In vitro selection of Plasmodium falciparum 3D7 for expression of variant surface antigens associated with severe malaria in African children

Parasite Immunology

Volumn 25, Issue 8-9, 2003, Pages 421-427

  Staalsoe, Trine ^a   Nielsen, Morten A ^b   Vestergaard, Lasse S ^b   Jensen, Anja T R ^b   Theander, Thor G ^b   Hviid, Lars ^b  

^a Rigshospitalet   (Denmark)

^b NONE

Author keywords

Antibodies; Antigenic variation; Cell adhesion; Erythrocyte membrane; Plasmodium falciparum; Variant surface antigens

Indexed keywords

IMMUNOGLOBULIN G; MEMBRANE ANTIGEN; PARASITE ANTIGEN;

AFRICA; ANIMAL CELL; ANTIGEN EXPRESSION; ANTIGENIC VARIATION; ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; GENOMICS; GEOGRAPHIC DISTRIBUTION; GEOGRAPHICAL VARIATION (SPECIES); HUMAN; HUMAN CELL; IMMUNE ADHERENCE; IMMUNOREACTIVITY; IN VITRO SELECTION; MALARIA FALCIPARUM; MOLECULAR CLONING; MOLECULAR RECOGNITION; NONHUMAN; PARASITE IDENTIFICATION; PARASITE ISOLATION; PARASITE TRANSMISSION; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN VARIANT;

ADOLESCENT; ADULT; AFRICA; ANIMALS; ANTIBODIES, PROTOZOAN; ANTIGENS, CD36; ANTIGENS, PROTOZOAN; CELL ADHESION; CHILD; CHO CELLS; CRICETINAE; ERYTHROCYTES; GENE EXPRESSION; HUMANS; IMMUNOGLOBULIN G; MALARIA, FALCIPARUM; MIDDLE AGED; PLASMODIUM FALCIPARUM; SELECTION (GENETICS); VARIANT SURFACE GLYCOPROTEINS, TRYPANOSOMA;

ANIMALIA; PLASMODIUM FALCIPARUM; PROTOZOA;

EID: 0347986639     PISSN: 01419838     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-3024.2003.00652.x     Document Type: Article

References (42)

1. Leech JH, Barnwell JW, Miller LH & Howard RJ. Identification of a strain-specific malarial antigen exposed on the surface of Plasmodium falciparum-infected erythrocytes. J Exp Med 1984; 159: 1567-1575.
2. Roberts DJ, Craig AG, Berendt AR et al. Rapid switching to multiple antigenic and adhesive phenotypes in malaria. Nature 1992; 357: 689-692.
3. Baruch DI, Pasloske BL, Singh HB et al. Cloning the P. falciparum gene encoding PfEMP1, a malarial variant antigen and adherence receptor on the surface of parasitized human erythrocytes. Cell 1995; 82: 77-87.
4. Su X, Heatwole VM, Wertheimer SP et al. The large diverse gene family var encodes proteins involved in cytoadherence and antigenic variation of Plasmodium falciparum-infected erythrocytes. Cell 1995; 82: 89-100.
5. Cheng Q, Cloonan N, Fischer K et al. stevor and rif are Plasmodium falciparum multicopy gene families which potentially encode variant antigens. Mol Biochem Parasitol 1998; 97: 161-176.
6. Fernandez V, Hommel M, Chen QJ, Hagblom P & Wahlgren M. Small, clonally variant antigens expressed on the surface of the Plasmodium falciparum-infected erythrocyte are encoded by the rif gene family and are the target of human immune responses. J Exp Med 1999; 190: 1393-1403.
7. Kyes SA, Rowe JA, Kriek N & Newbold CI. Rifins: a second family of clonally variant proteins expressed on the surface of red cells infected with Plasmodium falciparum. Proc Natl Acad Sci USA 1999; 96: 9333-9338.
8. Kyes S, Horrocks P & Newbold C. Antigenic variation at the infected red cell surface in malaria. Annu Rev Microbiol 2001; 55: 673-707.
9. Marsh K, Otoo L, Hayes RJ, Carson DC & Greenwood BM. Antibodies to blood stage antigens of Plasmodium falciparum in rural Gambians and their relation to protection against infection. Trans R Soc Trop Med Hyg 1989; 83: 293-303.
10. Bull PC, Lowe BS, Kortok M et al. Parasite antigens on the infected red cell are targets for naturally acquired immunity to malaria. Nature Med 1998; 4: 358-360.
11. Dodoo D, Staalsoe T, Giha H et al. Antibodies to variant antigens on the surfaces of infected erythrocytes are associated with protection from malaria in Ghanaian children. Infect Immun 2001; 69: 3713-3718.
12. Nielsen MA, Staalsoe T, Kurtzhals JAL et al. Plasmodium falciparum variant surface antigen expression varies between isolates causing severe and non-severe malaria and is modified by acquired immunity. J Immunol 2002; 168: 3444-3450.
13. Ofori MF, Dodoo D, Staalsoe T et al. Malaria-induced acquisition of antibodies to Plasmodium falciparum variant surface antigens. Infect Immun 2002; 70: 2982-2988.
14. Marsh K. Malaria - a neglected disease? Parasitology 1992; 104: S53-S69.
15. Bull PC, Lowe BS, Kortok M & Marsh K. Antibody recognition of Plasmodium falciparum erythrocyte surface antigens in Kenya: evidence for rare and prevalent variants. Infect Immun 1999; 67: 733-739.
16. Bull PC, Kortok M, Kai O et al. Plasmodium falciparum-infected erythrocytes: agglutination by diverse Kenyan plasma is associated with severe disease and young host age. J Infect Dis 2000; 182: 252-259.
17. Gardner MJ, Hall N, Fung E et al. Genome sequence of the human malaria parasite Plasmodium falciparum. Nature 2002; 419: 498-511.
18. Salanti A, Staalsoe T, Lavstsen T et al. Selective upregulation of a single distinctly structured var gene in CSA-adhering Plasmodium falciparum involved in pregnancy-associated malaria. Mol Microbiol 2003; 49: 179-191.
19. Delemarre BJ & Van der Kaay HJ. Malaria tropica op natuurlijke wijze verkregen in Nederland. Ned Tijdschr Geneeskd 1979; 123: 1981-1982.
20. Walliker D, Quakyi IA, Wellems TE et al. Genetic analysis of the human malaria parasite Plasmodium falciparum. Science 1987; 236: 1661-1666.
21. Theander TG. Unstable malaria in Sudan: the influence of the dry season. Malaria in areas of unstable and seasonal transmission. Lessons from Daraweesh. Trans R Soc Trop Med Hyg 1998; 92: 589-592.
22. Massaga JJ, Kitua AY, Lemnge MM et al. Effect of intermittent treatment with amodiaquine on anaemia and malarial fevers in infants in Tanzania: a randomised placebo-controlled trial. Lancet 2003; 361: 1853-1860.
23. Cranmer SL, Magowan C, Liang J, Coppel RL & Cooke BM. An alternative to serum for cultivation of Plasmodium falciparum in vitro. Trans R Soc Trop Med Hyg 1997; 91: 363-365.
24. Theander TG, Hviid L, Dodoo D et al. Human T-cell recognition of synthetic peptides representing conserved and variant sequences from the merozoite surface protein 2 of Plasmodium falciparum. Immunol Lett 1997; 58: 1-8.
25. Jensen JB. Concentration from continuous culture of erythrocytes infected with trophozoites and schizonts of Plasmodium falciparum. Am J Trop Med Hyg 1978; 27: 1274-1276.
26. Staalsoe T, Giha HA, Dodoo D, Theander TG & Hviid L. Detection of antibodies to variant antigens on Plasmodium falciparum-infected erythrocytes by flow cytometry. Cytometry 1999; 35: 329-336.
27. Hasler T, Albrecht GR, Van Schravendijk MR et al. An improved microassay for Plasmodium falciparum cytoadherence using stable transformants of Chinese hamster ovary cells expressing CD36 or intercellular adhesion molecule-1. Am J Trop Med Hyg 1993; 48: 332-347.
28. Rogerson SJ, Chaiyaroj SC, Ng K, Reeder JC & Brown GV. Chondroitin sulfate A is a cell surface receptor for Plasmodium falciparum-infected erythrocytes. J Exp Med 1995; 182: 15-20.
29. Ho M, Singh B, Looaresuwan S et al. Clinical correlates of in vitro Plasmodium falciparum cytoadherence. Infect Immun 1991; 59: 873-878.
30. Newbold C, Warn P, Black G et al. Receptor-specific adhesion and clinical disease in Plasmodium falciparum. Am J Trop Meet Hyg 1997; 57: 389-398.
31. Marsh K, Marsh VM, Brown J, Whittle HC & Greenwood BM. Plasmodium falciparum: the behaviour of clinical isolates in an in vitro model of infected red blood cell sequestration. Exp Parasitol 1988; 65: 202-208.
32. Ockenhouse CF, Ho M, Tandon NN et al. Molecular basis of sequestration in severe and uncomplicated Plasmodium falciparum malaria: differential adhesion of infected erythrocytes to CD36 and ICAM-1. J Infect Dis 1991; 164: 163-169.
33. Turner GDH, Morrison H, Jones M et al. An immunohistochemical study of the pathology of fatal malaria: evidence for widespread endothelial activation and a potential role for intercellular adhesion molecule-1 in cerebral sequestration. Am J Pathol 1994; 145: 1057-1069.
34. Fernandez V, Treutiger CJ, Nash GB & Wahlgren M. Multiple adhesive phenotypes linked to rosetting binding of erythrocytes in Plasmodium falciparum malaria. Infect Immun 1998; 66: 2969-2975.
35. Heddini A, Pettersson F, Kai O et al. Fresh isolates from children with severe Plasmodium falciparum malaria bind to multiple receptors. Infect Immun 2001; 69: 5849-5856.
36. Chen QJ, Heddini A, Barragan A et al. The semiconserved head structure of Plasmodium falciparum erythrocyte membrane protein 1 mediates binding to multiple independent host receptors. J Exp Med 2000; 192: 1-9.
37. Rowe JA, Kyes SA, Rogerson SJ, Babiker HA & Raza A. Identification of a conserved Plasmodium falciparum var gene implicated in malaria in pregnancy. J Infect Dis 2002; 185: 1207-1211.
38. Salanti A, Jensen ATR, Zornig HD et al. A sub-family of common and highly conserved var genes expressed by CSA-adhering Plasmodium falciparum. Mol Biocliem Parasitol 2002; 122: 111-115.
39. Kyes SA, Christodoulou Z, Raza A et al. A well-conserved Plasmodium falciparum var gene shows an unusual stage-specific transcript pattern. Mol Microbiol 2003; 48: 1339-1348.
40. Aguiar JC, Albrecht GR, Cegielski P et al. Agglutination of Plasmodium falciparum-infected erythrocytes from East and West African isolates by human sera from distant geographic regions. Am J Trop Med Hyg 1992; 47: 621-632.
41. Giha HA, Staalsoe T, Dodoo D et al. Overlapping antigenic repertoires of variant antigens expressed on the surface of erythrocytes infected by Plasmodium falciparum. Parasitology 1999; 119: 7-17.
42. Gupta S & Day KP. A strain theory of malaria transmission. Parasitol Today 1994; 10: 476-481.