Preferential Mesenteric Fat Accumulation and Enhanced Portal Free Fatty Acid Delivery in a High-Carbohydrate Diet Fed Rats

Journal of Clinical Biochemistry and Nutrition

Volumn 33, Issue 2, 2003, Pages 53-59

  Shirai, Yoko ^a   Suzuki, Masashige ^a,b  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b WASEDA UNIVERSITY   (Japan)

Author keywords

Dietary carbohydrate; Lipogenesis; Mesenteric fat; Portal free fatty acid

Indexed keywords

FATTY ACID; GLUCOSE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; UNCOUPLING PROTEIN 2;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY FAT; CARBOHYDRATE DIET; CONTROLLED STUDY; GENE EXPRESSION; GLUCOSE INTAKE; LIPID DIET; MALE; MESENTERIC VEIN; MESENTERY; METABOLIC DISORDER; NONHUMAN; OBESITY; RAT;

ANIMALIA;

EID: 0347419155     PISSN: 09120009     EISSN: None     Source Type: Journal    
DOI: 10.3164/jcbn.33.53     Document Type: Article

References (35)

1. Wajchenberg, B.L.: Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome. Endocr. Rev., 21, 697-738, 2000.
2. Bragg, L.E., Thompson, J.S., and Rikkers, L.F.: Influence of nutrient delivery on gut structure and function. Nutrition, 7, 237-243, 1991.
3. Tansy, M.F. and Kendall, F.M.: Gastrointestinal hormones and the quantitation of spontaneous duodenal motor activity. Toxicol. Pathol., 16, 118-122, 1998.
4. Dowling, R.H.: Cellular and molecular basis of intestinal and pancreatic adaptation. Scand. J. Gastroenterol., 193, Suppl., 64-67, 1992.
5. Miyawaki, K., Yamada, Y., Ban, N., Ihara, Y., Tsukiyama, K., Zhou, H., Fujimoto, S., Oku, A., Tsuda, K., Toyokuni, S., Hiai, H., Mizunoya, W., Fushiki, T., Holst, J.J., Makino, M., Tashita, A., Kobara, Y., Tsubamoto, Y., Jinnouchi, T., Jomori, T., and Seino, Y.: Inhibition of gastric inhibitory polypeptide signalling prevents obesity. Nat. Med., 8, 738-742, 2002.
6. Keno, Y., Matsuzawa, Y., Tokunaga, K., Fujioka, S., Kawamoto, T., Kobatake, T., and Tarui, S.: High sucrose diet increases visceral fat accumulation in VMH-lesioned obese rats. Int. J. Obes., 15, 205-211, 1991.
7. West, D.B., Prinz, W.A., and Greenwood, M.R.: Regional changes in adipose tissue blood flow and metabolism in rats after a meal. Am. J. Physiol., 257, R711-716, 1989.
8. Comuzzie, A.G. and Allison, D.B.: The search for human obesity genes. Science, 280, 1374-1377, 1998.
9. Arner, P.: Obesity - a genetic disease of adipose tissue? Br. J. Nutr., 83, Suppl., 1, S9-16, 2000.
10. Auwerx, J., Martin, G., Guerre-Millo, M., and Staels, B.: Transcription, adipocyte differentiation, and obesity. J. Mol. Med., 74, 347-352, 1996.
11. Barsh, G.S., Farooqi, I.S., and O'Rahilly, S.: Genetics of body-weight regulation. Nature, 404, 644-651, 2000.
12. Tontonoz, P., Hu, E., Graves, R.A., Budavari, A.I., and Spiegelman, B.M.: mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer. Genes. Dev., 8, 1224-1234, 1994.
13. Chawla, A., Schwarz, E.T., Dimaculangan, D.D., and Lazar, M.A.: Peroxisome proliferator-activated receptor (PPAR) γ: adipose-predominant expression and induction early in adipocyte differentiation. Endocrinology, 135, 798-800, 1994.
14. Folch, J., Lees, M., and Sloane-Stanley, G.H.: A simple method for the isolation and purification of total lipids from animal tissues. J. Biol. Chem., 226, 497-509, 1957.
15. Romieu, I., Willett, W.C., Stampfer, M.J., Colditz, G.A., Sampson, L., Rosner, B., Hennekens, C.H., and Speizer, F.E.: Energy intake and other determinants of relative weight. Am. J. Clin. Nutr., 47, 406-412, 1988.
16. Dreon, D.M., Frey-Hewitt, B., Ellsworth, N., Williams, P.T., Terry, R.B., and Wood, P.D.: Dietary fat: carbohydrate ratio and obesity in middle-aged men. Am. J. Clin. Nutr., 47, 995-1000, 1988.
17. Klesges, R.C., Klesges, L.M., Haddock, C.K., and Eck, L.H.: A longitudinal analysis of the impact of dietary intake and physical activity on weight change in adults. Am. J. Clin. Nutr., 55, 818-822, 1992.
18. Björntorp, P. and Brodoff, B.N.: Resional obesity, in Obesity, ed. by Björntorp, P., J. B. Lippincott Company, Philadelphia, pp. 579-586, 1992.
19. Björntorp, P.: "Portal" adipose tissue as a generator of risk factors for cardiovascular disease and diabetes. Artheriosclerosis, 10, 493-496, 1990.
20. Kersten, S., Desvergne, B., and Wahli, W.: Roles of PPARs in health and disease. Nature, 405, 421-424, 2000.
21. Schoonjans, K., Staels, B., and Auwerx, J.: Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression. J. Lipid Res., 37, 907-925, 1996.
22. Nisoli, E., Carruba, M.O., Tonello, C., Macor, C., Federspil, G., and Vettor, R.: Induction of fatty acid translocase/CD36, peroxisome proliferator-activated receptor-γ 2, leptin, uncoupling proteins 2 and 3, and tumor necrosis factor-α gene expression in human subcutaneous fat by lipid infusion. Diabetes, 49, 319-324, 2000.
23. Camirand, A., Marie, V., Rabelo, R., and Silva, J.E.: Thiazolidinediones stimulate uncoupling protein-2 expression in cell lines representing white and brown adipose tissues and skeletal muscle. Endocrinology, 139, 428-431, 1998.
24. Viguerie-Bascands, N., Saulnier-Blanche, J.S., Dandine, M., Dauzats, M., Daviaud, D., and Langin, D.: Increase in uncoupling protein-2 mRNA expression by BRL49653 and bromopalmitate in human adipocytes. Biochem. Biophys. Res. Commun., 256, 138-141, 1999.
25. Aubert, J., Champigny, O., Saint-Marc, P., Negrel, R., Collins, S., Ricquier, D., and Ailhaud, G.: Up-regulation of UCP-2 gene expression by PPAR agonists in preadipose and adipose cells. Biochem. Biophys. Res. Commun., 238, 606-611, 1997.
26. Tchkonia, T., Giorgadze, N., Pirtskhalava, T., Tchoukalova, Y., Karagiannides, L., Forse, R.A., DePonte, M., Stevenson, M., Guo, W., Han, J., Waloga, G., Lash, T.L., Jensen, M.D., and Kirkland, J.L.: Fat depot origin affects adipogenesis in primary cultured and cloned human preadipocytes. Am. J. Physiol., 282, R1286-1296, 2002.
27. Caserta, F., Tchkonia, T., Civelek, V.N., Prentki, M., Brown, N.F., McGarry, J.D., Forse, R.A., Corkey, B.E., Hamilton, J.A., and Kirkland, J.L.: Fat depot origin affects fatty acid handling in cultured rat and human preadipocytes. Am. J. Physiol., 280, E238-247, 2001.
28. Rousseau, V., Becker, D.J., Ongemba, L.N., Rahier, J., Henquin, J.C., and Brichard, S.M.: Developmental and nutritional changes of ob and PPAR γ 2 gene expression in rat white adipose tissue. Biochem. J., 321, 451-456, 1997.
29. Shimomura, I., Tokunaga, K., Kotani, K., Keno, Y., Yanase-Fujiwara, M., Kanosue, K., Jiao, S., Funahashi, T., Kobatake, T., Yamamoto, T., and Matsuzawa, Y.: Marked reduction of acyl-CoA synthetase activity and mRNA in intra-abdominal visceral fat by physical exercise. Am. J. Physiol., 265, E44-50, 1993.
30. Matsuzawa, Y., Shimomura, I., Nakamura, T., Keno, Y., and Tokunaga, K.: Pathophysiology and pathogenesis of visceral fat obesity. Ann. N. Y. Acad. Sci. USA, 676, 270-278, 1993.
31. Rebuffe-Scrive, M. and Björntorp, P.: Resional adipose tissue metabolism in man, in Metabolic Complications of Human Obesities, ed. by Vague, J., Elsevier Science Publishers, Amsterdam, pp. 149-159, 1985.
32. Schwartz, J.H., Young, J.B., and Landsberg, L.: Effect of dietary fat on sympathetic nervous system activity in the rat. J. Clin. Invest., 72, 361-370, 1983.
33. Rappaport, E.B., Young, J.B., and Landsberg, L.: Effects of 2-deoxy-D-glucose on the cardiac sympathetic nerves and the adrenal medulla in the rat: further evidence for a dissociation of sympathetic nervous system and adrenal medullary responses. Endocrinology, 110, 650-656, 1982.
34. Van Harmelen, V., Lonnqvist, F., Therne, A., Wennlund, A., Large, V., Reynisdottir, S., and Arner, P.: Noradrenaline-induced lipolysis in isolated mesenteric, omental and subcutaneous adipocytes from obese subjects. Int. J. Obes. Relat. Metab. Disord., 21, 972-979, 1997.
35. Kakinuma, Y., Miyauchi, T., Kobayashi, T., Yuk, K., Maeda, S., Sakai, S., Goto, K., and Yamaguchi, I.: Myocardial expression of endothelin-2 is altered reciprocally to that of endothelin-1 during ischemia of cardiomyocytes in vitro during heart failure in vivo. Life Sci., 65, 1671-1683, 1999.