The insulator effect of the 5′HS4 region from the β-globin chicken locus on the rabbit WAP gene promoter activity in transgenic mice

Transgenic Research

Volumn 12, Issue 6, 2003, Pages 723-730

  Rival Gervier, Sylvie ^a   Pantano, Thais ^b   Viglietta, Céline ^a   Maeder, Caroline ^a   Prince, Sonia ^a   Attal, Joe ^a   Jolivet, Geneviève ^a   Houdebine, Louis Marie ^a  

^a CEMAGREF   (France)

^b Bioprotein Technologies   (France)

Author keywords

5 HS4 element; Insulator; Mammary gland; Transgenesis; Whey acidic protein

Indexed keywords

GLOBIN; LUCIFERASE; MILK PROTEIN; WHEY ACIDIC PROTEINS;

ANIMAL; ARTICLE; CHICKEN; GENE TRANSFER; GENETICS; METABOLISM; MOUSE; PLASMID; PROMOTER REGION; RABBIT; REPORTER GENE; TRANSGENIC ANIMAL; TRANSGENIC MOUSE; UDDER;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; CHICKENS; GENE TRANSFER TECHNIQUES; GENES, REPORTER; GLOBINS; LUCIFERASES; MAMMARY GLANDS, ANIMAL; MICE; MICE, TRANSGENIC; MILK PROTEINS; PLASMIDS; PROMOTER REGIONS (GENETICS); RABBITS;

ANIMALIA; GALLUS GALLUS; MUS MUSCULUS; ORYCTOLAGUS CUNICULUS;

EID: 0347693155     PISSN: 09628819     EISSN: None     Source Type: Journal    
DOI: 10.1023/B:TRAG.0000005242.72076.d1     Document Type: Article

References (35)

1. Burdon T, Sankaran L, Wall RJ, Spencer M and Hennighausen L (1991) Expression of a whey acidic protein transgene during mammary development. Evidence for different mechanisms of regulation during pregnancy and lactation. J Biol Chem 266: 6909-6914.
2. Chung JH, Whiteley M and Felsenfeld G (1993) A 5′ element of the chicken beta-globin domain serves as an insulator in human erythroid cells and protects against position effect in Drosophila. Cell 74: 505-514.
3. De Wet JR, Wood KV, DeLuca M, Helinski DR and Subramani S (1987) Firefly luciferase gene: structure and expression in mammalian cells. Mol Cell Biol 7: 725-737.
4. Echelard Y (1998) Increasing efficiency of transgenesis. Genetically engineering and cloning animals. Deer Valley Utah USA.
5. Emery DW, Yannaki E, Tubb J and Stamatoyannopoulos G (2000) A chromatin insulator protects retrovirus vectors from chromosomal position effects. Proc Natl Acad Sci USA 97: 9150-9155.
6. Farini E and Whitelaw CB (1995) Ectopic expression of beta-lactoglobulin transgenes. Mol Gen Genet 246: 734-738.
7. Festenstein R, Tolaini M, Corbella P, Mamalaki C, Parrington J, Fox M et al. (1996) Locus control region function and heterochromatin-induced position effect variegation. Science 271: 1123-1125.
8. Geyer PK and Corces VG (1992) DNA position-specific repression of transcription by a Drosophila zinc finger protein. Genes Dev 6: 1865-1873.
9. Hasegawa K and Nakatsuji N (2002) Insulators prevent transcriptional interference between two promoters in a double gene construct for transgenesis. FEBS Lett 520: 47-52.
10. Hogan B, Costantini F and Lacy E (1986) In Manipulating the Mouse Embryo: A Laboratory Manual (pp. 174-175).
11. Holdridge C and Dorsett D (1991) Repression of hsp70 heat shock gene transcription by the suppressor of hairy-wing protein of Drosophila melanogaster. Mol Cell Biol 11: 1894-1900.
12. Houdebine LM (2000) Transgenic animal bioreactors. Transgenic Res 9: 305-320.
13. Kellum R and Schedl P (1992) A group of ses elements function as domain boundaries in an enhancer-blocking assay. Mol Cell Biol 12: 2424-2431.
14. Lee TH, Kim SJ, Han YM, Yu DY, Lee CS, Choi YJ et al. (1998) Matrix attachment region sequences enhanced the expression frequency of a whey acidic protein/human lactoferrin fusion gene in the mammary gland of transgenic mice. Mol Cells 8: 530-536.
15. McKnight RA, Shamay A, Sankaran L, Wall RJ and Hennighausen L (1992) Matrix-attachment regions can impart position-independent regulation of a tissue-specific gene in transgenic mice. Proc Natl Acad Sci USA 89: 6943-6947.
16. Menck M, Mercier Y, Campion E, Lobo RB, Heyman Y, Renard JP et al. (1998) Prediction of transgene integration by noninvasive bioluminescent screening of microinjected bovine embryos. Transgenic Res 7: 331-341.
17. Milot E, Strouboulis J, Trimborn T, Wijgerde M, de Boer E, Langeveld A et al. (1996) Heterochromatin effects on the frequency and duration of LCR-mediated gene transcription. Cell 87: 105-114.
18. Pantano T, Jolivet G, Prince S, Menck-Le Bourhis C, Maeder C, Viglietta C et al. (2002) Effect of the rabbit alphas 1-casein gene distal enhancer on the expression of a reporter gene in vitro and in vivo. Biochem Biophys Res Commun 290: 53-61.
19. Petitclerc D, Attal J, Theron MC, Bearzotti M, Bolifraud P, Kann G et al. (1995) The effect of various introns and transcription terminators on the efficiency of expression vectors in various cultured cell lines and in the mammary gland of transgenic mice. J Biotechnol 40: 169-178.
20. Pikaart MJ, Recillas-Targa F and Felsenfeld G (1998) Loss of transcriptional activity of a transgene is accompanied by DNA methylation and histone deacetylation and is prevented by insulators. Genes Dev 12: 2852-2862.
21. Potts W, Tucker D, Wood H and Martin C (2000) Chicken beta-globin 5′HS4 insulators function to reduce variability in transgenic founder mice. Biochem Biophys Res Commun 273: 1015-1018.
22. Prioleau MN, Nony P, Simpson M and Felsenfeld G (1999) An insulator element and condensed chromatin region separate the chicken beta-globin locus from an independently regulated erythroid-specific folate receptor gene. EMBO J 18: 4035-4048.
23. Recillas-Targa F, Bell AC and Felsenfeld G (1999) Positional enhancer-blocking activity of the chicken beta-globin insulator in transiently transfected cells. Proc Natl Acad Sci USA 96: 14354-14359.
24. Recillas-Targa F, Pikaart MJ, Burgess-Beusse B, Bell AC, Litt MD, West AG et al. (2002) Position-effect protection and enhancer blocking by the chicken beta-globin insulator are separable activities. Proc Natl Acad Sci USA 99: 6883-6888.
25. Roseman RR, Pirrotta V and Geyer PK (1993) The su(Hw) protein insulates expression of the Drosophila melanogaster white gene from chromosomal position-effects. EMBO J 12: 435-442.
26. Sambrook J, Fritsch EF and Maniatis T (1989) Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor.
27. Taboit-Dameron F, Malassagne B, Viglietta C, Puissant C, Leroux-Coyau M, Chereau C et al. (1999) Association of the 5′HS4 sequence of the chicken beta-globin locus control region with human EF1 alpha gene promoter induces ubiquitous and high expression of human CD55 and CD59 cDNAs in transgenic rabbits. Transgenic Res 8: 223-235.
28. Thépot D, Devinoy E, Fontaine ML, Stinnakre MG, Massoud M, Kann G et al. (1995) Rabbit whey acidic protein gene upstream region controls high-level expression of bovine growth hormone in the mammary gland of transgenic mice. Mol Reprod Dev 42: 261-267.
29. Van Cott KE, Williams B, Velander WH, Gwazdauskas F, Lee T, Lubon H et al. (1996) Affinity purification of biologically active and inactive forms of recombinant human protein C produced in porcine mammary gland. J Mol Recog 9: 407-414.
30. Wall RJ (1999) Biotechnology for the production of modified and innovative animal products: transgenic livestock bioreactors. Livestock Production Sci 59: 243-255.
31. Walters MC, Fiering S, Bouhassira EE, Scalzo D, Goeke S, Magis W et al. (1999) The chicken beta-globin 5′HS4 boundary element blocks enhancer-mediated suppression of silencing. Mol Cell Biol 19: 3714-3726.
32. Wang Y, DeMayo FJ, Tsai SY and O'Malley BW (1997) Ligand-inducible and liver-specific target gene expression in transgenic mice. Nat Biotechnol 15: 239-243.
33. Wen J, Kawamata Y, Tojo H, Tanaka S and Tachi C (1995) Expression of whey acidic protein (WAP) genes in tissues other than the mammary gland in normal and transgenic mice expressing mWAP/hGH fusion gene. Mol Reprod Dev 41: 399-406.
34. Willoughby DA, Vilalta A and Oshima RG (2000) An Alu element from the K18 gene confers position-independent expression in transgenic mice. J Biol Chem 275: 759-768.
35. Zhong XP and Krangel MS (1999) Enhancer-blocking activity within the DNase I hypersensitive site 2 to 6 region between the TCR alpha and Dad1 genes. J Immunol 163: 295-300.