Characterization of the human protein S gene promoter: A possible role of transcription factors Sp1 and HNF3 in liver

Thrombosis and Haemostasis

Volumn 90, Issue 6, 2003, Pages 1029-1039

  Tatewaki, Hideki ^a   Tsuda, Hiroko ^a   Kanaji, Taisuke ^a   Yokoyama, Kazunari ^b   Hamasaki, Naotaka ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b RIKEN TSUKUBA INSTITUTE   (Japan)

Author keywords

Gene expression; Protein C S pathway; Transcription factors

Indexed keywords

DNA; MESSENGER RNA; PROTEIN S; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR HNF3; TRANSCRIPTION FACTOR MAZ; TRANSCRIPTION FACTOR SP1; UNCLASSIFIED DRUG;

5' UNTRANSLATED REGION; ARTICLE; CELL LINE; CELL STRAIN HEPG2; DNA BINDING MOTIF; GENE; GENE EXPRESSION; GENE ISOLATION; GENETIC ANALYSIS; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LIVER; LIVER CELL; MOLECULAR CLONING; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN FUNCTION; REPORTER GENE; RESTRICTION MAPPING;

EID: 0347533987     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/th03-07-0443     Document Type: Article

References (30)

1. Allaart CF, Briet E. Familial venous thrombophilia. In: Haemostasis and Thrombosis. Bloom AL, Forbes CB, eds. Edinburgh: Churchill Livingstone 1994; 1349-60.
2. Dahlbäck B, Carlsson M, Svensson PJ. Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: Prediction of a cofactor to activated protein C. Proc Natl Acad Sci U S A 1993; 90: 1004-8.
3. Bertina RM, Koeleman BP, Koster T, et al. Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature 1994; 369: 64-7.
4. Rosendaal FR. Risk factors for venous thrombosis: Prevalence, risk, and interaction. Semin Hematol 1997; 34: 171-87.
5. Tsuda H, Hattori S, Tanabe S, et al. Screening for aetiology of thrombophilia: A high prevalence of protein S abnormality. Ann Clin Biochem 1999; 36: 423-32.
6. Watkins PC, Eddy R, Fukushima Y, et al. The gene for protein S maps near the centromere of human chromosome 3. Blood 1988; 71: 238-41.
7. Edenbrandt CM, Lundwall A, Wydro R, et al. Molecular analysis of the gene for vitamin K dependent protein S and its pseudogene cloning and partial gene organization. Biochemistry 1990; 29: 7861-8.
8. Schmidel DK, Tatro AV, Phelps LG, et al. Organization of the human protein S gene. Biochemistry 1990; 29: 7845-52.
9. Pools Van Amstel HK, Reitsma PH, Van Der Logt PE, et al. Intron-exon organization of the active human protein S gene PSα and its pseudogene PSβ1: Duplication and silencing during primate evolution. Biochemistry 1990; 29: 7853-61.
10. Fair DS, Marlar RA. Biosynthesis and secretion of factor VII, protein C, protein S, and the protein C inhibitor from a human hepatoma cell line. Blood 1986; 67: 64-70.
11. Fair DS, Marlar RA. Human endothelial cells synthesize protein S. Blood 1986; 67: 1168-71.
12. Stern DM, Brett J, Harris K, et al. Participation of endothelial cells in the protein C-protein S anticoagulant pathway: The synthesis and release of protein S. J Cell Biol 1986; 102: 1971-8.
13. Schwartz HP, Heeb MJ, Wencel-Drake JD, et al. Identification and quantitation of protein S in human platelets. Blood 1985; 66: 1452-5.
14. Ogura M, Tanabe N, Nishioka J, et al. Biosynthesis and secretion of functional protein S by a human megakaryoblastic cell line (MEG-01). Blood 1987; 70: 301-6.
15. Malm J, He X, Bjartell A, et al. Vitamin K-dependent protein S in leydig cells of human testis. Biochem J 1994; 302: 845-50.
16. He X, Shen L, Bjartell A, et al. The gene encoding vitamin K-dependent anticoagulant protein S is expressed in multiple rabbit organs as demonstrated by northern blotting, in situ hybridization, and immunohistochemistry. J Histochem Cytochem 1995; 43: 85-96.
17. Maillard C, Berruyer M, Serre CM, et al. Protein S, a vitamin K-dependent protein, is a bone matrix component synthesized and secreted by osteoblasts. Endocrinology 1992; 130: 1599-1604.
18. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987; 162: 156-9.
19. Dignam JD, Lebovitz RM, Roeder RG. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res 1983; 11: 1475-89.
20. He XD, Dahlbáck B. Molecular cloning, expression and functional characterization of rabbit anticoagulant vitamin-K-dependent protein S. Eur J Biochem 1993; 217: 857-65.
21. Azizkhan JC, Jensen DE, Pierce AJ, et al. Transcription from TATA-less promoters: Dihydrofolate reductase as a model. Crit Rev Euk Gene Expr 1993; 3: 229-54.
22. Gill G, Pascal E, Tseng ZH, et al. A glutamine-rich hydrophobic patch in transcription factor Sp1 contacts the dTAFII110 component of the drosophilia TFIID complex and mediates transcriptional activation. Proc Natl Acad Sci U S A 1994; 91: 192-6.
23. Goodrich JA, Tjian R. TBP-TAF complexes: Selectivity factors for eukaryotic transcription. Curr Opin Cell Biol 1994; 13: 5710-24.
24. Pugh BF, Tijan R. Mechanism of transcriptional activation by Sp1: Evidence of coactivators. Cell 1990; 61: 1187-97.
25. Parks CL, Shenk T. The serotonin 1a receptor gene contains a TATA-less promoter that responds to MAZ and Sp1. J Biol Chem 1996; 271: 4417-30.
26. Dalhbáck B. Inhibition of protein Ca cofactor function of human and bovine protein S by C4b-binding protein. J Biol Chem 1986; 261: 12022-7.
27. Arenzena N, Rodriguez De Cordoba S. Promoter region of the human gene coding for β-chain of C4b binding protein. J. Immunol 1996; 156: 168-75.
28. Tsay W, Lee YM, Shen MC, et al. Synergistic transactivation of HNF-1α, HNF-3, and NF-1 contributes to the activation of the liver-specific protein C gene. DNA Cell Biol 1997; 16: 569-77
29. Hayashi T, Usui M, Nishioka J, et al. Regulation of the human protein C inhibitor gene expression in HepG2 cells: Role of Sp1 and AP2. Biochem J 1998; 332: 573-82.
30. Rance JB, Follows GA, Cockerill PN, et al. Regulation of the human endothelial cell protein C receptor gene promoter by multiple Sp1 binding sites. Blood 2003; 101: 4393-401.