A C77G point mutation in CD45 exon 4, which is associated with the development of multiple sclerosis and increased susceptibility to HIV-1 infection, is undetectable in Japanese population

European Journal of Neurology

Volumn 10, Issue 6, 2003, Pages 737-739

  Sabouri, A H ^a,b   Saito, M ^a   Matsumoto, W ^a   Kodama, D ^a   Farid, R ^b   Izumo, S ^c   Usuku, K ^a   Osame, M ^a  

^a KAGOSHIMA UNIVERSITY   (Japan)

^b MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c KAGOSHIMA UNIVERSITY   (Japan)

Author keywords

CD45; Disease susceptibility; HAM TSP; HTLV 1; Multiple sclerosis; Point mutation

Indexed keywords

CD45 ANTIGEN; GENE PRODUCT; MUTANT PROTEIN; PROTEIN C77C; PROTEIN C77G; UNCLASSIFIED DRUG;

ALLELE; ANTIGEN DETECTION; ARTICLE; DISEASE ASSOCIATION; ENDEMIC DISEASE; EXON; GENETIC ASSOCIATION; GEOGRAPHIC DISTRIBUTION; GERMANY; HETEROZYGOSITY; HETEROZYGOTE; HOMOZYGOSITY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN T CELL LEUKEMIA VIRUS 1; JAPAN; MAJOR CLINICAL STUDY; MULTIPLE SCLEROSIS; POINT MUTATION; POLYMERASE CHAIN REACTION; POPULATION DYNAMICS; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SEQUENCE ANALYSIS; SPASTIC PARESIS; SPINAL CORD DISEASE; TREATMENT OUTCOME; UNITED KINGDOM; WILD TYPE;

ANTIGENS, CD45; CARRIER STATE; EXONS; GENE FREQUENCY; HIV INFECTIONS; HUMAN T-LYMPHOTROPIC VIRUS 1; HUMANS; JAPAN; MULTIPLE SCLEROSIS; PARAPARESIS, TROPICAL SPASTIC; POINT MUTATION; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 0347595359     PISSN: 13515101     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1468-1331.2003.00679.x     Document Type: Article

References (11)

1. Bangham CRM (2000). The immune response to HTLV-1. Curr Opin Immunol 12:397-402.
2. Barcellos LF, Caillier S, Dragone L et al. (2001). PTPRC (CD45) is not associated with the development of multiple sclerosis in U.S. patients. Nat Genet 29:23-24.
3. Furukawa Y, Yamashita M, Usuku K et al. (2000). Phylogenetic subgroups of human T cell lymphotropic virus (HTLV) type 1 in the tax gene and their association with different risks for HTLV-I-associated myelopathy/tropical spastic paraparesis. J Infect Dis 182: 1343-1349.
4. Gessain A, Barin F, Vernant JC et al. (1985). Antibodies to human T-lymphotropic virus type-1 in patients with tropical spastic paraparesis. Lancet 2:407-410.
5. Jacobsen M, Schweer D, Ziegler A et al. (2000). A point mutation in PTPRC is associated with the development of multiple sclerosis. Nat Genet 26:495-499.
6. Kira J, Kanai T, Nishimura Y et al. (1996). Western versus Asian types of multiple sclerosis: immunogenetically and clinically distinct disorders. Ann Neurol 40:569-574.
7. Osame M, Usuku K, Izumo S et al. (1986). HTLV-I associated myelopathy, a new clinical entity. Lancet 1:1031-1032.
8. Tchilian EZ, Wallace DL, Dawes R et al. (2001). A point mutation in CD45 may be associated with an increased risk of HIV-1 infection. AIDS 15:1892-1894.
9. Tchilian EZ, Dawes R, Ramaley PA et al. (2002). A CD45 polymorphism associated with abnormal splicing is absent in African populations. Immunogenetics 53:980-983.
10. Vorechovsky I, Kralovicova J, Tchilian E et al. (2001). Does 77C-> G in PTPRC modify autoimmune disorders linked to the major histocompatibility locus? Nat Genet 29:22-23.
11. Wood JP, Bieda K, Segni M et al. (2002). CD45 exon 4 point mutation does not confer susceptibility to type 1 diabetes mellitus or Graves' disease. Eur J Immunogenet 29:73-74.