Expression and distribution of the calcitonin receptor-like receptor in the developing rat heart

Anatomy and Embryology

Volumn 207, Issue 4-5, 2003, Pages 307-315

  Dvorakova, Magdalena ^a   Haberberger, Rainer V ^b   Hagner, Stefanie ^c   McGregor, Gerard P ^c   Slavikova, Jana ^a   Kummer, Wolfgang ^b  

^a CHARLES UNIVERSITY   (Czech Republic)

^b JUSTUS LIEBIG UNIVERSITY   (Germany)

^c PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

Adrenomedullin; Coronary vasculature; Endothelial cells; Immunohistochemistry; Receptor activity modifying protein

Indexed keywords

CALCITONIN RECEPTOR LIKE RECEPTOR; MONOCLONAL ANTIBODY; RECA PROTEIN; VASCULOTROPIN RECEPTOR 2;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONNECTIVE TISSUE; CONTROLLED STUDY; CORONARY ARTERY; CORONARY BLOOD VESSEL; CORONARY VEIN; EMBRYO; ENDOCARDIUM; ENDOTHELIUM CELL; FEMALE; HEART DEVELOPMENT; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRECURSOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SMOOTH MUSCLE FIBER;

ANIMALS; ANIMALS, NEWBORN; CORONARY VESSELS; ENDOTHELIUM, VASCULAR; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEART; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; MYOCARDIUM; ORGANOGENESIS; PREGNANCY; RATS; RATS, WISTAR; RECEPTORS, CALCITONIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

ANIMALIA;

EID: 0347986565     PISSN: 03402061     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00429-003-0344-3     Document Type: Article

References (34)

1. Autelitano DJ (1998) Cardiac expression of genes encoding putative adrenomedullin/calcitonin gene-related peptide receptors. Biochem Biophys Res Commun 250:689-693
2. Autelitano DJ, Ridings R (2001) Adrenomedullin signalling in cardiomyocytes is dependent upon CRLR and RAMP2 expression. Peptides 22:1851-1857
3. Bogers AJJC, Gittenberger-de Groot AC, Dubbeldam JA, Huysmans HA (1988) The inadequacy of existing theories on development of the proximal coronary arteries. Int J Cardiol 20:117-123
4. Caron KM, Smithies O (2001) Extreme hydrops fetalis and cardiovascular abnormalities in mice lacking a functional adrenomedullin gene. Proc Natl Acad Sci U S A 98:615-619
5. Chakravarty P, Suthar TP, Coppock HA, Nicholl CG, Bloom SR, Legon S, Smith DM (2000) CGRP and adrenomedullin binding correlates with transcript levels for calcitonin receptor-like receptor (CRLR) and receptor activity modifying proteins (RAMPs) in rat tissues. Br J Pharmacol 130:189-195
6. Cormier-Regard S, Nguyen SV, Claycomb WC (1998) Adrenomedullin gene expression is developmentally regulated and induced by hypoxia in rat ventricular cardiac myocytes. J Biol Chem 273:17787-17792
7. Drake CJ, Fleming PA (2000) Vasculogenesis in day 6.5 to 9.5 mouse embryo. Blood 95:1671-1679
8. Duijvestein MA, Goor H van, Klatter F, Majoor GD, Bussel E van, Breda Vriesman PJ van (1992) Antibodies defining rat endothelial cells: RECA-1 a pan-endothelial cell specific monoclonal antibody. Lab Invest 66:459-466
9. Hagner S, Haberberger R, Kummer W, Springer J, Fischer A, Bohm S, Goke B, McGregor GP (2001) Immunohistochemical detection of calcitonin gene-related peptide receptor (CGRPR)-1 in the endothelium of human coronary artery and bronchial blood vessels. Neuropeptides 35:58-64
10. Hagner S, Stahl U, Knoblauch B, McGregor GP, Lang RE (2002) Calcitonin receptor-like receptor: identification and distribution in human peripheral tissues. Cell Tissue Res 310:41-50
11. Hanze J, Dittrich K, Dotsch J, Rascher W (1997) Molecular cloning of a novel human receptor gene with homology to the rat adrenomedullin receptor and high expression in heart and immune system. Biochem Biophys Res Commun 240:183-188
12. Hay DL, Smith DM (2001) Knockouts and transgenics confirm the importance of adrenomedullin in the vasculature. Trends Pharmacol Sci 22:57-59
13. He H, Bessho H, Fujisawa Y et al. (1995) Effects of synthetic rat adrenomedullin on regional hemodynamics in rats. Eur J Pharmacol 273:209-214
14. Heintzberger CFM (1983) Development of myocardial vascularization in the rat. Acta Morphol Neerl-Scand 21:267-284
15. Kapas S, Catt KJ, Clark AJL (1995) Cloning and expression of cDNA encoding a rat adrenomedullin receptor. J Biol Chem 270:25344-25347
16. Kitamura K, Kangawa K, Kawamoto M, Ichiki Y, Nakamura S, Matsuo H, Eto T (1993) Adrenomedullin: a novel hypotensive peptide isolated from human pheochromocytoma. Biochem Biophys Res Commun 192:553-560
17. Lee YM, Jeong CH, Koo SY et al. (2001) Determination of hypoxic region by hypoxia marker in developing mouse embryos in vivo: a possible signal for vessel development. Dev Dyn 220:175-186
18. Lippton H, Chang JK, Hao Q, Summer W, Hyman AL (1994) Adrenomedullin dilates the pulmonary vascular bed in vivo. J Appl Physiol 76:2154-2156
19. Lu JT, Son Y-J, Lee J et al. (1999) Mice lacking α-calcitonin gene-regulated peptide exhibit normal cardiovascular regulation and neuromuscular development. Mol Cell Neurosci 14:99-120
20. McLatchie LM, Fraser NM, Main MJ et al. (1998) RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor. Nature 393:333-339
21. Mishima K, Kato J, Kuwasako K, Ito K, Imamura T, Kitamura K, Eto T (2001) Effects of endothelin on adrenomedullin secretion and expression of adrenomedullin receptors in rat cardiomyocytes. Biochem Biophys Res Comm 287:264-269
22. Montuenga LM, Martinez A, Miller MJ, Unsworth EJ, Cuttitta F (1997) Expression of adrenomedullin and its receptor during embryogenesis suggests autocrine or paracrine modes of action. Endocrinology 138:440-451
23. Oie E, Vinge LE, Yndestand A, Sandberg C, Grogaard HK, Attramadal H (2000) Induction of a myocardial adrenomedullin signaling system during ischemic heart failure in rats. Circulation 101:415-422
24. Ostadal B, Schiebler TH, Rychter Z (1975) Relations between development of the capillary wall and myoarchitecture of the rat heart. Adv Exp Med Biol 53:375-388
25. Ratajska A, Fiejka E (1999) Prenatal development of coronary arteries in the rat: morphologic patterns. Anat Embryol 200:533-540
26. Ratajska A, Zarska M, Quensel C, Kramer J (2001) Differentiation of the smooth muscle cell phenotypes during embryonic development of coronary vessels in the rat. Histochem Cell Biol 116:79-87
27. Shoba T, Tay SSW (2000) Nitridergic and peptidergic innervation in the developing rat heart. Anat Embryol 201:491-500
28. Sugo S, Minamino N, Kangawa K et al. (1994) Endothelial cells actively synthesize and secrete adrenomedullin. Biochem Biophys Res Commun 201:1160-1166
29. Sugo S, Minamino N, Shoji H, Kangawa K, Kitamura K, Eto T, Matsuo H (1995) Interleukin-1, tumor necrosis factor and lipopolysacharide additively stimulate production of adrenomedullin in vascular smooth muscle cells. Biochem Biophys Res Commun 207:25-32
30. Terrado J, Gerrikagoitia I, Domingues L, Raldua D, Martinez-Millan L, Sarasa M (1999) Expression of the genes for α-type and β-type calcitonin gene-related peptide during rat embryogenesis. Neuroscience 92:713-727
31. Tomoda Y, Kikumoto K, Isumi Y et al. (2001) Cardiac fibroblasts are major production and target cells of adrenomedullin in the rat heart in vitro. Cardiovasc Res 49:721-730
32. Totsune K, Takahashi K, Mackenzie SH et al. (2000) Increased gene expression of adrenomedullin and adrenomedullin-receptor complexes, receptor-activity modifying protein (RAMP)2 and calcitonin-receptor-like receptor (CRLR) in the hearts of rats with congestive heart failure. Clin Sci 99:541-546
33. Vrancken-Peeters MPFM, Gittenberger-de Groot AC, Mentink MMT, Poelmann RE (1999) Smooth muscle cells and fibroblasts of the coronary arteries derive from epithelial-mesenchymal transformation of the epicardium. Anat Embryol 199:367-378
34. Yamaguchi TP, Dumont DJ, Conlon RA, Breitman ML, Rossant J (1993) flk-1, an flt-related receptor tyrosine kinase is an early marker for endothelial cell precursors. Development 118:489-498