Endotoxin releases a precursor to vasodilation from large veins in an NF-κB-dependent manner

Journal of Surgical Research

Volumn 116, Issue 1, 2004, Pages 151-155

  Campsen, P Jeff ^a   Snyder, James G ^a   Prewitt, Russell L ^a   Britt, L D ^a  

^a EASTERN VIRGINIA MEDICAL SCHOOL   (United States)

Author keywords

Endotoxin; Isolated arteriole; NF B; PDTC; Sepsis; Vena cava

Indexed keywords

BUFFER; ENDOTOXIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PYRROLIDINE DITHIOCARBAMATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; ARTERIOLE; ARTICLE; CANNULATION; CAPACITANCE BLOOD VESSEL; CAVA VEIN; CONTROLLED STUDY; EXPERIMENTAL MODEL; INFERIOR CAVA VEIN; MALE; NONHUMAN; PLASMA; PRESSURE; PRIORITY JOURNAL; RAT; SEPSIS; VASODILATATION; VEIN DILATATION; VEIN TONE;

EID: 0347721108     PISSN: 00224804     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jss.2003.07.002     Document Type: Article

References (11)

1. Glembot T.M., Britt L.D., Hill M.A. Endotoxin interacts with tumor necrosis factor α to induce vasodilation of isolated rat skeletal muscle arterioles. Shock. 5:(4):1996;251.
2. Minghini A., Britt L.D., Hill M.A. Interleukin-1 and interlukin-6 mediate skeletal muscle arteriolar vasodilation In vitro versus vivo studies . Shock. 9:(3):1998;210.
3. Glembot T.M., Britt L.D., Hill M.A. Lack of direct endotoxin-induced vasoactive effects on isolated skeletal muscle arterioles. Shock. 3:1995;216.
4. Wu C.C., Chen S.J., Yen M.H. Nitric oxide-independent activation of soluble guanylyl cyclase contributes to endotoxin shock in rats. Am. J. Physiol. 275:1998;H1148.
5. Muller J.M., LomsZiegler-Heitbrock H.W., Baeuerle P.A. Nuclear factor kappa B, a mediator of lipopolysaccharide effects. Immunobiology. 187:1993;233.
6. Munoz C., Pascual-Salcedo D., Castellanos M.C., Alfranca A., Aragones J., Vara A., Redondo M.J., de Landazuri M.D. Pyrrolidine Dithiocarbamate inhibits the production of interlukin-6, interlukin-8, and granulocyte-macrophage colony-stimulating factor by human endothelial cells in response to inflammatory mediators Modulation of NF-κB and AP-1 transcription factors activity . Blood. 88:(9):1996;3482.
7. Snyder J.G., Prewitt R., Campsen J., Britt L.D. PDTC and MG132, inhibitors of NF-κB, block endotoxin induced vasodilation of isolated rat skeletal muscle arterioles and has a dual site of action. Shock. 17:2002;304.
8. Lush C.W., Kvietys P.R. Microvascular dysfunction in sepsis. Microcirculation. 7:2000;83.
9. Liu S.F., Ye X., Malik A.B. In vivo inhibition of nuclear factor-κB activation prevents inducible nitric oxide synthase expression and systemic hypotension in a rat model of septic shock. J. Immunol. 159:1997;3976.
10. Mackenzie I.M. The haemodynamics of human septic shock. Anesthesia. 56:(2):2001;130.
11. Hishikawa K., Oemar B.S., Yang Z., Luscher T.F. Pulsatile stretch stimulates superoxide production and activates nuclear factor-κB in human coronary smooth muscle. Circ. Res. 81:(5):1997;797.