-
1
-
-
0035871538
-
Comparison of oral capecitabine versus intravenous fluorouracil plus leucovorin as first-line treatment in 605 patients with metastatic colorectal cancer: Results of a randomized Phase III study
-
HOFF PM, ANSARI R, BATIST G et al.: Comparison of oral capecitabine versus intravenous fluorouracil plus leucovorin as first-line treatment in 605 patients with metastatic colorectal cancer: results of a randomized Phase III study. J. Clin. Oncol. (2001) 19:2282-2292.
-
(2001)
J. Clin. Oncol.
, vol.19
, pp. 2282-2292
-
-
Hoff, P.M.1
Ansari, R.2
Batist, G.3
-
2
-
-
0035503151
-
Oral capecitabine compared with intravenous fluorouracil plus leucovorin in patients with metastatic colorectal cancer: Results of a large Phase III study
-
VAN CUTSEM E, TWELVES C, CASSIDY J et al: Oral capecitabine compared with intravenous fluorouracil plus leucovorin in patients with metastatic colorectal cancer: results of a large Phase III study. J. Clin. Oncol. (2001) 19:4097-4106.
-
(2001)
J. Clin. Oncol.
, vol.19
, pp. 4097-4106
-
-
Van Cutsem, E.1
Twelves, C.2
Cassidy, J.3
-
3
-
-
0034727063
-
Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer
-
Irinotecan Study Group
-
SALTZ LB, COX JV, BLANKE C et al.: Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer. Irinotecan Study Group. N. Engl. J. Med. (2000) 343:905-914.
-
(2000)
N. Engl. J. Med.
, vol.343
, pp. 905-914
-
-
Saltz, L.B.1
Cox, J.V.2
Blanke, C.3
-
4
-
-
0034712536
-
Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: A multicentre randomised trial
-
DOUILLARD JY, CUNNINGHAM D, ROTH AD et al.: Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial. Lancet (2000) 355:1041-1047.
-
(2000)
Lancet
, vol.355
, pp. 1041-1047
-
-
Douillard, J.Y.1
Cunningham, D.2
Roth, A.D.3
-
5
-
-
0033874892
-
Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer
-
DE GRAMONT A, FIGER A, SEYMOUR M et al.: Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer. J. Clin. Oncol. (2000) 18:2938-2947.
-
(2000)
J. Clin. Oncol.
, vol.18
, pp. 2938-2947
-
-
De Gramont, A.1
Figer, A.2
Seymour, M.3
-
6
-
-
0042213493
-
N9741: Oxaliplatin (Oxal) or CPT-11 + 5-fluorouracil (5FU)/leucovorin (LV) or oxal + CPT-11 in advanced colorectal cancer (CRC). Updated efficacy and quality of life (QOL) data from an intergroup study
-
(Abstract 1009)
-
GOLDBERG RM, MORTON RF, SARGENT DJ et al.: N9741: oxaliplatin (Oxal) or CPT-11 + 5-fluorouracil (5FU)/leucovorin (LV) or oxal + CPT-11 in advanced colorectal cancer (CRC). Updated efficacy and quality of life (QOL) data from an intergroup study. Proc. Am. Soc. Clin. Onc. (2003) 22 (Abstract 1009).
-
(2003)
Proc. Am. Soc. Clin. Onc.
, vol.22
-
-
Goldberg, R.M.1
Morton, R.F.2
Sargent, D.J.3
-
7
-
-
0141959354
-
Biweekly oxaliplatin (OXA) or irinotecan (IRI) with high dose folinic acid (FA) and 5-fluorouracil (FU) i.v. bolus in advanced colorectal carcinoma (ACC)
-
Southern Italy Cooperative Oncology Group (SICOG 0103) randomized study (Abstract 1123)
-
COMELLA P, MASSIDDA B, FILIPPELLI G et al.: Biweekly oxaliplatin (OXA) or irinotecan (IRI) with high dose folinic acid (FA) and 5-fluorouracil (FU) i.v. bolus in advanced colorectal carcinoma (ACC). Southern Italy Cooperative Oncology Group (SICOG 0103) randomized study. Proc. Am. Soc. Clin. Onc. (2003) 22 (Abstract 1123).
-
(2003)
Proc. Am. Soc. Clin. Onc.
, vol.22
-
-
Comella, P.1
Massidda, B.2
Filippelli, G.3
-
8
-
-
0003226922
-
FOLFIRI followed by FOLFOX versus FOLFOX followed by FOLFIRI in metastatic colorectal cancer (MCRC): Final results of a Phase III study
-
(Abstract 494)
-
TOURNIGAND C, LOUVET C, QUINAUX E et al.: FOLFIRI followed by FOLFOX versus FOLFOX followed by FOLFIRI in metastatic colorectal cancer (MCRC): final results of a Phase III study. Proc. Am. Soc. Clin. Onc. (2001) 20 (Abstract 494).
-
(2001)
Proc. Am. Soc. Clin. Onc.
, vol.20
-
-
Tournigand, C.1
Louvet, C.2
Quinaux, E.3
-
9
-
-
0037531121
-
Superiority of oxaliplatin and fluorouracil-leucovorin compared with either therapy alone in patients with progressive colorectal cancer after irinotecan and fluorouracil-leucovorin: Interim results of a Phase III trial
-
ROTHENBERG ML, OZA AM, BIGELOW RH et al.: Superiority of oxaliplatin and fluorouracil-leucovorin compared with either therapy alone in patients with progressive colorectal cancer after irinotecan and fluorouracil-leucovorin: interim results of a Phase III trial. J. Clin. Oncol. (2003) 21:2059-2069.
-
(2003)
J. Clin. Oncol.
, vol.21
, pp. 2059-2069
-
-
Rothenberg, M.L.1
Oza, A.M.2
Bigelow, R.H.3
-
10
-
-
0043215754
-
Final results of a Phase III trial of 5-FU/leucovorin versus oxaliplatin versus the combination in patients with metastatic colorecral cancer following irinotecan, 5-FU, and leucovorin
-
(Abstract 1011)
-
ROTHENBERG ML, OZA AM, BURGER B et al.: Final results of a Phase III trial of 5-FU/leucovorin versus oxaliplatin versus the combination in patients with metastatic colorecral cancer following irinotecan, 5-FU, and leucovorin. Proc. Am. Soc. Clin. Onc. (2003) 22 (Abstract 1011).
-
(2003)
Proc. Am. Soc. Clin. Onc.
, vol.22
-
-
Rothenberg, M.L.1
Oza, A.M.2
Burger, B.3
-
11
-
-
0026494947
-
A dideazatetrahydrofolate analogue lacking a chiral center at C-6, N-[4-[2-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-d]pyrimidin-5- yl)ethyl]benzoyl]-L-glutamic acid, is an inhibitor of thymidylate synthase
-
TAYLOR EC, KUHNT D, SHIH C et al.: A dideazatetrahydrofolate analogue lacking a chiral center at C-6, N-[4-[2-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-d]pyrimidin-5- yl)ethyl]benzoyl]-L-glutamic acid, is an inhibitor of thymidylate synthase J. Med. Chem. (1992) 35:4450-4454.
-
(1992)
J. Med. Chem.
, vol.35
, pp. 4450-4454
-
-
Taylor, E.C.1
Kuhnt, D.2
Shih, C.3
-
12
-
-
0041629528
-
Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma
-
VOGELZANG NJ, RUSTHOVEN JJ, SYMANOWSKI J et al.: Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma. J. Clin. Oncol. (2003) 21:2636-2644.
-
(2003)
J. Clin. Oncol.
, vol.21
, pp. 2636-2644
-
-
Vogelzang, N.J.1
Rusthoven, J.J.2
Symanowski, J.3
-
13
-
-
0037842139
-
Phase II study of pemetrexed with and without folic acid and vitamin B12 as front-line therapy in malignant pleural mesothelioma
-
SCAGLIOTTI GV, SHIN DM, KINDLER HL et al.: Phase II study of pemetrexed with and without folic acid and vitamin B12 as front-line therapy in malignant pleural mesothelioma. J. Clin. Oncol. (2003) 21:1556-1561.
-
(2003)
J. Clin. Oncol.
, vol.21
, pp. 1556-1561
-
-
Scagliotti, G.V.1
Shin, D.M.2
Kindler, H.L.3
-
14
-
-
0036562507
-
Homocysteine and methylmalonic acid: Markers to predict and avoid toxicity from pemetrexed therapy
-
NIYIKIZA C, BAKER SD, SEITZ DE et al.: Homocysteine and methylmalonic acid: markers to predict and avoid toxicity from pemetrexed therapy. Mol. Cancer. Ther. (2002) 1:545-552.
-
(2002)
Mol. Cancer. Ther.
, vol.1
, pp. 545-552
-
-
Niyikiza, C.1
Baker, S.D.2
Seitz, D.E.3
-
15
-
-
0028849683
-
Initial Phase I evaluation of the novel thymidylate synthase inhibitor, LY231514, using the modified continual reassessment method for dose escalation
-
RINALDI DA, BURRIS HA, DORR FA et al.: Initial Phase I evaluation of the novel thymidylate synthase inhibitor, LY231514, using the modified continual reassessment method for dose escalation. J. Clin. Oncol. (1995) 13:2842-2850.
-
(1995)
J. Clin. Oncol.
, vol.13
, pp. 2842-2850
-
-
Rinaldi, D.A.1
Burris, H.A.2
Dorr, F.A.3
-
16
-
-
0034655141
-
Activity of multitargeted antifolate (pemetrexed disodium, LY231514) in patients with advanced colorectal carcinoma: Results from a Phase II study
-
JOHN W, PICUS J, BLANKE CD et al.: Activity of multitargeted antifolate (pemetrexed disodium, LY231514) in patients with advanced colorectal carcinoma: results from a Phase II study. Cancer (2000) 88:1807-1813.
-
(2000)
Cancer
, vol.88
, pp. 1807-1813
-
-
John, W.1
Picus, J.2
Blanke, C.D.3
-
17
-
-
0036673489
-
Pemetrexed disodium combined with oxaliplatin, SN38, or 5-fluorouracil, based on the quantitation of drug interactions in human HT29 colon cancer cells
-
RAYMOND E, LOUVET C, TOURNIGAND C et al.: Pemetrexed disodium combined with oxaliplatin, SN38, or 5-fluorouracil, based on the quantitation of drug interactions in human HT29 colon cancer cells. Int. J. Oncol. (2002) 21:361-367.
-
(2002)
Int. J. Oncol.
, vol.21
, pp. 361-367
-
-
Raymond, E.1
Louvet, C.2
Tournigand, C.3
-
18
-
-
0346063885
-
Pemetrexed and oxaliplatin for first-line treatment of patients with advanced colorectal cancer: A Phase II trial of the NSABP foundation research program
-
(Abstract 1108)
-
ATKINS JN, JACOBS S, WIEAND S et al.: Pemetrexed and oxaliplatin for first-line treatment of patients with advanced colorectal cancer: a Phase II trial of the NSABP foundation research program. Proc. Am. Soc. Clin. Onc. (2003) 22 (Abstract 1108).
-
(2003)
Proc. Am. Soc. Clin. Onc.
, vol.22
-
-
Atkins, J.N.1
Jacobs, S.2
Wieand, S.3
-
19
-
-
0347325037
-
Pemetrexed and irinotecan as second-line therapy for locally advanced or metastatic colorectal cancer: A Phase I dose escalation study
-
(Abstract 1459)
-
KROENING H, HOCHSTER H, GROTHEY A et al.: Pemetrexed and irinotecan as second-line therapy for locally advanced or metastatic colorectal cancer: A Phase I dose escalation study. Proc. Am. Soc. Clin. Onc. (2003) 22 (Abstract 1459).
-
(2003)
Proc. Am. Soc. Clin. Onc.
, vol.22
-
-
Kroening, H.1
Hochster, H.2
Grothey, A.3
-
20
-
-
0029126764
-
MDR1/P-glycoprotein expression in colorectal cancer
-
LINN SC, GIACCONE G: MDR1/P-glycoprotein expression in colorectal cancer. Eur. J. Cancer (1995) 31A.1291-1294.
-
(1995)
Eur. J. Cancer
, vol.31 A
, pp. 1291-1294
-
-
Linn, S.C.1
Giaccone, G.2
-
21
-
-
0029049468
-
Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action
-
BOLLAG DM, MCQUENEY PA, ZHU J et al.: Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action. Cancer Res. (1995) 55:2325-2333.
-
(1995)
Cancer Res.
, vol.55
, pp. 2325-2333
-
-
Bollag, D.M.1
McQueney, P.A.2
Zhu, J.3
-
22
-
-
0034895987
-
BMS-247550: A novel epothilone analog with a mode of action similar to paclitaxel but possessing superior antitumor efficacy
-
LEE FY, BORZILLERI R, FAIRCHILD CR et al.: BMS-247550: a novel epothilone analog with a mode of action similar to paclitaxel but possessing superior antitumor efficacy. Clin. Cancer Res. (2001) 7:1429-1437.
-
(2001)
Clin. Cancer Res.
, vol.7
, pp. 1429-1437
-
-
Lee, F.Y.1
Borzilleri, R.2
Fairchild, C.R.3
-
23
-
-
0037838495
-
EPO906 (epothilone B): A promising novel microtubule stabilizer
-
ROTHERMEL J, WARTMANN M, CHEN T, HOHNEKER J: EPO906 (epothilone B): a promising novel microtubule stabilizer. Semin. Oncol. (2003) 30:51-55.
-
(2003)
Semin. Oncol.
, vol.30
, pp. 51-55
-
-
Rothermel, J.1
Wartmann, M.2
Chen, T.3
Hohneker, J.4
-
24
-
-
0346063886
-
The epothilone analogue, BMS-247550, in patients (pts) with advanced colorectal cancer (CRC)
-
(Abstract 1134)
-
ENG C, KINDLER HL, SKOOG L et al.: The epothilone analogue, BMS-247550, in patients (pts) with advanced colorectal cancer (CRC). Proc. Am. Soc. Clin. Onc. (2003) 22 (Abstract 1134).
-
(2003)
Proc. Am. Soc. Clin. Onc.
, vol.22
-
-
Eng, C.1
Kindler, H.L.2
Skoog, L.3
-
25
-
-
0347325038
-
Safety and efficacy of EPO906 in patients with advanced colorectal cancer: A review of 2 Phase II trials
-
(Abstract 1135)
-
POPLIN E, MOORE M, O'DWYER P et al: Safety and efficacy of EPO906 in patients with advanced colorectal cancer: A review of 2 Phase II trials. Proc. Am. Soc. Clin. Onc. (2003) 22 (Abstract 1135).
-
(2003)
Proc. Am. Soc. Clin. Onc.
, vol.22
-
-
Poplin, E.1
Moore, M.2
O'Dwyer, P.3
-
26
-
-
0347325036
-
Phase I trial of novel epothilone B analog BMS-310705 IV q 21 days
-
(Abstract 515)
-
MEKHAIL T, CHUNG C, HOLDEN S et al.: Phase I trial of novel epothilone B analog BMS-310705 IV q 21 days. Proc. Am. Sec. Clin. Onc. (2003) 22 (Abstract 515).
-
(2003)
Proc. Am. Sec. Clin. Onc.
, vol.22
-
-
Mekhail, T.1
Chung, C.2
Holden, S.3
-
27
-
-
0033199091
-
Mode of action of a new indolocarbazole anticancer agent, J-107088, targeting topoisomerase I
-
YOSHINARI T, OHKUBO M, FUKASAWA K et al.: Mode of action of a new indolocarbazole anticancer agent, J-107088, targeting topoisomerase I. Cancer Res. (1999) 59:4271-4275.
-
(1999)
Cancer Res.
, vol.59
, pp. 4271-4275
-
-
Yoshinari, T.1
Ohkubo, M.2
Fukasawa, K.3
-
28
-
-
0013327918
-
Phase I trial of J-107088, a novel topoisomerase I inhibitor, administered once every 21 days
-
(Abstract 767)
-
PECK R: Phase I trial of J-107088, a novel topoisomerase I inhibitor, administered once every 21 days. Proc. Am. Soc. Clin. Onc. (2000) 19 (Abstract 767).
-
(2000)
Proc. Am. Soc. Clin. Onc.
, vol.19
-
-
Peck, R.1
-
29
-
-
0013422886
-
A Phase-I study of the novel topoisomerase-I inhibitor J-107088 administered on a multiple-dose schedule
-
(Abstract 688)
-
LEWIS L, PEREZ R, PETROS W et al.: a Phase-I study of the novel topoisomerase-I inhibitor J-107088 administered on a multiple-dose schedule. Proc. Am. Soc. Clin. Onc. (2000) 19 (Abstract 688).
-
(2000)
Proc. Am. Soc. Clin. Onc.
, vol.19
-
-
Lewis, L.1
Perez, R.2
Petros, W.3
-
30
-
-
0347325039
-
Phase I trial of J-107088, a novel topoisomerase I inhibitor, administered once every 21 days
-
(Abstract 385)
-
YAMADA Y, YAMAMOTO N, SHIMOYAMA T et al.: Phase I trial of J-107088, a novel topoisomerase I inhibitor, administered once every 21 days. Proc. Am. Soc. Clin. Onc. (2002) 21 (Abstract 385).
-
(2002)
Proc. Am. Soc. Clin. Onc.
, vol.21
-
-
Yamada, Y.1
Yamamoto, N.2
Shimoyama, T.3
-
31
-
-
0346694514
-
Phase II efficacy and tolerability study of edotecarin (J-107088) in patients with irinotecan-naïve metastatic colorectal cancer (MCRC)
-
(Abstract 1099)
-
NAHUM K, SHIBA D, PADAVANIJA P et al.: Phase II efficacy and tolerability study of edotecarin (J-107088) in patients with irinotecan-naïve metastatic colorectal cancer (MCRC). Proc. Am. Soc. Clin. Onc. (2003) 22 (Abstract 1099).
-
(2003)
Proc. Am. Soc. Clin. Onc.
, vol.22
-
-
Nahum, K.1
Shiba, D.2
Padavanija, P.3
-
32
-
-
0036718689
-
Phase I clinical trials of tezacitabine, [(E)-2′-deoxy-2′-(fluoromethylene)cytidine] in patients with refractory solid tumors
-
RODRIGUEZ GI, JONES RE, ORENBERG EK, STOLTZ ML, BROOKS DJ: Phase I clinical trials of tezacitabine, [(E)-2′-deoxy-2′-(fluoromethylene)cytidine] in patients with refractory solid tumors. Clin. Cancer Res. (2002) 8:2828-2834.
-
(2002)
Clin. Cancer Res.
, vol.8
, pp. 2828-2834
-
-
Rodriguez, G.I.1
Jones, R.E.2
Orenberg, E.K.3
Stoltz, M.L.4
Brooks, D.J.5
-
33
-
-
13244272996
-
Phase II study of tezacitabine in subjects with advanced/recurrent colorectal cancer
-
(Abstract 1122)
-
BROOKS DJ, COX J, BERMAN BS et al.: Phase II study of tezacitabine in subjects with advanced/recurrent colorectal cancer. Proc. Am. Soc. Clin. Onc. (2003) 22 (Abstract 1122).
-
(2003)
Proc. Am. Soc. Clin. Onc.
, vol.22
-
-
Brooks, D.J.1
Cox, J.2
Berman, B.S.3
-
34
-
-
0038514919
-
Inhibition of vascular endothelial growth factor in the treatment of colorectal cancer
-
FERNANDO NH, HURWITZ HI: Inhibition of vascular endothelial growth factor in the treatment of colorectal cancer. Semin. Oncol. (2003) 30:39-50.
-
(2003)
Semin. Oncol.
, vol.30
, pp. 39-50
-
-
Fernando, N.H.1
Hurwitz, H.I.2
-
35
-
-
0028935608
-
Regulation by vascular endothelial growth factor of human colon cancer tumorigenesis in a mouse model of experimental liver metastasis
-
WARREN RS, YUAN H, MATLI MR, GILLETT NA, FERRARA N: Regulation by vascular endothelial growth factor of human colon cancer tumorigenesis in a mouse model of experimental liver metastasis. J. Clin. Invest. (1995) 95:1789-1797.
-
(1995)
J. Clin. Invest.
, vol.95
, pp. 1789-1797
-
-
Warren, R.S.1
Yuan, H.2
Matli, M.R.3
Gillett, N.A.4
Ferrara, N.5
-
36
-
-
0037208589
-
Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer
-
KABBINAVAR F, HURWITZ HI, FEHRENBACHER L et al.: Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer. J. Clin. Oncol. (2003) 21:60-65.
-
(2003)
J. Clin. Oncol.
, vol.21
, pp. 60-65
-
-
Kabbinavar, F.1
Hurwitz, H.I.2
Fehrenbacher, L.3
-
37
-
-
0346694519
-
The role of VEGF expression in response to bevacizumab plus capecitabine in metastatic breast cancer (MBC)
-
(Abstract 766)
-
HILLAN KJ, KOEPPEN HKW TOBIN P et al.: The role of VEGF expression in response to bevacizumab plus capecitabine in metastatic breast cancer (MBC). Proc. Am. Sec. Clin. Onc. (2003) 22 (Abstract 766).
-
(2003)
Proc. Am. Sec. Clin. Onc.
, vol.22
-
-
Hillan, K.J.1
Koeppen, H.K.W.2
Tobin, P.3
-
38
-
-
0003250698
-
Carboplatin (C) + paclitaxel (T) + RhuMab-VEGF (AVF) may prolong survival in advanced non-squamous lung cancer
-
(Abstract 1256)
-
JOHNSON DH, DEVORE R, KABBINAVAR F et al.: Carboplatin (C) + paclitaxel (T) + RhuMab-VEGF (AVF) may prolong survival in advanced non-squamous lung cancer. Proc. Am. Soc. Clin. Onc. (2001) 20 (Abstract 1256).
-
(2001)
Proc. Am. Soc. Clin. Onc.
, vol.20
-
-
Johnson, D.H.1
Devore, R.2
Kabbinavar, F.3
-
39
-
-
0043177668
-
Bevacizumab (a monoclonal antibody to vascular endothelial growth factor) prolongs survival in first-line colorectal cancer (CRC): Results of a Phase III trial of bevacizumab in combination with bolus IFL (irinotecan, 5-fluorouracil, leucovorin) as first-line therapy in subjects with metastatic CRC
-
(Abstract 3646)
-
HURWITZ H, FEHRENBACHER L, CARTWRIGHT T et al.: Bevacizumab (a monoclonal antibody to vascular endothelial growth factor) prolongs survival in first-line colorectal cancer (CRC): Results of a Phase III trial of bevacizumab in combination with bolus IFL (irinotecan, 5-fluorouracil, leucovorin) as first-line therapy in subjects with metastatic CRC. Proc. Am. Soc. Clin. Onc. (2003) 22 (Abstract 3646).
-
(2003)
Proc. Am. Soc. Clin. Onc.
, vol.22
-
-
Hurwitz, H.1
Fehrenbacher, L.2
Cartwright, T.3
-
40
-
-
0042344925
-
Angiogenesis. A boost for tumor starvation
-
MARX J: Angiogenesis. A boost for tumor starvation. Science (2003) 301:452-454.
-
(2003)
Science
, vol.301
, pp. 452-454
-
-
Marx, J.1
-
41
-
-
0035869407
-
Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2
-
SLAMON DJ, LEYLAND-JONES B, SHAK S et al.: Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N. Engl. J Med. (2001) 344:783-792.
-
(2001)
N. Engl. J Med.
, vol.344
, pp. 783-792
-
-
Slamon, D.J.1
Leyland-Jones, B.2
Shak, S.3
-
42
-
-
0034114769
-
Blockade of receptors for growth factors: An anticancer therapy - The fourth annual Joseph H Burchenal American Association of Cancer Research Clinical Research Award Lecture
-
MENDELSON J: Blockade of receptors for growth factors: an anticancer therapy - the fourth annual Joseph H Burchenal American Association of Cancer Research Clinical Research Award Lecture. Clin. Cancer Res. (2000) 6:747-753.
-
(2000)
Clin. Cancer Res.
, vol.6
, pp. 747-753
-
-
Mendelson, J.1
-
43
-
-
0022501030
-
Transforming growth factor-alpha: A more potent angiogenic mediator than epidermal growth factor
-
1232
-
SCHREIBER AB, WINKLER ME, DERYNCK R: Transforming growth factor-alpha: a more potent angiogenic mediator than epidermal growth factor. Science (1986) 232:1250-1253.
-
(1986)
Science
, pp. 1250-1253
-
-
Schreiber, A.B.1
Winkler, M.E.2
Derynck, R.3
-
44
-
-
84920241849
-
Epidermal-growth-factor receptors in human bladder cancer: Comparison of invasive and superficial tumours
-
NEAL DE, MARSH C, BENNETT MK et al.: Epidermal-growth-factor receptors in human bladder cancer: comparison of invasive and superficial tumours. Lancet (1985) 1:366-368.
-
(1985)
Lancet
, vol.1
, pp. 366-368
-
-
Neal, D.E.1
Marsh, C.2
Bennett, M.K.3
-
45
-
-
0035447953
-
Epidermal growth factor receptor immunohistochemical reactivity in patients with American Joint Committee on Cancer Stage IV Colon Adenocarcinoma: Implications for a standardized scoring system
-
GOLDSTEIN NS, ARMIN M: Epidermal growth factor receptor immunohistochemical reactivity in patients with American Joint Committee on Cancer Stage IV Colon Adenocarcinoma: implications for a standardized scoring system. Cancer (2001) 92:1331-1346.
-
(2001)
Cancer
, vol.92
, pp. 1331-1346
-
-
Goldstein, N.S.1
Armin, M.2
-
46
-
-
0025052403
-
Epidermal growth factor regulates the in vitro sensitivity of human ovarian carcinoma cells to cisplatin
-
CHRISTEN RD, HOM DK, PORTER DC et al.: Epidermal growth factor regulates the in vitro sensitivity of human ovarian carcinoma cells to cisplatin. J. Clin. Invest. (1990) 86:1632-1640.
-
(1990)
J. Clin. Invest.
, vol.86
, pp. 1632-1640
-
-
Christen, R.D.1
Hom, D.K.2
Porter, D.C.3
-
47
-
-
0027428571
-
Antitumor effect of anti-epidermal growth factor receptor monoclonal antibodies plus cis-diamminedichloroplatinum on well established A431 cell xenografts
-
FAN Z, BASELGA J, MASUI H, MENDELSOHN J: Antitumor effect of anti-epidermal growth factor receptor monoclonal antibodies plus cis-diamminedichloroplatinum on well established A431 cell xenografts. Cancer Res. (1993) 53:4637-4642.
-
(1993)
Cancer Res.
, vol.53
, pp. 4637-4642
-
-
Fan, Z.1
Baselga, J.2
Masui, H.3
Mendelsohn, J.4
-
48
-
-
0028223853
-
Epidermal growth factor modifies cell cycle control in A431 human squamous carcinoma cells damaged by ionizing radiation
-
LADEROUTE KR, AUSSERER WA, KNAPP AM, GRANT TD, SUTHERLAND RM: Epidermal growth factor modifies cell cycle control in A431 human squamous carcinoma cells damaged by ionizing radiation. Cancer Res. (1994) 54:1407-1411.
-
(1994)
Cancer Res.
, vol.54
, pp. 1407-1411
-
-
Laderoute, K.R.1
Ausserer, W.A.2
Knapp, A.M.3
Grant, T.D.4
Sutherland, R.M.5
-
49
-
-
0027929971
-
Effect of epidermal growth factor on the growth and radiation sensitivity of human breast cancer cells in vitro
-
WOLLMAN R, YAHALOM J, MAXY R, PINTO J, FUKS Z: Effect of epidermal growth factor on the growth and radiation sensitivity of human breast cancer cells in vitro. Int. J. Radiat. Oncol. Biol. Phys. (1994) 30:91-98.
-
(1994)
Int. J. Radiat. Oncol. Biol. Phys.
, vol.30
, pp. 91-98
-
-
Wollman, R.1
Yahalom, J.2
Maxy, R.3
Pinto, J.4
Fuks, Z.5
-
50
-
-
0033499814
-
Role of an anti-epidermal growth factor receptor in treating cancer
-
WAKSAL HW. Role of an anti-epidermal growth factor receptor in treating cancer. Cancer Metastasis Rev. (1999) 18:427-436.
-
(1999)
Cancer Metastasis Rev.
, vol.18
, pp. 427-436
-
-
Waksal, H.W.1
-
51
-
-
0002823211
-
Cetuximab (IMC-C225) Plus Irinotecan (CPT-11) is Active in CPT-11-Refractory Colorectal Cancer (CRC) that Expresses Epidermal Growth Factor Receptor (EGFR)
-
(Abstract 7)
-
SALTZ L, RUBIN M, HOCHSTER H et al.: Cetuximab (IMC-C225) Plus Irinotecan (CPT-11) is Active in CPT-11-Refractory Colorectal Cancer (CRC) that Expresses Epidermal Growth Factor Receptor (EGFR). Proc. Am. Soc. Clin. Onc. (2001) 20 (Abstract 7).
-
(2001)
Proc. Am. Soc. Clin. Onc.
, vol.20
-
-
Saltz, L.1
Rubin, M.2
Hochster, H.3
-
52
-
-
0037862765
-
Cetuximab (C225) alone or in combination with irinotecan (CPT-11) in patients with epidermal growth factor receptor (EGFR)-positive, irinotecan-refractory metastatic colorectal cancer (MCRC)
-
(Abstract 1012)
-
CUNNINGHAM D, HUMBLET Y, SIENA S et al.: Cetuximab (C225) alone or in combination with irinotecan (CPT-11) in patients with epidermal growth factor receptor (EGFR)-positive, irinotecan-refractory metastatic colorectal cancer (MCRC). Proc. Am. Soc. Clin. Onc. (2003) 22 (Abstract 1012).
-
(2003)
Proc. Am. Soc. Clin. Onc.
, vol.22
-
-
Cunningham, D.1
Humblet, Y.2
Siena, S.3
-
53
-
-
0344773402
-
The presence and intensity of the cetuximab-induced acne-like rash predicts increased survival in studies across multiple malignancies
-
(Abstract 817)
-
SALTZ L, KIES M, ABBRUZZESE JL, AZARNIA N, NEEDLE M: The presence and intensity of the cetuximab-induced acne-like rash predicts increased survival in studies across multiple malignancies. Proc. Am. Soc. Clin. Onc. (2003) 22 (Abstract 817).
-
(2003)
Proc. Am. Soc. Clin. Onc.
, vol.22
-
-
Saltz, L.1
Kies, M.2
Abbruzzese, J.L.3
Azarnia, N.4
Needle, M.5
-
54
-
-
0035117355
-
Development of ABX-EGF, a fully human anti-EGF receptor monoclonal antibody, for cancer therapy
-
YANG XD, JIA XC, CORVALAN JR, WANG P, DAVIS CG: Development of ABX-EGF, a fully human anti-EGF receptor monoclonal antibody, for cancer therapy. Crit. Rev Oncol. Hematol. (2001) 38:17-23.
-
(2001)
Crit. Rev Oncol. Hematol.
, vol.38
, pp. 17-23
-
-
Yang, X.D.1
Jia, X.C.2
Corvalan, J.R.3
Wang, P.4
Davis, C.G.5
-
55
-
-
0347615106
-
A Phase I PK and serial tumor and skin pharmacodynamic (PD) study of weekly (q1w), every 2-week (q2w) or every 3-week (q3w) 1-hour (h) infusion EMD72000, a humanized monoclonal anti-epidermal growth factor receptor (EGFR) antibody, in patients (pt) with advanced tumors
-
(Abstract 770)
-
TABERNERO J, ROJO F, JIMENE E et al.: A Phase I PK and serial tumor and skin pharmacodynamic (PD) study of weekly (q1w), every 2-week (q2w) or every 3-week (q3w) 1-hour (h) infusion EMD72000, a humanized monoclonal anti-epidermal growth factor receptor (EGFR) antibody, in patients (pt) with advanced tumors. Proc. Am. Soc. Clin. Onc. (2003) 22 (Abstract 770).
-
(2003)
Proc. Am. Soc. Clin. Onc.
, vol.22
-
-
Tabernero, J.1
Rojo, F.2
Jimene, E.3
-
56
-
-
0012381722
-
Multi-institutional randomized Phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer
-
FUKUOKA M, YANO S, GIACCONE G et al.: Multi-institutional randomized Phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer. J. Clin. Oncol. (2003) 21:2237-2246.
-
(2003)
J. Clin. Oncol.
, vol.21
, pp. 2237-2246
-
-
Fukuoka, M.1
Yano, S.2
Giaccone, G.3
-
57
-
-
0036842170
-
Phase I safety, pharmacokinetic, and pharmacodynamic trial of ZD1839, a selective oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with five selected solid tumor types
-
BASELGA J, RISCHIN D, RANSON M et al.: Phase I safety, pharmacokinetic, and pharmacodynamic trial of ZD1839, a selective oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with five selected solid tumor types. J. Clin. Oncol. (2002) 20:4292-4302.
-
(2002)
J. Clin. Oncol.
, vol.20
, pp. 4292-4302
-
-
Baselga, J.1
Rischin, D.2
Ranson, M.3
-
58
-
-
0345636045
-
Phase II study of erlotinib (OSI-774) in patients with metastatic colorectal cancer
-
(Abstract 785)
-
OZA AM, TOWNSLEY LL, SIUP, MAJOR D: Phase II study of erlotinib (OSI-774) in patients with metastatic colorectal cancer. Proc. Am. Soc. Clin. Onc. (2003) 22 (Abstract 785).
-
(2003)
Proc. Am. Soc. Clin. Onc.
, vol.22
-
-
Oza, A.M.1
Townsley, L.L.2
Siup, A.3
Major, D.4
-
59
-
-
0344341539
-
Safety, clinical efficacy, and biologic assessments from EGF 10004: A randomized Phase IB study of GW572016 for patients with metastatic carcinomas overexpressing EGFR or erbB2
-
(Abstract 772)
-
SPECTOR N, RAEFSKY E, HURWITZ H et al.: Safety, clinical efficacy, and biologic assessments from EGF 10004: A randomized Phase IB study of GW572016 for patients with metastatic carcinomas overexpressing EGFR or erbB2. Proc. Am. Soc. Clin. Onc. (2003) 22 (Abstract 772).
-
(2003)
Proc. Am. Soc. Clin. Onc.
, vol.22
-
-
Spector, N.1
Raefsky, E.2
Hurwitz, H.3
-
60
-
-
0347955437
-
A Phase II, open-label, multicenter study of GW572016 in patients with metastatic colorectal cancer refractory to 5-FU5-FU in combination with irinotecan and/or oxaliplatin
-
(Abstract 978)
-
BELANGER M, JONES CM, GERMOND C, BERGER MS: A Phase II, open-label, multicenter study of GW572016 in patients with metastatic colorectal cancer refractory to 5-FU5-FU in combination with irinotecan and/or oxaliplatin. Proc. Am. Soc. Clin. Onc. (2003) 22 (Abstract 978).
-
(2003)
Proc. Am. Soc. Clin. Onc.
, vol.22
-
-
Belanger, M.1
Jones, C.M.2
Germond, C.3
Berger, M.S.4
-
62
-
-
0346063884
-
A Phase II study of an oral MEK inhibitor, CI-1040, in patients with advanced nonsmall-cell lung, breast, colon, or pancreatic cancer
-
(Abstract 816)
-
WATERHOUSE DM, RINEHART J, ADJEI AA et al.: A Phase II study of an oral MEK inhibitor, CI-1040, in patients with advanced nonsmall-cell lung, breast, colon, or pancreatic cancer. Proc. Am. Soc. Clin. Onc. (2003) 22 (Abstract 816).
-
(2003)
Proc. Am. Soc. Clin. Onc.
, vol.22
-
-
Waterhouse, D.M.1
Rinehart, J.2
Adjei, A.A.3
-
63
-
-
0347955438
-
A randomized, double-blind, placebo controlled Phase III study of monoclonal antibody 3H1 plus 5-fluorouracil (5-FU)/leucovorin (LV) in stage IV colorectal carcinoma
-
(Abstract 1041)
-
BHATNAGAR A, CARMICHAEL J, COSGRIFF T et al.: A randomized, double-blind, placebo controlled Phase III study of monoclonal antibody 3H1 plus 5-fluorouracil (5-FU)/leucovorin (LV) in stage IV colorectal carcinoma. Proc. Am. Soc. Clin. Onc. (2003) 22 (Abstract 1041).
-
(2003)
Proc. Am. Soc. Clin. Onc.
, vol.22
-
-
Bhatnagar, A.1
Carmichael, J.2
Cosgriff, T.3
-
64
-
-
0032905030
-
Control of inducible chemoresistance: Enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-kappaB
-
WANG CY, CUSACK JC Jr., LIU R, BALDWIN AS Jr: Control of inducible chemoresistance: enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-kappaB. Nat.. Med. (1999) 5:412-417.
-
(1999)
Nat. Med.
, vol.5
, pp. 412-417
-
-
Wang, C.Y.1
Cusack Jr., J.C.2
Liu, R.3
Baldwin Jr., A.S.4
-
65
-
-
0035328584
-
Enhanced chemosensitivity to CPT-11 with proteasome inhibitor PS-341: Implications for systemic nuclear factor-kappaB inhibition
-
CUSACK JC Jr, LIU R, HOUSTON M et al.: Enhanced chemosensitivity to CPT-11 with proteasome inhibitor PS-341: implications for systemic nuclear factor-kappaB inhibition. Cancer Res. (2001) 61:3535-3540.
-
(2001)
Cancer Res.
, vol.61
, pp. 3535-3540
-
-
Cusack Jr., J.C.1
Liu, R.2
Houston, M.3
-
66
-
-
0042019045
-
Phase I dose-escalation and pharmacokinetic (PK) study of the VEGF inhibitor PTK787/ZK 222584 (PTK/ZK) in patients with liver metastases
-
Abstract 1142)
-
DREVS J, MROSS K, MEDINGE M et al.: Phase I dose-escalation and pharmacokinetic (PK) study of the VEGF inhibitor PTK787/ZK 222584 (PTK/ZK) in patients with liver metastases. Proc. Am. Soc. Clin. Onc. (2003) 22 Abstract 1142).
-
(2003)
Proc. Am. Soc. Clin. Onc.
, vol.22
-
-
Drevs, J.1
Mross, K.2
Medinge, M.3
-
67
-
-
0346796282
-
Extended Phase I study of the oral vascular endothelial growth factor (VEGF) receptor inhibitor PTK787/ZK 222584 in combination with oxaliplatin/5-fluorouracil (5-FU)/leucovorin as first line treatment for metastatic colorectal cancer
-
(Abstract 1098)
-
STEWARD WP, THOMAS AL, MORGAN B et al.: Extended Phase I study of the oral vascular endothelial growth factor (VEGF) receptor inhibitor PTK787/ZK 222584 in combination with oxaliplatin/5-fluorouracil (5-FU)/leucovorin as first line treatment for metastatic colorectal cancer. Proc. Am. Soc. Clin. Onc. (2003) 22 (Abstract 1098).
-
(2003)
Proc. Am. Soc. Clin. Onc.
, vol.22
-
-
Steward, W.P.1
Thomas, A.L.2
Morgan, B.3
-
68
-
-
0042519908
-
Phase I study of the oral vascular endothelial growth factor (VEGF) receptor inhibitor PTK787/ZK 222584 (PTK/ZK) in combination with irinotecan/5-fluorouracil/leucovorin in patients with metastatic colorectal cancer
-
(Abstract 1144)
-
TRARBACH T, SCHLEUCHER N, RIEDEL U et al.: Phase I study of the oral vascular endothelial growth factor (VEGF) receptor inhibitor PTK787/ZK 222584 (PTK/ZK) in combination with irinotecan/5-fluorouracil/leucovorin in patients with metastatic colorectal cancer. Proc. Am. Soc. Clin. Onc. (2003) 22 (Abstract 1144).
-
(2003)
Proc. Am. Soc. Clin. Onc.
, vol.22
-
-
Trarbach, T.1
Schleucher, N.2
Riedel, U.3
-
69
-
-
0037268322
-
A targeted approach for antiangiogenic therapy of metastatic human colon cancer
-
ELLIS LM: A targeted approach for antiangiogenic therapy of metastatic human colon cancer. Am. Surg. (2003) 69:3-10.
-
(2003)
Am. Surg.
, vol.69
, pp. 3-10
-
-
Ellis, L.M.1
-
70
-
-
0038476608
-
Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors
-
BERGERS G, SONG S, MEYER-MORSE N, BERGSLAND E, HANAHAN D: Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors. J. Clin. Invest. (2003) 111:1287-1295.
-
(2003)
J. Clin. Invest.
, vol.111
, pp. 1287-1295
-
-
Bergers, G.1
Song, S.2
Meyer-Morse, N.3
Bergsland, E.4
Hanahan, D.5
|