Inhibition of Stimulated Ascorbic Acid and Luteinizing Hormone-Releasing Hormone Release by Nitric Oxide Synthase or Guanyl Cyclase Inhibitors

Experimental Biology and Medicine

Volumn 229, Issue 1, 2004, Pages 72-79

  Karanth, Sharada ^a   Yu, Wen H ^a   Mastronardi, Claudio A ^a   McCann, Samuel M ^a  

^a PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

Author keywords

High K + media; LY 83583 (NOS inhibitor); NMDA; O.D.Q. (GC inhibitor)

Indexed keywords

1H 1,2,4 OXADIAZOLO[4,3 A]QUINOXALIN 1 ONE; 6 ANILINO 5,8 QUINOLINEQUINONE; ANTIOXIDANT; ASCORBIC ACID; BICARBONATE; CYCLIC GMP; GONADORELIN; GUANYLATE CYCLASE INHIBITOR; N METHYL DEXTRO ASPARTIC ACID; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE INHIBITOR; POTASSIUM ION;

ANIMAL TISSUE; ARTICLE; CELL MEMBRANE DEPOLARIZATION; CONTROLLED STUDY; ENZYME INHIBITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYPOTHALAMUS; HYPOTHESIS; IN VITRO STUDY; INCUBATION TIME; LUTEINIZING HORMONE RELEASE; MALE; NONHUMAN; RADIOIMMUNOASSAY; RAT;

ANIMALIA;

EID: 0347763430     PISSN: 15353702     EISSN: None     Source Type: Journal    
DOI: 10.1177/153537020422900109     Document Type: Article

References (55)

1. Rebec GV, Pierce RC. A vitamin as neuromodulator: ascorbate release into the extracellular fluid of the brain regulates dopaminergic and glutamatergic transmission (Review). Pro Neurobiol 43:537-565, 1994.
2. Spector R, Lorenzo AV. Ascorbic acid homeostasis in the central nervous system. Am J Phyiol 226:1468-1473, 1974.
3. Grunewald RA. Ascorbic acid in the brain. Brain Res Rev 18:123-133, 1993.
4. Spector R, Lorenzo AV. Ascorbic acid homeostasis in the central nervous system. Am J Physiol 225:757-763, 1973.
5. Chatterjee IB, Majumdar AK, Nandi BK, Subramanian N. Synthesis and some major functions of vitamin C in animals. Ann N Y Acad Sci 258:24-47, 1975.
6. Schenko IO, Miller E, Gaddis R, Adams RN. Homeostatic control of ascorbate concentration in CNS extracellular fluid. Brain Res 253:353-356, 1982.
7. Oke AF, May L, Adams RN. Ascorbic acid distribution patterns in human brain: comparison with nonhuman mammalian species (review). Ann N Y Acad Sci 498:1-12, 1987.
8. Agus DB, Gambhir SS, Pardridge WM, Spielholtz C, Baselga J, Vera JC, Gold DW. Vitamin C crosses the blood-brain barrier in the oxidized form through the glucose transporters. J Clin Invest 100:2842-2848, 1997.
9. Washko P, Rotrosen D, Levine M. Ascorbic acid transport and accumulation in human neutrophils. J Biol Chem 264:18996-19002, 1989.
10. Tsukaguchi H, Tokui T, Mackenzie TB, Berger UV, Chen XZ, Wang Y, Brubaker RF, Hediger MA. A family of mammalian Na+-dependent L-ascorbic acid transporters. Nature 399:70-75, 1999.
11. Wang Y, Mackenzie B, Tsukaguchi H, Weremowicz S, Morton CC, Hediger MA. Human vitamin C (L-ascorbic acid) transporter SVCT1. Biochem Biophys Res Commun 267:488-494, 2000.
12. Chatterjee IB. Ascorbic acid metabolism (review). World Rev Nutr Diet 30:69-87, 1978.
13. Schreibe M, Trojan S. Ascorbic acid in the brain (review). Physiol Res 40:413-418, 1991.
14. Das PC, Das KP, Bagchi K, Dey CD. Evaluation of tissue ascorbic acid status in different hormonal states of female rat. Life Sci 52:1493-1498, 1993.
15. Palmer RM, Ferrige AG, Moncada S. Nitric oxide release accounts for the biological activity of endothelium derived relaxing factor. Nature 327:524-526, 1987.
16. Dawson TM, Snyder SH. Gases as biological messengers: nitric oxide and carbon monoxide in the brain. J Neurosci 14:5147-5159, 1994.
17. Schuman EM, Madison DV. Nitric oxide and synaptic function. Ann Rev Neuro 17:153-183, 1994.
18. Garthwaite J, Charles SJ, Chess-Williams R. Endothelium-derived relaxing factor release on activation of NMDA receptor suggests role as intercellular messenger in the brain, Nature 336:385-388, 1988.
19. Moncada S, Palmer RM, Higgs EA. Nitric oxide: physiology, pathophysiology and pharmacology. Pharmacol Rev 43:109-142, 1991.
20. Garthwaite J. Glutamate, nitric oxide and cell-cell signaling in the nervous system. Trends Neurosci 14:60-67, 1991.
21. Knowles RG, Palacios M, Palmer RM, Moncada S. Formation of nitric oxide from L-arginine in the central nervous system: a transduction mechanism for stimulation of the soluble guanylate cyclase. Proc Natl Acad Sci U S A 86:5159-5162, 1989.
22. Bredt DS, Snyder SH. Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum. Proc Natl Acad Sci U S A 86:9030-9033, 1989.
23. Moncada S, Higgs A. The L-arginine-nitric oxide pathway. N Engl J Med 329:2002-2012, 1993.
24. Ignarro LJ. Heme-dependent activation of guanylate cyclase by nitric oxide: a novel-signal transduction mechanism (review). Blood Vessels 28:67-73, 1991.
25. Johnstone MT, Creager SJ, Sceals KM, Cusco JA, Lee BK, Creager MA. Impaired-endothelium dependent vasodilation in patients with insulin-dependent diabetes mellitus. Circulation 88:2510-2516, 1993.
26. Chirkov YY, Chirkova LP, Horowitz JD. Suppressed anti-aggregating and cGMP-elevating effects of sodium nitroprusside in platelets from patients with stable angina pectoris. Naunyn Schmiedebergs Arch Pharmacol 354:520-525, 1996.
27. Kojda G, Kottenberg K, Hacker A, Noack E. Alterations of the vascular and the myocardial guanylate cyclase/cGMP-system induced by long term hypertension in rats. Pharm Acta Helv 73:27-35, 1998.
28. Creagar MA, Cooke JP, Mendelsohn ME, Gallagher SJ, Coleman SM, Loscalzo J, Dzau VJ. Impaired vasodilation of forearm resistance vessels in hypercholesterolemic humans. J Clin Invest 86:228-234, 1990.
29. Drexler H, Hayoz D, Munzel T, Just H, Zelis R, Brunner HR. Endothelial function in congestive heart failure (review). Am Heart J 126:761-764, 1993.
30. Taddei S, Virdis A, Ghiadoni L, Magagna A, Salvetti A. Vitamin C improves endothelium-dependent vasodilation by restoring nitric oxide activity in essential hypertension. Circulation 97:2222-2229, 1998.
31. Bhat G, Mahesh VR, Aguon K, Brann DW. Evidence that brain nitric oxide synthase is the major nitric oxide synthase isoform in the hypothalamus of the adult female rat and that nitric oxide potently regulates hypothalamic cGMP levels. Neuroendocrinology 64:93-102, 1996.
32. Rettori V, Belova N, Dees WL, Nyberg CL, Gimeno M, McCann SM. Role of nitric oxide in the control of luteinizing hormone releasing hormone release in vitro. Proc Natl Acad Sci U S A 90:10130-10134, 1993.
33. Mayer B, Koesling D, Bohne E. Characterization of nitric oxide synthase, soluble guanylyl cyclase and Ca2+/calmodulin-stimulated cGMP phosphodiesterase as components of neuronal signal transduction. Adv Second Messenger Phosphoprotein Res 28:111-119, 1993.
34. Valleboona F, Raiteri M. Monitoring of cyclic GMP during cerebellar microdialysis in freely-moving rats as an index of nitric oxide synthase activity. Neuroscience 57:577-585, 1993.
35. Uno H, Arakawa T, Fukuda T, Yu H, Fujiwara Y, Higuchi K, Inoue M, Kobayashi K. Nitric oxide stimulates prostaglandin synthesis in cultured rabbit gastric cells. Prostaglandins 53:153-162, 1997.
36. 2 release from the hypothalamus. Proc Natl Acad Sci U S A 89:11543-11546, 1992.
37. Karanth S, Yu WH, Walczewska A, Mastronardi C, McCann SM. Ascorbic acid acts as an inhibitory transmitter in the hypothalamus to inhibit stimulated luteinizing hormone-releasing hormone release by scavenging nitric oxide. Proc Natl Acad Sci U S A 97:1891-1896, 2000.
38. Bonovera JJ, Sahu A, Kalra PS, Kalra SP. Evidence that nitric oxide may mediate the ovarian steroid induced luteinizing hormone surge: involvement of excitatory amino acids in vitro. Endocrinology 133:2481-2487, 1993.
39. Donoso AO, Lopez FJ, Negro-Vilar A. Glutamate receptors of the non-N-methyl D-aspartic acid type mediate the increase in luteinizing hormone releasing hormone release by excitatory amino acids in vitro. Endocrinology 126:414-420, 1990.
40. Bourguignon JP, Gerard A, Methieu J, Simons J, Franchimont P. Pulsatile release of gonadotropin releasing hormone from hypothalamic explants is restrained by blockade of N-methyl-d-aspartate receptors. Endocrinology 125:1090-1096, 1989.
41. Rettori V, Kamat A, McCann SM. Nitric oxide mediates the stimulation of luteinizing hormone releasing hormone release induced by glutamic acid in vitro. Brain Res Bull 33:501-503, 1994.
42. Moretto M, Lopez FJ, Negro-Vilar A. Nitric oxide regulates luteinizing hormone-releasing hormone secretion. Endocrinology 133:2399-2402, 1993.
43. Mahachoklertwattana P, Black SM, Kaplan SL, Bristow JD, Grumbach MM. Nitric oxide synthesized by gonadotropin releasing hormone neurons is a mediator of N-methyl-D-aspartate (NMDA) induced GnRH secretion. Endocrinology 135:1709-1712, 1994.
44. Diamond J, Chu EB. A novel cyclic GMP-lowering agent, LY 83583, blocks carbachol-induced cyclic GMP elevation in rabbit atrial strips without blocking the negative ionotropic effects of carbachol. Can J Physiol Pharmacol 68:908-911, 1985.
45. Schmidt MJ, Sawyer BD, Truex LL, Marshall WS, Fleisch JH. LY 83583: an agent that lowers intracellular levels of cyclic guanosine 3′5′ -monophosphate. J Pharmacol Exp Ther 232:764-769, 1985.
46. Garthwaite J, Southam E, Boulton CL, Nielsen EB, Schmidt KB, Mayer B. Potent and selective inhibition of nitric oxide sensitive guanylyl cyclase by IH-[1,2,4] oxadiazolo-[4,3-a] quinoxalin-1-one. Mol Pharmacol 48:184-188, 1995.
47. Fedele E, Jin Y, Varnier G, Raiteri M. In vivo microdialysis study of a specific inhibitor of soluble guanylyl cyclase on the glutamate receptor/nitric oxide/cyclic GMP pathway. Br J Pharmacol 119:590-594, 1996.
48. Schrammel A, Koesling D, Schmidt K, Mayer B. Inhibition of purified soluble guanylyl cyclase by L-ascorbic acid. Cardiovasc Res 47:602-608, 2000.
49. Harapanhalli RS, Howell RW, Rao DV. Testicular and plasma ascorbic acid levels in mice following dietary intake: a high performance liquid chromatographic analysis. J Chromatogr 614:233-243, 1993.
50. Petralia RS, Yokotani N, Wenthold RJ. Light and electron microscope distribution of the NMDA receptor subunit NMDA-R 1 in the rat nervous system using a selective antipeptide antibody. J Neurosci 14:667-696, 1994.
51. Bhat G, Mahesh VB, Lamar C, Ping L, Aguan K, Brann DW. Histochemical localization of nitric oxide neurons in the hypothalamus: association with gonadotropin-releasing hormone neurons and colocalization with N-methyl-D-aspartate receptors. Neuroendocrinology 62:187-197, 1995.
52. Chinkers M, Garbers DL. Signal transduction by guanylyl cyclases. Ann Rev Biochem 60:553-575, 1991.
53. Koestling D, Bohme E, Schultz G. Guanylyl cyclases, a growing family of signal transducing enzymes. FASEB J 5:2785-2791, 1991.
54. Murphy ME. Ascorbate and dehydroascorbate modulate nitric oxide-induced vasodilations of rat coronary arteries. J Cardiovasc Pharmacol 34:295-303, 1999.
55. Kamagai Y, Midorikawa K, Nakai Y, Yoshikawa T, Kushida K, Homma-Takeda S, Shimojo N. Inhibition of nitric oxide formation and superoxide generation during reduction of LY 83583 by neuronal nitric oxide synthase. Eur J Pharmacol 360:213-218, 1998.