FcεRI-dependent gene expression in human mast cells is differentially controlled by T helper type 2 cytokines

Journal of Allergy and Clinical Immunology

Volumn 112, Issue 6, 2003, Pages 1119-1126

  Lora, José M ^a   Al Garawi, Amal ^a   Pickard, Michael D ^a   Price, Kursteen S ^b,c   Bagga, Savita ^b,c   Sicoli, Jaclyn ^c   Hodge, Martin R ^a   Gutiérrez Ramos, José Carlos ^a   Briskin, Michael J ^a   Boyce, Joshua A ^b,c,d  

^a MILLENNIUM PHARMACEUTICALS INC   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d Partners Asthma Center   (United States)

Author keywords

Activation; Asthma; Cytokines; Mast cells

Indexed keywords

FC RECEPTOR; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 9;

ALLERGIC REACTION; ARTICLE; CELL DIFFERENTIATION; CELL GROWTH; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; CROSS LINKING; CYTOKINE RELEASE; GENE ACTIVATION; GENE EXPRESSION REGULATION; GENE INDUCTION; GENETIC ASSOCIATION; HUMAN; HUMAN CELL; IMMUNOMODULATION; MAST CELL; PRIORITY JOURNAL; RECEPTOR AFFINITY; RECEPTOR UPREGULATION; T LYMPHOCYTE ACTIVATION; TH2 CELL; UMBILICAL CORD BLOOD;

EID: 0347626025     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaci.2003.08.042     Document Type: Article

References (55)

1. Casale TB, Wood D, Richerson HB, Zehr B, Zavala D, Hunninghake GW. Direct evidence of a role for mast cells in the pathogenesis of antigen-induced bronchoconstriction. J Clin Invest 1987;80:1507-11.
2. Brightling CE, Bradding P, Symon FA, Holgate ST, Wardlaw AJ, Pavord ID. Mast-cell infiltration of airway smooth muscle in asthma. N Engl J Med 2002;346:1699-705.
3. Lorentz A, Schwengberg S, Sellge G, Manns MP, Bischoff SC. Human intestinal mast cells are capable of producing different cytokine profiles: role of IgE receptor cross-linking and IL-4. J Immunol 2000;164:43-8.
4. Gordon JR, Galli SJ. Mast cells as a source of both preformed and immunologically inducible TNF-α/cachectin. Nature 1990;346:274-6.
5. Plaut M, Pierce JH, Watson CJ, Hanley-Hyde J, Nordan RP, Paul WE. Mast cell lines produce lymphokines in response to cross-linkage of FceRI or to calcium ionophores. Nature 1989;339:64-7.
6. Kobayasi T, Asboe-Hansen G. Degranulation and regranulation of human mast cells. Acta Derm Venerol 1969;49:369-81.
7. Xiang Z, Ahmed AA, Moller C, Nakayama K, Hatakeyama S, Nilsson G. Essential role of the prosurvival bcl-2 homologue A1 in mast cell survival after allergic activation. J Exp Med 2001;194:1561-9.
8. Kitamura Y, Go S, Hatanaka K. Decrease of mast cells in W/Wv mice and their increase by bone marrow transplantation. Blood 1978;52:447-52.
9. Kitamura Y, Go S. Decreased production of mast cells in Sl/Sld anemic mice. Blood 1979;53:492-7.
10. Huang C, Sali A, Stevens RL. Regulation and function of mast cell proteases in inflammation. J Clin Immunol 1998;18:169-83.
11. Wong GW, Yasuda S, Madhusudhan MS, Li L, Yang Y, Krilis SA, et al. Human tryptase epsilon (PRSS22), a new member of the chromosome 16p13.3 family of human serine proteases expressed in airway epithelial cells. J Biol Chem 2001;276:49169-82.
12. Urata H, Kinoshita A, Perez DM, Misono KS, Bumpus FM, Graham RM, et al. Cloning of the gene and cDNA for human heart chymase. J Biol Chem 1991;266:17173-9.
13. Schechter NM, Irani AM, Sprows JL, Abernethy J, Wintroub B, Schwartz LB. Identification of a cathepsin G-like proteinase in the MCTC type of human mast cell. J Immunol 1990;145:2652-61.
14. Irani AM, Goldstein SM, Wintroub BU, Bradford T, Schwartz LB. Human mast cell carboxypeptidase. Selective localization to MCTC cells. J Immunol 1991;147:247-53.
15. Ruitenberg EJ, Elgersma A. Absence of intestinal mast cell response in congenitally athymic mice during Trichinella spiralis infection. Nature (Lond) 1976;264:258-60.
16. Irani AA, Craig SS, DeBlois G, Elson CO, Schechter NM, Schwartz LB. Deficiency of the tryptase-positive, chymase-negative mast cell type in gastrointestinal mucosa of patients with defective T lymphocyte function. J Immunol 1987;138:4381-6.
17. Finkelman FD, Shea-Donohue T, Goldhill J, Sullivan CA, Morris SC, Madden KB, et al. Cytokine regulation of host defense against parasitic gastrointestinal nematodes. Ann Rev Immunol 1997;15:505-33.
18. Laitinen LA, Laitinen A, Haahtela T. Airway mucosal inflammation even in patients with newly diagnosed asthma. Am Rev Respir Dis 1993;147:697-704.
19. Pesci A, Foresi A, Bertorelli G, Chetta A, Oliveri D. Histochemical characteristics and degranulation of mast cells in epithelium and lamina propria of bronchial biopsies from asthmatic and normal subjects. Am Rev Respir Dis 1993;147:684-9.
20. Anderson DF, MacLeod JD, Baddeley SM, Bacon AS, McGill JI, Holgate ST, et al. Seasonal allergic conjunctivitis is accompanied by increased mast cell numbers in the absence of leukocyte infiltration. Clin Exp Allergy 1997;27:1060-6.
21. Amin K, Rinne J, Haahtela T, Simola M, Peterson CG, Roomans GM, et al. Inflammatory cell and epithelial characteristics of perennial allergic and nonallergic rhinitis with a symptom history of 1 to 3 years' duration. J Allergy Clin Immunol 2001;107:249-57.
22. Straumann A, Bauer M, Fischer B, Blaser K, Simon HU. Idiopathic eosinophilic esophagitis is associated with a Th2-type allergic inflammatory response. J Allergy Clin Immunol 2001;108:954-61.
23. Ochi H, Hirani WM, Yuan Q, Friend DS, Austen KF, Boyce JA. T helper type-2 cytokine-mediated comitogenic responses and CCR3 expression during differentiation of human mast cells in vitro. J Exp Med 1999;190:267-80.
24. Bischoff SC, Sellge G, Lornetz A, Sebald W, Raab R, Manns MP. IL-4 enhances proliferation and mediator release in mature human mast cells. Proc Natl Acad Sci U S A 1999;96:8080-5.
25. Matsuzawa S, Sakashita K, Kinoshita T, Ito S, Yamashita T, Koike K. IL-9 enhances the growth of human mast cell progenitors under stimulation with stem cell factor. J Immunol 2003;170:3461-7.
26. Yanagida M, Fukamachi H, Ohgami K, Kuwaki T, Ishii H, Uzumaki H, et al. Effects of T-helper 2-type cytokines, interleukin-3 (IL-3), IL-4, IL-5, and IL-6 on the survival of cultured human mast cells. Blood 1995;86:3705-14.
27. Hsieh FH, Lam BK, Penrose JF, Austen KF, Boyce JA. T helper cell type 2 cytokines coordinately regulate IgE-dependent cysteinyl leukotriene production by human cord blood-derived mast cells: profound induction of leukotriene C4 synthase expression by interleukin 4. J Exp Med 2001;193:123-33.
28. Ochi H, De Jesus NH, Hsieh F, Austen KF, Boyce JA. Interleukins 4 and 5 prime human mast cells for different profiles of IgE-dependent cytokine production. Proc Natl Acad Sci U S A 2000;97:10509-13.
29. Manji GA, Wang L, Geddes BJ, Brown M, Merriam S, Al-Garawi A, et al. PYPAF1: a PYRIN-containing Apafl-like protein that assembles with ASC and regulates activation of NF-κB. J Biol Chem 2002;277:11570-5.
30. Yowe D, Farlow D, Lora J, Drabic S, Gutiérrez-Ramos JC. Using microarrays for studying the host transcriptional response to microbial infection. In: Kaufmann SHE, Kabelitz D, editors. Immunology of infection. 2nd ed. London: Academic Press; 2002. p. 521-32.
31. Venter CJ, Adams MK, Myers EW, Li PW, Mural RJ, Sutton GG, et al. The sequence of the human genome. Science 2001;291:1304-51.
32. Tamayo SD, Mesirov J, Zhu Q, Kitareewan S, Dmitrovsky E, Lander ES, et al. Interpreting patterns of gene expression with self-organizing maps: methods and application to hematopoietic differentiation. Proc Natl Acad Sci U S A 1999;96:2907-12.
33. Xiong Y, Hannon GJ, Zhang H, Casso D, Kobayashi R, Beach D. P21 is a universal inhibitor of cyclin kinases. Nature 1993;366:701-4.
34. Smith ML, Chen IT, Zhan Q, Bae I, Chen CY, Gilmer TM, et al. Interaction of the p53-regulated protein GADD45 with proliferating cell nuclear antigen. Science 1994;266:1376-80.
35. Del Sal G, Collavin L, Ruaro ME, Edomi P, Saccone S, Valle GD, et al. Structure, function, and chromosome mapping of the growth-suppressing human homologue of the murine gas1 gene. Proc Natl Acad Sci U S A 1994;91:1848-52.
36. Inohara N, Koseki T, Chen S, Wu X, Nunez G. CIDE, a novel family of cell death activators with homology to the 45 kDa subunit of the DNA fragmentation factor. EMBO J 1998;17:2526-33.
37. Oltavi ZN, Milliman CL, Korsmeyer SJ. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 1993;74:609-19.
38. Lantz CS, Boesiger J, Song CH, Mach N, Kobayashi T, Mulligan RC, et al. Role for interleukin-3 in mast cell and basophil development and in immunity to parasites. Nature (Lond) 1998;92:90-3.
39. Madden KB, Urban JF Jr, Ziltener HJ, Schrader JW, Finkelman FD, Katona IM. Antibodies to IL-3 and IL-4 suppress helminth-induced intestinal mastocytosis. J Immunol 1991;147:1387-91.
40. Godfraind C, Louahed J, Faulkner H, Vink A, Warnier G, Grencis R, et al. Intraepithelial infiltration by mast cells with both connective tissue-type and mucosal-type characteristics in gut, trachea, and kidneys of IL-9 transgenic mice. J Immunol 1998;160:3989-96.
41. Temann UA, Geba GP, Rankin JA, Flavell RA. Expression of interleukin 9 in the lungs of transgenic mice causes airway inflammation, mast cell hyperplasia, and bronchial hyperresponsiveness. J Exp Med 1998;188:1307-20.
42. Friend DS, Ghildyal N, Gurish MF, Hunt J, Hu X, Austen KF, et al. Reversible expression of tryptases and chymases in the jejunal mast cells of mice infected with Trichinella spiralis. J Immunol 1998;160:5537-45.
43. Gebhardt T, Sellge G, Lorentz A, Raab R, Manns MP, Bischoff SC. Cultured human intestinal mast cells express functional IL-3 receptors and respond to IL-3 by enhancing growth and IgE receptor-dependent mediator release. Eur J Immunol 2002;32:2308-16.
44. Toru H, Ra C, Nonoyama S, Suzuki K, Yata J, Nakahata T. Induction of the high-affinity IgE receptor (FcεRI) on human mast cells by IL-4. Int Immunol 1996;8:1367-73.
45. Sayama K, Diehn M, Matsuda K, Lunderius C, Tsai M, Tam SY, et al. Transcriptional profiling of mast cells stimulated via the FcεRI and identification of mast cells as a source of IL-11. BMC Immunol 2002;3:3-5.
46. Nakajima T, Inagaki N, Tanaka H, Tanaka A, Yoshikawa M, Tamari M, et al. Marked increase in CC chemokine gene expression in both human and mouse mast cell transcriptomes following Fcepsilon receptor 1 cross-linking: an interspecies comparison. Blood 2002;100:3861-8.
47. Pesce M, Di Carlo A, De Felici M. The c-kit receptor is involved in the adhesion of mouse primordial germ cells to somatic cells in culture. Mech Dev 1997;68:37-44.
48. Toru H, Pawankar R, Ra C, Yata J, Nakahata T. Human mast cells produce IL-13 by high-affinity IgE receptor cross-linking: enhanced IL-13 production by IL-4-primed human mast cells. J Allergy Clin Immunol 1998;102:491-02.
49. Bischoff SC, Sellge G, Manns MP, Lorentz A. Interleukin-4 induces a switch of human intestinal mast cells from proinflammatory cells toTh2-type cells. Internat Arch Allergy Immunol 2001;124:151-4.
50. Mellor EA, Austen KF, Boyce JA. Cysteinyl leukotrienes and uridine diphosphate induce cytokine generation by human mast cells through an interleukin 4-regulated pathway that is inhibited by leukotriene receptor antagonists. J Exp Med 2002;195:583-92.
51. Zhang C, Baumgartner RA, Yamada K, Beaven MA. Mitogen-activated protein (MAP) kinase regulates production of tumor necrosis factor-α and release of arachidonic acid in mast cells. Indications of communication between p38 and p42 MAP kinases. J Biol Chem 1997;272:13397-402.
52. Oskeritzian CA, Wang Z, Kochan JP, Grimes M, Du Z, Chang HW, et al. Recombinant human (rh)IL-4-mediated apoptosis and recombinant human IL-6-mediated protection of recombinant human stem cell factor-dependent human mast cells derived from cord blood mononuclear cell progenitors. J Immunol 1999;163:5105-15.
53. Takagi M, Nakahata T, Koike K, Kobayashi T, Tsuji K, Kojima S, et al. Stimulation of connective tissue-type mast cell proliferation by crosslinking of cell-bound IgE. J Exp Med 1989;170:233-44.
54. Levi-Schaffer F, Shalit M. Proliferation and functional responses of bone marrow-derived mast cells after activation. Cell Immunol 1993;148:435-43.
55. Rennick D, Hunte B, Holland G, Thompson-Snipes L. Cofactors are essential for stem cell factor-dependent growth and maturation of mast cell progenitors: comparative effects of interleukin-3 (IL-3), IL-4, IL-10, and fibroblasts. Blood 1995;85:57-65