메뉴 건너뛰기




Volumn 12, Issue 12, 2003, Pages 1939-1949

Novel chemotherapeutic and targeted agents in metastatic colorectal cancer: The time has arrived

Author keywords

5 fluorouracil; Angiogenesis inhibitors; Bevacizumab; Capecitabine; Cetuximab; Colorectal neoplasms; Drug therapy; Edotecarin; Epidermal growth factor receptor inhibitors; Epothilone B; Irinotecan; Metastatic; Oxaliplatin; Pemetrexed; Tezacitabine; Tyrosine kinase inhibitors

Indexed keywords

6 FORMYLAMINO 12,13 DIHYDRO 1,11 DIHYDROXY 5H INDOLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE 5,7(6H) DIONE 13 GLUCOSIDE; ANGIOSTATIN; ANTHRACYCLINE; ANTINEOPLASTIC AGENT; BEVACIZUMAB; CAPECITABINE; CETUXIMAB; CISPLATIN; CYANOCOBALAMIN; CYTOTOXIC AGENT; DNA TOPOISOMERASE INHIBITOR; EDOTECARIN; ENDOSTATIN; EPIDERMAL GROWTH FACTOR; EPIPODOPHYLLOTOXIN DERIVATIVE; EPOTHILONE B; EPOTHILONE DERIVATIVE; FLUOROURACIL; FOLIC ACID; FOLINIC ACID; IRINOTECAN; IXABEPILONE; MONOCLONAL ANTIBODY; MULTIDRUG RESISTANCE PROTEIN; OXALIPLATIN; PACLITAXEL; PEMETREXED; TAXANE DERIVATIVE; TEZACITABINE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VASCULOTROPIN;

EID: 0347519273     PISSN: 13543784     EISSN: None     Source Type: Journal    
DOI: 10.1517/13543784.12.12.1939     Document Type: Review
Times cited : (12)

References (70)
  • 1
    • 0035871538 scopus 로고    scopus 로고
    • Comparison of oral capecitabine versus intravenous fluorouracil plus leucovorin as first-line treatment in 605 patients with metastatic colorectal cancer: Results of a randomized Phase III study
    • HOFF PM, ANSARI R, BATIST G et al.: Comparison of oral capecitabine versus intravenous fluorouracil plus leucovorin as first-line treatment in 605 patients with metastatic colorectal cancer: results of a randomized Phase III study. J. Clin. Oncol. (2001) 19:2282-2292.
    • (2001) J. Clin. Oncol. , vol.19 , pp. 2282-2292
    • Hoff, P.M.1    Ansari, R.2    Batist, G.3
  • 2
    • 0035503151 scopus 로고    scopus 로고
    • Oral capecitabine compared with intravenous fluorouracil plus leucovorin in patients with metastatic colorectal cancer: Results of a large Phase III study
    • VAN CUTSEM E, TWELVES C, CASSIDY J et al: Oral capecitabine compared with intravenous fluorouracil plus leucovorin in patients with metastatic colorectal cancer: results of a large Phase III study. J. Clin. Oncol. (2001) 19:4097-4106.
    • (2001) J. Clin. Oncol. , vol.19 , pp. 4097-4106
    • Van Cutsem, E.1    Twelves, C.2    Cassidy, J.3
  • 3
    • 0034727063 scopus 로고    scopus 로고
    • Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer
    • Irinotecan Study Group
    • SALTZ LB, COX JV, BLANKE C et al.: Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer. Irinotecan Study Group. N. Engl. J. Med. (2000) 343:905-914.
    • (2000) N. Engl. J. Med. , vol.343 , pp. 905-914
    • Saltz, L.B.1    Cox, J.V.2    Blanke, C.3
  • 4
    • 0034712536 scopus 로고    scopus 로고
    • Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: A multicentre randomised trial
    • DOUILLARD JY, CUNNINGHAM D, ROTH AD et al.: Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial. Lancet (2000) 355:1041-1047.
    • (2000) Lancet , vol.355 , pp. 1041-1047
    • Douillard, J.Y.1    Cunningham, D.2    Roth, A.D.3
  • 5
    • 0033874892 scopus 로고    scopus 로고
    • Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer
    • DE GRAMONT A, FIGER A, SEYMOUR M et al.: Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer. J. Clin. Oncol. (2000) 18:2938-2947.
    • (2000) J. Clin. Oncol. , vol.18 , pp. 2938-2947
    • De Gramont, A.1    Figer, A.2    Seymour, M.3
  • 6
    • 0042213493 scopus 로고    scopus 로고
    • N9741: Oxaliplatin (Oxal) or CPT-11 + 5-fluorouracil (5FU)/leucovorin (LV) or oxal + CPT-11 in advanced colorectal cancer (CRC). Updated efficacy and quality of life (QOL) data from an intergroup study
    • (Abstract 1009)
    • GOLDBERG RM, MORTON RF, SARGENT DJ et al.: N9741: oxaliplatin (Oxal) or CPT-11 + 5-fluorouracil (5FU)/leucovorin (LV) or oxal + CPT-11 in advanced colorectal cancer (CRC). Updated efficacy and quality of life (QOL) data from an intergroup study. Proc. Am. Soc. Clin. Onc. (2003) 22 (Abstract 1009).
    • (2003) Proc. Am. Soc. Clin. Onc. , vol.22
    • Goldberg, R.M.1    Morton, R.F.2    Sargent, D.J.3
  • 7
    • 0141959354 scopus 로고    scopus 로고
    • Biweekly oxaliplatin (OXA) or irinotecan (IRI) with high dose folinic acid (FA) and 5-fluorouracil (FU) i.v. bolus in advanced colorectal carcinoma (ACC)
    • Southern Italy Cooperative Oncology Group (SICOG 0103) randomized study (Abstract 1123)
    • COMELLA P, MASSIDDA B, FILIPPELLI G et al.: Biweekly oxaliplatin (OXA) or irinotecan (IRI) with high dose folinic acid (FA) and 5-fluorouracil (FU) i.v. bolus in advanced colorectal carcinoma (ACC). Southern Italy Cooperative Oncology Group (SICOG 0103) randomized study. Proc. Am. Soc. Clin. Onc. (2003) 22 (Abstract 1123).
    • (2003) Proc. Am. Soc. Clin. Onc. , vol.22
    • Comella, P.1    Massidda, B.2    Filippelli, G.3
  • 8
    • 0003226922 scopus 로고    scopus 로고
    • FOLFIRI followed by FOLFOX versus FOLFOX followed by FOLFIRI in metastatic colorectal cancer (MCRC): Final results of a Phase III study
    • (Abstract 494)
    • TOURNIGAND C, LOUVET C, QUINAUX E et al.: FOLFIRI followed by FOLFOX versus FOLFOX followed by FOLFIRI in metastatic colorectal cancer (MCRC): final results of a Phase III study. Proc. Am. Soc. Clin. Onc. (2001) 20 (Abstract 494).
    • (2001) Proc. Am. Soc. Clin. Onc. , vol.20
    • Tournigand, C.1    Louvet, C.2    Quinaux, E.3
  • 9
    • 0037531121 scopus 로고    scopus 로고
    • Superiority of oxaliplatin and fluorouracil-leucovorin compared with either therapy alone in patients with progressive colorectal cancer after irinotecan and fluorouracil-leucovorin: Interim results of a Phase III trial
    • ROTHENBERG ML, OZA AM, BIGELOW RH et al.: Superiority of oxaliplatin and fluorouracil-leucovorin compared with either therapy alone in patients with progressive colorectal cancer after irinotecan and fluorouracil-leucovorin: interim results of a Phase III trial. J. Clin. Oncol. (2003) 21:2059-2069.
    • (2003) J. Clin. Oncol. , vol.21 , pp. 2059-2069
    • Rothenberg, M.L.1    Oza, A.M.2    Bigelow, R.H.3
  • 10
    • 0043215754 scopus 로고    scopus 로고
    • Final results of a Phase III trial of 5-FU/leucovorin versus oxaliplatin versus the combination in patients with metastatic colorecral cancer following irinotecan, 5-FU, and leucovorin
    • (Abstract 1011)
    • ROTHENBERG ML, OZA AM, BURGER B et al.: Final results of a Phase III trial of 5-FU/leucovorin versus oxaliplatin versus the combination in patients with metastatic colorecral cancer following irinotecan, 5-FU, and leucovorin. Proc. Am. Soc. Clin. Onc. (2003) 22 (Abstract 1011).
    • (2003) Proc. Am. Soc. Clin. Onc. , vol.22
    • Rothenberg, M.L.1    Oza, A.M.2    Burger, B.3
  • 11
    • 0026494947 scopus 로고
    • A dideazatetrahydrofolate analogue lacking a chiral center at C-6, N-[4-[2-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-d]pyrimidin-5- yl)ethyl]benzoyl]-L-glutamic acid, is an inhibitor of thymidylate synthase
    • TAYLOR EC, KUHNT D, SHIH C et al.: A dideazatetrahydrofolate analogue lacking a chiral center at C-6, N-[4-[2-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-d]pyrimidin-5- yl)ethyl]benzoyl]-L-glutamic acid, is an inhibitor of thymidylate synthase J. Med. Chem. (1992) 35:4450-4454.
    • (1992) J. Med. Chem. , vol.35 , pp. 4450-4454
    • Taylor, E.C.1    Kuhnt, D.2    Shih, C.3
  • 12
    • 0041629528 scopus 로고    scopus 로고
    • Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma
    • VOGELZANG NJ, RUSTHOVEN JJ, SYMANOWSKI J et al.: Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma. J. Clin. Oncol. (2003) 21:2636-2644.
    • (2003) J. Clin. Oncol. , vol.21 , pp. 2636-2644
    • Vogelzang, N.J.1    Rusthoven, J.J.2    Symanowski, J.3
  • 13
    • 0037842139 scopus 로고    scopus 로고
    • Phase II study of pemetrexed with and without folic acid and vitamin B12 as front-line therapy in malignant pleural mesothelioma
    • SCAGLIOTTI GV, SHIN DM, KINDLER HL et al.: Phase II study of pemetrexed with and without folic acid and vitamin B12 as front-line therapy in malignant pleural mesothelioma. J. Clin. Oncol. (2003) 21:1556-1561.
    • (2003) J. Clin. Oncol. , vol.21 , pp. 1556-1561
    • Scagliotti, G.V.1    Shin, D.M.2    Kindler, H.L.3
  • 14
    • 0036562507 scopus 로고    scopus 로고
    • Homocysteine and methylmalonic acid: Markers to predict and avoid toxicity from pemetrexed therapy
    • NIYIKIZA C, BAKER SD, SEITZ DE et al.: Homocysteine and methylmalonic acid: markers to predict and avoid toxicity from pemetrexed therapy. Mol. Cancer. Ther. (2002) 1:545-552.
    • (2002) Mol. Cancer. Ther. , vol.1 , pp. 545-552
    • Niyikiza, C.1    Baker, S.D.2    Seitz, D.E.3
  • 15
    • 0028849683 scopus 로고
    • Initial Phase I evaluation of the novel thymidylate synthase inhibitor, LY231514, using the modified continual reassessment method for dose escalation
    • RINALDI DA, BURRIS HA, DORR FA et al.: Initial Phase I evaluation of the novel thymidylate synthase inhibitor, LY231514, using the modified continual reassessment method for dose escalation. J. Clin. Oncol. (1995) 13:2842-2850.
    • (1995) J. Clin. Oncol. , vol.13 , pp. 2842-2850
    • Rinaldi, D.A.1    Burris, H.A.2    Dorr, F.A.3
  • 16
    • 0034655141 scopus 로고    scopus 로고
    • Activity of multitargeted antifolate (pemetrexed disodium, LY231514) in patients with advanced colorectal carcinoma: Results from a Phase II study
    • JOHN W, PICUS J, BLANKE CD et al.: Activity of multitargeted antifolate (pemetrexed disodium, LY231514) in patients with advanced colorectal carcinoma: results from a Phase II study. Cancer (2000) 88:1807-1813.
    • (2000) Cancer , vol.88 , pp. 1807-1813
    • John, W.1    Picus, J.2    Blanke, C.D.3
  • 17
    • 0036673489 scopus 로고    scopus 로고
    • Pemetrexed disodium combined with oxaliplatin, SN38, or 5-fluorouracil, based on the quantitation of drug interactions in human HT29 colon cancer cells
    • RAYMOND E, LOUVET C, TOURNIGAND C et al.: Pemetrexed disodium combined with oxaliplatin, SN38, or 5-fluorouracil, based on the quantitation of drug interactions in human HT29 colon cancer cells. Int. J. Oncol. (2002) 21:361-367.
    • (2002) Int. J. Oncol. , vol.21 , pp. 361-367
    • Raymond, E.1    Louvet, C.2    Tournigand, C.3
  • 18
    • 0346063885 scopus 로고    scopus 로고
    • Pemetrexed and oxaliplatin for first-line treatment of patients with advanced colorectal cancer: A Phase II trial of the NSABP foundation research program
    • (Abstract 1108)
    • ATKINS JN, JACOBS S, WIEAND S et al.: Pemetrexed and oxaliplatin for first-line treatment of patients with advanced colorectal cancer: a Phase II trial of the NSABP foundation research program. Proc. Am. Soc. Clin. Onc. (2003) 22 (Abstract 1108).
    • (2003) Proc. Am. Soc. Clin. Onc. , vol.22
    • Atkins, J.N.1    Jacobs, S.2    Wieand, S.3
  • 19
    • 0347325037 scopus 로고    scopus 로고
    • Pemetrexed and irinotecan as second-line therapy for locally advanced or metastatic colorectal cancer: A Phase I dose escalation study
    • (Abstract 1459)
    • KROENING H, HOCHSTER H, GROTHEY A et al.: Pemetrexed and irinotecan as second-line therapy for locally advanced or metastatic colorectal cancer: A Phase I dose escalation study. Proc. Am. Soc. Clin. Onc. (2003) 22 (Abstract 1459).
    • (2003) Proc. Am. Soc. Clin. Onc. , vol.22
    • Kroening, H.1    Hochster, H.2    Grothey, A.3
  • 20
    • 0029126764 scopus 로고
    • MDR1/P-glycoprotein expression in colorectal cancer
    • LINN SC, GIACCONE G: MDR1/P-glycoprotein expression in colorectal cancer. Eur. J. Cancer (1995) 31A.1291-1294.
    • (1995) Eur. J. Cancer , vol.31 A , pp. 1291-1294
    • Linn, S.C.1    Giaccone, G.2
  • 21
    • 0029049468 scopus 로고
    • Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action
    • BOLLAG DM, MCQUENEY PA, ZHU J et al.: Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action. Cancer Res. (1995) 55:2325-2333.
    • (1995) Cancer Res. , vol.55 , pp. 2325-2333
    • Bollag, D.M.1    McQueney, P.A.2    Zhu, J.3
  • 22
    • 0034895987 scopus 로고    scopus 로고
    • BMS-247550: A novel epothilone analog with a mode of action similar to paclitaxel but possessing superior antitumor efficacy
    • LEE FY, BORZILLERI R, FAIRCHILD CR et al.: BMS-247550: a novel epothilone analog with a mode of action similar to paclitaxel but possessing superior antitumor efficacy. Clin. Cancer Res. (2001) 7:1429-1437.
    • (2001) Clin. Cancer Res. , vol.7 , pp. 1429-1437
    • Lee, F.Y.1    Borzilleri, R.2    Fairchild, C.R.3
  • 23
    • 0037838495 scopus 로고    scopus 로고
    • EPO906 (epothilone B): A promising novel microtubule stabilizer
    • ROTHERMEL J, WARTMANN M, CHEN T, HOHNEKER J: EPO906 (epothilone B): a promising novel microtubule stabilizer. Semin. Oncol. (2003) 30:51-55.
    • (2003) Semin. Oncol. , vol.30 , pp. 51-55
    • Rothermel, J.1    Wartmann, M.2    Chen, T.3    Hohneker, J.4
  • 24
    • 0346063886 scopus 로고    scopus 로고
    • The epothilone analogue, BMS-247550, in patients (pts) with advanced colorectal cancer (CRC)
    • (Abstract 1134)
    • ENG C, KINDLER HL, SKOOG L et al.: The epothilone analogue, BMS-247550, in patients (pts) with advanced colorectal cancer (CRC). Proc. Am. Soc. Clin. Onc. (2003) 22 (Abstract 1134).
    • (2003) Proc. Am. Soc. Clin. Onc. , vol.22
    • Eng, C.1    Kindler, H.L.2    Skoog, L.3
  • 25
    • 0347325038 scopus 로고    scopus 로고
    • Safety and efficacy of EPO906 in patients with advanced colorectal cancer: A review of 2 Phase II trials
    • (Abstract 1135)
    • POPLIN E, MOORE M, O'DWYER P et al: Safety and efficacy of EPO906 in patients with advanced colorectal cancer: A review of 2 Phase II trials. Proc. Am. Soc. Clin. Onc. (2003) 22 (Abstract 1135).
    • (2003) Proc. Am. Soc. Clin. Onc. , vol.22
    • Poplin, E.1    Moore, M.2    O'Dwyer, P.3
  • 26
    • 0347325036 scopus 로고    scopus 로고
    • Phase I trial of novel epothilone B analog BMS-310705 IV q 21 days
    • (Abstract 515)
    • MEKHAIL T, CHUNG C, HOLDEN S et al.: Phase I trial of novel epothilone B analog BMS-310705 IV q 21 days. Proc. Am. Sec. Clin. Onc. (2003) 22 (Abstract 515).
    • (2003) Proc. Am. Sec. Clin. Onc. , vol.22
    • Mekhail, T.1    Chung, C.2    Holden, S.3
  • 27
    • 0033199091 scopus 로고    scopus 로고
    • Mode of action of a new indolocarbazole anticancer agent, J-107088, targeting topoisomerase I
    • YOSHINARI T, OHKUBO M, FUKASAWA K et al.: Mode of action of a new indolocarbazole anticancer agent, J-107088, targeting topoisomerase I. Cancer Res. (1999) 59:4271-4275.
    • (1999) Cancer Res. , vol.59 , pp. 4271-4275
    • Yoshinari, T.1    Ohkubo, M.2    Fukasawa, K.3
  • 28
    • 0013327918 scopus 로고    scopus 로고
    • Phase I trial of J-107088, a novel topoisomerase I inhibitor, administered once every 21 days
    • (Abstract 767)
    • PECK R: Phase I trial of J-107088, a novel topoisomerase I inhibitor, administered once every 21 days. Proc. Am. Soc. Clin. Onc. (2000) 19 (Abstract 767).
    • (2000) Proc. Am. Soc. Clin. Onc. , vol.19
    • Peck, R.1
  • 29
    • 0013422886 scopus 로고    scopus 로고
    • A Phase-I study of the novel topoisomerase-I inhibitor J-107088 administered on a multiple-dose schedule
    • (Abstract 688)
    • LEWIS L, PEREZ R, PETROS W et al.: a Phase-I study of the novel topoisomerase-I inhibitor J-107088 administered on a multiple-dose schedule. Proc. Am. Soc. Clin. Onc. (2000) 19 (Abstract 688).
    • (2000) Proc. Am. Soc. Clin. Onc. , vol.19
    • Lewis, L.1    Perez, R.2    Petros, W.3
  • 30
    • 0347325039 scopus 로고    scopus 로고
    • Phase I trial of J-107088, a novel topoisomerase I inhibitor, administered once every 21 days
    • (Abstract 385)
    • YAMADA Y, YAMAMOTO N, SHIMOYAMA T et al.: Phase I trial of J-107088, a novel topoisomerase I inhibitor, administered once every 21 days. Proc. Am. Soc. Clin. Onc. (2002) 21 (Abstract 385).
    • (2002) Proc. Am. Soc. Clin. Onc. , vol.21
    • Yamada, Y.1    Yamamoto, N.2    Shimoyama, T.3
  • 31
    • 0346694514 scopus 로고    scopus 로고
    • Phase II efficacy and tolerability study of edotecarin (J-107088) in patients with irinotecan-naïve metastatic colorectal cancer (MCRC)
    • (Abstract 1099)
    • NAHUM K, SHIBA D, PADAVANIJA P et al.: Phase II efficacy and tolerability study of edotecarin (J-107088) in patients with irinotecan-naïve metastatic colorectal cancer (MCRC). Proc. Am. Soc. Clin. Onc. (2003) 22 (Abstract 1099).
    • (2003) Proc. Am. Soc. Clin. Onc. , vol.22
    • Nahum, K.1    Shiba, D.2    Padavanija, P.3
  • 32
    • 0036718689 scopus 로고    scopus 로고
    • Phase I clinical trials of tezacitabine, [(E)-2′-deoxy-2′-(fluoromethylene)cytidine] in patients with refractory solid tumors
    • RODRIGUEZ GI, JONES RE, ORENBERG EK, STOLTZ ML, BROOKS DJ: Phase I clinical trials of tezacitabine, [(E)-2′-deoxy-2′-(fluoromethylene)cytidine] in patients with refractory solid tumors. Clin. Cancer Res. (2002) 8:2828-2834.
    • (2002) Clin. Cancer Res. , vol.8 , pp. 2828-2834
    • Rodriguez, G.I.1    Jones, R.E.2    Orenberg, E.K.3    Stoltz, M.L.4    Brooks, D.J.5
  • 33
    • 13244272996 scopus 로고    scopus 로고
    • Phase II study of tezacitabine in subjects with advanced/recurrent colorectal cancer
    • (Abstract 1122)
    • BROOKS DJ, COX J, BERMAN BS et al.: Phase II study of tezacitabine in subjects with advanced/recurrent colorectal cancer. Proc. Am. Soc. Clin. Onc. (2003) 22 (Abstract 1122).
    • (2003) Proc. Am. Soc. Clin. Onc. , vol.22
    • Brooks, D.J.1    Cox, J.2    Berman, B.S.3
  • 34
    • 0038514919 scopus 로고    scopus 로고
    • Inhibition of vascular endothelial growth factor in the treatment of colorectal cancer
    • FERNANDO NH, HURWITZ HI: Inhibition of vascular endothelial growth factor in the treatment of colorectal cancer. Semin. Oncol. (2003) 30:39-50.
    • (2003) Semin. Oncol. , vol.30 , pp. 39-50
    • Fernando, N.H.1    Hurwitz, H.I.2
  • 35
    • 0028935608 scopus 로고
    • Regulation by vascular endothelial growth factor of human colon cancer tumorigenesis in a mouse model of experimental liver metastasis
    • WARREN RS, YUAN H, MATLI MR, GILLETT NA, FERRARA N: Regulation by vascular endothelial growth factor of human colon cancer tumorigenesis in a mouse model of experimental liver metastasis. J. Clin. Invest. (1995) 95:1789-1797.
    • (1995) J. Clin. Invest. , vol.95 , pp. 1789-1797
    • Warren, R.S.1    Yuan, H.2    Matli, M.R.3    Gillett, N.A.4    Ferrara, N.5
  • 36
    • 0037208589 scopus 로고    scopus 로고
    • Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer
    • KABBINAVAR F, HURWITZ HI, FEHRENBACHER L et al.: Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer. J. Clin. Oncol. (2003) 21:60-65.
    • (2003) J. Clin. Oncol. , vol.21 , pp. 60-65
    • Kabbinavar, F.1    Hurwitz, H.I.2    Fehrenbacher, L.3
  • 37
    • 0346694519 scopus 로고    scopus 로고
    • The role of VEGF expression in response to bevacizumab plus capecitabine in metastatic breast cancer (MBC)
    • (Abstract 766)
    • HILLAN KJ, KOEPPEN HKW TOBIN P et al.: The role of VEGF expression in response to bevacizumab plus capecitabine in metastatic breast cancer (MBC). Proc. Am. Sec. Clin. Onc. (2003) 22 (Abstract 766).
    • (2003) Proc. Am. Sec. Clin. Onc. , vol.22
    • Hillan, K.J.1    Koeppen, H.K.W.2    Tobin, P.3
  • 38
    • 0003250698 scopus 로고    scopus 로고
    • Carboplatin (C) + paclitaxel (T) + RhuMab-VEGF (AVF) may prolong survival in advanced non-squamous lung cancer
    • (Abstract 1256)
    • JOHNSON DH, DEVORE R, KABBINAVAR F et al.: Carboplatin (C) + paclitaxel (T) + RhuMab-VEGF (AVF) may prolong survival in advanced non-squamous lung cancer. Proc. Am. Soc. Clin. Onc. (2001) 20 (Abstract 1256).
    • (2001) Proc. Am. Soc. Clin. Onc. , vol.20
    • Johnson, D.H.1    Devore, R.2    Kabbinavar, F.3
  • 39
    • 0043177668 scopus 로고    scopus 로고
    • Bevacizumab (a monoclonal antibody to vascular endothelial growth factor) prolongs survival in first-line colorectal cancer (CRC): Results of a Phase III trial of bevacizumab in combination with bolus IFL (irinotecan, 5-fluorouracil, leucovorin) as first-line therapy in subjects with metastatic CRC
    • (Abstract 3646)
    • HURWITZ H, FEHRENBACHER L, CARTWRIGHT T et al.: Bevacizumab (a monoclonal antibody to vascular endothelial growth factor) prolongs survival in first-line colorectal cancer (CRC): Results of a Phase III trial of bevacizumab in combination with bolus IFL (irinotecan, 5-fluorouracil, leucovorin) as first-line therapy in subjects with metastatic CRC. Proc. Am. Soc. Clin. Onc. (2003) 22 (Abstract 3646).
    • (2003) Proc. Am. Soc. Clin. Onc. , vol.22
    • Hurwitz, H.1    Fehrenbacher, L.2    Cartwright, T.3
  • 40
    • 0042344925 scopus 로고    scopus 로고
    • Angiogenesis. A boost for tumor starvation
    • MARX J: Angiogenesis. A boost for tumor starvation. Science (2003) 301:452-454.
    • (2003) Science , vol.301 , pp. 452-454
    • Marx, J.1
  • 41
    • 0035869407 scopus 로고    scopus 로고
    • Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2
    • SLAMON DJ, LEYLAND-JONES B, SHAK S et al.: Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N. Engl. J Med. (2001) 344:783-792.
    • (2001) N. Engl. J Med. , vol.344 , pp. 783-792
    • Slamon, D.J.1    Leyland-Jones, B.2    Shak, S.3
  • 42
    • 0034114769 scopus 로고    scopus 로고
    • Blockade of receptors for growth factors: An anticancer therapy - The fourth annual Joseph H Burchenal American Association of Cancer Research Clinical Research Award Lecture
    • MENDELSON J: Blockade of receptors for growth factors: an anticancer therapy - the fourth annual Joseph H Burchenal American Association of Cancer Research Clinical Research Award Lecture. Clin. Cancer Res. (2000) 6:747-753.
    • (2000) Clin. Cancer Res. , vol.6 , pp. 747-753
    • Mendelson, J.1
  • 43
    • 0022501030 scopus 로고
    • Transforming growth factor-alpha: A more potent angiogenic mediator than epidermal growth factor
    • 1232
    • SCHREIBER AB, WINKLER ME, DERYNCK R: Transforming growth factor-alpha: a more potent angiogenic mediator than epidermal growth factor. Science (1986) 232:1250-1253.
    • (1986) Science , pp. 1250-1253
    • Schreiber, A.B.1    Winkler, M.E.2    Derynck, R.3
  • 44
    • 84920241849 scopus 로고
    • Epidermal-growth-factor receptors in human bladder cancer: Comparison of invasive and superficial tumours
    • NEAL DE, MARSH C, BENNETT MK et al.: Epidermal-growth-factor receptors in human bladder cancer: comparison of invasive and superficial tumours. Lancet (1985) 1:366-368.
    • (1985) Lancet , vol.1 , pp. 366-368
    • Neal, D.E.1    Marsh, C.2    Bennett, M.K.3
  • 45
    • 0035447953 scopus 로고    scopus 로고
    • Epidermal growth factor receptor immunohistochemical reactivity in patients with American Joint Committee on Cancer Stage IV Colon Adenocarcinoma: Implications for a standardized scoring system
    • GOLDSTEIN NS, ARMIN M: Epidermal growth factor receptor immunohistochemical reactivity in patients with American Joint Committee on Cancer Stage IV Colon Adenocarcinoma: implications for a standardized scoring system. Cancer (2001) 92:1331-1346.
    • (2001) Cancer , vol.92 , pp. 1331-1346
    • Goldstein, N.S.1    Armin, M.2
  • 46
    • 0025052403 scopus 로고
    • Epidermal growth factor regulates the in vitro sensitivity of human ovarian carcinoma cells to cisplatin
    • CHRISTEN RD, HOM DK, PORTER DC et al.: Epidermal growth factor regulates the in vitro sensitivity of human ovarian carcinoma cells to cisplatin. J. Clin. Invest. (1990) 86:1632-1640.
    • (1990) J. Clin. Invest. , vol.86 , pp. 1632-1640
    • Christen, R.D.1    Hom, D.K.2    Porter, D.C.3
  • 47
    • 0027428571 scopus 로고
    • Antitumor effect of anti-epidermal growth factor receptor monoclonal antibodies plus cis-diamminedichloroplatinum on well established A431 cell xenografts
    • FAN Z, BASELGA J, MASUI H, MENDELSOHN J: Antitumor effect of anti-epidermal growth factor receptor monoclonal antibodies plus cis-diamminedichloroplatinum on well established A431 cell xenografts. Cancer Res. (1993) 53:4637-4642.
    • (1993) Cancer Res. , vol.53 , pp. 4637-4642
    • Fan, Z.1    Baselga, J.2    Masui, H.3    Mendelsohn, J.4
  • 48
    • 0028223853 scopus 로고
    • Epidermal growth factor modifies cell cycle control in A431 human squamous carcinoma cells damaged by ionizing radiation
    • LADEROUTE KR, AUSSERER WA, KNAPP AM, GRANT TD, SUTHERLAND RM: Epidermal growth factor modifies cell cycle control in A431 human squamous carcinoma cells damaged by ionizing radiation. Cancer Res. (1994) 54:1407-1411.
    • (1994) Cancer Res. , vol.54 , pp. 1407-1411
    • Laderoute, K.R.1    Ausserer, W.A.2    Knapp, A.M.3    Grant, T.D.4    Sutherland, R.M.5
  • 49
    • 0027929971 scopus 로고
    • Effect of epidermal growth factor on the growth and radiation sensitivity of human breast cancer cells in vitro
    • WOLLMAN R, YAHALOM J, MAXY R, PINTO J, FUKS Z: Effect of epidermal growth factor on the growth and radiation sensitivity of human breast cancer cells in vitro. Int. J. Radiat. Oncol. Biol. Phys. (1994) 30:91-98.
    • (1994) Int. J. Radiat. Oncol. Biol. Phys. , vol.30 , pp. 91-98
    • Wollman, R.1    Yahalom, J.2    Maxy, R.3    Pinto, J.4    Fuks, Z.5
  • 50
    • 0033499814 scopus 로고    scopus 로고
    • Role of an anti-epidermal growth factor receptor in treating cancer
    • WAKSAL HW. Role of an anti-epidermal growth factor receptor in treating cancer. Cancer Metastasis Rev. (1999) 18:427-436.
    • (1999) Cancer Metastasis Rev. , vol.18 , pp. 427-436
    • Waksal, H.W.1
  • 51
    • 0002823211 scopus 로고    scopus 로고
    • Cetuximab (IMC-C225) Plus Irinotecan (CPT-11) is Active in CPT-11-Refractory Colorectal Cancer (CRC) that Expresses Epidermal Growth Factor Receptor (EGFR)
    • (Abstract 7)
    • SALTZ L, RUBIN M, HOCHSTER H et al.: Cetuximab (IMC-C225) Plus Irinotecan (CPT-11) is Active in CPT-11-Refractory Colorectal Cancer (CRC) that Expresses Epidermal Growth Factor Receptor (EGFR). Proc. Am. Soc. Clin. Onc. (2001) 20 (Abstract 7).
    • (2001) Proc. Am. Soc. Clin. Onc. , vol.20
    • Saltz, L.1    Rubin, M.2    Hochster, H.3
  • 52
    • 0037862765 scopus 로고    scopus 로고
    • Cetuximab (C225) alone or in combination with irinotecan (CPT-11) in patients with epidermal growth factor receptor (EGFR)-positive, irinotecan-refractory metastatic colorectal cancer (MCRC)
    • (Abstract 1012)
    • CUNNINGHAM D, HUMBLET Y, SIENA S et al.: Cetuximab (C225) alone or in combination with irinotecan (CPT-11) in patients with epidermal growth factor receptor (EGFR)-positive, irinotecan-refractory metastatic colorectal cancer (MCRC). Proc. Am. Soc. Clin. Onc. (2003) 22 (Abstract 1012).
    • (2003) Proc. Am. Soc. Clin. Onc. , vol.22
    • Cunningham, D.1    Humblet, Y.2    Siena, S.3
  • 53
    • 0344773402 scopus 로고    scopus 로고
    • The presence and intensity of the cetuximab-induced acne-like rash predicts increased survival in studies across multiple malignancies
    • (Abstract 817)
    • SALTZ L, KIES M, ABBRUZZESE JL, AZARNIA N, NEEDLE M: The presence and intensity of the cetuximab-induced acne-like rash predicts increased survival in studies across multiple malignancies. Proc. Am. Soc. Clin. Onc. (2003) 22 (Abstract 817).
    • (2003) Proc. Am. Soc. Clin. Onc. , vol.22
    • Saltz, L.1    Kies, M.2    Abbruzzese, J.L.3    Azarnia, N.4    Needle, M.5
  • 54
    • 0035117355 scopus 로고    scopus 로고
    • Development of ABX-EGF, a fully human anti-EGF receptor monoclonal antibody, for cancer therapy
    • YANG XD, JIA XC, CORVALAN JR, WANG P, DAVIS CG: Development of ABX-EGF, a fully human anti-EGF receptor monoclonal antibody, for cancer therapy. Crit. Rev Oncol. Hematol. (2001) 38:17-23.
    • (2001) Crit. Rev Oncol. Hematol. , vol.38 , pp. 17-23
    • Yang, X.D.1    Jia, X.C.2    Corvalan, J.R.3    Wang, P.4    Davis, C.G.5
  • 55
    • 0347615106 scopus 로고    scopus 로고
    • A Phase I PK and serial tumor and skin pharmacodynamic (PD) study of weekly (q1w), every 2-week (q2w) or every 3-week (q3w) 1-hour (h) infusion EMD72000, a humanized monoclonal anti-epidermal growth factor receptor (EGFR) antibody, in patients (pt) with advanced tumors
    • (Abstract 770)
    • TABERNERO J, ROJO F, JIMENE E et al.: A Phase I PK and serial tumor and skin pharmacodynamic (PD) study of weekly (q1w), every 2-week (q2w) or every 3-week (q3w) 1-hour (h) infusion EMD72000, a humanized monoclonal anti-epidermal growth factor receptor (EGFR) antibody, in patients (pt) with advanced tumors. Proc. Am. Soc. Clin. Onc. (2003) 22 (Abstract 770).
    • (2003) Proc. Am. Soc. Clin. Onc. , vol.22
    • Tabernero, J.1    Rojo, F.2    Jimene, E.3
  • 56
    • 0012381722 scopus 로고    scopus 로고
    • Multi-institutional randomized Phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer
    • FUKUOKA M, YANO S, GIACCONE G et al.: Multi-institutional randomized Phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer. J. Clin. Oncol. (2003) 21:2237-2246.
    • (2003) J. Clin. Oncol. , vol.21 , pp. 2237-2246
    • Fukuoka, M.1    Yano, S.2    Giaccone, G.3
  • 57
    • 0036842170 scopus 로고    scopus 로고
    • Phase I safety, pharmacokinetic, and pharmacodynamic trial of ZD1839, a selective oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with five selected solid tumor types
    • BASELGA J, RISCHIN D, RANSON M et al.: Phase I safety, pharmacokinetic, and pharmacodynamic trial of ZD1839, a selective oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with five selected solid tumor types. J. Clin. Oncol. (2002) 20:4292-4302.
    • (2002) J. Clin. Oncol. , vol.20 , pp. 4292-4302
    • Baselga, J.1    Rischin, D.2    Ranson, M.3
  • 58
    • 0345636045 scopus 로고    scopus 로고
    • Phase II study of erlotinib (OSI-774) in patients with metastatic colorectal cancer
    • (Abstract 785)
    • OZA AM, TOWNSLEY LL, SIUP, MAJOR D: Phase II study of erlotinib (OSI-774) in patients with metastatic colorectal cancer. Proc. Am. Soc. Clin. Onc. (2003) 22 (Abstract 785).
    • (2003) Proc. Am. Soc. Clin. Onc. , vol.22
    • Oza, A.M.1    Townsley, L.L.2    Siup, A.3    Major, D.4
  • 59
    • 0344341539 scopus 로고    scopus 로고
    • Safety, clinical efficacy, and biologic assessments from EGF 10004: A randomized Phase IB study of GW572016 for patients with metastatic carcinomas overexpressing EGFR or erbB2
    • (Abstract 772)
    • SPECTOR N, RAEFSKY E, HURWITZ H et al.: Safety, clinical efficacy, and biologic assessments from EGF 10004: A randomized Phase IB study of GW572016 for patients with metastatic carcinomas overexpressing EGFR or erbB2. Proc. Am. Soc. Clin. Onc. (2003) 22 (Abstract 772).
    • (2003) Proc. Am. Soc. Clin. Onc. , vol.22
    • Spector, N.1    Raefsky, E.2    Hurwitz, H.3
  • 60
    • 0347955437 scopus 로고    scopus 로고
    • A Phase II, open-label, multicenter study of GW572016 in patients with metastatic colorectal cancer refractory to 5-FU5-FU in combination with irinotecan and/or oxaliplatin
    • (Abstract 978)
    • BELANGER M, JONES CM, GERMOND C, BERGER MS: A Phase II, open-label, multicenter study of GW572016 in patients with metastatic colorectal cancer refractory to 5-FU5-FU in combination with irinotecan and/or oxaliplatin. Proc. Am. Soc. Clin. Onc. (2003) 22 (Abstract 978).
    • (2003) Proc. Am. Soc. Clin. Onc. , vol.22
    • Belanger, M.1    Jones, C.M.2    Germond, C.3    Berger, M.S.4
  • 62
    • 0346063884 scopus 로고    scopus 로고
    • A Phase II study of an oral MEK inhibitor, CI-1040, in patients with advanced nonsmall-cell lung, breast, colon, or pancreatic cancer
    • (Abstract 816)
    • WATERHOUSE DM, RINEHART J, ADJEI AA et al.: A Phase II study of an oral MEK inhibitor, CI-1040, in patients with advanced nonsmall-cell lung, breast, colon, or pancreatic cancer. Proc. Am. Soc. Clin. Onc. (2003) 22 (Abstract 816).
    • (2003) Proc. Am. Soc. Clin. Onc. , vol.22
    • Waterhouse, D.M.1    Rinehart, J.2    Adjei, A.A.3
  • 63
    • 0347955438 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo controlled Phase III study of monoclonal antibody 3H1 plus 5-fluorouracil (5-FU)/leucovorin (LV) in stage IV colorectal carcinoma
    • (Abstract 1041)
    • BHATNAGAR A, CARMICHAEL J, COSGRIFF T et al.: A randomized, double-blind, placebo controlled Phase III study of monoclonal antibody 3H1 plus 5-fluorouracil (5-FU)/leucovorin (LV) in stage IV colorectal carcinoma. Proc. Am. Soc. Clin. Onc. (2003) 22 (Abstract 1041).
    • (2003) Proc. Am. Soc. Clin. Onc. , vol.22
    • Bhatnagar, A.1    Carmichael, J.2    Cosgriff, T.3
  • 64
    • 0032905030 scopus 로고    scopus 로고
    • Control of inducible chemoresistance: Enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-kappaB
    • WANG CY, CUSACK JC Jr., LIU R, BALDWIN AS Jr: Control of inducible chemoresistance: enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-kappaB. Nat.. Med. (1999) 5:412-417.
    • (1999) Nat. Med. , vol.5 , pp. 412-417
    • Wang, C.Y.1    Cusack Jr., J.C.2    Liu, R.3    Baldwin Jr., A.S.4
  • 65
    • 0035328584 scopus 로고    scopus 로고
    • Enhanced chemosensitivity to CPT-11 with proteasome inhibitor PS-341: Implications for systemic nuclear factor-kappaB inhibition
    • CUSACK JC Jr, LIU R, HOUSTON M et al.: Enhanced chemosensitivity to CPT-11 with proteasome inhibitor PS-341: implications for systemic nuclear factor-kappaB inhibition. Cancer Res. (2001) 61:3535-3540.
    • (2001) Cancer Res. , vol.61 , pp. 3535-3540
    • Cusack Jr., J.C.1    Liu, R.2    Houston, M.3
  • 66
    • 0042019045 scopus 로고    scopus 로고
    • Phase I dose-escalation and pharmacokinetic (PK) study of the VEGF inhibitor PTK787/ZK 222584 (PTK/ZK) in patients with liver metastases
    • Abstract 1142)
    • DREVS J, MROSS K, MEDINGE M et al.: Phase I dose-escalation and pharmacokinetic (PK) study of the VEGF inhibitor PTK787/ZK 222584 (PTK/ZK) in patients with liver metastases. Proc. Am. Soc. Clin. Onc. (2003) 22 Abstract 1142).
    • (2003) Proc. Am. Soc. Clin. Onc. , vol.22
    • Drevs, J.1    Mross, K.2    Medinge, M.3
  • 67
    • 0346796282 scopus 로고    scopus 로고
    • Extended Phase I study of the oral vascular endothelial growth factor (VEGF) receptor inhibitor PTK787/ZK 222584 in combination with oxaliplatin/5-fluorouracil (5-FU)/leucovorin as first line treatment for metastatic colorectal cancer
    • (Abstract 1098)
    • STEWARD WP, THOMAS AL, MORGAN B et al.: Extended Phase I study of the oral vascular endothelial growth factor (VEGF) receptor inhibitor PTK787/ZK 222584 in combination with oxaliplatin/5-fluorouracil (5-FU)/leucovorin as first line treatment for metastatic colorectal cancer. Proc. Am. Soc. Clin. Onc. (2003) 22 (Abstract 1098).
    • (2003) Proc. Am. Soc. Clin. Onc. , vol.22
    • Steward, W.P.1    Thomas, A.L.2    Morgan, B.3
  • 68
    • 0042519908 scopus 로고    scopus 로고
    • Phase I study of the oral vascular endothelial growth factor (VEGF) receptor inhibitor PTK787/ZK 222584 (PTK/ZK) in combination with irinotecan/5-fluorouracil/leucovorin in patients with metastatic colorectal cancer
    • (Abstract 1144)
    • TRARBACH T, SCHLEUCHER N, RIEDEL U et al.: Phase I study of the oral vascular endothelial growth factor (VEGF) receptor inhibitor PTK787/ZK 222584 (PTK/ZK) in combination with irinotecan/5-fluorouracil/leucovorin in patients with metastatic colorectal cancer. Proc. Am. Soc. Clin. Onc. (2003) 22 (Abstract 1144).
    • (2003) Proc. Am. Soc. Clin. Onc. , vol.22
    • Trarbach, T.1    Schleucher, N.2    Riedel, U.3
  • 69
    • 0037268322 scopus 로고    scopus 로고
    • A targeted approach for antiangiogenic therapy of metastatic human colon cancer
    • ELLIS LM: A targeted approach for antiangiogenic therapy of metastatic human colon cancer. Am. Surg. (2003) 69:3-10.
    • (2003) Am. Surg. , vol.69 , pp. 3-10
    • Ellis, L.M.1
  • 70
    • 0038476608 scopus 로고    scopus 로고
    • Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors
    • BERGERS G, SONG S, MEYER-MORSE N, BERGSLAND E, HANAHAN D: Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors. J. Clin. Invest. (2003) 111:1287-1295.
    • (2003) J. Clin. Invest. , vol.111 , pp. 1287-1295
    • Bergers, G.1    Song, S.2    Meyer-Morse, N.3    Bergsland, E.4    Hanahan, D.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.