Isolation of Two Triterpenoids and a Biflavanone with Anti-Inflammatory Activity from Schinus molle Fruits

Planta Medica

Volumn 69, Issue 10, 2003, Pages 893-898

  Yueqin, Zeng ^a   Recio, M Carmen ^a   Máñez, Salvador ^a   Giner, Rosa M ^a   Cerda Nicolas M ^a   Rios, José Luis ^a  

^a UNIVERSITY OF VALENCIA   (Spain)

Author keywords

Anacardiaceae; Anti inflammatory activity; Biflavanone; Chamaejasmin; Leukotriene B4; Phospholipase A2; Schinus molle; Triterpenoids

Indexed keywords

3 EPIISOMASTICADIENOLALIC ACID; ANTIINFLAMMATORY AGENT; BIFLAVANONE; CARRAGEENAN; CHAMAEJASMIN; ISOMASTICADIENOLALIC ACID; MYELOPEROXIDASE; PHORBOL 13 ACETATE 12 MYRISTATE; PHOSPHOLIPASE A2; SCHINUS MOLLE EXTRACT; TRITERPENOID; UNCLASSIFIED DRUG;

ANACARDIACEAE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL INFILTRATION; CHRONIC INFLAMMATION; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG IDENTIFICATION; DRUG ISOLATION; DRUG STRUCTURE; ECZEMA; ENZYME ACTIVITY; FEMALE; FRUIT; IC 50; MEDIATOR RELEASE; MOUSE; NEUTROPHIL; NONHUMAN; PERITONEUM CELL; SCHINUS MOLLE; STRUCTURE ACTIVITY RELATION;

ANACARDIACEAE; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CARRAGEENAN; EDEMA; FEMALE; FLAVONOIDS; FRUIT; INHIBITORY CONCENTRATION 50; MICE; NEUTROPHILS; PHOSPHOLIPASES A; PHYTOTHERAPY; PLANT EXTRACTS; TETRADECANOYLPHORBOL ACETATE; TRITERPENES;

ANACARDIACEAE; ANIMALIA; SCHINUS MOLLE;

EID: 0347477307     PISSN: 00320943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2003-45096     Document Type: Article

References (24)

1. Duke J. CRC Handbook of Medicinal Herbs. CRC Press, Boca Raton: 1985: p. 434
2. Bello R, Barrachina MD, Moreno L, Primo-Yúfera E, Esplugues J. Effects on arterial blood pressure of the methanol and dichloromethanol extracts from Schinus molle L. in rats. Phytother Res 1996; 10: 634-5
3. Barrachina MD, Bello R, Martínez-Cuesta MA, Primo-Yúfera E, Esplugues J. Analgesic and central depressor effects of the dichloromethanol extract from Schinus molle L. Phytother Res 1997; 11: 317-9
4. Bello R, Beltrán B, Moreno L, Calatayud S, Primo-Yúfera E, Esplugues J. In vitro pharmacological evaluation of the dichloromethanol extract from Schinus molle L. Phytother Res 1998; 12: 523-5
5. Pozzo-Balbi T, Nobile L, Scapini G, Cini M. The triterpenoid acids of Schinus molle. Phytochemistry 1978; 17: 2107-10
6. Olafsson K, Jaroszewski JW, Smitt UW, Nyman U. Isolation of angiotensin converting enzyme (ACE) inhibiting triterpenes from Schinus molle. Planta Med 1997; 63: 352-5
7. Giner-Larza EM, Máñez S, Recio MC, Giner RM, Ríos JL. A review on the pharmacology of lanostanes and related tetracyclic triterpenes. Res Adv Phytochem 2000; 1: 65-82
8. Niwa M, Otsuji S, Tatematsu H, Liu G-Q, Chen X-F, Hirata Y. Stereo-structures of two biflavanones from Stellera chamaejasme L. Chem Pharm Bull 1986; 34: 3249-51
9. 2-induced oedema in rat paw. Eur J Pharmacol 1989; 166: 505-10
10. Giner-Larza EM, Máñez S, Recio MC, Giner RM, Prieto JM, Cerdá-Nicolás M, Ríos JL. Oleanonic acid, a 3-oxotriterpene from Pistacia, inhibits leukotriene synthesis and has anti-inflammatory activity. Eur J Pharmacol 2001; 428: 137-43
11. Sugishita E, Amagaya S, Ogihara Y. Anti-inflammatory testing methods: comparative evaluation of mice and rats. J Pharm Dyn 1981; 4: 565-75
12. Giner RM, Villalba ML, Recio MC, Máñez S, Cerdá-Nicolás M, Ríos JL. Anti-inflammatory glycoterpenoids from Scrophularia auriculata. Eur J Pharmacol 2001; 389: 243-52
13. Stanley PL, Steiner S, Havens M, Tramposch KM. Mouse skin inflammation induced by multiple topical applications of 12-0-tetradecanoylphorbol 13-acetate. Skin Pharmacol 1991; 4: 262-71
14. Prieto JM, Giner RM, Recio MC, Schinella G, Máñez S, Ríos JL. Diphyllin acetylapioside, a 5-lipoxygenase inhibitor from Haplophyllum hispanicum. Planta Med 2002; 68: 359-60
15. 2 inhibitors. J Nat Prod 1996; 59: 977-9
16. Giner-Larza EM, Máñez S, Recio MC, Giner RM, Cerdá-Nicolás M, Ríos JL. In vivo studies on the anti-inflammatory activity of pachymic and dehydrotumulosic acids. Planta Med 2000; 66: 221-7
17. Giner-Larza EM, Máñez S, Giner RM, Recio MC, Prieto JM, Cerdá-Nicolás M, Ríos JL. Anti-inflammatory triterpenes from Pistacia terebinthus galls. Planta Med 2002; 68: 311-5
18. 2 from berries of Schinus terebinthifolius. Phytochemistry 1995; 39: 537-47
19. Kim HK, Son KH, Chang HW, Kang SS, Kim HP. Amentoflavone, a plant biflavone: a new potential anti-inflammatory agent. Arch Pharm Res 1998; 21: 406-10
20. Kim HP, Mani I, Iversen L, Ziboh VA. Effects of naturally occurring flavonoids and biflavonoids on epidermal cyclooxygenase and lipoxygenase from guinea-pigs. Prostagl Leukotr Essential Fatty Acids 1998; 58: 17-24
21. Kim HK, Son KH, Chang HW, Kang SS, Kim HP. Inhibition of rat adjuvant-induced arthritis by ginkgetin, a biflavone from Ginkgo biloba leaves. Planta Med; 1999; 65: 465-7
22. 2. Prostagl Leukotr Essential Fatty Acids 2001; 65: 281-6
23. 2 on TNF, iNOS, and COX-2 expression inactivated macrophages.Shock 1999; 12: 473-8
24. Kwak WJ, Han CK, Son KH, Chang SS, Kang SS, Park BK, Kim HP. Effects of ginkgetin from Ginkgo biloba leaves on cyclooxygenases and in vivo skin inflammation. Planta Med 2002; 68: 316-21