A sub-family of common and highly conserved Plasmodium falciparum var genes

Molecular and Biochemical Parasitology

Volumn 122, Issue 1, 2002, Pages 111-115

  Salanti, Ali ^a,d   Jensen, Anja T R ^a   Zornig, Hanne D ^a   Staalsoe, Trine ^a   Joergensen, Louise ^a   Nielsen, Morten A ^a   Khattab, Ayman ^b   Arnot, David E ^c   Klinkert, Mo Q ^b   Hviid, Lars ^a   Theander, Thor G ^a  

^a Rigshospitalet   (Denmark)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

^d UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Antigenic variation; Malaria; PfEMP1; Plasmodium falciparum; var genes

Indexed keywords

ERYTHROCYTE BAND 4.1 PROTEIN;

ARTICLE; CONTROLLED STUDY; CROSS REACTION; EXON; GENE EXPRESSION; GENE IDENTIFICATION; GENOTYPE; HUMAN; MOLECULAR CLONING; MULTIGENE FAMILY; NONHUMAN; NUCLEOTIDE SEQUENCE; PLASMODIUM FALCIPARUM; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; ANIMALS; CONSERVED SEQUENCE; GENES, PROTOZOAN; MOLECULAR SEQUENCE DATA; PHYLOGENY; PLASMODIUM FALCIPARUM; PROTOZOAN PROTEINS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID;

PLASMODIUM FALCIPARUM; PROTOZOA;

EID: 0036079183     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-6851(02)00080-4     Document Type: Article

References (18)

1. Cloning the P. falciparum gene encoding PfEMP1, a malarial variant antigen and adherence receptor on the surface of parasitized human erythrocytes
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4. Variant proteins on the surface of malaria-infected erythrocytes - Developing vaccines
5. Maternal antibodies block malaria
6. Overlapping antigenic repertoires of variant antigens expressed on the surface of erythrocytes infected by Plasmodium falciparum
7. BioEdit: A user-friendly biological sequence alignment editor and analysis program for Windows 95/98/NT
8. Isolation of multiple sequences from the Plasmodium falciparum genome that encode conserved domains homologous to those in erythrocyte-binding proteins
9. The adhesion of Plasmodium falciparum-infected erythrocytes to chondroitin sulfate A is mediated by P. falciparum erythrocyte membrane protein 1
10. Plasma antibodies from malaria-exposed pregnant women recognize variant surface antigens on Plasmodium falciparum-infected erythrocytes in a parity-dependent manner and block parasite adhesion to chondroitin sulphate A
11. Rapid switching to multiple antigenic and adhesive phenotypes in malaria
12. Identification of a conserved Plasmodium falciparum var gene implicated in malaria in pregnancy
13. Antigenic variation in malaria: In situ switching, relaxed and mutually exclusive transcription of var genes during intra-erythrocytic development in Plasmodium falciparum
14. Switches in expression of Plasmodium falciparum var genes correlate with changes in antigenic and cytoadherent phenotypes of infected erythrocytes
15. Antibody reactivity to conserved linear epitopes of Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1)
16. Acquisition and decay of antibodies to pregnancy-associated variant antigens on the surface of Plasmodium falciparum infected erythrocytes that are associated with protection against placental parasitemia
17. The large diverse gene family var encodes proteins involved in cytoadherence and antigenic variation of Plasmodium falciparum-infected erythrocytes
18. Analysis of Plasmodium falciparum PfEMP-1/var genes indicates that recombination rearranges constrained sequences