Reduced cumulative incidence of diabetes but not insulitis following administration of chimeric human IL-15-murine IgG2b in NOD mice

Diabetes/Metabolism Research and Reviews

Volumn 19, Issue 6, 2003, Pages 464-468

  Signore, Alberto ^a   Annovazzi, A ^a   Giacalone, P ^a   Beales, P E ^b   Valorani, M G ^b   Vestri, A R ^a   Ruberti, G ^c   Manfrini, S ^d   Pozzilli, P ^d   Bulfone Paus, S ^e  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

^c CNR   (Italy)

^d UNIVERSITY CAMPUS BIO MEDICO   (Italy)

^e RESEARCH CENTER BORSTEL   (Germany)

Author keywords

Diabetes; IL 15; Insulitis; NOD mouse

Indexed keywords

IMMUNOGLOBULIN G2B; INTERLEUKIN 15; RECOMBINANT CYTOKINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE SEVERITY; DOWN REGULATION; DRUG MECHANISM; FEMALE; INCIDENCE; INSULITIS; MODULATION; MOUSE; MULTIPLE DRUG DOSE; NONHUMAN; PRIORITY JOURNAL; REVIEW; SINGLE DRUG DOSE; STATISTICAL SIGNIFICANCE;

ANIMALS; DIABETES MELLITUS, TYPE 1; GLYCOSURIA; HUMANS; IMMUNOGLOBULIN G; INCIDENCE; INTERLEUKIN-15; MICE; MICE, INBRED NOD; RECOMBINANT FUSION PROTEINS; TIME FACTORS;

EID: 0348038689     PISSN: 15207552     EISSN: None     Source Type: Journal    
DOI: 10.1002/dmrr.400     Document Type: Review

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