New orally active PDE4 inhibitors with therapeutic potential

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 1, 2004, Pages 29-32

  Ochiai, Hiroshi ^a   Ishida, Akiharu ^a   Ohtani, Tazumi ^a   Kusumi, Kensuke ^a   Kishikawa, Katuya ^a   Obata, Takaaki ^a   Nakai, Hisao ^a   Toda, Masaaki ^a  

^a ONO PHARMACEUTICAL CO   (Japan)

Author keywords

Inhibitor; Orally active; PDE4; Pyrazolopyrioline

Indexed keywords

FUNCTIONAL GROUP; PHOSPHODIESTERASE IV INHIBITOR; PYRAZOLOPYRIDINE DERIVATIVE; PYRIDINE DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRONCHOSPASM; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; NONHUMAN; PROTEIN SYNTHESIS INHIBITION; RAT; STOMACH EMPTYING; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; VOMITING;

EID: 0348147643     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2003.10.025     Document Type: Article

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