Exploring the Overproduction of Amino Acids Using the Bilevel Optimization Framework OptKnock

Biotechnology and Bioengineering

Volumn 84, Issue 7, 2003, Pages 887-899

  Pharkya, Priti ^a   Burgard, Anthony P ^a   Maranas, Costas D ^a  

^a The Pennsylvania State University   (United States)

Author keywords

Amino acid overproduction; Bilevel optimization; Energy consuming producing pathways; Transport rates

Indexed keywords

AMINO ACIDS; AMMONIA; BIODEGRADATION; BIOSYNTHESIS; CARBON DIOXIDE; COMPUTATIONAL METHODS; DEHYDROGENATION; ENZYMES; ESCHERICHIA COLI; METABOLISM; METABOLITES; OPTIMIZATION;

MUTANTS;

BIOTECHNOLOGY;

6 PHOSPHOFRUCTOKINASE; ADENOSINE TRIPHOSPHATASE; ALANINE; AMINO ACID; AMMONIA; CARBON DIOXIDE; FORMATE ACETYLTRANSFERASE; GLUTAMIC ACID; LYASE; OXOGLUTARATE DEHYDROGENASE; OXYGEN; PHOSPHATE ACETYLTRANSFERASE; PYRUVATE DEHYDROGENASE; PYRUVATE KINASE; UNCLASSIFIED DRUG;

ANALYTIC METHOD; CHEMICAL REACTION; ESCHERICHIA COLI; GENE DELETION; GENE IDENTIFICATION; MATHEMATICAL ANALYSIS; MOLECULAR MODEL; NONHUMAN; REACTION ANALYSIS; REVIEW;

ALGORITHMS; AMINO ACIDS; COMBINATORIAL CHEMISTRY TECHNIQUES; ESCHERICHIA COLI; GENE EXPRESSION REGULATION, BACTERIAL; MODELS, BIOLOGICAL; PROTEIN ENGINEERING; RECOMBINANT PROTEINS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY;

ESCHERICHIA COLI;

EID: 0347762731     PISSN: 00063592     EISSN: None     Source Type: Journal    
DOI: 10.1002/bit.10857     Document Type: Review

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