Alcohol-induced liver disease: From molecular damage to treatment;Enfermedad hepática alcohólica: Desde el daño molecular a su tratamiento

Revista Medica de Chile

Volumn 130, Issue 6, 2002, Pages 681-690

  Fernández Checa, José C ^a   Bellentani, Stefano ^b   Tiribelli, Claudio ^b,c  

^a CSIC   (Spain)

^b Fegato ONLUS   (Italy)

^c UNIVERSITY OF TRIESTE   (Italy)

Author keywords

Alcohol dehydrogenase; Alcohol induced disorders; Cytokines; Liver diseases, alcoholic; Tumor necrosis factor

Indexed keywords

ALCOHOL LIVER CIRRHOSIS; ALCOHOL LIVER DISEASE; ANIMAL; ANIMAL MODEL; FEMALE; GENETICS; HUMAN; PATHOPHYSIOLOGY; RAT; REVIEW; RISK FACTOR;

ANIMALS; FEMALE; HUMANS; LIVER CIRRHOSIS, ALCOHOLIC; LIVER DISEASES, ALCOHOLIC; MODELS, ANIMAL; RATS; RISK FACTORS;

EID: 0347938661     PISSN: 00349887     EISSN: None     Source Type: Journal    
DOI: 10.4067/S0034-98872002000600013     Document Type: Article

References (67)

1. BECKER U, DEIS A, SORENSEN TI, GRONBAEK M, BORCH-JOHNSEN K, MULLER CF ET AL. Prediction of risk of liver disease by alcohol intake, sex, and age: a prospective population study. Hepatology 1996; 23: 1025-9.
2. KUTSKY AL, ARMSTRONG MA, FRIEDMAN GD. Alcohol and mortality. Ann Intern Med 1992; 117: 646-54.
3. GRANT BF, DUFOUR MC, HARFORD TC. Epidemiology of alcoholic liver disease. Semin Liver Dis 1988; 8: 12-25.
4. BELLENTANI S, TIRIBELLI C, SACCOCCIO G, SODDE M, FRATTI N, DE MARTIN C ET AL. Prevalence of chronic liver disease in the general population of northern Italy: the Dionysos Study. Hepatology 1994; 20: 1442-9.
5. BELLENTANI S, TIRIBELLI C. The spectrum of liver disease in the general population: lesson from the Dionysos study. J Hepatol 2001; 35: 531-7.
6. TIRIBELLI C, MELATO M, CROCE LS, GIARELLI L, OKUDA K, OHNISHI K. Prevalence of hepatocellular carcinoma and relation to cirrhosis: comparison of two different cities of the world Trieste, Italy, and Chiba, Japan. Hepatology 1989; 10: 998-1002.
7. STANTA G, CROCE LS, BONIN S, TISMINETZKY SG, BARAUE FE, TIRIBELLI C. Cohort effect of HCV infection in liver cirrhosis assessed by a 25 year study. J Clin Virol 2000; 17: 51-6.
8. LELBACH WK. Cirrhosis in the alcoholic and its relation to the volume of alcohol abuse. Ann N Y Acad Sci 1975; 252: 85-105.
9. CORRAO G, ZAMBON A, TORCHIO P, ARICO S, LA VECCHIA C, DI ORIO F. Attributable risk for symptomatic liver cirrhosis in Italy. Collaborative Groups for the Study of Liver Diseases in Italy. J Hepatol 1998; 28: 608-14.
10. COATES RA, HALLIDAY ML, RANKIN JG, FEINMAN SV, FISHER MM. Risk of fatty infiltration or cirrhosis of the liver in relation to ethanol consumption: a case-control study. Clin Invest Med 1986; 9: 26-32.
11. BELLENTANI S, SACCOCCIO G, COSTA G, TIRIBELLI C, MANENTI F, SODDE M ET AL. Drinking habits as cofactors of risk for alcohol induced liver damage. The Dionysos Study Group. Gut 1997; 41: 845-50.
12. DEVOR EJ, REICH T, CLONINGER CR. Genetics of alcoholism and related end-organ damage. Semin Liver Dis 1988; 8: 1-11.
13. BELLENTANI S, SACCOCCIO G, MASUTTI F, GIACCA M, MONZONI A, MIGLIOLI L, TIRIBELLI C. Risk factors for alcoholic liver disease. Addiction Biol 2000; 5: 261-8.
14. LIST S, GLUUD C. A meta-analysis of HLA-antigen prevalences in alcoholics and alcoholic liver disease. Alcohol Alcohol 1994; 29: 757-64.
15. YAMAUCHI M, MAEZAWA Y, TODA G, SUZUKI H, SAKURAI S. Association of a restriction fragment length polymorphism in the alcohol dehydrogenase 2 gene with Japanese alcoholic liver cirrhosis. J Hepatol 1995; 23: 519-23.
16. CHAO YC, YOUNG TH, CHANG WK, TANG HS, HSU CT. An investigation of whether polymorphisms of cytochrome P4502E1 are genetic markers of susceptibility to alcoholic end-stage organ damage in a Chinese population. Hepatotogy 1995; 22: 1409-14.
17. TSUTSUMI M, TAKADA A, WANG JS. Genetic polymorphisms of cytochrome P4502E1 related to the development of alcoholic liver disease. Gastroenterology 1994; 107: 1430-5.
18. DAY CP, BASHIR R, JAMES OF, BASSENDINE MF, CRABB DW, THOMASSON HR ET AL. Investigation of the role of polymorphisms at the alcohol and aldehyde dehydrogenase loci in genetic predisposition to alcohol related end organ damage. Hepatology 1991; 14: 798-801.
19. DAY CP, JAMES OF, BASSENDINE MF, CRABB DW, LI TK. Alcohol dehydrogenase polymorphisms and predisposition to alcoholic cirrhosis. Hepatology 1993; 18: 230-2.
20. WHITFIELD JB. Meta-analysis of the effects of alcohol dehydrogenase genotype on alcohol dependence and alcoholic liver disease. Alcohol Alcohol 1997; 32: 613-9.
21. MONZONI A; MASITITI F, SACCOCCIO G, BELLENTANI S, TIRIBELLI C, GIACCA M. Genetic determinants of ethanol-induced liver damage. Mol Med 2001; 7: 255-62.
22. NEUMAN MG, KOREN G, TIRIBELLI C. In vitro assessment of the ethanol-induced hepatotoxicity on HepG2 cell line. Biochem Biophys Res Commun 1993; 197: 932-41.
23. NEUMAN MG, SHEAR NH, BELLENTANI S, TIRIBELLI C. Role of cytokines in ethanol-induced cytotoxicity in vitro in Hep G2 cells. Gastroenterology 1998; 115: 157-66.
24. NEUMAN MG, CAMERON RG, SHEAR NH, BELLENTANI S, TIRIBELLI C. Effect of tauroursodeoxycholic and ursodeoxycholic acid on ethanol induced cell injuries in the human Hep G2 cell line. Gastroenterology 1995; 109: 555-63.
25. MCCLAIN CJ, COHEN DA. Increased tumor necrosis factor production by monocytes in alcoholic hepatitis. Hepatology 1989; 9: 349-51.
26. DEVIERE J, CONTENT J, DENYS C, VANDENBUSSCHE P, SCHANDENE L, WYBRAN J ET AL. Excessive in vitro bacterial lipopolysaccharide-induced production of monokines in cirrhosis. Hepatology 1990; 11: 628-34.
27. KHORUTS A, STAHNKE L, MCCLAIN CJ, LOGAN G, ALLEN JI. Circulating tumor necrosis factor, interleukin-1 and interleukin-6 concentrations in chronic alcoholic patients. Hepatology 1991; 13: 267-76.
28. ROMAN J, COLELL A, BLASCO C, CABALLERIA J, PARES A, RODES J ET AL. Differential role of ethanol and acetaldehyde in the induction of oxidative stress in HEP G2 cells: effect on transcription factors AP-1 and NF-kappaB. Hepatology 1999; 30: 1473-80.
29. ROMÁN J, GIMÉNEZ A, LLUIS JM, GASSO M, RUBIO M, CABALLERIA J ET AL. Enhanced DNA binding and activation of transcription factors NF-kappa B and AP-1 by acetaldehyde in HEPG2 cells. J Biol Chem 2000; 275: 14684-90.
30. LIEBER CS, SPRITZ N. Effects of prolonged ethanol intake in man: role of dietary adipose, and endogenously synthesized fatty acids in the pathogenesis of the alcoholic fatty liver. J Clin Invest 1966; 45: 1400-11.
31. LIEBER CS, DECARLI LM. Liquid diet technique of ethanol administration: 1989 update. Alcohol Alcohol 1989; 24: 197-211.
32. FERNÁNDEZ-CHECA JC, GARCÍA-RUIZ C, COLELL A. Mitochindria in alcoholic liver disease. In: Lemasters JJ, Nieminen AL, eds. Mitochondria in pathogenesis. New York, NY, USA: Kluver Academic Publisher 2001; 359-75.
33. TSUKAMOTO H, REIDELBERGER RD, FRENCH SW, LARGMAN C. Long-term cannulation model for blood sampling and intragastric infusion in the rat. Am J Physiol 1984; 247: R595-R599.
34. FRENCH SW, MIYAMOTO K, TSUKAMOTO H. Ethanolinduced hepatic fibrosis in the rat: role of the amount of dietary fat. Alcohol Clin Exp Res 1986; 10: 13S-9S.
35. HIRANO T, KAPLOWITZ N, TSUKAMOTO H, KAMIMURA S, FERNÁNDEZ-CHECA JC. Hepatic mitochondrial glutathione depletion and progression of experimental alcoholic liver disease in rats. Hepatology 1992; 16: 1423-7.
36. FERNÁNDEZ-CHECA JC, KAPLOWITZ N, GARCÍA-RUIZ C, COLELL A. Mitochondrial glutathione: importance and transport. Semin Liver Dis 1998; 18: 389-401.
37. TSUKAMOTO H, LU SC. Current concepts in the pathogenesis of alcoholic liver injury. FASEB J 2001; 15: 1335-49.
38. ADACHI Y, BRADFORD BU, GAO W, BOJES HK, THURMAN RG. Inactivation of Kupffer cells prevents early alcohol-induced liver injury. Hepatology 1994; 20: 453-60.
39. NANJI AA, KHETTRY U, SADRZADEH SM. Lactobacillus feeding reduces endotoxemia and severity of experimental alcoholic liver (disease). Proc Soc Exp Biol Med 1994; 205: 243-7.
40. IIMURO Y, GALLUCCI RM, LUSTER MI, KONO H, THURMAN RG. Antibodies to tumor necrosis factor alfa attenuate hepatic necrosis and inflammation caused by chronic exposure to ethanol in the rat. Hepatology 1997; 26: 1530-7.
41. COLELL A, GARCÍA-RUIZ C, MIRANDA M, AKDITE E, MARI M, MORALES A ET AL. Selective glutathione depletion of mitochondria by ethanol sensitizes hepatocytes to tumor necrosis factor. Gastroenterology 1998; 115: 1541-51.
42. COLELL A, GARCÍA-RUIZ C, MORALES A, BALLESTA A, OOKHTENS M, RODES J ET AL. Transport of reduced glutathione in hepatic mitochondria and mitoplasts from ethanol-treated rats: effect of membrane physical properties and S-adenosyl-L-methionine. Hepatology 1997; 26: 699-708.
43. COLELL A, COLL O, GARCÍA-RUIZ C, PARIS R, TIRIBELLI C, KAPLOWITZ N ET AL. Tauroursodeoxycholic acid protects hepatocytes from ethanol-fed rats against tumor necrosis factor-induced cell death by replenishing mitochondrial glutathione. Hepatology 2001; 34: 964-71.
44. ENOMOTO N, YAMASHINA S, KONO H, SCHEMMER P, RIVERA CA, ENOMOTO A ET AL. Development of a new, simple rat model of early alcohol-induced liver injury based on sensitization of Kupffer cells. Hepatology 1999; 29: 1680-9.
45. LINDROS KO, JARVELAINEN HA. A new oral low-carbohydrate alcohol liquid diet producing liver lesions: a preliminary account. Alcohol Alcohol 1998; 33: 347-53.
46. LINDROS KO. Alcoholic liver disease: pathobiological aspects. J Hepatol 1995; 23 Suppl 1: 7-15.
47. NOLAN JP. Intestinal endotoxins as mediators of hepatic injury an idea whose time has come again. Hepatology 1989; 10: 887-91.
48. PENNINGTON HL, HALL PM, WILCE PA, WORRALL S. Ethanol feeding enhances inflammatory cytokine expression in lipopolysaccharide-induced hepatitis. J Gastroenterol Hepatol 1997; 12: 305-13.
49. JARVELAINEN HA, FANG C, INGELMAN-SUNDBERG M, LINDROS KO. Effect of chronic coadministration of endotoxin and ethanol on rat liver pathology and proinflammatory and anti-inflammatory cytokines. Hepatology 1999; 29: 1503-10.
50. LIEBER CS. Hepatic, metabolic and toxic effects of ethanol: 1991 update. Alcohol Clin Exp Res 1991; 15: 573-92.
51. CRONHOLM T, NORSTEN-HOOG C, EKSTROM G, HANDLER JA, THURMAN RG, INGELMAN-SUNDDERG M. Oxidoreduction of butanol in deermice (Peromyscus maniculatus) lacking hepatic cytosolic alcohol dehydrogenase. Eur J Biochem 1992; 204: 353-7.
52. LIEBER CS. Microsomal ethanol-oxidizing system. Enzyme 1987; 37: 45-56.
53. HANDLER JA, KOOP DR, COON MJ, TAKEI Y, THURMAN RG. Identification of P-450ALC in microsomes from alcohol dehydrogenase-deficient deermice: contribution to ethanol elimination in vivo. Arch Biochem Biophys 1988; 264: 114-24.
54. HANDLER JA, THURMAN RG. Redox interactions between catalase and alcohol dehydrogenase pathways of ethanol metabolism in the perfused rat liver. J Biol Chem 1990; 265: 1510-5.
55. LIEBER CS. Alcohol and the liver: 1994 update. Gastroenterology 1994; 106: 1085-105.
56. NIEMELA O, PARKKILA S, YLA-HERTTUALA S, VILLANUEVA J, RUEBNER B, HALSTED CH. Sequential acetaldehyde production, lipid peroxidation, and fibrogenesis in micropig model of alcohol-induced liver disease. Hepatology 1995; 22: 1208-14.
57. ISHAK KG, ZIMMERMAN HJ, RAY MB. Alcoholic liver disease: pathologic, pathogenetic and clinical aspects. Alcohol Clin Exp Res 1991; 15: 45-66.
58. GARCÍA-RUIZ C, MORALES A, BALLESTA A, RODES J, KAPLOUTTZ N, FERNÁNDEZ-CHECA JC. Effect of chronic ethanol feeding on glutathione and functional integrity of mitochondria in periportal and perivenous rat hepatocytes. J Clin Invest 1994; 94: 193-201.
59. LANGE LG. Mechanism of fatty acid ethyl ester formation and biological significance. Ann N Y Acad Sci 1991; 625: 802-5.
60. LANGE LG, SODEL BE. Mitochondrial dysfunction induced by fatty acid ethyl esters, myocardial metabolites of ethanol. J Clin Invest 1983; 72: 724-31.
61. LAPOSATA EA, LANGE LG. Presence of nonoxidative ethanol metabolism in human organs commonly damaged by ethanol abuse. Science 1986; 231: 497-9.
62. LIEBER CS. Metabolic effects of acetaldehyde. Biochem Soc Trans 1988; 16: 241-7.
63. BRUGUERA M, BERTRÁN A, BOMBI JA, RODES J. Giant mitochondria in hepatocytes: a diagnostic hint for alcoholic liver disease. Gastroenterology 1977; 73: 1383-7.
64. CUNNINGHAM CC, COLEMAN WB, SPACH PI. The effects of chronic ethanol consumption on hepatic mitochondrial energy metabolism. Alcohol Alcohol 1990; 25: 127-36.
65. QUINTANILLA ME, TAMPIER L. Sensitivity of liver mitochondrial functions to various levels of ethanol intake in the rat. Alcohol Clin Exp Res 1989; 13: 280-3.
66. SPACH PI, CUNNINGHAM CC. Control of state 3 respiration in liver mitochondria from rats subjected to chronic ethanol consumption. Biochim Biophys Acta 1987; 894: 460-7.
67. ARAI M, LEO MA, NAKANO M, GORDON ER, LIEBER CS. Biochemical and morphological alterations of baboon hepatic mitochondria after chronic ethanol consumption. Hepatology 1984; 4: 165-74.