORT SURVEY; SYSTEMIC LUPUS ERYTHEMATOSUS; ANIMAL; DISEASE MODEL; MOUSE; MOUSE MUTANT; REVIEW;

ANIMALS; AUTOANTIGENS; DISEASE MODELS, ANIMAL; HUMANS; LUPUS ERYTHEMATOSUS, SYSTEMIC; MICE; MICE, KNOCKOUT; RIBONUCLEOPROTEINS; RNA, SMALL CYTOPLASMIC;

EID: 0348222672     PISSN: 14714906     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.it.2003.10.014     Document Type: Short Survey

References (27)

1. Schur P.H. Genetics of systemic lupus erythematosus. Lupus. 4:1995;425-437.
2. Tsao B.P. The genetics of of human systemic lupus erythematosus. Trends Immunol. 24:2003;595-602.
3. Xue D., et al. A lupus-like syndrome develops in mice lacking the Ro 60-kDa protein, a major lupus autoantigen. Proc. Natl. Acad. Sci. U. S. A. 100:2003;7503-7508.
4. Tan E.M., et al. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 25:1982;1271-1277.
5. Hochberg M.C. Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 40:1997;1725.
6. Wolin S.L., Steitz J.A. Genes for two small cytoplasmic Ro RNAs are adjacent and appear to be single-copy in the human genome. Cell. 32:1983;735-744.
7. Harley J.B., et al. Anti-Ro in Sjögren's syndrome and systemic lupus erythematosus. Rheum. Dis. Clin. North Am. 18:1992;337-358.
8. Farris A.D., et al. Y3 is the most conserved small RNA component of Ro ribonucleoprotein complexes in vertebrate species. Gene. 154:1995;193-198.
9. O'Brien C.A., et al. Xenopus Ro ribonucleoproteins: members of an evolutionarily conserved class of cytoplasmic ribonucleoproteins. Proc. Natl. Acad. Sci. U. S. A. 90:1993;7250-7254.
10. Van Horn D.J., et al. Caenorhabditis elegans embryos contain only one major species of Ro RNP. RNA. 1:1995;293-303.
11. Chen X., et al. Ro ribonucleoproteins contribute to the resistance of Deinococcus radiodurans to ultraviolet irradiation. Genes Dev. 14:2000;777-782.
12. O'Brien C.A., Wolin S.L. A possible role for the 60-kD Ro autoantigen in a discard pathway for defective 5S rRNA precursors. Genes Dev. 8:1994;2891-2903.
13. Mohan C. Murine lupus genetics: lessons learned. Curr. Opin. Rheumatol. 13:2001;352-360.
14. Kelly J.A., et al. The genetics of systemic lupus erythematosus: putting the pieces together. Genes Immun. 3:(Suppl 1):2002;S71-S85.
15. Lindqvist A.K., et al. A susceptibility locus for human systemic lupus erythematosus (hSLE1), on chromosome 2q. J. Autoimmun. 14:2000;169-178.
16. Prokunina L., et al. A regulatory polymorphism in PDCD1 is associated with susceptibility to systemic lupus erythematosus in humans. Nat. Genet. 32:2002;666-669.
17. Morel L., et al. The major murine systemic lupus erythematosus susceptibility locus, Sle1, is a cluster of functionally related genes. Proc. Natl. Acad. Sci. U. S. A. 98:2001;1787-1792.
18. Nose M., et al. Genome analysis of collagen disease in MRL/lpr mice: polygenic inheritance resulting in the complex pathological manifestations. Int. J. Cardiol. 75:(Suppl 1):2000;S53-S61.
19. Morel L., et al. Epistatic modifiers of autoimmunity in a murine model of lupus nephritis. Immunity. 11:1999;131-139.
20. Walport M.J., et al. C1q and systemic lupus erythematosus. Immunobiology. 199:1998;265-285.
21. Napirei M., et al. Features of systemic lupus erythematosus in Dnase1-deficient mice. Nat. Genet. 25:2000;177-181.
22. Rathmell J.C. Apoptosis and B cell tolerance. Curr. Dir. Autoimmun. 6:2003;38-60.
23. Afford S., Randhawa S. Apoptosis. Mol. Pathol. 53:2000;55-63.
24. Frank M.B., et al. The mapping of the human 52-kD Ro/SSA autoantigen gene to human chromosome 11, and its polymorphisms. Am. J. Hum. Genet. 52:1993;183-191.
25. Tsugu H., et al. The location of a disease-associated polymorphism and genomic structure of the human 52-kDa Ro/SSA locus (SSA1). Genomics. 24:1994;541-548.
26. Lee L.A., et al. Pattern of cutaneous immunoglobulin G deposition in subacute cutaneous lupus erythematosus is reproduced by infusing purified anti-Ro (SSA), autoantibodies into human skin-grafted mice. J. Clin. Invest. 83:1989;1556-1562.
27. LeFeber W.P., et al. Ultraviolet light induces binding of antibodies to selected nuclear antigens on cultured human keratinocytes. J. Clin. Invest. 74:1984;1545-1551.