Phosphorylation and Mutation of Human Cardiac Troponin I Deferentially Destabilize the Interaction of the Functional Regions of Troponin I with Troponin C

Biochemistry

Volumn 42, Issue 49, 2003, Pages 14460-14468

  Li, Monica X ^a   Wang, Xu ^a   Lindhout, Darrin A ^a   Buscemi, Nina ^b   Van Eyk, Jennifer E ^b   Sykes, Brian D ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b QUEEN S UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CARDIOLOGY; CHEMICAL BONDS; MUSCLE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PATHOLOGY; PHYSIOLOGY; PROTEINS; REDUCTION;

FAMILIAL HYPERTROPIC CARDIOMYOPATHY (FHC);

BIOCHEMISTRY;

MUTANT PROTEIN; PHOSPHOTRANSFERASE; PROTEIN KINASE C; PROTEIN P21; TROPONIN C; TROPONIN I;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; BINDING ASSAY; CONFORMATIONAL TRANSITION; CORRELATION ANALYSIS; ENZYME PHOSPHORYLATION; FAMILIAL HYPERTROPHIC CARDIOMYOPATHY; GENE MUTATION; HEART CONTRACTION; HUMAN; MYOFILAMENT; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN STRUCTURE; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ANALYSIS;

AMINO ACID SEQUENCE; ARGININE; CALCIUM; CARDIOMYOPATHY, HYPERTROPHIC, FAMILIAL; GLYCINE; HUMANS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MYOCARDIUM; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PEPTIDE FRAGMENTS; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SERINE; THREONINE; TROPONIN C; TROPONIN I; TRYPTOPHAN;

EID: 0347481142     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi035408y     Document Type: Article

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